DE69420375D1 - Matrix aus optischen biosensoren - Google Patents

Matrix aus optischen biosensoren

Info

Publication number
DE69420375D1
DE69420375D1 DE69420375T DE69420375T DE69420375D1 DE 69420375 D1 DE69420375 D1 DE 69420375D1 DE 69420375 T DE69420375 T DE 69420375T DE 69420375 T DE69420375 T DE 69420375T DE 69420375 D1 DE69420375 D1 DE 69420375D1
Authority
DE
Germany
Prior art keywords
matrix
optical biosensors
biosensors
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69420375T
Other languages
English (en)
Other versions
DE69420375T2 (de
Inventor
Helmut Rudigier
Roland Pfefferkorn
Kurt Tiefenthaler
Veronique Briguet
Alois Zetting
Peter Marbach
Francois Legay
Peter End
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Artificial Sensing Instruments ASI AG
OC Oerlikon Balzers AG
Original Assignee
Artificial Sensing Instruments ASI AG
Balzers AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Artificial Sensing Instruments ASI AG, Balzers AG filed Critical Artificial Sensing Instruments ASI AG
Publication of DE69420375D1 publication Critical patent/DE69420375D1/de
Application granted granted Critical
Publication of DE69420375T2 publication Critical patent/DE69420375T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N21/774—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure
    • G01N21/7743—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides the reagent being on a grating or periodic structure the reagent-coated grating coupling light in or out of the waveguide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4788—Diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/04—Batch operation; multisample devices
    • G01N2201/0446—Multicell plate, sequential

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
DE69420375T 1993-07-20 1994-07-18 Matrix aus optischen biosensoren Expired - Lifetime DE69420375T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939314991A GB9314991D0 (en) 1993-07-20 1993-07-20 Mechanical device
PCT/EP1994/002361 WO1995003538A1 (en) 1993-07-20 1994-07-18 Optical biosensor matrix

Publications (2)

Publication Number Publication Date
DE69420375D1 true DE69420375D1 (de) 1999-10-07
DE69420375T2 DE69420375T2 (de) 2000-05-18

Family

ID=10739102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69420375T Expired - Lifetime DE69420375T2 (de) 1993-07-20 1994-07-18 Matrix aus optischen biosensoren

Country Status (6)

Country Link
US (1) US5738825A (de)
EP (1) EP0660924B1 (de)
JP (3) JPH08504955A (de)
DE (1) DE69420375T2 (de)
GB (1) GB9314991D0 (de)
WO (1) WO1995003538A1 (de)

Families Citing this family (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08116961A (ja) * 1994-10-25 1996-05-14 Hamamatsu Photonics Kk 培養観測用容器及び観測装置
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
MX9708698A (es) * 1995-05-12 1998-02-28 Novartis Ag Plataforma de sensor y metodo para la deteccion paralela de una pluralidad de analitos utilizando luminescencia evanescentemente excitada.
US6611634B2 (en) 1996-03-19 2003-08-26 University Of Utah Research Foundation Lens and associatable flow cell
US6356676B1 (en) 1996-03-19 2002-03-12 University Of Utah Research Foundation Lens and associatable flow cell
EP0928416A4 (de) * 1996-03-19 2000-03-29 Univ Utah Res Found Linse und damit zusammenhängende durchflusszelle
DE19615366B4 (de) * 1996-04-19 2006-02-09 Carl Zeiss Jena Gmbh Verfahren und Einrichtung zum Nachweis physikalischer, chemischer, biologischer oder biochemischer Reaktionen und Wechselwirkungen
DE19712484C2 (de) 1997-03-25 1999-07-08 Greiner Gmbh Microplatte mit transparentem Boden und Verfahren zu deren Herstellung
US6426050B1 (en) * 1997-05-16 2002-07-30 Aurora Biosciences Corporation Multi-well platforms, caddies, lids and combinations thereof
US6517781B1 (en) * 1997-06-02 2003-02-11 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
DE19725050C2 (de) * 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
US6258326B1 (en) 1997-09-20 2001-07-10 Ljl Biosystems, Inc. Sample holders with reference fiducials
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6071748A (en) 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US5955378A (en) * 1997-08-20 1999-09-21 Challener; William A. Near normal incidence optical assaying method and system having wavelength and angle sensitivity
US6455004B1 (en) 1997-09-10 2002-09-24 Kurt Tiefenthaler Optical sensor and optical method for characterizing a chemical or biological substance
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
WO2000006991A2 (en) 1998-07-27 2000-02-10 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
DE19806681B4 (de) * 1998-02-18 2006-07-27 Carl Zeiss Jena Gmbh Mikrotiterplatte
US6861035B2 (en) * 1998-02-24 2005-03-01 Aurora Discovery, Inc. Multi-well platforms, caddies, lids and combinations thereof
ES2184434T3 (es) 1998-03-27 2003-04-01 Aventis Pharma Gmbh Placa de microtitulacion miniaturizada para exploracion de alto rendimiento.
AU4999099A (en) * 1998-07-15 2000-02-07 Ljl Biosystems, Inc. Evanescent field illumination devices and methods
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
US6320991B1 (en) 1998-10-16 2001-11-20 Imation Corp. Optical sensor having dielectric film stack
DE19853640C2 (de) * 1998-11-20 2002-01-31 Molecular Machines & Ind Gmbh Mehrgefäßanordnung mit verbesserter Empfindlichkeit für die optische Analytik, Verfahren zu ihrer Herstellung sowie ihre Verwendung in optischen Analyseverfahren
AU3005400A (en) 1999-02-23 2000-09-14 Ljl Biosystems, Inc. Frequency-domain light detection device
EP1031828B1 (de) 1999-02-25 2006-09-13 C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa Integrierter optischer Sensor und Verfahren zum integrierten optischen Nachweis einer Substanz
EP1190236A1 (de) * 1999-06-05 2002-03-27 Zeptosens AG Sensorplatform und verfahren zur multianalytbestimmung
US6399394B1 (en) 1999-06-30 2002-06-04 Agilent Technologies, Inc. Testing multiple fluid samples with multiple biopolymer arrays
US6771376B2 (en) * 1999-07-05 2004-08-03 Novartis Ag Sensor platform, apparatus incorporating the platform, and process using the platform
EP1192448B1 (de) * 1999-07-05 2006-09-27 Novartis AG Verfahren zur anwendung einer sensoreinheit
AU6834700A (en) * 1999-08-13 2001-03-13 Zeptosens Ag Device and method for determining multiple analytes
DE19948087B4 (de) * 1999-10-06 2008-04-17 Evotec Ag Verfahren zur Herstellung eines Reaktionssubstrats
US7167615B1 (en) 1999-11-05 2007-01-23 Board Of Regents, The University Of Texas System Resonant waveguide-grating filters and sensors and methods for making and using same
US8111401B2 (en) * 1999-11-05 2012-02-07 Robert Magnusson Guided-mode resonance sensors employing angular, spectral, modal, and polarization diversity for high-precision sensing in compact formats
US6587197B1 (en) 1999-12-06 2003-07-01 Royce Technologies Llc Multiple microchannels chip for biomolecule imaging, and method of use thereof
US6961490B2 (en) * 2000-01-27 2005-11-01 Unaxis-Balzers Aktiengesellschaft Waveguide plate and process for its production and microtitre plate
US6510263B1 (en) * 2000-01-27 2003-01-21 Unaxis Balzers Aktiengesellschaft Waveguide plate and process for its production and microtitre plate
DE10006083B4 (de) * 2000-02-11 2004-01-22 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Verfahren zur quantitativen und/oder qualitativen Bestimmung von Schichtdicken sowie ein Mikroreaktionsgefäß und eine Titerplatte
DE10012793C2 (de) * 2000-03-13 2002-01-24 Fraunhofer Ges Forschung Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten
EP1272829A1 (de) * 2000-04-14 2003-01-08 Zeptosens AG Gitter-wellenleiter-struktur zur verstärkung eines anregungsfeldes und deren verwendung
AU2001253655A1 (en) * 2000-04-19 2001-11-07 Corning Incorporated Multi-well plate and method of manufacture
US20030138208A1 (en) * 2000-05-06 2003-07-24 Michael Pawlak Grating optical waveguide structure for multi-analyte determinations and the use thereof
DE10060560A1 (de) * 2000-05-26 2001-12-06 Bruker Optik Gmbh Mikrotiterplatte für Infrarotmessungen
AU2001274068A1 (en) * 2000-06-02 2001-12-11 Zeptosens Ag Kit and method for determining a plurality of analytes
WO2002001194A1 (en) * 2000-06-25 2002-01-03 Affymetrix, Inc. Optically active substrates
US6643010B2 (en) 2000-08-07 2003-11-04 Royce Technologies Llc Multiple microchannels chip for biomolecule imaging
WO2002012865A1 (de) * 2000-08-09 2002-02-14 Artificial Sensing Instruments Asi Ag Wellenleitergitterstruktur und optische messanordnung
WO2002012866A1 (de) * 2000-08-09 2002-02-14 Artificial Sensing Instruments Asi Ag Nachweismethode
US6951715B2 (en) * 2000-10-30 2005-10-04 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
US7023544B2 (en) 2000-10-30 2006-04-04 Sru Biosystems, Inc. Method and instrument for detecting biomolecular interactions
US7524625B2 (en) 2000-10-30 2009-04-28 Sru Biosystems, Inc. Real time binding analysis of antigens on a biosensor surface
US7153702B2 (en) * 2000-10-30 2006-12-26 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7371562B2 (en) 2000-10-30 2008-05-13 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US20030113766A1 (en) * 2000-10-30 2003-06-19 Sru Biosystems, Llc Amine activated colorimetric resonant biosensor
US7175980B2 (en) * 2000-10-30 2007-02-13 Sru Biosystems, Inc. Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities
US7306827B2 (en) * 2000-10-30 2007-12-11 Sru Biosystems, Inc. Method and machine for replicating holographic gratings on a substrate
US7300803B2 (en) * 2000-10-30 2007-11-27 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7070987B2 (en) * 2000-10-30 2006-07-04 Sru Biosystems, Inc. Guided mode resonant filter biosensor using a linear grating surface structure
US20030092075A1 (en) * 2000-10-30 2003-05-15 Sru Biosystems, Llc Aldehyde chemical surface activation processes and test methods for colorimetric resonant sensors
US7202076B2 (en) * 2000-10-30 2007-04-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7264973B2 (en) * 2000-10-30 2007-09-04 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant optical biosensor
US7217574B2 (en) 2000-10-30 2007-05-15 Sru Biosystems, Inc. Method and apparatus for biosensor spectral shift detection
US7101660B2 (en) * 2000-10-30 2006-09-05 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7615339B2 (en) * 2000-10-30 2009-11-10 Sru Biosystems, Inc. Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
US7875434B2 (en) * 2000-10-30 2011-01-25 Sru Biosystems, Inc. Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor
US7118710B2 (en) * 2000-10-30 2006-10-10 Sru Biosystems, Inc. Label-free high-throughput optical technique for detecting biomolecular interactions
US7142296B2 (en) * 2000-10-30 2006-11-28 Sru Biosystems, Inc. Method and apparatus for detecting biomolecular interactions
US7575939B2 (en) * 2000-10-30 2009-08-18 Sru Biosystems, Inc. Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements
EP1892518A3 (de) * 2000-10-30 2008-03-12 SRU Biosystems, Inc. Markierungsfreies optisches Verfahren mit hohem Durchsatz für den Nachweis biomolekularer Wechselwirkungen
JP2002139418A (ja) * 2000-11-01 2002-05-17 Nikon Corp マイクロウエルプレート及びマイクロウエルプレートを備える蛍光検出装置
US20020132360A1 (en) * 2000-11-17 2002-09-19 Flir Systems Boston, Inc. Apparatus and methods for infrared calorimetric measurements
US20040110301A1 (en) * 2000-11-17 2004-06-10 Neilson Andy C Apparatus and methods for measuring reaction byproducts
AU2002249778A1 (en) * 2000-11-17 2002-08-12 Thermogenic Imaging, Inc. Apparatus and methods for infrared calorimetric measurements
US20040069948A1 (en) * 2000-12-18 2004-04-15 Arno Feisst Device and method for analysing the qualitative and/or quantitative composition of liquids
DE60127821D1 (de) * 2001-05-25 2007-05-24 Corning Inc Verfahren zur Bestimmung der Reaktionen und der Metabolischen Aktivitat mit Fluoreszentem temperaturempfindlichem Material
DE10126152C2 (de) * 2001-05-30 2003-12-24 Inst Mikrotechnik Mainz Gmbh Ortsaufgelöstes Ellipsometrie-Verfahren zur quantitativen und/oder qualitativen Bestimmung von Probenänderungen, Biochip und Meßanordnung
US6710877B2 (en) 2001-07-23 2004-03-23 Corning Incorporated Apparatus and methods for determining biomolecular interactions
US6707958B2 (en) * 2001-11-20 2004-03-16 Agilent Technologies, Inc. Biochemical assay device using frustrated total internal reflection modulator with an imaging optical waveguide
US7098041B2 (en) * 2001-12-11 2006-08-29 Kimberly-Clark Worldwide, Inc. Methods to view and analyze the results from diffraction-based diagnostics
DE10163657B4 (de) * 2001-12-21 2008-05-08 Gedig, Erk, Dr. Vorrichtung und Verfahren zur Untersuchung dünner Schichten
AU2003210523B2 (en) * 2002-01-28 2008-03-20 Sru Biosystems, Inc. A guided mode resonant filter biosensor using a linear grating surface structure
JP3712677B2 (ja) * 2002-01-29 2005-11-02 富士写真フイルム株式会社 生化学解析用ユニット
US20030215815A1 (en) * 2002-05-20 2003-11-20 Clark William G. Screening method
US7537936B2 (en) * 2002-05-31 2009-05-26 Agilent Technologies, Inc. Method of testing multiple fluid samples with multiple biopolymer arrays
EP1371966A1 (de) * 2002-06-14 2003-12-17 Stiftung Für Diagnostische Forschung Küvette für ein Lesegerät zur Bestimmung von Substanzen mittels der Evaneszenzfeldmethode
US20030232427A1 (en) * 2002-06-18 2003-12-18 Montagu Jean I. Optically active substrates for examination of biological materials
US7927822B2 (en) 2002-09-09 2011-04-19 Sru Biosystems, Inc. Methods for screening cells and antibodies
US7429492B2 (en) * 2002-09-09 2008-09-30 Sru Biosystems, Inc. Multiwell plates with integrated biosensors and membranes
US6810067B2 (en) 2002-09-26 2004-10-26 Photodigm, Inc. Single mode grating-outcoupled surface emitting laser with broadband and narrow-band DBR reflectors
US6987897B2 (en) * 2002-10-31 2006-01-17 Luna Innovations Incorporated Fiber-optic flow cell and method relating thereto
US20040091397A1 (en) * 2002-11-07 2004-05-13 Corning Incorporated Multiwell insert device that enables label free detection of cells and other objects
US7309614B1 (en) 2002-12-04 2007-12-18 Sru Biosystems, Inc. Self-referencing biodetection method and patterned bioassays
EP1616169B1 (de) 2003-03-27 2009-06-24 Corning Incorporated Markierungsfreier nachweis biologischer und chemischer stoffe mittels evaneszenzfeld
US7497992B2 (en) * 2003-05-08 2009-03-03 Sru Biosystems, Inc. Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
SE527896C2 (sv) * 2003-05-20 2006-07-04 Aamic Ab Optisk testanordning för biologiska prover, samt en microarray till anordningen och metoden för dess användning
US7057720B2 (en) 2003-06-24 2006-06-06 Corning Incorporated Optical interrogation system and method for using same
US20050018944A1 (en) * 2003-07-25 2005-01-27 Mozdy Eric J. Polarization modulation interrogation of grating-coupled waveguide sensors
US6985664B2 (en) * 2003-08-01 2006-01-10 Corning Incorporated Substrate index modification for increasing the sensitivity of grating-coupled waveguides
DE10336849A1 (de) 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
US7223609B2 (en) * 2003-08-14 2007-05-29 Agilent Technologies, Inc. Arrays for multiplexed surface plasmon resonance detection of biological molecules
US8298780B2 (en) 2003-09-22 2012-10-30 X-Body, Inc. Methods of detection of changes in cells
US20050070027A1 (en) * 2003-09-30 2005-03-31 Jacques Gollier Double resonance interrogation of grating-coupled waveguides
US6829073B1 (en) 2003-10-20 2004-12-07 Corning Incorporated Optical reading system and method for spectral multiplexing of resonant waveguide gratings
JP2007510928A (ja) * 2003-11-06 2007-04-26 エス アール ユー バイオシステムズ，インコーポレイテッド 高密度アミン機能化表面
US7233391B2 (en) * 2003-11-21 2007-06-19 Perkinelmer Las, Inc. Optical device integrated with well
US20050148063A1 (en) * 2003-12-24 2005-07-07 Cracauer Raymond F. Disposable reaction vessel with integrated optical elements
US20050173059A1 (en) * 2004-02-11 2005-08-11 Nalge Nunc International Corporation Methods of making a multi-well test plate having an adhesively secured transparent bottom panel
US7271885B2 (en) * 2004-03-25 2007-09-18 Perkinelmer Las, Inc. Plasmon resonance measuring method and apparatus
US20060019265A1 (en) * 2004-04-30 2006-01-26 Kimberly-Clark Worldwide, Inc. Transmission-based luminescent detection systems
US20050244953A1 (en) * 2004-04-30 2005-11-03 Kimberly-Clark Worldwide, Inc. Techniques for controlling the optical properties of assay devices
US7815854B2 (en) * 2004-04-30 2010-10-19 Kimberly-Clark Worldwide, Inc. Electroluminescent illumination source for optical detection systems
US7796266B2 (en) * 2004-04-30 2010-09-14 Kimberly-Clark Worldwide, Inc. Optical detection system using electromagnetic radiation to detect presence or quantity of analyte
US7709247B2 (en) * 2004-08-04 2010-05-04 Intel Corporation Methods and systems for detecting biomolecular binding using terahertz radiation
US20070121113A1 (en) * 2004-12-22 2007-05-31 Cohen David S Transmission-based optical detection systems
US7629173B2 (en) * 2004-12-29 2009-12-08 Corning Incorporated Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors
US7604984B2 (en) * 2004-12-29 2009-10-20 Corning Incorporated Spatially scanned optical reader system and method for using same
US20060141527A1 (en) * 2004-12-29 2006-06-29 Caracci Stephen J Method for creating a reference region and a sample region on a biosensor and the resulting biosensor
US7349080B2 (en) * 2004-12-30 2008-03-25 Corning Incorporated Label-independent detection of unpurified analytes
US7327908B1 (en) * 2005-03-07 2008-02-05 Lightsmyth Technologies Inc. Integrated optical sensor incorporating sets of diffractive elements
US20060223051A1 (en) * 2005-04-05 2006-10-05 Ye Fang System and method for performing G protein coupled receptor (GPCR) cell assays using waveguide-grating sensors
EP2631652A1 (de) 2005-04-05 2013-08-28 Corning Incorporated Markierungsfreie Biosensoren
NZ562794A (en) * 2005-04-12 2010-07-30 Sru Biosystems Inc Proteolipid membrane & lipid membrane biosensor using a titanium surface
US7521769B2 (en) * 2005-07-08 2009-04-21 Sru Biosystems, Inc. Photonic crystal biosensor structure and fabrication method
US7479404B2 (en) 2005-07-08 2009-01-20 The Board Of Trustees Of The University Of Illinois Photonic crystal biosensor structure and fabrication method
CN104076162A (zh) 2005-07-20 2014-10-01 康宁股份有限公司 无标记高通量生物分子筛选系统和方法
NZ564642A (en) 2005-08-11 2010-05-28 Sru Biosystems Inc Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
CN101268337A (zh) * 2005-09-21 2008-09-17 皇家飞利浦电子股份有限公司 用于检测主体运动的系统
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8062900B2 (en) * 2005-12-30 2011-11-22 Corning Incorporated Optically readable microplate
JP2009529671A (ja) * 2006-03-10 2009-08-20 コーニング インコーポレイテッド 基準マイクロプレート並びに基準マイクロプレートの製造及び使用方法
US20070264155A1 (en) * 2006-05-09 2007-11-15 Brady Michael D Aerosol jet deposition method and system for creating a reference region/sample region on a biosensor
JP2008020412A (ja) * 2006-07-14 2008-01-31 Sony Corp バイオアッセイ用基板、及び、バイオアッセイ方法
US7976217B2 (en) * 2006-09-15 2011-07-12 Corning Incorporated Screening system and method for analyzing a plurality of biosensors
KR20090086235A (ko) * 2006-10-31 2009-08-11 에스알유 바이오시스템즈, 인코포레이티드 작용기화된 표면 상에서 비­특이적 단백질 결합을 차단하는 방법
US7737392B2 (en) 2006-11-09 2010-06-15 The Board Of Trustees Of The University Of Illinois Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
US7867783B2 (en) * 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7776609B2 (en) 2007-03-09 2010-08-17 Corning Incorporated Reference microplates and methods for making and using the reference microplates
WO2008130488A1 (en) * 2007-04-19 2008-10-30 Corning Incorporated Live-cell signals of pathogen intrusion and methods thereof
CN101743465A (zh) * 2007-04-19 2010-06-16 Sru生物系统公司 应用生物传感器检测与固定化靶标分子直接结合的小分子的方法
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US9778267B2 (en) 2007-07-11 2017-10-03 X-Body, Inc. Methods for identifying modulators of ion channels
US9134307B2 (en) 2007-07-11 2015-09-15 X-Body, Inc. Method for determining ion channel modulating properties of a test reagent
US20090309617A1 (en) * 2007-08-24 2009-12-17 Ye Fang Biosensor antibody functional mapping
US20090093011A1 (en) * 2007-10-05 2009-04-09 Ye Fang Biosensors for ligand-directed functional selectivity
US20090325211A1 (en) * 2007-10-06 2009-12-31 Ye Fang System and method for dual-detection of a cellular response
US8426148B2 (en) 2007-10-06 2013-04-23 Corning Incorporated Label-free methods using a resonant waveguide grating biosensor to determine GPCR signaling pathways
US8703428B2 (en) * 2007-10-06 2014-04-22 Corning Incorporated Single-cell label-free assay
US20090181409A1 (en) * 2008-01-10 2009-07-16 Ye Fang Optical biosensor method for cell-cell interaction
US8759013B2 (en) 2008-03-05 2014-06-24 Corning Incorporated Dual-target biosensor cell assays
US8846575B2 (en) 2008-03-05 2014-09-30 Corning Incorporated High-throughput high-information content label-free cell biology screening methods
US8313898B2 (en) 2008-03-05 2012-11-20 Corning Incorporated Dual-target biosensor cell assays
US8257936B2 (en) 2008-04-09 2012-09-04 X-Body Inc. High resolution label free analysis of cellular properties
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
ITTO20080395A1 (it) * 2008-05-26 2009-11-27 Techfab S R L Sistema e dispositivo per la stimolazione e/o il controllo dinamici di cellule e tessuti in coltura
WO2009149285A1 (en) 2008-06-04 2009-12-10 Sru Biosystems, Inc. Detection of promiscuous small submicrometer aggregates
JP5432186B2 (ja) * 2008-12-24 2014-03-05 株式会社日立ハイテクノロジーズ 蛍光検出装置
US20100273185A1 (en) * 2009-04-27 2010-10-28 Sru Biosystems, Inc. Detection of Biased Agonist Activation
US20100291575A1 (en) * 2009-05-15 2010-11-18 Sru Biosystems, Inc. Detection of Changes in Cell Populations and Mixed Cell Populations
US8593630B2 (en) * 2009-10-07 2013-11-26 The Board Of Trustees Of The University Of Illinois Discrete frequency spectroscopy and instrumentation
CN102665916B (zh) 2009-11-23 2014-09-24 3M创新有限公司 微孔阵列制品及使用方法
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
DE102010001714A1 (de) * 2010-02-09 2011-08-11 Robert Bosch GmbH, 70469 Vorrichtung und Verfahren zur optischen Parallelanalyse einer Probenanordnung und entsprechendes Herstellungsverfahren
US20110207789A1 (en) * 2010-02-19 2011-08-25 Ye Fang Methods related to casein kinase ii (ck2) inhibitors and the use of purinosome-disrupting ck2 inhibitors for anti-cancer therapy agents
EP3150690B1 (de) 2010-02-23 2022-04-06 Luminex Corporation Vorrichtung für die manipulation von kartuschen zur isolierung und amplifizierung von nukleinsäuren
WO2011120042A1 (en) * 2010-03-26 2011-09-29 Sru Biosystems, Inc. Use of induced pluripotent cells and other cells for screening compound libraries
US9897535B2 (en) 2011-02-22 2018-02-20 Corning Incorporated Optical reader systems and methods for microplate position detection
US8922860B2 (en) 2011-02-22 2014-12-30 Corning Incorporated Motion control systems and methods for biosensor scanning
WO2012129068A1 (en) * 2011-03-22 2012-09-27 Research Triangle Institute, International Optical sensing device for sensing analytes and related apparatus and methods
EP3081301B1 (de) 2011-05-04 2019-08-14 Luminex Corporation Vorrichtung und verfahren für integrierte probenzubereitung, - reaktion und -erkennung
US9325947B2 (en) * 2011-06-28 2016-04-26 Inview Technology Corporation High-speed event detection using a compressive-sensing hyperspectral-imaging architecture
JP2014532856A (ja) 2011-10-20 2014-12-08 コーニング インコーポレイテッド 急速マイクロプレート位置検出の光学読取システム及び方法
WO2013148626A1 (en) * 2012-03-27 2013-10-03 Corning Incorporated Micro-feature methods for over-molding substrate
EP2741074A1 (de) 2012-12-04 2014-06-11 F. Hoffmann-La Roche AG Vorrichtung zur Verwendung bei der Bindeaffinitätserkennung
EP2824446A1 (de) * 2013-07-12 2015-01-14 F. Hoffmann-La Roche AG Vorrichtung zur Verwendung bei der Bindeaffinitätserkennung
JP6392876B2 (ja) * 2013-12-23 2018-09-19 セエスウエム サントル スイス デレクトロニクエ ドゥ ミクロテクニク ソシエテ アノニム−ルシェルシェ エ デブロップマン 導波モード共鳴デバイス
EP3161168B1 (de) 2014-06-30 2021-08-04 Bluelight Therapeutics, Inc. Systeme und verfahren zur analyse mit hohem durchsatz von konformation in biologischen entitäten
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
CN107850592A (zh) * 2015-03-09 2018-03-27 工业研究与发展基金会有限公司 确定细胞表型的方法
CN107615045A (zh) 2015-04-08 2018-01-19 巴克图森斯技术有限公司 高灵敏度实时细菌监测器
AU2016208337B2 (en) * 2015-07-27 2018-03-22 Personal Genomics, Inc. Sensing module and sensing method
EP3205512B1 (de) 2016-02-09 2018-06-13 CSEM Centre Suisse d'Electronique et de Microtechnique SA - Recherche et Développement Optische sicherheitsvorrichtung
EP3586189B1 (de) * 2017-02-23 2024-01-10 Nikon Corporation Messung einer änderung bei einer geometrischen eigenschaft und / oder position eines werkstücks
CA3057249A1 (en) * 2017-03-31 2018-10-04 University Of Strathclyde Infra-red spectroscopy system
FI127799B (en) * 2017-06-02 2019-02-28 Dispelix Oy Process for producing a diffraction grating
CN111512189B (zh) 2017-10-02 2023-02-21 瑞士Csem电子显微技术研发中心 谐振波导光栅及其应用
TWI653449B (zh) 2018-01-31 2019-03-11 國立交通大學 光子晶體與磁珠結合的螢光免疫檢測裝置和方法
WO2020112408A1 (en) 2018-11-30 2020-06-04 Corning Incorporated System and method for analyzing extracellular vesicles with an optical biosensor
US20210055255A1 (en) * 2019-08-21 2021-02-25 Life Technologies Corporation Devices incorporating multilane flow cell
US11198845B2 (en) * 2020-04-17 2021-12-14 Multiply Labs Inc. System, method, and apparatus facilitating automated modular manufacture of cell therapy
TWI796944B (zh) * 2022-01-28 2023-03-21 國立中山大學 螢光增強基板及螢光檢測裝置

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987006008A2 (en) * 1986-03-26 1987-10-08 Beckman Instruments, Inc. Automated multi-purposse analytical chemistry processing center and laboratory work station
GB2190195A (en) * 1986-05-09 1987-11-11 Cambridge Life Sciences Microtitre plate reader
US5082629A (en) * 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
EP0455067B1 (de) * 1990-05-03 2003-02-26 F. Hoffmann-La Roche Ag Mikrooptischer Sensor
CH681920A5 (de) * 1991-07-02 1993-06-15 Artificial Sensing Instr Asi A

Also Published As

Publication number Publication date
EP0660924B1 (de) 1999-09-01
JP4181209B2 (ja) 2008-11-12
JP4181179B2 (ja) 2008-11-12
US5738825A (en) 1998-04-14
DE69420375T2 (de) 2000-05-18
JP2006194903A (ja) 2006-07-27
JPH08504955A (ja) 1996-05-28
WO1995003538A1 (en) 1995-02-02
EP0660924A1 (de) 1995-07-05
GB9314991D0 (en) 1993-09-01
JP2008175826A (ja) 2008-07-31

Similar Documents

Publication Publication Date Title
DE69420375T2 (de) Matrix aus optischen biosensoren
DE69416031D1 (de) Optischer Verstärker
DE69400790T2 (de) Optischer Verstärker
DE69404540D1 (de) Photovervielfacher
DE69403857D1 (de) Photovervielfacher
DE69406709T2 (de) Photovervielfacher
DE69620575D1 (de) Härtbare polymethylsilsesquioxanzusammensetzung
DE69405494T2 (de) Optischen Modulator
DE69404079D1 (de) Photovervielfacher
DE69404538D1 (de) Photovervielfacher
DE69421039D1 (de) Informationsaufzeichnungsverfahren
DE69413252D1 (de) Verbesserungen an schreibinstrumenten
FI954422A0 (fi) Ferroseenin käyttö
DE59405241D1 (de) Sauerstoffmessfühler
DE69420655T2 (de) Optisches Aufzeichnungsmaterial
DE69604204D1 (de) Schreibgeräte
DE69404080D1 (de) Photovervielfacher
DE59406406D1 (de) Radaufhängung
KR950002031U (ko) 깃봉
FR2732803B1 (fr) Mediator magnetique
KR940027860U (ko) 자기저항 소자 홀더의 결합 구조
KR950000843U (ko) 인장겸용 필기구
DE69406764D1 (de) Photovervielfacher
KR960700237A (ko) 치환된 신규 티오쎄미카르바존티온류(Novel Substituted Thiosemicarbazonethiones)
MA23759A1 (fr) Porte-matrice

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: GROSSE, BOCKHORNI, SCHUMACHER, 81476 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: BOCKHORNI & KOLLEGEN, 80687 MUENCHEN