DE69433120D1 - Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen - Google Patents

Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen

Info

Publication number
DE69433120D1
DE69433120D1 DE69433120T DE69433120T DE69433120D1 DE 69433120 D1 DE69433120 D1 DE 69433120D1 DE 69433120 T DE69433120 T DE 69433120T DE 69433120 T DE69433120 T DE 69433120T DE 69433120 D1 DE69433120 D1 DE 69433120D1
Authority
DE
Germany
Prior art keywords
taxane
type diterpene
high yields
culture cells
produce
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69433120T
Other languages
English (en)
Other versions
DE69433120T2 (de
Inventor
Yukihito Yukimune
Yosuhiro Hara
Yosuke Higashi
Naoto Ohnishi
Homare Tabata
Chuzo Suga
Kouichi Matsubara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Chemicals Inc
Original Assignee
Mitsui Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27576895&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69433120(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP28489393A external-priority patent/JP3488492B2/ja
Priority claimed from JP6104211A external-priority patent/JPH07308196A/ja
Priority claimed from JP6104212A external-priority patent/JPH07308197A/ja
Priority claimed from JP14682694A external-priority patent/JP3434892B2/ja
Priority claimed from JP6201150A external-priority patent/JPH0856680A/ja
Priority claimed from JP6201151A external-priority patent/JPH0856681A/ja
Priority claimed from JP6252528A external-priority patent/JPH08116981A/ja
Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc
Publication of DE69433120D1 publication Critical patent/DE69433120D1/de
Application granted granted Critical
Publication of DE69433120T2 publication Critical patent/DE69433120T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69433120T 1993-11-15 1994-11-09 Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen Expired - Lifetime DE69433120T2 (de)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
JP28489393A JP3488492B2 (ja) 1993-11-15 1993-11-15 タキサン型ジテルペン高産生培養細胞の取得方法
JP28489393 1993-11-15
JP3615694 1994-03-07
JP3615694 1994-03-07
JP6104211A JPH07308196A (ja) 1994-05-18 1994-05-18 タキサン型ジテルペンの製造方法
JP10421394 1994-05-18
JP6104212A JPH07308197A (ja) 1994-05-18 1994-05-18 タキサン型ジテルペンの製造方法
JP10421194 1994-05-18
JP10421394 1994-05-18
JP10421294 1994-05-18
JP14682694A JP3434892B2 (ja) 1994-06-28 1994-06-28 タキサン型ジテルペンの製造方法
JP14682694 1994-06-28
JP20115194 1994-08-25
JP20115094 1994-08-25
JP6201151A JPH0856681A (ja) 1994-08-25 1994-08-25 タキサン型ジテルペンの製造方法
JP6201150A JPH0856680A (ja) 1994-08-25 1994-08-25 タキサン型ジテルペンの製造方法
JP25252894 1994-10-18
JP6252528A JPH08116981A (ja) 1994-10-18 1994-10-18 タキサン型ジテルペンの製造方法

Publications (2)

Publication Number Publication Date
DE69433120D1 true DE69433120D1 (de) 2003-10-09
DE69433120T2 DE69433120T2 (de) 2004-07-01

Family

ID=27576895

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69426692T Expired - Lifetime DE69426692T2 (de) 1993-11-15 1994-11-09 Methode zur herstellung von taxan-diterpen und methode zum einten von kulturzellen, die taxan-diterpen in hohen ausbeuten herstellen
DE69433120T Expired - Lifetime DE69433120T2 (de) 1993-11-15 1994-11-09 Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen
DE69431135T Expired - Lifetime DE69431135T2 (de) 1993-11-15 1994-11-09 Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69426692T Expired - Lifetime DE69426692T2 (de) 1993-11-15 1994-11-09 Methode zur herstellung von taxan-diterpen und methode zum einten von kulturzellen, die taxan-diterpen in hohen ausbeuten herstellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69431135T Expired - Lifetime DE69431135T2 (de) 1993-11-15 1994-11-09 Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen

Country Status (8)

Country Link
US (3) US5637484A (de)
EP (5) EP0683232B1 (de)
KR (1) KR0172606B1 (de)
CN (4) CN1058054C (de)
CA (1) CA2153986C (de)
DE (3) DE69426692T2 (de)
HK (2) HK1029807A1 (de)
WO (1) WO1995014103A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) * 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2163614C (en) 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
KR960037826A (ko) * 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
KR19990072075A (ko) * 1995-12-12 1999-09-27 지켐 인코포레이티드 식물세포 배양에 의해 식물 화학물질을 생산하기 위한 생산 및스크리닝 방법
KR100290004B1 (ko) * 1996-01-15 2001-05-15 허일섭 생물반응기에서 주목세포 배양에 의한 탁솔 및 그 유도체의 고수율 생산방법
BR9709361B1 (pt) * 1996-05-24 2009-05-05 produção aumentada de taxanos por culturas de células de espécie taxus.
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
KR100266448B1 (ko) * 1997-06-26 2000-09-15 박종헌 식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
DE69901819T2 (de) 1998-01-14 2003-01-30 Bristol-Myers Squibb Co., Princeton Neue kristallkomplexe von baccatin iii mit imidazol, 2-methylimidazol or isopropanol
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US7238514B2 (en) * 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
US6946283B2 (en) 2001-01-05 2005-09-20 William Marsh Rice University Ginkgo biloba levopimaradiene synthase
US20030092178A1 (en) * 2001-11-15 2003-05-15 Biospherix, Ltd. Cell culture incubator with dynamic oxygen control
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
EP1498475A1 (de) * 2003-07-18 2005-01-19 Meristem Therapeutics S.A. Bioreaktor und Verfahren zur kontinuierlichen Züchtung von Pflanzenzellen
US8936940B2 (en) 2005-06-03 2015-01-20 Samyang Biopharmaceuticals Corporation Mass production of secondary metabolite in plant cell culture by treatment of saccharide mixture in medium
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
DK2617714T3 (da) * 2005-12-07 2016-06-27 Univ Ramot Kemiske derivater af jasmonat, farmaceutiske præparater og fremgangsmåder til anvendelse deraf
US8247439B2 (en) * 2005-12-07 2012-08-21 Sepal Pharma Ltd. Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
WO2008054815A2 (en) * 2006-11-03 2008-05-08 Valent Biosciences Corporation Enhanced amino acid formulations
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
CN110105312B (zh) * 2019-06-05 2023-05-09 云南大学 一种7-差向紫杉烷差向化转化形成紫杉烷的方法
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5244971A (en) * 1975-10-03 1977-04-08 Fuji Jidoki Kk Automatic pile up apparatus of narrow width plates
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
DE4122208C1 (de) * 1991-07-04 1992-07-30 B.A.T. Cigarettenfabriken Gmbh, 2000 Hamburg, De
KR930702323A (ko) * 1991-07-17 1993-09-08 하지메 나까가와 항종양 활성을 가진 화합물(nsc-lsc1) 및 그의 제조방법
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
JPH05244971A (ja) * 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法
JPH08500973A (ja) * 1992-05-21 1996-02-06 ザ ペン ステイト リサーチ ファウンデーション タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織

Also Published As

Publication number Publication date
WO1995014103A1 (fr) 1995-05-26
CN1083011C (zh) 2002-04-17
US6403343B2 (en) 2002-06-11
EP1063300B1 (de) 2003-09-03
DE69433120T2 (de) 2004-07-01
EP1054065A1 (de) 2000-11-22
EP1063300A2 (de) 2000-12-27
CA2153986C (en) 2002-12-31
US5968789A (en) 1999-10-19
EP1348764A1 (de) 2003-10-01
KR0172606B1 (ko) 1999-02-01
EP1063299A2 (de) 2000-12-27
HK1030021A1 (en) 2001-04-20
DE69426692D1 (de) 2001-03-22
CN1248630A (zh) 2000-03-29
US20020012976A1 (en) 2002-01-31
CN1119028A (zh) 1996-03-20
CN1251391A (zh) 2000-04-26
DE69431135T2 (de) 2003-03-27
EP1063299A3 (de) 2002-01-02
US5637484A (en) 1997-06-10
EP1054065B1 (de) 2002-07-31
KR960700044A (ko) 1996-01-19
EP0683232A1 (de) 1995-11-22
EP0683232A4 (de) 1995-11-29
DE69431135D1 (de) 2002-09-05
CN1083010C (zh) 2002-04-17
EP0683232B1 (de) 2001-02-14
EP1063300A3 (de) 2002-01-02
CA2153986A1 (en) 1995-05-26
HK1029807A1 (en) 2001-04-12
CN1248629A (zh) 2000-03-29
CN1058054C (zh) 2000-11-01
CN1083012C (zh) 2002-04-17
DE69426692T2 (de) 2001-06-21

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