ATE184646T1 - Kallus-zellen-induktion und herstellung von taxanen - Google Patents

Kallus-zellen-induktion und herstellung von taxanen

Info

Publication number
ATE184646T1
ATE184646T1 AT93105668T AT93105668T ATE184646T1 AT E184646 T1 ATE184646 T1 AT E184646T1 AT 93105668 T AT93105668 T AT 93105668T AT 93105668 T AT93105668 T AT 93105668T AT E184646 T1 ATE184646 T1 AT E184646T1
Authority
AT
Austria
Prior art keywords
taxanes
production
cell induction
callus cell
callus
Prior art date
Application number
AT93105668T
Other languages
English (en)
Inventor
Paul M Cino
Steven R Schwarz
Dana L Cazzulino
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of ATE184646T1 publication Critical patent/ATE184646T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
AT93105668T 1992-04-07 1993-04-06 Kallus-zellen-induktion und herstellung von taxanen ATE184646T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86482692A 1992-04-07 1992-04-07

Publications (1)

Publication Number Publication Date
ATE184646T1 true ATE184646T1 (de) 1999-10-15

Family

ID=25344160

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93105668T ATE184646T1 (de) 1992-04-07 1993-04-06 Kallus-zellen-induktion und herstellung von taxanen

Country Status (9)

Country Link
US (2) US5527702A (de)
EP (1) EP0568821B1 (de)
JP (1) JP3228592B2 (de)
AT (1) ATE184646T1 (de)
CA (2) CA2092849C (de)
DE (1) DE69326377T2 (de)
DK (1) DK0568821T3 (de)
ES (1) ES2136099T3 (de)
GR (1) GR3032105T3 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2092849C (en) * 1992-04-07 2003-11-18 Paul M. Cino Callus cell induction and the preparation of taxanes
WO1996006852A1 (fr) * 1994-08-26 1996-03-07 Taisho Pharmaceutical Co., Ltd. Nouveau derive du taxol
US20050158699A1 (en) * 1995-06-07 2005-07-21 Kadkade Prakash G. Cryopreservation of plant cells
US5965438A (en) * 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
DE69735059T2 (de) 1996-05-24 2006-08-31 Phyton, Inc. Erhöhte produktion von taxanen durch zellkulturen von taxus-arten
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
KR20070086651A (ko) 2003-05-23 2007-08-27 스태니슬로 카르핀스키 400 ｎｍ 내지 700ｎｍ의 파장의 광선을 주사하여 식물세포 내의 식물성 화학물질의 농도를 변경하는 방법 및기구
EP1739184A1 (de) * 2005-06-28 2007-01-03 Centro Biotecnologie Avanzate Verfahren zur Herstellung von Taxol und/oder Taxanen aus Haselnusszellkulturen
CN1932024B (zh) * 2006-09-15 2010-09-29 清华大学 紫杉醇的生物合成方法及其专用培养基
CN100427588C (zh) * 2006-09-15 2008-10-22 清华大学 紫杉细胞的培养方法及其专用培养基
JP4563493B2 (ja) * 2009-02-25 2010-10-13 タヒボジャパン株式会社 ナフトキノン系抗がん活性成分の効率的製造

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2747334A (en) * 1952-05-20 1956-05-29 Pfizer & Co C Cultivation of plant tissue
GB1495709A (en) * 1974-01-28 1977-12-21 British Petroleum Co Method and apparatus for growing plant cells
US4038778A (en) * 1976-09-27 1977-08-02 Gte Laboratories Incorporated Tissue culture technique for asexual plant reproduction and a medium for use therewith
US4152214A (en) * 1977-10-07 1979-05-01 The United States Of America As Represented By The Secretary Of Agriculture Production of homodeoxyharringtonine and other cephalotaxine esters by tissue culture
US4206221A (en) 1979-01-03 1980-06-03 The United States Of America As Represented By The Secretary Of Agriculture Cephalomannine and its use in treating leukemic tumors
US4463522A (en) * 1979-07-26 1984-08-07 Eckhart Lindemann System and apparatus for plant tissue culture propagation
US4501815A (en) * 1979-10-29 1985-02-26 Albert Einstein College Of Medicine Of Yeshiva University Article for culturing differentiated cells
US4352887A (en) * 1979-10-29 1982-10-05 Albert Einstein College Of Medicine Of Yeshiva University Method and article for culturing differentiated cells
DE3165272D1 (en) * 1980-11-06 1984-09-06 Albright & Wilson Callus culture in nutrient flow
IL69333A (en) * 1983-07-26 1986-04-29 Biolog Ind Process for plant tissue culture propagation
CH665217A5 (de) * 1985-02-15 1988-04-29 Agrogen Stiftung Verfahren und vorrichtung zur in vitro kultur von pflanzenzellen, pflanzengeweben, pflanzenorganen, pflanzenteilen sowie zur mikropropagation und regeneration von ganzen pflanzen.
JPS61254127A (ja) * 1985-05-02 1986-11-11 三浦　喜温 ニチニチソウ器官培養によるインド−ルアルカロイドの製造方法
US4960703A (en) * 1986-04-23 1990-10-02 Personnalite Juridique De La Station Des Cultures Fruitieres Et Maraicheres Composition for in vitro micropropagation of plants
CA1289902C (en) * 1987-05-15 1991-10-01 Jean Archambault Surface immobilization of plant cells
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
WO1992013961A1 (en) * 1991-02-12 1992-08-20 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
US5413928A (en) * 1991-06-21 1995-05-09 Worcester Polytechnic Institute Process for extracting enhanced amounts of plant secondary metabolites with limited loss of plant viability
CA2092705C (en) * 1991-07-17 1995-11-07 Koji Saito Compound having antitumor activity, nsc-lsc1, and process for producing the same
US5344775A (en) * 1991-11-15 1994-09-06 Escagenetics Corporation Synthesis of taxanes in culture using pseudocalluscells
IT1258838B (it) * 1992-01-31 1996-02-29 Indena Spa Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus
US5407816A (en) * 1992-02-20 1995-04-18 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
JPH05244971A (ja) * 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法
EP0633719A4 (de) * 1992-04-01 1995-12-20 Union Camp Corp Induktion von somatischem embryogenese bei taxus und produktion daraus von alkaloiden mit einem taxane-ring.
CA2092849C (en) * 1992-04-07 2003-11-18 Paul M. Cino Callus cell induction and the preparation of taxanes
US5322779A (en) * 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
EP0642586A4 (de) * 1992-05-21 1995-11-29 Penn State Res Found IN KULTUR GEHALTENES -i(TAXUS) GEWEBE ALS QUELLE VON TAXOL, VERWANDTEN TAXANEN UND ANDEREN NEUEN ANTI-TUMOR/ANTI-VIRALEN STOFFEN(20.01.94).
CA2069122A1 (en) * 1992-05-21 1993-11-22 Richard N. Arteca Methods and compositions for the production of taxol, taxol precursors and derivatives of taxol from plant tissue culture
JP2967532B2 (ja) * 1992-06-11 1999-10-25 日石三菱株式会社 タキサン類化合物の製造方法

Also Published As

Publication number Publication date
DE69326377D1 (de) 1999-10-21
JP3228592B2 (ja) 2001-11-12
CA2092849A1 (en) 1993-10-08
EP0568821A1 (de) 1993-11-10
GR3032105T3 (en) 2000-03-31
EP0568821B1 (de) 1999-09-15
JPH0678758A (ja) 1994-03-22
US5527702A (en) 1996-06-18
US5665576A (en) 1997-09-09
CA2092849C (en) 2003-11-18
CA2434692A1 (en) 1993-10-08
DK0568821T3 (da) 2000-03-06
DE69326377T2 (de) 2000-05-11
ES2136099T3 (es) 1999-11-16

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