NO996107L - C-4"-substituerte makrolidderivater - Google Patents

C-4"-substituerte makrolidderivater

Info

Publication number
NO996107L
NO996107L NO996107A NO996107A NO996107L NO 996107 L NO996107 L NO 996107L NO 996107 A NO996107 A NO 996107A NO 996107 A NO996107 A NO 996107A NO 996107 L NO996107 L NO 996107L
Authority
NO
Norway
Prior art keywords
macrolide derivatives
substituted macrolide
substituted
derivatives
macrolide
Prior art date
Application number
NO996107A
Other languages
English (en)
Other versions
NO315560B1 (no
NO996107D0 (no
Inventor
Brian Scott Bronk
Takushi Kaneko
Michael Anthony Letavic
Hengmiao Cheng
Edward Alan Glazer
Bingwei Vera Yang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO996107D0 publication Critical patent/NO996107D0/no
Publication of NO996107L publication Critical patent/NO996107L/no
Publication of NO315560B1 publication Critical patent/NO315560B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19996107A 1997-06-11 1999-12-10 C-4"-substituerte makrolidderivater og fremgangsmåte for fremstilling derav, samt farmasöytisk blanding NO315560B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11
PCT/IB1998/000799 WO1998056801A1 (en) 1997-06-11 1998-05-25 C-4''-substituted macrolide derivatives

Publications (3)

Publication Number Publication Date
NO996107D0 NO996107D0 (no) 1999-12-10
NO996107L true NO996107L (no) 2000-02-10
NO315560B1 NO315560B1 (no) 2003-09-22

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19996107A NO315560B1 (no) 1997-06-11 1999-12-10 C-4"-substituerte makrolidderivater og fremgangsmåte for fremstilling derav, samt farmasöytisk blanding

Country Status (39)

Country Link
EP (1) EP0988309B1 (no)
JP (1) JP3262806B2 (no)
KR (1) KR100369959B1 (no)
CN (1) CN1145636C (no)
AP (1) AP1189A (no)
AR (1) AR013085A1 (no)
AT (1) ATE310742T1 (no)
AU (1) AU745006C (no)
BG (1) BG64357B1 (no)
BR (1) BR9810097A (no)
CA (1) CA2293397C (no)
CO (1) CO4950584A1 (no)
DE (1) DE69832486T2 (no)
DZ (1) DZ2515A1 (no)
EA (1) EA002440B1 (no)
ES (1) ES2251081T3 (no)
GT (1) GT199800075A (no)
HN (1) HN1998000074A (no)
HR (1) HRP980315A2 (no)
HU (1) HUP0004076A3 (no)
ID (1) ID24530A (no)
IL (1) IL132808A (no)
IS (1) IS1979B (no)
MA (1) MA24563A1 (no)
MY (1) MY133027A (no)
NO (1) NO315560B1 (no)
NZ (1) NZ500652A (no)
OA (1) OA11226A (no)
PA (1) PA8452001A1 (no)
PE (1) PE79999A1 (no)
PL (1) PL337497A1 (no)
SK (1) SK168299A3 (no)
TN (1) TNSN98084A1 (no)
TW (2) TWI224106B (no)
UA (1) UA70298A (no)
UY (1) UY25041A1 (no)
WO (1) WO1998056801A1 (no)
YU (1) YU62999A (no)
ZA (1) ZA985016B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CZ20011512A3 (cs) 1998-11-03 2001-09-12 Pfizer Products Inc. Nová makrolidová antibiotika
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
CA2380455C (en) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides with antibacterial activity
BRPI0017013B1 (pt) * 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
CN1297564C (zh) * 2001-04-27 2007-01-31 辉瑞产品公司 4″－取代－9－脱氧－9a－氮杂－9a－高红霉素A衍生物的制备方法
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
US7109176B2 (en) * 2002-07-08 2006-09-19 Pliva-Istrazivacki Institut D.O.O. Nonsteroidal anti-inflammatory substances, compositions and methods for their use
JP4790263B2 (ja) 2002-07-08 2011-10-12 グラクソ グループ リミテッド 炎症性の疾患および病態を治療する新規な化合物、組成物および方法
AU2003264917A1 (en) 2002-07-08 2004-01-23 Pliva - Istrazivacki Institut D.O.O. Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
EP3738591A3 (en) * 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
US8293715B2 (en) 2007-08-06 2012-10-23 Taisho Pharmaceutical Co., Ltd. 10a-Azalide compound crosslinked at 10a- and 12-positions
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
JPWO2009139181A1 (ja) 2008-05-15 2011-09-15 大正製薬株式会社 ４員環構造を有する１０ａ−アザライド化合物
DK2358379T3 (en) 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
HK1242920A1 (zh) 2014-10-08 2018-07-06 哈佛大学的校长及成员们 14-元酮内酯及其制备和使用方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
WO2021183754A1 (en) * 2020-03-12 2021-09-16 Zoetis Services Llc Immunomodulating trifluoromethyl-aminal azalides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
EA002440B1 (ru) 2002-04-25
WO1998056801A1 (en) 1998-12-17
EP0988309A1 (en) 2000-03-29
IS5250A (is) 1999-11-16
HK1025974A1 (en) 2000-12-01
AP1189A (en) 2003-07-16
ATE310742T1 (de) 2005-12-15
YU62999A (sh) 2002-10-18
CO4950584A1 (es) 2000-09-01
AU745006C (en) 2006-02-23
TWI224106B (en) 2004-11-21
NZ500652A (en) 2001-10-26
BG103969A (en) 2000-07-31
CN1259955A (zh) 2000-07-12
DZ2515A1 (fr) 2003-02-01
AP9801254A0 (en) 1998-06-30
KR100369959B1 (ko) 2003-02-12
NO315560B1 (no) 2003-09-22
DE69832486T2 (de) 2006-07-27
HN1998000074A (es) 1999-01-08
EA199901014A1 (ru) 2000-06-26
JP2000514097A (ja) 2000-10-24
ZA985016B (en) 1999-12-10
GT199800075A (es) 1999-11-30
OA11226A (en) 2003-07-16
AR013085A1 (es) 2000-12-13
CA2293397C (en) 2004-08-31
HUP0004076A3 (en) 2003-05-28
SK168299A3 (en) 2000-09-12
BG64357B1 (bg) 2004-11-30
HRP980315A2 (en) 1999-04-30
DE69832486D1 (de) 2005-12-29
ID24530A (id) 2000-07-20
KR20010013633A (ko) 2001-02-26
NO996107D0 (no) 1999-12-10
TW200418871A (en) 2004-10-01
PE79999A1 (es) 1999-08-25
AU7228198A (en) 1998-12-30
PA8452001A1 (es) 2000-05-24
MY133027A (en) 2007-10-31
HUP0004076A2 (hu) 2001-04-28
UA70298C2 (uk) 2004-10-15
IS1979B (is) 2005-01-14
TNSN98084A1 (fr) 2005-03-15
IL132808A0 (en) 2001-03-19
EP0988309B1 (en) 2005-11-23
CN1145636C (zh) 2004-04-14
MA24563A1 (fr) 1998-12-31
UY25041A1 (es) 2000-09-29
CA2293397A1 (en) 1998-12-17
UA70298A (uk) 2004-10-15
ES2251081T3 (es) 2006-04-16
PL337497A1 (en) 2000-08-28
BR9810097A (pt) 2000-08-08
AU745006B2 (en) 2002-03-07
IL132808A (en) 2004-08-31
JP3262806B2 (ja) 2002-03-04

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