PE79999A1 - Derivados de macrolidos c-4" sustituidos - Google Patents

Derivados de macrolidos c-4" sustituidos

Info

Publication number
PE79999A1
PE79999A1 PE1998000469A PE00046998A PE79999A1 PE 79999 A1 PE79999 A1 PE 79999A1 PE 1998000469 A PE1998000469 A PE 1998000469A PE 00046998 A PE00046998 A PE 00046998A PE 79999 A1 PE79999 A1 PE 79999A1
Authority
PE
Peru
Prior art keywords
alkyl
alkynyl
hydroxy
heteroaryl
polyclic
Prior art date
Application number
PE1998000469A
Other languages
English (en)
Inventor
Brian Scott Bronk
Takushi Kaneko
Hengmiao Cheng
Bingwei Vera Yang
Edward Alan Glazer
Michael Anthony Letavic
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE79999A1 publication Critical patent/PE79999A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE X ES -CH(NR9R10)-, -C(O), C(=NOR9)-, ENTRE OTROS; R1 ES H, HIDROXI o METOXI; R2 ES HIDROXI; R3 ES ALQUILO C1-C10, -CH2S(O)nR8, -(CH2)m(ARILO C6-C10), n ES 0-2, m ES 0-4; o R2 Y R3 FORMAN UN OXAZOLILO DE FORMULA (a); R4 ES H, -C(O)R9, -C(O)NR9R10; R5 ES SR8, -(CH2)nC(O)R8, ALQUILO C1-C10, ALQUENILO C2-C10, ENTRE OTROS, R6 Y R7 SON H, HIDROXI, ALCOXI C1-C6, ENTRE OTROS; R8 ES H, ALQUILO C1-C10, -(CH2)qCR11CR12(CH2)rNR13R14, q Y r SON 0-3 PERO NO SON AMBOS CERO, R8 ES -CH2NR8R15, R15 Y R8 FORMAN UN ANILLO SATURADO DE 4-10 MIEMBROS o POLICICLICO SATURADO o HETEROARILO DE 5-10 MIEMBROS CON 1-2 O, S, N(R8); CADA R9 Y R10 SON H o ALQUILO C1-C6; R11, R12, R13 Y R14 SON H o ALQUILO C1-C10, -(CH2)m(ARILO C6-C10) Y (CH2)m(HETEROARILO DE 5-10 MIEMBROS); o R11 Y R13 FORMAN JUNTOS -(CH2)p-, p ES 0-3 o R13 Y R14 FORMAN UN ANILLO SATURADO MONO O POLICICLICO DE 4-10 MIEMBROS o UN HETEROARILO DE 5-10 MIEMBROS CON 1-2 O, S Y -N(R8)-; R15 ES H, ALQUILO C1-C10, ALQUENILO C2-10 o ALQUINILO C2-C10; R16 ES HALOGENO, CIANO, NITRO, ENTRE OTROS; R17 ES H, ALQUILO C1-C10, ALQUENILO C2-C10, ENTRE OTROS; CUANDO R3 ES CH2S(O)nR8, R8 NO ES H. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE UNA INFECCION BACTERIANA O PROTOZOARIA
PE1998000469A 1997-06-11 1998-06-08 Derivados de macrolidos c-4" sustituidos PE79999A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4998097P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
PE79999A1 true PE79999A1 (es) 1999-08-25

Family

ID=21962765

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000469A PE79999A1 (es) 1997-06-11 1998-06-08 Derivados de macrolidos c-4" sustituidos

Country Status (40)

Country Link
EP (1) EP0988309B1 (es)
JP (1) JP3262806B2 (es)
KR (1) KR100369959B1 (es)
CN (1) CN1145636C (es)
AP (1) AP1189A (es)
AR (1) AR013085A1 (es)
AT (1) ATE310742T1 (es)
AU (1) AU745006C (es)
BG (1) BG64357B1 (es)
BR (1) BR9810097A (es)
CA (1) CA2293397C (es)
CO (1) CO4950584A1 (es)
DE (1) DE69832486T2 (es)
DZ (1) DZ2515A1 (es)
EA (1) EA002440B1 (es)
ES (1) ES2251081T3 (es)
GT (1) GT199800075A (es)
HK (1) HK1025974A1 (es)
HN (1) HN1998000074A (es)
HR (1) HRP980315A2 (es)
HU (1) HUP0004076A3 (es)
ID (1) ID24530A (es)
IL (1) IL132808A (es)
IS (1) IS1979B (es)
MA (1) MA24563A1 (es)
MY (1) MY133027A (es)
NO (1) NO315560B1 (es)
NZ (1) NZ500652A (es)
OA (1) OA11226A (es)
PA (1) PA8452001A1 (es)
PE (1) PE79999A1 (es)
PL (1) PL337497A1 (es)
SK (1) SK168299A3 (es)
TN (1) TNSN98084A1 (es)
TW (2) TW200418871A (es)
UA (1) UA70298C2 (es)
UY (1) UY25041A1 (es)
WO (1) WO1998056801A1 (es)
YU (1) YU62999A (es)
ZA (1) ZA985016B (es)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
EP1011689B8 (en) * 1997-09-10 2007-05-09 Merial Ltd. USE OF 9a-AZALIDES AS VETERINARY ANTIMICROBIAL AGENTS
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
AP2001002131A0 (en) 1998-11-03 2001-06-30 Pfizer Prod Inc Novel macrolide antibiotics.
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
WO2001014397A1 (en) * 1999-08-24 2001-03-01 Abbott Laboratories 9a-azalides with antibacterial activity
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
WO2001055158A1 (en) * 2000-01-27 2001-08-02 Pfizer Products Inc. Azalide antibiotic compositions
EP1383780A1 (en) * 2001-04-27 2004-01-28 Pfizer Products Inc. Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
JP2003040782A (ja) * 2001-05-31 2003-02-13 Pfizer Prod Inc アザリド抗生物質組成物
RS20050007A (en) * 2002-07-08 2007-09-21 Glaxo Smith Kline Istraživački Centar Zagreb D.O.O., Novel nonsteroidal anti- inflammatory substances, compositions and methods for their use
CA2489402A1 (en) 2002-07-08 2004-01-15 Pliva-Istrazivacki Institut D.O.O. New compounds, compositions and methods for treatment of inflammatory diseases and conditions
DE60327341D1 (de) 2002-07-08 2009-06-04 Glaxosmithkline Zagreb Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
CA2801100A1 (en) * 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Macrolides and processes for their preparation
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
JP5383037B2 (ja) 2004-02-27 2014-01-08 リブ−エックス ファーマシューティカルズ，インコーポレイテッド 大環状化合物およびそれらを製造し使用する方法
EP2177526A4 (en) 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd 10A-AZALIDE COMPOUND CROSS-LINKED IN POSITION 10A AND POSITION 12
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
US8299035B2 (en) 2008-05-15 2012-10-30 Taisho Pharmaceutucal Co., Ltd. 10a-azalide compound having 4-membered ring structure
SI2358379T1 (sl) 2008-10-24 2016-05-31 Cempra Pharmaceuticals, Inc. Postopki biološke obrambe z makrolidi, ki vsebujejo triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
IN2014DN08939A (es) 2012-03-27 2015-05-22 Cempra Pharmaceuticals Inc
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
EP4095146A1 (en) 2013-04-04 2022-11-30 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
EP3211997A4 (en) 2014-10-08 2018-10-24 President and Fellows of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150220A (en) * 1977-02-04 1979-04-17 Pfizer Inc. Semi-synthetic 4"-erythromycin A derivatives
SE445223B (sv) * 1977-02-04 1986-06-09 Pfizer Sett att framstella 4"-amino-erytomylin-a-derivat
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
CA2064634C (en) * 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
US5412982A (en) * 1994-03-10 1995-05-09 Potts; James K. Windsock support

Also Published As

Publication number Publication date
CN1145636C (zh) 2004-04-14
TW200418871A (en) 2004-10-01
YU62999A (sh) 2002-10-18
EP0988309A1 (en) 2000-03-29
DE69832486D1 (de) 2005-12-29
IS1979B (is) 2005-01-14
IL132808A0 (en) 2001-03-19
NZ500652A (en) 2001-10-26
WO1998056801A1 (en) 1998-12-17
PL337497A1 (en) 2000-08-28
ATE310742T1 (de) 2005-12-15
AP1189A (en) 2003-07-16
AU7228198A (en) 1998-12-30
TNSN98084A1 (fr) 2005-03-15
BG64357B1 (bg) 2004-11-30
CN1259955A (zh) 2000-07-12
MA24563A1 (fr) 1998-12-31
CO4950584A1 (es) 2000-09-01
NO315560B1 (no) 2003-09-22
MY133027A (en) 2007-10-31
HUP0004076A3 (en) 2003-05-28
ES2251081T3 (es) 2006-04-16
SK168299A3 (en) 2000-09-12
PA8452001A1 (es) 2000-05-24
DZ2515A1 (fr) 2003-02-01
UY25041A1 (es) 2000-09-29
OA11226A (en) 2003-07-16
ID24530A (id) 2000-07-20
EP0988309B1 (en) 2005-11-23
ZA985016B (en) 1999-12-10
CA2293397A1 (en) 1998-12-17
HRP980315A2 (en) 1999-04-30
JP3262806B2 (ja) 2002-03-04
JP2000514097A (ja) 2000-10-24
EA002440B1 (ru) 2002-04-25
GT199800075A (es) 1999-11-30
HN1998000074A (es) 1999-01-08
IL132808A (en) 2004-08-31
UA70298A (uk) 2004-10-15
BG103969A (en) 2000-07-31
HUP0004076A2 (hu) 2001-04-28
AU745006C (en) 2006-02-23
KR100369959B1 (ko) 2003-02-12
UA70298C2 (uk) 2004-10-15
KR20010013633A (ko) 2001-02-26
AP9801254A0 (en) 1998-06-30
EA199901014A1 (ru) 2000-06-26
CA2293397C (en) 2004-08-31
BR9810097A (pt) 2000-08-08
AR013085A1 (es) 2000-12-13
AU745006B2 (en) 2002-03-07
NO996107L (no) 2000-02-10
NO996107D0 (no) 1999-12-10
TWI224106B (en) 2004-11-21
HK1025974A1 (en) 2000-12-01
DE69832486T2 (de) 2006-07-27
IS5250A (is) 1999-11-16

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