JPH08508291A - 複素環誘導体 - Google Patents

複素環誘導体

Info

Publication number
JPH08508291A
JPH08508291A JP6521810A JP52181094A JPH08508291A JP H08508291 A JPH08508291 A JP H08508291A JP 6521810 A JP6521810 A JP 6521810A JP 52181094 A JP52181094 A JP 52181094A JP H08508291 A JPH08508291 A JP H08508291A
Authority
JP
Japan
Prior art keywords
formula
compound
pyridyl
alkylene
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6521810A
Other languages
English (en)
Japanese (ja)
Inventor
ウエイン，マイケル・ガース
スミザーズ，マイケル・ジェイムズ
レイナー，ジョン・ウォール
フォール，アラン・ウェリントン
ピアース，ロバート・ジェイムズ
ブルースター，アンドリュー・ジョージ
シャット，リチャード・エデン
ミルズ，スチュアート・デネット
コールケット，ピーター・ウィリアム・ロドニー
Original Assignee
ゼネカ・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by ゼネカ・リミテッド filed Critical ゼネカ・リミテッド
Publication of JPH08508291A publication Critical patent/JPH08508291A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
JP6521810A 1993-03-29 1994-03-28 複素環誘導体 Pending JPH08508291A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB9306453.3 1993-03-29
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives
GB9325605.5 1993-12-15
PCT/GB1994/000647 WO1994022834A1 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Publications (1)

Publication Number Publication Date
JPH08508291A true JPH08508291A (ja) 1996-09-03

Family

ID=26302668

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6521810A Pending JPH08508291A (ja) 1993-03-29 1994-03-28 複素環誘導体

Country Status (26)

Country Link
US (1) US5556977A (enExample)
EP (2) EP0825184B1 (enExample)
JP (1) JPH08508291A (enExample)
KR (1) KR100231089B1 (enExample)
CN (1) CN1120334A (enExample)
AT (2) ATE168678T1 (enExample)
AU (1) AU692438B2 (enExample)
BR (1) BR9406613A (enExample)
CA (1) CA2156070A1 (enExample)
CZ (1) CZ250995A3 (enExample)
DE (2) DE69411900T2 (enExample)
DK (2) DK0691959T3 (enExample)
ES (2) ES2119184T3 (enExample)
FI (1) FI954616L (enExample)
GB (1) GB9406143D0 (enExample)
GR (2) GR3027751T3 (enExample)
HU (2) HUT72088A (enExample)
IL (1) IL109144A (enExample)
NO (1) NO305244B1 (enExample)
NZ (1) NZ262941A (enExample)
PL (1) PL310889A1 (enExample)
PT (1) PT825184E (enExample)
SK (1) SK120895A3 (enExample)
TW (1) TW276254B (enExample)
WO (1) WO1994022834A1 (enExample)
ZW (1) ZW4294A1 (enExample)

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PL318440A1 (en) * 1995-06-01 1997-06-09 Zeneca Ltd (-)-(3r)-3-methyl-4-{4-[4-pyridyl)piperazin-1-yl]phenoxy}butyric acid as cellular adhesion inhibitor
FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
SK282833B6 (sk) * 1995-11-17 2002-12-03 Warner-Lambert Company Sulfónamidové inhibítory matricových metaloproteináz a farmaceutická kompozícia obsahujúca tieto inhibítory
GB9525620D0 (en) * 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) * 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
EP0885205A4 (en) * 1996-02-28 2002-11-27 Merck & Co Inc Fibrinogen Receptor Antagonists
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
WO1997036887A1 (en) * 1996-03-29 1997-10-09 Meiji Seika Kaisha, Ltd. Novel heterocyclic compounds having platelet aggregation inhibitory effects
CA2257937A1 (en) * 1996-06-28 1998-01-08 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5990107A (en) * 1996-06-28 1999-11-23 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5932582A (en) * 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
JP2000514061A (ja) * 1996-06-28 2000-10-24 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
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UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US5945545A (en) * 1996-12-13 1999-08-31 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1998035956A1 (en) 1997-02-13 1998-08-20 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
JP2001511799A (ja) 1997-02-13 2001-08-14 ゼネカ・リミテッド オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US6221902B1 (en) 1998-05-12 2001-04-24 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002516305A (ja) 1998-05-12 2002-06-04 アメリカン・ホーム・プロダクツ・コーポレイション インスリン抵抗性および高血糖症の治療に有用な２，３，５−置換ビフェニル
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
AU5239999A (en) * 1998-07-31 2000-02-21 Eli Lilly And Company Heterocyclyl sulphonamide derivatives
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AU4250200A (en) * 1999-04-19 2000-11-02 Coelacanth Corporation Ppar-(gamma) agonists as agents for the treatment of type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
DE60144284D1 (de) 2000-11-01 2011-05-05 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
US11629135B2 (en) 2017-11-06 2023-04-18 Jubilant Prodell Llc Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
RS65576B1 (sr) 2017-11-24 2024-06-28 Jubilant Episcribe Llc Heterociklična jedinjenja kao inhibitori prmt5
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

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Also Published As

Publication number Publication date
ATE168678T1 (de) 1998-08-15
EP0825184B1 (en) 2001-06-20
CZ250995A3 (en) 1996-01-17
DE69427548D1 (de) 2001-07-26
CA2156070A1 (en) 1994-10-13
PT825184E (pt) 2001-11-30
NO953837D0 (no) 1995-09-28
GB9406143D0 (en) 1994-05-18
DE69427548T2 (de) 2002-04-18
NZ262941A (en) 1997-07-27
IL109144A0 (en) 1994-06-24
BR9406613A (pt) 1996-02-06
IL109144A (en) 2000-02-29
ATE202345T1 (de) 2001-07-15
TW276254B (enExample) 1996-05-21
AU6288994A (en) 1994-10-24
EP0691959A1 (en) 1996-01-17
NO953837L (no) 1995-09-28
HU9502290D0 (en) 1995-10-30
SK120895A3 (en) 1996-06-05
AU692438B2 (en) 1998-06-11
KR100231089B1 (ko) 1999-11-15
US5556977A (en) 1996-09-17
FI954616A0 (fi) 1995-09-28
ES2119184T3 (es) 1998-10-01
DK0825184T3 (da) 2001-09-10
HU211336A9 (en) 1995-11-28
DE69411900D1 (de) 1998-08-27
ES2159798T3 (es) 2001-10-16
WO1994022834A1 (en) 1994-10-13
FI954616A7 (fi) 1995-09-28
GR3036640T3 (en) 2001-12-31
NO305244B1 (no) 1999-04-26
ZW4294A1 (en) 1994-12-21
EP0691959B1 (en) 1998-07-22
DE69411900T2 (de) 1998-12-10
FI954616L (fi) 1995-09-28
GR3027751T3 (en) 1998-11-30
PL310889A1 (en) 1996-01-08
EP0825184A1 (en) 1998-02-25
DK0691959T3 (da) 1999-04-26
HUT72088A (en) 1996-03-28
CN1120334A (zh) 1996-04-10

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