DE69411900T2 - Heterozyklische derivate als plätchenaggregationsinhibitoren - Google Patents

Heterozyklische derivate als plätchenaggregationsinhibitoren

Info

Publication number
DE69411900T2
DE69411900T2 DE69411900T DE69411900T DE69411900T2 DE 69411900 T2 DE69411900 T2 DE 69411900T2 DE 69411900 T DE69411900 T DE 69411900T DE 69411900 T DE69411900 T DE 69411900T DE 69411900 T2 DE69411900 T2 DE 69411900T2
Authority
DE
Germany
Prior art keywords
formula
compound
pyridyl
alkylene
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69411900T
Other languages
German (de)
English (en)
Other versions
DE69411900D1 (de
Inventor
Andrew George Macclesfield Cheshire Sk10 5Qu Brewster
Peter William Rodney Macclesfield Cheshire Sk10 1Lx Caulkett
Alan Wellington Macclesfield Cheshire Sk10 5La Faull
Stuart Dennett Macclesfield Cheshire Sk11 9Rd Mills
Robert James Wilmslow Cheshire Sk9 5Ja Pearce
John Wall Stockport Cheshire Sk7 6Ns Rayner
Richard Eden Macclesfield Cheshire Sk10 3Af Shute
Michael James Macclesfield Cheshire Sk11 8Lt Smithers
Michael Garth Stoke On Trent Staffs St8 7Tb Wayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69411900D1 publication Critical patent/DE69411900D1/de
Application granted granted Critical
Publication of DE69411900T2 publication Critical patent/DE69411900T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
DE69411900T 1993-03-29 1994-03-28 Heterozyklische derivate als plätchenaggregationsinhibitoren Expired - Fee Related DE69411900T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
DE69411900D1 DE69411900D1 (de) 1998-08-27
DE69411900T2 true DE69411900T2 (de) 1998-12-10

Family

ID=26302668

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69411900T Expired - Fee Related DE69411900T2 (de) 1993-03-29 1994-03-28 Heterozyklische derivate als plätchenaggregationsinhibitoren
DE69427548T Expired - Fee Related DE69427548T2 (de) 1993-03-29 1994-03-28 Heterozyklische Derivate als Plätchenaggregationsinhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69427548T Expired - Fee Related DE69427548T2 (de) 1993-03-29 1994-03-28 Heterozyklische Derivate als Plätchenaggregationsinhibitoren

Country Status (26)

Country Link
US (1) US5556977A (enExample)
EP (2) EP0825184B1 (enExample)
JP (1) JPH08508291A (enExample)
KR (1) KR100231089B1 (enExample)
CN (1) CN1120334A (enExample)
AT (2) ATE168678T1 (enExample)
AU (1) AU692438B2 (enExample)
BR (1) BR9406613A (enExample)
CA (1) CA2156070A1 (enExample)
CZ (1) CZ250995A3 (enExample)
DE (2) DE69411900T2 (enExample)
DK (2) DK0691959T3 (enExample)
ES (2) ES2119184T3 (enExample)
FI (1) FI954616L (enExample)
GB (1) GB9406143D0 (enExample)
GR (2) GR3027751T3 (enExample)
HU (2) HUT72088A (enExample)
IL (1) IL109144A (enExample)
NO (1) NO305244B1 (enExample)
NZ (1) NZ262941A (enExample)
PL (1) PL310889A1 (enExample)
PT (1) PT825184E (enExample)
SK (1) SK120895A3 (enExample)
TW (1) TW276254B (enExample)
WO (1) WO1994022834A1 (enExample)
ZW (1) ZW4294A1 (enExample)

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FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
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JP2002516305A (ja) 1998-05-12 2002-06-04 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
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US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
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AU4250200A (en) * 1999-04-19 2000-11-02 Coelacanth Corporation Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
RS65576B1 (sr) 2017-11-24 2024-06-28 Jubilant Episcribe Llc Heterociklična jedinjenja kao inhibitori prmt5
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

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Also Published As

Publication number Publication date
ATE168678T1 (de) 1998-08-15
EP0825184B1 (en) 2001-06-20
CZ250995A3 (en) 1996-01-17
DE69427548D1 (de) 2001-07-26
CA2156070A1 (en) 1994-10-13
PT825184E (pt) 2001-11-30
NO953837D0 (no) 1995-09-28
GB9406143D0 (en) 1994-05-18
DE69427548T2 (de) 2002-04-18
NZ262941A (en) 1997-07-27
IL109144A0 (en) 1994-06-24
BR9406613A (pt) 1996-02-06
IL109144A (en) 2000-02-29
ATE202345T1 (de) 2001-07-15
TW276254B (enExample) 1996-05-21
AU6288994A (en) 1994-10-24
JPH08508291A (ja) 1996-09-03
EP0691959A1 (en) 1996-01-17
NO953837L (no) 1995-09-28
HU9502290D0 (en) 1995-10-30
SK120895A3 (en) 1996-06-05
AU692438B2 (en) 1998-06-11
KR100231089B1 (ko) 1999-11-15
US5556977A (en) 1996-09-17
FI954616A0 (fi) 1995-09-28
ES2119184T3 (es) 1998-10-01
DK0825184T3 (da) 2001-09-10
HU211336A9 (en) 1995-11-28
DE69411900D1 (de) 1998-08-27
ES2159798T3 (es) 2001-10-16
WO1994022834A1 (en) 1994-10-13
FI954616A7 (fi) 1995-09-28
GR3036640T3 (en) 2001-12-31
NO305244B1 (no) 1999-04-26
ZW4294A1 (en) 1994-12-21
EP0691959B1 (en) 1998-07-22
FI954616L (fi) 1995-09-28
GR3027751T3 (en) 1998-11-30
PL310889A1 (en) 1996-01-08
EP0825184A1 (en) 1998-02-25
DK0691959T3 (da) 1999-04-26
HUT72088A (en) 1996-03-28
CN1120334A (zh) 1996-04-10

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