DE69433120T2 - Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen - Google Patents
Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen Download PDFInfo
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- DE69433120T2 DE69433120T2 DE69433120T DE69433120T DE69433120T2 DE 69433120 T2 DE69433120 T2 DE 69433120T2 DE 69433120 T DE69433120 T DE 69433120T DE 69433120 T DE69433120 T DE 69433120T DE 69433120 T2 DE69433120 T2 DE 69433120T2
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- cultivation
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- taxane
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- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 description 1
- 241001116495 Taxaceae Species 0.000 description 1
- 241001149649 Taxus wallichiana var. chinensis Species 0.000 description 1
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- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
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- TWALRKRJQBCJOW-UHFFFAOYSA-J azanide;cobalt(2+);tetranitrite Chemical compound [NH2-].[NH2-].[Co+2].[O-]N=O.[O-]N=O.[O-]N=O.[O-]N=O TWALRKRJQBCJOW-UHFFFAOYSA-J 0.000 description 1
- OVMSOCFBDVBLFW-JMIYRAKGSA-N baccatin v Chemical compound C1([C@@]2(CC(O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)C(O)C[C@H]3OC[C@]3(C21)OC(C)=O)=O)OC(=O)C)O)OC(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-JMIYRAKGSA-N 0.000 description 1
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- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
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- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
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- DBXFAPJCZABTDR-WBYYIXQISA-N cephalomannine Chemical compound O([C@@H]1[C@]2(O)C[C@@H](C(=C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@H]4OC[C@]4([C@H]31)OC(C)=O)C2(C)C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C(/C)=C/C)C=1C=CC=CC=1)C(=O)C1=CC=CC=C1 DBXFAPJCZABTDR-WBYYIXQISA-N 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940011182 cobalt acetate Drugs 0.000 description 1
- AVWLPUQJODERGA-UHFFFAOYSA-L cobalt(2+);diiodide Chemical compound [Co+2].[I-].[I-] AVWLPUQJODERGA-UHFFFAOYSA-L 0.000 description 1
- BSUSEPIPTZNHMN-UHFFFAOYSA-L cobalt(2+);diperchlorate Chemical compound [Co+2].[O-]Cl(=O)(=O)=O.[O-]Cl(=O)(=O)=O BSUSEPIPTZNHMN-UHFFFAOYSA-L 0.000 description 1
- INDBQWVYFLTCFF-UHFFFAOYSA-L cobalt(2+);dithiocyanate Chemical compound [Co+2].[S-]C#N.[S-]C#N INDBQWVYFLTCFF-UHFFFAOYSA-L 0.000 description 1
- PCCFDYRZIBCUHO-UHFFFAOYSA-L cobalt(2+);potassium;sulfate Chemical compound [K].[Co+2].[O-]S([O-])(=O)=O PCCFDYRZIBCUHO-UHFFFAOYSA-L 0.000 description 1
- ATORBMMJNYFMAK-UHFFFAOYSA-L cobalt(2+);selenate Chemical compound [Co+2].[O-][Se]([O-])(=O)=O ATORBMMJNYFMAK-UHFFFAOYSA-L 0.000 description 1
- FNSSFVZEEUSWJP-UHFFFAOYSA-K cobalt(3+);ethane-1,2-diamine;trichloride Chemical compound NCCN.Cl[Co](Cl)Cl FNSSFVZEEUSWJP-UHFFFAOYSA-K 0.000 description 1
- WBMVTRUQSMZIKW-UHFFFAOYSA-K cobalt(3+);ethane-1,2-diamine;trichloride;trihydrate Chemical compound O.O.O.[Cl-].[Cl-].[Cl-].[Co+3].NCCN.NCCN.NCCN WBMVTRUQSMZIKW-UHFFFAOYSA-K 0.000 description 1
- QAHREYKOYSIQPH-UHFFFAOYSA-L cobalt(II) acetate Chemical compound [Co+2].CC([O-])=O.CC([O-])=O QAHREYKOYSIQPH-UHFFFAOYSA-L 0.000 description 1
- BZRRQSJJPUGBAA-UHFFFAOYSA-L cobalt(ii) bromide Chemical compound Br[Co]Br BZRRQSJJPUGBAA-UHFFFAOYSA-L 0.000 description 1
- YCYBZKSMUPTWEE-UHFFFAOYSA-L cobalt(ii) fluoride Chemical compound F[Co]F YCYBZKSMUPTWEE-UHFFFAOYSA-L 0.000 description 1
- BTMQKQSSEQVSAS-UHFFFAOYSA-N cobalt;ethane-1,2-diamine Chemical compound [Co].NCCN BTMQKQSSEQVSAS-UHFFFAOYSA-N 0.000 description 1
- LOEIHGYNJPKGLG-UHFFFAOYSA-N cobalt;ethane-1,2-diamine Chemical compound [Co].NCCN.NCCN.NCCN LOEIHGYNJPKGLG-UHFFFAOYSA-N 0.000 description 1
- RKBAPHPQTADBIK-UHFFFAOYSA-N cobalt;hexacyanide Chemical compound [Co].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] RKBAPHPQTADBIK-UHFFFAOYSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- NISGSNTVMOOSJQ-UHFFFAOYSA-N cyclopentanamine Chemical compound NC1CCCC1 NISGSNTVMOOSJQ-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 150000004985 diamines Chemical class 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 150000004683 dihydrates Chemical class 0.000 description 1
- BTVWZWFKMIUSGS-UHFFFAOYSA-N dimethylethyleneglycol Natural products CC(C)(O)CO BTVWZWFKMIUSGS-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006345 epimerization reaction Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 125000003104 hexanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003898 horticulture Methods 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- GRHBQAYDJPGGLF-UHFFFAOYSA-N isothiocyanic acid Chemical compound N=C=S GRHBQAYDJPGGLF-UHFFFAOYSA-N 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
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- 238000005259 measurement Methods 0.000 description 1
- 239000012533 medium component Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 229960004011 methenamine Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001298 n-hexoxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 125000005385 peroxodisulfate group Chemical group 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000007363 regulatory process Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- SLUXPOIDTZWGCG-UHFFFAOYSA-N rhizobitoxine Natural products OCC(N)COC=CC(N)C(O)=O SLUXPOIDTZWGCG-UHFFFAOYSA-N 0.000 description 1
- 244000195895 saibo Species 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- CQLFBEKRDQMJLZ-UHFFFAOYSA-M silver acetate Chemical compound [Ag+].CC([O-])=O CQLFBEKRDQMJLZ-UHFFFAOYSA-M 0.000 description 1
- 229940071536 silver acetate Drugs 0.000 description 1
- SDLBJIZEEMKQKY-UHFFFAOYSA-M silver chlorate Chemical compound [Ag+].[O-]Cl(=O)=O SDLBJIZEEMKQKY-UHFFFAOYSA-M 0.000 description 1
- 229940100890 silver compound Drugs 0.000 description 1
- 150000003379 silver compounds Chemical class 0.000 description 1
- 229940096017 silver fluoride Drugs 0.000 description 1
- REYHXKZHIMGNSE-UHFFFAOYSA-M silver monofluoride Chemical compound [F-].[Ag+] REYHXKZHIMGNSE-UHFFFAOYSA-M 0.000 description 1
- 229910001494 silver tetrafluoroborate Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- FQCUWQFKTUBVLA-PGBLWRDZSA-N taxagifine Chemical compound O([C@H]1C[C@@H]([C@]2([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@]3(O)[C@@]4(C)CO[C@]3(C)C(=O)C[C@H]4[C@@H](OC(C)=O)[C@@H]2C1=C)C)OC(=O)C)C(=O)\C=C\C1=CC=CC=C1 FQCUWQFKTUBVLA-PGBLWRDZSA-N 0.000 description 1
- RRXYKLNOTDQWHQ-UHFFFAOYSA-N taxagifine Natural products CC(=O)OCC1CC(OC(=O)C=Cc2ccccc2)C(=C)C3C(OC(=O)C)C4CC(=O)C5(C)OCC4(C)C5(O)C(OC(=O)C)C(OC(=O)C)C13C RRXYKLNOTDQWHQ-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 229960001124 trientine Drugs 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/04—Plant cells or tissues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0025—Culture media for plant cell or plant tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP28489393A JP3488492B2 (ja) | 1993-11-15 | 1993-11-15 | タキサン型ジテルペン高産生培養細胞の取得方法 |
| JP28489393 | 1993-11-15 | ||
| JP3615694 | 1994-03-07 | ||
| JP3615694 | 1994-03-07 | ||
| JP6104211A JPH07308196A (ja) | 1994-05-18 | 1994-05-18 | タキサン型ジテルペンの製造方法 |
| JP10421394 | 1994-05-18 | ||
| JP10421394 | 1994-05-18 | ||
| JP10421294 | 1994-05-18 | ||
| JP6104212A JPH07308197A (ja) | 1994-05-18 | 1994-05-18 | タキサン型ジテルペンの製造方法 |
| JP10421194 | 1994-05-18 | ||
| JP14682694A JP3434892B2 (ja) | 1994-06-28 | 1994-06-28 | タキサン型ジテルペンの製造方法 |
| JP14682694 | 1994-06-28 | ||
| JP20115094 | 1994-08-25 | ||
| JP6201151A JPH0856681A (ja) | 1994-08-25 | 1994-08-25 | タキサン型ジテルペンの製造方法 |
| JP20115194 | 1994-08-25 | ||
| JP6201150A JPH0856680A (ja) | 1994-08-25 | 1994-08-25 | タキサン型ジテルペンの製造方法 |
| JP25252894 | 1994-10-18 | ||
| JP6252528A JPH08116981A (ja) | 1994-10-18 | 1994-10-18 | タキサン型ジテルペンの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69433120D1 DE69433120D1 (de) | 2003-10-09 |
| DE69433120T2 true DE69433120T2 (de) | 2004-07-01 |
Family
ID=27576895
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69433120T Expired - Lifetime DE69433120T2 (de) | 1993-11-15 | 1994-11-09 | Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen |
| DE69431135T Expired - Lifetime DE69431135T2 (de) | 1993-11-15 | 1994-11-09 | Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen |
| DE69426692T Expired - Lifetime DE69426692T2 (de) | 1993-11-15 | 1994-11-09 | Methode zur herstellung von taxan-diterpen und methode zum einten von kulturzellen, die taxan-diterpen in hohen ausbeuten herstellen |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69431135T Expired - Lifetime DE69431135T2 (de) | 1993-11-15 | 1994-11-09 | Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen |
| DE69426692T Expired - Lifetime DE69426692T2 (de) | 1993-11-15 | 1994-11-09 | Methode zur herstellung von taxan-diterpen und methode zum einten von kulturzellen, die taxan-diterpen in hohen ausbeuten herstellen |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US5637484A (en:Method) |
| EP (5) | EP1063299A3 (en:Method) |
| KR (1) | KR0172606B1 (en:Method) |
| CN (4) | CN1058054C (en:Method) |
| CA (1) | CA2153986C (en:Method) |
| DE (3) | DE69433120T2 (en:Method) |
| WO (1) | WO1995014103A1 (en:Method) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7264951B1 (en) | 1992-02-20 | 2007-09-04 | Phyton, Inc. | Enhanced production of taxol and taxanes by cell cultures of Taxus species |
| CA2163614C (en) | 1994-11-25 | 2002-12-31 | Yukihito Yukimune | Method of producing a taxane-type diterpene |
| JP3019736B2 (ja) | 1994-12-07 | 2000-03-13 | 三井化学株式会社 | タキサン型ジテルペンの製造方法 |
| KR960037826A (ko) * | 1995-04-27 | 1996-11-19 | 김경환 | 택서스속 식물세포의 반연속식 배양방법 |
| US6248572B1 (en) * | 1995-04-27 | 2001-06-19 | Samyang, Genex, Corporation | Production of taxol from taxus plant cell culture adding silver nitrate |
| WO1997021801A2 (en) * | 1995-12-12 | 1997-06-19 | Xechem, Inc. | Production and screening process for phytochemical production by plant cell cultures |
| KR100290004B1 (ko) * | 1996-01-15 | 2001-05-15 | 허일섭 | 생물반응기에서 주목세포 배양에 의한 탁솔 및 그 유도체의 고수율 생산방법 |
| EP1538214A1 (en) * | 1996-05-24 | 2005-06-08 | Phyton, Inc. | Enhanced production of taxanes by cell cultures of taxus species |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5244971A (en) * | 1975-10-03 | 1977-04-08 | Fuji Jidoki Kk | Automatic pile up apparatus of narrow width plates |
| US5019504A (en) * | 1989-03-23 | 1991-05-28 | The United States Of America As Represented By The Secretary Of Agriculture | Production of taxol or taxol-like compounds in cell culture |
| US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
| DE4122208C1 (en:Method) * | 1991-07-04 | 1992-07-30 | B.A.T. Cigarettenfabriken Gmbh, 2000 Hamburg, De | |
| CA2092705C (en) * | 1991-07-17 | 1995-11-07 | Koji Saito | Compound having antitumor activity, nsc-lsc1, and process for producing the same |
| US5407816A (en) * | 1992-02-20 | 1995-04-18 | Phyton Catalytic, Inc. | Enhanced production of taxol and taxanes by cell cultures of taxus species |
| JPH05244971A (ja) * | 1992-03-06 | 1993-09-24 | Nippon Oil Co Ltd | タキサン類化合物の製造方法 |
| AU4242993A (en) * | 1992-05-21 | 1993-12-13 | Penn State Research Foundation, The | Cultured (taxus) tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds |
-
1994
- 1994-11-09 US US08/491,844 patent/US5637484A/en not_active Expired - Lifetime
- 1994-11-09 EP EP00115405A patent/EP1063299A3/en not_active Withdrawn
- 1994-11-09 DE DE69433120T patent/DE69433120T2/de not_active Expired - Lifetime
- 1994-11-09 EP EP00115410A patent/EP1054065B1/en not_active Expired - Lifetime
- 1994-11-09 WO PCT/JP1994/001880 patent/WO1995014103A1/ja not_active Ceased
- 1994-11-09 EP EP00115406A patent/EP1063300B1/en not_active Expired - Lifetime
- 1994-11-09 KR KR1019950702779A patent/KR0172606B1/ko not_active Expired - Lifetime
- 1994-11-09 CA CA002153986A patent/CA2153986C/en not_active Expired - Lifetime
- 1994-11-09 EP EP94931697A patent/EP0683232B1/en not_active Expired - Lifetime
- 1994-11-09 CN CN94191435A patent/CN1058054C/zh not_active Expired - Lifetime
- 1994-11-09 DE DE69431135T patent/DE69431135T2/de not_active Expired - Lifetime
- 1994-11-09 EP EP03015169A patent/EP1348764A1/en not_active Withdrawn
- 1994-11-09 DE DE69426692T patent/DE69426692T2/de not_active Expired - Lifetime
-
1997
- 1997-02-28 US US08/808,218 patent/US5968789A/en not_active Expired - Lifetime
-
1999
- 1999-04-28 US US09/301,075 patent/US6403343B2/en not_active Expired - Lifetime
- 1999-06-30 CN CN99110152A patent/CN1083011C/zh not_active Expired - Lifetime
- 1999-06-30 CN CN99110153A patent/CN1083012C/zh not_active Expired - Lifetime
- 1999-06-30 CN CN99110151A patent/CN1083010C/zh not_active Expired - Lifetime
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