ZA967319B - Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form - Google Patents

Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Info

Publication number
ZA967319B
ZA967319B ZA967319A ZA967319A ZA967319B ZA 967319 B ZA967319 B ZA 967319B ZA 967319 A ZA967319 A ZA 967319A ZA 967319 A ZA967319 A ZA 967319A ZA 967319 B ZA967319 B ZA 967319B
Authority
ZA
South Africa
Prior art keywords
hemoglobins
preparation
heat treatment
pharmaceutical grade
partially oxygenated
Prior art date
Application number
ZA967319A
Other languages
English (en)
Inventor
Mahmood Rezazadeh Azari
August A Ebeling
John E Picken
Timothy N Estep
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of ZA967319B publication Critical patent/ZA967319B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
ZA967319A 1995-09-22 1996-08-29 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form ZA967319B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/532,293 US5741894A (en) 1995-09-22 1995-09-22 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Publications (1)

Publication Number Publication Date
ZA967319B true ZA967319B (en) 1997-03-04

Family

ID=24121176

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA967319A ZA967319B (en) 1995-09-22 1996-08-29 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Country Status (13)

Country Link
US (1) US5741894A (xx)
EP (1) EP0854725B1 (xx)
JP (1) JP2000500736A (xx)
KR (1) KR19990063654A (xx)
CN (1) CN1197392A (xx)
AU (1) AU716742B2 (xx)
BR (1) BR9610475A (xx)
CA (1) CA2229845A1 (xx)
DE (1) DE69625605T2 (xx)
NO (1) NO981270L (xx)
TW (1) TW360660B (xx)
WO (1) WO1997010831A1 (xx)
ZA (1) ZA967319B (xx)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US20110319332A1 (en) * 2010-06-23 2011-12-29 Bing Lou Wong Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CA3070172A1 (en) 2017-07-18 2019-01-24 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
WO2021037109A1 (en) 2019-08-29 2021-03-04 Billion King International Ltd. Thiosuccinyl-crosslinked hemoglobin analogs and methods of use and preparation thereof
WO2024081928A1 (en) * 2022-10-14 2024-04-18 Prolong Pharmaceuticals Llc A stable hemoglobin protein composition

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248475C3 (de) * 1972-10-03 1978-09-28 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Gewinnung von hepatitissicheren, lagerungsstabilen und infundierbaren Hämoglobinlösungen
US3959128A (en) * 1974-12-27 1976-05-25 Preventive Systems, Inc Process for removing endotoxin from biological fluids
US4059512A (en) * 1974-12-27 1977-11-22 Preventive Systems, Inc. Process for removing endotoxin from biological fluids
US3991181A (en) * 1975-06-18 1976-11-09 Warner-Lambert Company Injectable stroma free hemoglobin solution and its method of manufacture
JPS56106559A (en) * 1980-01-29 1981-08-24 Riyoushiyoku Kenkyukai Separation of globin
US4440679A (en) * 1980-03-05 1984-04-03 Cutter Laboratories, Inc. Pasteurized therapeutically active protein compositions
US4623717A (en) * 1980-03-05 1986-11-18 Miles Laboratories, Inc. Pasteurized therapeutically active protein compositions
EP0035204B2 (en) * 1980-03-05 1991-05-22 Miles Inc. Pasteurized therapeutically active protein compositions
US4291020A (en) * 1980-05-16 1981-09-22 The United States Of America As Represented By The Secretary Of Health & Human Services Inactivation of non-A, non-B hepatitis agent
DE3033932C2 (de) * 1980-09-10 1984-05-24 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten
JPS5754121A (en) * 1980-09-19 1982-03-31 Ajinomoto Co Inc Production of substance having antiviral and carcinostatic activity
US4314997A (en) * 1980-10-06 1982-02-09 Edward Shanbrom Purification of plasma protein products
US4381239A (en) * 1981-02-10 1983-04-26 Tanabe Seiyaku Co., Ltd. Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
US4465774A (en) * 1981-07-16 1984-08-14 Sherwood Medical Company Standard or control material for glysocylated or total hemoglobin determination
DE3130770C2 (de) * 1981-08-04 1986-06-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Gewinnung von hepatitissicheren, sterilen, pyrogenfreien und stromafreien Hämoglobinlösungen
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
US4438098A (en) * 1982-01-27 1984-03-20 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Heat treatment of a non-A, non-B hepatitis agent to prepare a vaccine
US4473494A (en) * 1983-05-04 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Preparation of stroma-free, non-heme protein-free hemoglobin
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
FR2548670B1 (fr) * 1983-07-07 1985-10-25 Merieux Inst Procede de preparation des principales proteines du sang hemolyse sous forme non denaturee
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
US5281579A (en) * 1984-03-23 1994-01-25 Baxter International Inc. Purified virus-free hemoglobin solutions and method for making same
DE3412144A1 (de) * 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US4886755A (en) * 1984-12-07 1989-12-12 Bioprobe International, Inc. Preparation of polymeric thiol gels for covalent bonding of biologically active ligands
US4632980A (en) * 1985-04-03 1986-12-30 Immunologics Ozone decontamination of blood and blood products
CA1244349A (en) * 1985-06-26 1988-11-08 Jen-Chang Hsia Purification of hemoglobin and modified hemoglobin by affinity chromatography
US4826811A (en) * 1986-06-20 1989-05-02 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5464814A (en) * 1986-06-20 1995-11-07 Northfield Laboratories, Inc. Acellular red blood cell substitute
US5194590A (en) * 1986-06-20 1993-03-16 Northfield Laboratories, Inc. Acellular red blood cell substitute
US4841023A (en) * 1986-06-25 1989-06-20 New York Blood Center, Inc. Inactivation of viruses in labile protein-containing compositions using fatty acids
US5084558A (en) * 1987-10-13 1992-01-28 Biopure Corporation Extra pure semi-synthetic blood substitute
CA1312009C (en) * 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
EP0277289B8 (en) * 1986-11-10 2003-05-21 Biopure Corporation Extra pure semi-synthetic blood substitute
US5189146A (en) * 1987-05-05 1993-02-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Pasteurizable, freeze-driable hemoglobin-based blood substitute
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
US4808314A (en) * 1987-09-18 1989-02-28 Scripps Clinic And Research Foundation Method for reducing bacterial endotoxin contamination in solutions of macromolecules
US4909940A (en) * 1987-12-30 1990-03-20 New York Blood Center, Inc. Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons
US4861867A (en) * 1988-02-03 1989-08-29 Baxter International, Inc. Purified hemoglobin solutions and method for making same
DE3805459A1 (de) * 1988-02-22 1989-08-31 Biotest Pharma Gmbh Verfahren zur sterilisation von blut, plasma, blut- und plasmaderivaten, zellsuspensionen oder dgl.
JPH01238534A (ja) * 1988-03-17 1989-09-22 Mitsui Toatsu Chem Inc エンドトキシンの除去方法
EP0379534A4 (en) * 1988-06-15 1991-03-13 Baxter International Inc. Method of purifying cross-linked hemoglobin
CA1338244C (en) * 1988-08-17 1996-04-09 Xiang-Fu Wu Purification of hemoglobin and methemoglobin by bioselective elution
ATE138575T1 (de) * 1989-06-15 1996-06-15 Rorer Int Overseas Verfahren zur inaktivierung von viren in mit viren verunreinigten pharmazeutischen zusammensetzungen
US5234903A (en) * 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5386014A (en) * 1989-11-22 1995-01-31 Enzon, Inc. Chemically modified hemoglobin as an effective, stable, non-immunogenic red blood cell substitute
US5312808A (en) * 1989-11-22 1994-05-17 Enzon, Inc. Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
EP0507870B1 (en) * 1989-12-29 1996-04-10 Texas Tech University Health Sciences Center Polyhemoglobin stabilized by purine derivatives and glutathione
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
EP0517790A1 (en) * 1990-02-27 1992-12-16 The Board Of Regents, The University Of Texas System Method for enhancing recovery of recombinant proteins
WO1992002239A1 (en) * 1990-08-06 1992-02-20 Baxter International Inc. Stable hemoglobin based composition and method to store same
US5204451A (en) * 1990-08-13 1993-04-20 Baxter International Inc. Activating hydroxyl groups of polymeric carriers using 4-fluorobenzenesulfonyl chloride for binding biologically active ligands
EP0500893A4 (en) * 1990-09-04 1993-03-10 Edward Shanbrom Preservation of blood, tissues and biological fluids
US5922854A (en) * 1991-06-14 1999-07-13 Kumar; Ramesh Purifying Human Hemogloblin from transgenic pig red cells and plasmids containing pig globin nucleic acids
CA2111348A1 (en) * 1991-06-14 1992-12-23 John S. Logan Production of human hemoglobin in transgenic pigs
CA2049275A1 (en) * 1991-08-15 1993-02-16 Paul Huntington Purification of sf hemoglobin
JP3331433B2 (ja) * 1992-02-05 2002-10-07 財団法人生産開発科学研究所 ヘモグロビン精製法
EP0655888A4 (en) * 1992-06-12 1997-06-11 Dnx Corp PRODUCTION OF HUMAN HEMOGLOBIN IN TRANSGENIC PIGS.
US5264555A (en) * 1992-07-14 1993-11-23 Enzon, Inc. Process for hemoglobin extraction and purification
JPH06105686A (ja) * 1992-09-28 1994-04-19 Toyobo Co Ltd ポルフィリンモノクロ−ナル抗体構造遺伝子
US5407579A (en) * 1993-07-02 1995-04-18 National Science Council Hemoglobin purification
ZA951034B (en) * 1993-09-21 1995-10-11 Hemosol Inc Displacements chromatography process and purified hemoglobin product
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5456835A (en) * 1993-11-08 1995-10-10 Hemasure, Inc. Device and process for removing free hemoglobin from blood
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US5631219A (en) * 1994-03-08 1997-05-20 Somatogen, Inc. Method of stimulating hematopoiesis with hemoglobin

Also Published As

Publication number Publication date
AU716742B2 (en) 2000-03-02
TW360660B (en) 1999-06-11
CA2229845A1 (en) 1997-03-27
CN1197392A (zh) 1998-10-28
JP2000500736A (ja) 2000-01-25
AU6853096A (en) 1997-04-09
BR9610475A (pt) 1999-05-11
EP0854725A4 (en) 1999-11-17
KR19990063654A (ko) 1999-07-26
EP0854725B1 (en) 2003-01-02
DE69625605T2 (de) 2003-10-16
WO1997010831A1 (en) 1997-03-27
MX9802059A (es) 1998-08-30
DE69625605D1 (de) 2003-02-06
EP0854725A1 (en) 1998-07-29
US5741894A (en) 1998-04-21
NO981270D0 (no) 1998-03-20
NO981270L (no) 1998-03-20

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