AU692438B2 - Heterocyclic derivatives as platelet aggregation inhibitors - Google Patents

Heterocyclic derivatives as platelet aggregation inhibitors Download PDF

Info

Publication number
AU692438B2
AU692438B2 AU62889/94A AU6288994A AU692438B2 AU 692438 B2 AU692438 B2 AU 692438B2 AU 62889/94 A AU62889/94 A AU 62889/94A AU 6288994 A AU6288994 A AU 6288994A AU 692438 B2 AU692438 B2 AU 692438B2
Authority
AU
Australia
Prior art keywords
compound
formula
pyridyl
piperazin
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU62889/94A
Other languages
English (en)
Other versions
AU6288994A (en
Inventor
Andrew George Brewster
Peter William Rodney Caulkett
Alan Wellington Faull
Stuart Dennett Mills
Robert James Pearce
John Wall Rayner
Richard Eden Shute
Michael James Smithers
Michael Garth Wayne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of AU6288994A publication Critical patent/AU6288994A/en
Application granted granted Critical
Publication of AU692438B2 publication Critical patent/AU692438B2/en
Assigned to ASTRAZENECA AB reassignment ASTRAZENECA AB Alteration of Name(s) in Register under S187 Assignors: ZENECA LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
AU62889/94A 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors Ceased AU692438B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB9306453 1993-03-29
GB9325605 1993-12-15
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
AU6288994A AU6288994A (en) 1994-10-24
AU692438B2 true AU692438B2 (en) 1998-06-11

Family

ID=26302668

Family Applications (1)

Application Number Title Priority Date Filing Date
AU62889/94A Ceased AU692438B2 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Country Status (26)

Country Link
US (1) US5556977A (enExample)
EP (2) EP0825184B1 (enExample)
JP (1) JPH08508291A (enExample)
KR (1) KR100231089B1 (enExample)
CN (1) CN1120334A (enExample)
AT (2) ATE168678T1 (enExample)
AU (1) AU692438B2 (enExample)
BR (1) BR9406613A (enExample)
CA (1) CA2156070A1 (enExample)
CZ (1) CZ250995A3 (enExample)
DE (2) DE69411900T2 (enExample)
DK (2) DK0691959T3 (enExample)
ES (2) ES2119184T3 (enExample)
FI (1) FI954616L (enExample)
GB (1) GB9406143D0 (enExample)
GR (2) GR3027751T3 (enExample)
HU (2) HUT72088A (enExample)
IL (1) IL109144A (enExample)
NO (1) NO305244B1 (enExample)
NZ (1) NZ262941A (enExample)
PL (1) PL310889A1 (enExample)
PT (1) PT825184E (enExample)
SK (1) SK120895A3 (enExample)
TW (1) TW276254B (enExample)
WO (1) WO1994022834A1 (enExample)
ZW (1) ZW4294A1 (enExample)

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PL318440A1 (en) * 1995-06-01 1997-06-09 Zeneca Ltd (-)-(3r)-3-methyl-4-{4-[4-pyridyl)piperazin-1-yl]phenoxy}butyric acid as cellular adhesion inhibitor
FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
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GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
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US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002516305A (ja) 1998-05-12 2002-06-04 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
AU5239999A (en) * 1998-07-31 2000-02-21 Eli Lilly And Company Heterocyclyl sulphonamide derivatives
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AU4250200A (en) * 1999-04-19 2000-11-02 Coelacanth Corporation Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
RS65576B1 (sr) 2017-11-24 2024-06-28 Jubilant Episcribe Llc Heterociklična jedinjenja kao inhibitori prmt5
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

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Also Published As

Publication number Publication date
ATE168678T1 (de) 1998-08-15
EP0825184B1 (en) 2001-06-20
CZ250995A3 (en) 1996-01-17
DE69427548D1 (de) 2001-07-26
CA2156070A1 (en) 1994-10-13
PT825184E (pt) 2001-11-30
NO953837D0 (no) 1995-09-28
GB9406143D0 (en) 1994-05-18
DE69427548T2 (de) 2002-04-18
NZ262941A (en) 1997-07-27
IL109144A0 (en) 1994-06-24
BR9406613A (pt) 1996-02-06
IL109144A (en) 2000-02-29
ATE202345T1 (de) 2001-07-15
TW276254B (enExample) 1996-05-21
AU6288994A (en) 1994-10-24
JPH08508291A (ja) 1996-09-03
EP0691959A1 (en) 1996-01-17
NO953837L (no) 1995-09-28
HU9502290D0 (en) 1995-10-30
SK120895A3 (en) 1996-06-05
KR100231089B1 (ko) 1999-11-15
US5556977A (en) 1996-09-17
FI954616A0 (fi) 1995-09-28
ES2119184T3 (es) 1998-10-01
DK0825184T3 (da) 2001-09-10
HU211336A9 (en) 1995-11-28
DE69411900D1 (de) 1998-08-27
ES2159798T3 (es) 2001-10-16
WO1994022834A1 (en) 1994-10-13
FI954616A7 (fi) 1995-09-28
GR3036640T3 (en) 2001-12-31
NO305244B1 (no) 1999-04-26
ZW4294A1 (en) 1994-12-21
EP0691959B1 (en) 1998-07-22
DE69411900T2 (de) 1998-12-10
FI954616L (fi) 1995-09-28
GR3027751T3 (en) 1998-11-30
PL310889A1 (en) 1996-01-08
EP0825184A1 (en) 1998-02-25
DK0691959T3 (da) 1999-04-26
HUT72088A (en) 1996-03-28
CN1120334A (zh) 1996-04-10

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