DE69233046D1 - Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen - Google Patents

Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen

Info

Publication number
DE69233046D1
DE69233046D1 DE69233046T DE69233046T DE69233046D1 DE 69233046 D1 DE69233046 D1 DE 69233046D1 DE 69233046 T DE69233046 T DE 69233046T DE 69233046 T DE69233046 T DE 69233046T DE 69233046 D1 DE69233046 D1 DE 69233046D1
Authority
DE
Germany
Prior art keywords
nucleoside
substituent
molecule
linking group
soluble vitamin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233046T
Other languages
English (en)
Other versions
DE69233046T2 (de
Inventor
Muthiah Manoharan
Dan Cook
Clarence Frank Bennett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69233046D1 publication Critical patent/DE69233046D1/de
Publication of DE69233046T2 publication Critical patent/DE69233046T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69233046T 1991-10-24 1992-10-23 Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen Expired - Lifetime DE69233046T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78237491A 1991-10-24 1991-10-24
US782374 1991-10-24
PCT/US1992/009196 WO1993007883A1 (en) 1991-10-24 1992-10-23 Derivatized oligonucleotides having improved uptake and other properties

Publications (2)

Publication Number Publication Date
DE69233046D1 true DE69233046D1 (de) 2003-06-12
DE69233046T2 DE69233046T2 (de) 2004-03-04

Family

ID=25125854

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233046T Expired - Lifetime DE69233046T2 (de) 1991-10-24 1992-10-23 Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen

Country Status (7)

Country Link
EP (2) EP0724447B1 (de)
JP (1) JP2823959B2 (de)
AT (1) ATE239484T1 (de)
AU (1) AU2916292A (de)
CA (1) CA2122030C (de)
DE (1) DE69233046T2 (de)
WO (1) WO1993007883A1 (de)

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EP1331011A3 (de) 2003-12-17
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ATE239484T1 (de) 2003-05-15
CA2122030C (en) 1997-03-04
AU2916292A (en) 1993-05-21
EP0724447A1 (de) 1996-08-07
JP2823959B2 (ja) 1998-11-11
CA2122030A1 (en) 1993-04-29
WO1993007883A1 (en) 1993-04-29
DE69233046T2 (de) 2004-03-04
EP1331011A2 (de) 2003-07-30

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