TW360660B - Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form - Google Patents

Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Info

Publication number
TW360660B
TW360660B TW085110487A TW85110487A TW360660B TW 360660 B TW360660 B TW 360660B TW 085110487 A TW085110487 A TW 085110487A TW 85110487 A TW85110487 A TW 85110487A TW 360660 B TW360660 B TW 360660B
Authority
TW
Taiwan
Prior art keywords
hemoglobin
crosslinked
pharmaceutical grade
hemoglobins
preparation
Prior art date
Application number
TW085110487A
Other languages
English (en)
Inventor
Mahmood Rezazadeh Azari
August A Ebeling
John E Picken
Timothy N Estep
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Application granted granted Critical
Publication of TW360660B publication Critical patent/TW360660B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
TW085110487A 1995-09-22 1996-08-28 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form TW360660B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/532,293 US5741894A (en) 1995-09-22 1995-09-22 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Publications (1)

Publication Number Publication Date
TW360660B true TW360660B (en) 1999-06-11

Family

ID=24121176

Family Applications (1)

Application Number Title Priority Date Filing Date
TW085110487A TW360660B (en) 1995-09-22 1996-08-28 Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form

Country Status (13)

Country Link
US (1) US5741894A (zh)
EP (1) EP0854725B1 (zh)
JP (1) JP2000500736A (zh)
KR (1) KR19990063654A (zh)
CN (1) CN1197392A (zh)
AU (1) AU716742B2 (zh)
BR (1) BR9610475A (zh)
CA (1) CA2229845A1 (zh)
DE (1) DE69625605T2 (zh)
NO (1) NO981270D0 (zh)
TW (1) TW360660B (zh)
WO (1) WO1997010831A1 (zh)
ZA (1) ZA967319B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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US6747132B2 (en) 2000-11-29 2004-06-08 Apex Biosciences, Inc. Methods for the synthesis of a modified hemoglobin solution
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US20110319332A1 (en) * 2010-06-23 2011-12-29 Bing Lou Wong Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
AU2018304174A1 (en) 2017-07-18 2020-02-06 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making
AU2020335811A1 (en) 2019-08-29 2022-03-31 Billion King International Ltd. Thiosuccinyl-crosslinked hemoglobin analogs and methods of use and preparation thereof
WO2024081928A1 (en) * 2022-10-14 2024-04-18 Prolong Pharmaceuticals Llc A stable hemoglobin protein composition

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Also Published As

Publication number Publication date
CN1197392A (zh) 1998-10-28
WO1997010831A1 (en) 1997-03-27
DE69625605D1 (de) 2003-02-06
KR19990063654A (ko) 1999-07-26
EP0854725B1 (en) 2003-01-02
CA2229845A1 (en) 1997-03-27
JP2000500736A (ja) 2000-01-25
DE69625605T2 (de) 2003-10-16
ZA967319B (en) 1997-03-04
AU6853096A (en) 1997-04-09
EP0854725A1 (en) 1998-07-29
BR9610475A (pt) 1999-05-11
US5741894A (en) 1998-04-21
EP0854725A4 (en) 1999-11-17
NO981270L (no) 1998-03-20
NO981270D0 (no) 1998-03-20
MX9802059A (es) 1998-08-30
AU716742B2 (en) 2000-03-02

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