DE69625605D1 - Die herstellung von hämoglobinen pharmazeutischer qualität durch eine hitzebehandlung in teilweise oxygenierter form - Google Patents

Die herstellung von hämoglobinen pharmazeutischer qualität durch eine hitzebehandlung in teilweise oxygenierter form

Info

Publication number
DE69625605D1
DE69625605D1 DE69625605T DE69625605T DE69625605D1 DE 69625605 D1 DE69625605 D1 DE 69625605D1 DE 69625605 T DE69625605 T DE 69625605T DE 69625605 T DE69625605 T DE 69625605T DE 69625605 D1 DE69625605 D1 DE 69625605D1
Authority
DE
Germany
Prior art keywords
hemoglobines
production
heat treatment
pharmaceutical quality
oxygenated form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69625605T
Other languages
English (en)
Other versions
DE69625605T2 (de
Inventor
Rezazadeh Azari
A Ebeling
E Picken
N Estep
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of DE69625605D1 publication Critical patent/DE69625605D1/de
Publication of DE69625605T2 publication Critical patent/DE69625605T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
DE69625605T 1995-09-22 1996-08-20 Die herstellung von hämoglobinen pharmazeutischer qualität durch eine hitzebehandlung in teilweise oxygenierter form Expired - Fee Related DE69625605T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/532,293 US5741894A (en) 1995-09-22 1995-09-22 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
PCT/US1996/013511 WO1997010831A1 (en) 1995-09-22 1996-08-20 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Publications (2)

Publication Number Publication Date
DE69625605D1 true DE69625605D1 (de) 2003-02-06
DE69625605T2 DE69625605T2 (de) 2003-10-16

Family

ID=24121176

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69625605T Expired - Fee Related DE69625605T2 (de) 1995-09-22 1996-08-20 Die herstellung von hämoglobinen pharmazeutischer qualität durch eine hitzebehandlung in teilweise oxygenierter form

Country Status (13)

Country Link
US (1) US5741894A (de)
EP (1) EP0854725B1 (de)
JP (1) JP2000500736A (de)
KR (1) KR19990063654A (de)
CN (1) CN1197392A (de)
AU (1) AU716742B2 (de)
BR (1) BR9610475A (de)
CA (1) CA2229845A1 (de)
DE (1) DE69625605T2 (de)
NO (1) NO981270D0 (de)
TW (1) TW360660B (de)
WO (1) WO1997010831A1 (de)
ZA (1) ZA967319B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US20110319332A1 (en) * 2010-06-23 2011-12-29 Bing Lou Wong Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
US11479597B2 (en) 2019-08-29 2022-10-25 Billion King International Limited Thiosuccinyl-crosslinked hemoglobin analogs and methods of use and preparation thereof
WO2024081928A1 (en) * 2022-10-14 2024-04-18 Prolong Pharmaceuticals Llc A stable hemoglobin protein composition

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US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
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DE69027187T2 (de) * 1989-06-15 1996-10-31 Rorer Int Overseas Verfahren zur inaktivierung von viren in mit viren verunreinigten pharmazeutischen zusammensetzungen
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Also Published As

Publication number Publication date
NO981270L (no) 1998-03-20
MX9802059A (es) 1998-08-30
WO1997010831A1 (en) 1997-03-27
CN1197392A (zh) 1998-10-28
BR9610475A (pt) 1999-05-11
CA2229845A1 (en) 1997-03-27
AU6853096A (en) 1997-04-09
TW360660B (en) 1999-06-11
NO981270D0 (no) 1998-03-20
DE69625605T2 (de) 2003-10-16
KR19990063654A (ko) 1999-07-26
EP0854725A4 (de) 1999-11-17
EP0854725A1 (de) 1998-07-29
ZA967319B (en) 1997-03-04
US5741894A (en) 1998-04-21
AU716742B2 (en) 2000-03-02
EP0854725B1 (de) 2003-01-02
JP2000500736A (ja) 2000-01-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee