JP2006194903A - 検出セルアレイプレート、分析装置及び試料作製方法 - Google Patents
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Abstract
【解決手段】検出セル(2)を、透明な基材プレート(8)及びこの基材プレート上の試料プレート(4)を含むように構成する。試料プレートは、その内部に延在する複数個のウエル(6)のマトリックスを有していて、それぞれのウエルで試料を収容する。基材プレートは、薄膜導波路及び回折格子手段を含んでいて、入射光の領域をウエルの下方の薄膜導波路中に入り結合して回折光の領域を発生させ、よって、薄膜導波路の有効屈折率の変化の検出を可能とする。
【選択図】図1
Description
(i)少なくとも1つの入射光領域を発生しかつその光領域を前記検出セルのウエルの下方の回折格子手段上に衝突させ、よって、薄膜導波路においてモード励起を発生させるための少なくとも1つの光源、
(ii)前記ウエルの下方の薄膜導波路から回折した光領域を集めるための少なくとも1つの集光手段、及び
(iii )集められた光領域の位置を監視するための少なくとも1つの位置感知デテクタを含む読み取りユニット、
を含んでなる分析装置(システム)を提供する。
図1は、検出プレートの斜視図であり、
図2は、図1の線分A−A’の断面図であり、
図3は、図2の領域Bの拡大図であり、
図4は、検出セル及び読み取りユニットを含むバイオセンサーシステムの説明図であり、
図5(a)〜(h)は、ウエルの下方の回折格子手段のいくつかの形状を図示したものであり、
図6(a)及び(b)は、出結合の絶対角を決定することのできる形状を図示したものであり、そして
図7図(a)〜(g)は、回折格子手段のいくつかの形状を図示したものである。
又は薄膜導波路8の内部に配置することができる。
4 試料プレート
6 ウエル
8 基材プレート
Claims (17)
- 光バイオセンサーの1成分として使用するための検出セルであって、透明な基材プレートと該基材プレート上の試料プレートとを含み、その際、前記試料プレートは、それぞれが試料を収容するための該プレート内を延在するウエルのマトリックスを有しており、そして前記基材プレートは、薄膜導波路及び、ウエルの下方の薄膜導波路中に入射光領域を入り結合させて回折光領域を発生させ、よって、薄膜導波路の有効屈折率における変化の検出を可能とするための回折格子手段を含んでいる、検出セル。
- 微量滴定プレートと同一の寸法を有しており、そしてそれと同一の数のウエルを含有している、請求項1に記載の検出セル。
- 薄膜導波路と基材プレートの間の界面に回折格子手段が形成されている、請求項1又は2に記載の検出セル。
- 回折格子手段が2種類の格子を有しており、そしてある種類のもののラインが別のセットのラインに直角で配列されている、請求項1〜3のいずれか1項に記載の検出セル。
- それぞれのウエルの下方に別々の回折格子手段を有している、請求項1〜4のいずれか1項に記載の検出セル。
- 薄膜導波路の自由表面にカプリング層を被覆して、そのカプリング層に対するウエル中の物質の選択的結合を可能にしている、請求項1〜5のいずれか1項に記載の検出セル。
- 薄膜導波路が二酸化チタンである、請求項1〜6のいずれか1項に記載の検出セル。
- 薄膜導波路が、酸化物Ta2 O5 、HfO2 、Si3 N4 、ZrO2 、酸化ニオブ、Al2 O3 もしくはSiO2 及びTiO2 の混合物のいずれかであるかもしくはオキシナイトライドHfON又はSiONのいずれかである、請求項1〜7のいずれか1項に記載の検出セル。
- 請求項1〜8のいずれか1項に記載の検出セル、及び
(i)少なくとも1つの光領域を発生しかつその光領域を前記検出セルのウエルの下方の回折格子手段上に衝突させ、よって、薄膜導波路においてモード励起を発生させるための少なくとも1つの光源、
(ii)前記ウエルの下方の薄膜導波路から回折した光領域を集めるための少なくとも1つの集光手段、及び
(iii )集められた光領域の位置を監視するための少なくとも1つの位置感知デテクタを含む読み取りユニット、
を含んでなる分析装置。 - 前記少なくとも1つの光源が、対向伝達方向においてモード励起を生じるために、2つの対称に配された扇形の光領域を発生して、該光領域を前記検出セルのウエルの下方の回折格子手段上に照射し、そして前記読み取りユニットが、回折された光領域を監視するため、2つの対称に配された位置感知光デテクタを有している、請求項9に記載の分析装置。
- 前記検出セルのマトリックスのそれぞれの行に読み取りユニットを有している、請求項9又は10に記載の分析装置。
- 前記検出セルをその検出セルのウエルに充填を行う充填ステーションから読み取りユニットと共働する位置まで移送するための移送手段をさらに有している、請求項9〜11のいずれか1項に記載の分析装置。
- 前記移送手段が、前記検出セルを所望とするそれぞれの場合に前記読み取りユニットに関して精確に同一の位置に固着することができるようにするために、位置固着手段を含んでいる、請求項12に記載の分析装置。
- 前記移送手段が、前記回折格子手段から回折された光領域を読み取りユニットで走査することを可能にするため、前記検出セルを前記読み取りユニットに関して連続的に移動させる、請求項12に記載の分析装置。
- 光バイオセンサーを使用して試料を自動化分析するための方法であって、請求項1〜8のいずれか1項に記載の検出セルのウエルにキャリヤ流体を充填すること、前記検出セルを、請求項9〜11のいずれか1項に記載の分析装置の読み取りユニットと共働する位置まで移送すること、それぞれのウエルからの出結合光を監視し、そして出結合光を参照値の提供のために記録すること、前記検出セルを滴定ステーションまで移送し、そしてそれぞれのウエルに試料を滴下すること、前記検出セルを移送して読み取りユニットまで戻し、そして検出セル内の回折格子手段上に光を照射すること、それぞれのウエルからの出結合光を監視すること、及び得られた結果を前記参照値に対比すること、を含んでなる、自動化分析方法。
- 光バイオセンサーを使用して試料を自動化分析するための方法であって、請求項1〜8のいずれか1項に記載の検出セルのウエルにキャリヤ流体を充填すること、前記検出セルを、請求項9〜11のいずれか1項に記載の分析装置の読み取りユニットと共働する位置まで移送すること、それぞれのウエルからの出結合光を監視し、そして出結合光を参照値の提供のために記録すること、前記検出セルを滴定ステーションまで移送し、そしてそれぞれのウエルに試料を滴下すること、前記検出セルを移送して読み取りユニットまで戻し、そして検出セル内の回折格子手段上に光を照射すること、それぞれのウエルからの出結合光を監視すること、前記試料をキャリヤ流体に置き換えること、前記検出セルを移送して読み取りユニットまで戻し、そして検出セル内の回折格子手段上に光を照射すること、それぞれのウエルからの出結合光を監視して第2の参照値を提供すること、及び前記試料の結果を前記参照値に対比すること、を含んでなる、自動化分析方法。
- 試料中の変化の動力学を測定するための方法であって、請求項1〜8のいずれか1項に記載の検出セルのウエルに試料を充填すること、前記検出セルを、請求項9〜11のいずれか1項に記載の分析装置の読み取りユニットと共働可能な位置まで移送すること、及びそれぞれのウエルからの異なる回折光領域を別々の間隔で繰り返し監視し、その際、あらゆるウエルのそれぞれの別々の間隔の時間を前記変化に要した時間よりも短くすること、を含んでなる、測定方法。
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- 1994-07-18 DE DE69420375T patent/DE69420375T2/de not_active Expired - Lifetime
- 1994-07-18 EP EP94921655A patent/EP0660924B1/en not_active Expired - Lifetime
- 1994-07-18 US US08/854,586 patent/US5738825A/en not_active Expired - Lifetime
- 1994-07-18 WO PCT/EP1994/002361 patent/WO1995003538A1/en active IP Right Grant
- 1994-07-18 JP JP7504928A patent/JPH08504955A/ja active Pending
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2006
- 2006-02-22 JP JP2006045281A patent/JP4181179B2/ja not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
---|---|
JP2008175826A (ja) | 2008-07-31 |
DE69420375D1 (de) | 1999-10-07 |
JPH08504955A (ja) | 1996-05-28 |
DE69420375T2 (de) | 2000-05-18 |
WO1995003538A1 (en) | 1995-02-02 |
GB9314991D0 (en) | 1993-09-01 |
US5738825A (en) | 1998-04-14 |
EP0660924B1 (en) | 1999-09-01 |
EP0660924A1 (en) | 1995-07-05 |
JP4181179B2 (ja) | 2008-11-12 |
JP4181209B2 (ja) | 2008-11-12 |
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