PT966462E - Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno - Google Patents

Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno

Info

Publication number
PT966462E
PT966462E PT98903175T PT98903175T PT966462E PT 966462 E PT966462 E PT 966462E PT 98903175 T PT98903175 T PT 98903175T PT 98903175 T PT98903175 T PT 98903175T PT 966462 E PT966462 E PT 966462E
Authority
PT
Portugal
Prior art keywords
cyclase
eskalene
uteric
inhibitors
oxide
Prior art date
Application number
PT98903175T
Other languages
English (en)
Inventor
George Robert Brown
Nicholas John Newcombe
Alan John Foubister
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9702945.8A external-priority patent/GB9702945D0/en
Priority claimed from GBGB9715735.8A external-priority patent/GB9715735D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PT966462E publication Critical patent/PT966462E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
PT98903175T 1997-02-13 1998-02-09 Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno PT966462E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9702945.8A GB9702945D0 (en) 1997-02-13 1997-02-13 Heterocyclic compounds
GBGB9715735.8A GB9715735D0 (en) 1997-07-26 1997-07-26 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
PT966462E true PT966462E (pt) 2003-10-31

Family

ID=26310985

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98903175T PT966462E (pt) 1997-02-13 1998-02-09 Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno

Country Status (10)

Country Link
US (1) US6391880B1 (pt)
EP (1) EP0966462B1 (pt)
JP (1) JP2001511799A (pt)
AT (1) ATE242774T1 (pt)
AU (1) AU5999798A (pt)
DE (1) DE69815509T2 (pt)
DK (1) DK0966462T3 (pt)
ES (1) ES2201438T3 (pt)
PT (1) PT966462E (pt)
WO (1) WO1998035959A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9715892D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
WO2000078317A1 (en) * 1999-06-23 2000-12-28 Merck & Co., Inc. Integrin receptor antagonists
EP1330444B1 (en) 2000-11-01 2011-03-23 Millennium Pharmaceuticals, Inc. Nitrogenous heterocyclic compounds and process for making them
NZ564758A (en) * 2005-06-30 2011-03-31 Prosidion Ltd G-protein coupled receptor agonists
WO2008119657A1 (en) * 2007-03-30 2008-10-09 F. Hoffmann-La Roche Ag Imidazolidinone derivatives
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT340933B (de) 1973-08-20 1978-01-10 Thomae Gmbh Dr K Verfahren zur herstellung neuer pyrimidinderivate und ihrer saureadditionssalze
US4167567A (en) 1978-05-05 1979-09-11 The Upjohn Company Antihypertensive 4-aminoquinolines
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
SE8203887D0 (sv) 1982-06-23 1982-06-23 Kabivitrum Ab Nya trombininhiberande foreningar
DE3246932A1 (de) 1982-12-16 1984-06-20 Schering AG, 1000 Berlin und 4709 Bergkamen Substituierte 5h-pyrimido(5,4-b)indole
FR2557570B1 (fr) 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4840963A (en) 1984-03-14 1989-06-20 Merck & Co., Inc. 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
GB8601160D0 (en) 1986-01-17 1986-02-19 Fujisawa Pharmaceutical Co Heterocyclic compounds
GB8603120D0 (en) 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
GB8710494D0 (en) 1987-05-02 1987-06-03 Pfizer Ltd Antiarrhythmic agents
JPH0696575B2 (ja) 1987-09-17 1994-11-30 三菱化成株式会社 ４−アミノピリジン誘導体及びその酸付加塩
US4871721A (en) 1988-01-11 1989-10-03 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
GB8817315D0 (en) 1988-07-20 1988-08-24 Pfizer Ltd Triazole antifungal agents
GB8819307D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
DE3943226C2 (de) 1989-01-13 1995-01-05 Mannesmann Ag Verfahren und Vorrichtung zur Erfassung von Ungänzen an langgestreckten Werkstücken
DE3905364A1 (de) 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
IE64358B1 (en) 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
US5032604A (en) 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
DE3943225A1 (de) 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5518735A (en) 1990-11-15 1996-05-21 Pentapharm Ag Meta-substituted phenylalanine derivatives
EP0495750A3 (en) 1991-01-14 1992-09-16 Ciba-Geigy Ag Heterocyclic hydroxylamine
IT1245712B (it) 1991-04-09 1994-10-14 Boehringer Mannheim Italia Ammine eterocicliche utili terapia dell'asma e dell'infiammazione delle vie aeree
FR2676054B1 (fr) 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH07502014A (ja) 1991-06-21 1995-03-02 ベーリンガー　マンハイム　イタリア　エス．ピー．エイ． 気道に対して抗喘息性、抗炎症性活性を有する２−アミノ−４−アリール−チアゾール
EP0604529A1 (en) 1991-09-19 1994-07-06 Smithkline Beecham Corporation Pyridine compounds for treating leukotriene-related diseases
PH31294A (en) 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
HU211995B (en) 1992-06-30 1996-01-29 Gyogyszerkutato Intezet Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them
US5371091A (en) 1992-08-31 1994-12-06 Bristol-Myers Squibb Company Heteroaromatic amine thrombin inhibitors
FR2697252B1 (fr) 1992-10-28 1994-12-09 Fournier Ind & Sante Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique.
DE4243858A1 (de) 1992-12-23 1994-06-30 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5332822A (en) 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
US5364865A (en) 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
DE4302485A1 (de) 1993-01-29 1994-08-04 Merck Patent Gmbh Piperazinderivate
CA2133761A1 (en) 1993-02-10 1994-08-18 Jorg Sturzebecher Piperazides of substituted phenylalanine derivates as thrombin inhibitors
DE4306506A1 (de) 1993-03-03 1994-09-08 Boehringer Mannheim Gmbh Neue 4-Alkylaminopyridine - Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel
TW257757B (pt) 1993-03-03 1995-09-21 Boehringer Mannheim Gmbh
CA2155307A1 (en) 1993-03-29 1994-10-13 Michael Garth Wayne Heterocyclic compounds as platelet aggregation inhibitors
GB9406143D0 (en) 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic derivatives
US5681954A (en) 1993-05-14 1997-10-28 Daiichi Pharmaceutical Co., Ltd. Piperazine derivatives
JPH07145060A (ja) 1993-11-25 1995-06-06 Teijin Ltd 細胞遊走阻害剤
WO1996005189A1 (de) 1994-08-09 1996-02-22 Pentapharm Ag Neue inhibitoren vom benzamidintyp
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5795893A (en) 1994-12-22 1998-08-18 Smithkline Beecham Corporation Fibrinogen receptor antagonists
WO1996019223A1 (en) 1994-12-22 1996-06-27 Smithkline Beecham Corporation Fibrinogen receptor antagonists
IL117149A0 (en) 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
IL117580A0 (en) 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
GB9516709D0 (en) * 1995-08-15 1995-10-18 Zeneca Ltd Medicament
EP0880501A1 (en) * 1996-02-02 1998-12-02 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9602294D0 (en) 1996-02-05 1996-04-03 Zeneca Ltd Heterocyclic compounds
DE69717268T2 (de) 1996-02-22 2003-09-04 Bristol-Myers Squibb Pharma Co., Wilmington M-amidinophenyl-analoga als faktor-xa-inhibitoren
PL331599A1 (en) 1996-08-14 1999-08-02 Zeneca Ltd Substituted derivatives of pyrimidine and their pharmaceutical application
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
GB9715892D0 (en) * 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
DK0966462T3 (da) 2003-09-22
US6391880B1 (en) 2002-05-21
JP2001511799A (ja) 2001-08-14
EP0966462B1 (en) 2003-06-11
WO1998035959A1 (en) 1998-08-20
EP0966462A1 (en) 1999-12-29
DE69815509D1 (de) 2003-07-17
ATE242774T1 (de) 2003-06-15
DE69815509T2 (de) 2004-05-13
ES2201438T3 (es) 2004-03-16
AU5999798A (en) 1998-09-08

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