YU62999A - C-4"-supstituisani derivati makrolida - Google Patents
C-4"-supstituisani derivati makrolidaInfo
- Publication number
- YU62999A YU62999A YU62999A YU62999A YU62999A YU 62999 A YU62999 A YU 62999A YU 62999 A YU62999 A YU 62999A YU 62999 A YU62999 A YU 62999A YU 62999 A YU62999 A YU 62999A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- formula
- relates
- macrolide derivatives
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ovaj se pronalazak odnosi na jedinjenja formule (1) i na njihove farmaceutski prihvatljive soli. Jedinjenja formule (1) jesu moćna antibakterijska sredstva koja se mogu koristiti kod lečenja raznih bakterijskih infekcija i oboljenja povezanih sa tim infekcijama. Pronalazak se takodje odnosi na farmaceutske komopzicije koje sadrže jedinjenja formule (1) i na postupke za lečenje bakterijskih infekcija davanjem jedinjenja formule (1). Pronalazak se takodje odnosi na pripremanje jedinjenja formule (1) i na medjuproizvode korisne za njihovo pripremanje.[This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts thereof. The compounds of formula (1) are potent antibacterial agents that may be used to treat various bacterial infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of treating bacterial infections by administering the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1) and to intermediates useful in such preparation.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4998097P | 1997-06-11 | 1997-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU62999A true YU62999A (sh) | 2002-10-18 |
Family
ID=21962765
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU62999A YU62999A (sh) | 1997-06-11 | 1998-05-25 | C-4"-supstituisani derivati makrolida |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP0988309B1 (sh) |
JP (1) | JP3262806B2 (sh) |
KR (1) | KR100369959B1 (sh) |
CN (1) | CN1145636C (sh) |
AP (1) | AP1189A (sh) |
AR (1) | AR013085A1 (sh) |
AT (1) | ATE310742T1 (sh) |
AU (1) | AU745006C (sh) |
BG (1) | BG64357B1 (sh) |
BR (1) | BR9810097A (sh) |
CA (1) | CA2293397C (sh) |
CO (1) | CO4950584A1 (sh) |
DE (1) | DE69832486T2 (sh) |
DZ (1) | DZ2515A1 (sh) |
EA (1) | EA002440B1 (sh) |
ES (1) | ES2251081T3 (sh) |
GT (1) | GT199800075A (sh) |
HK (1) | HK1025974A1 (sh) |
HN (1) | HN1998000074A (sh) |
HR (1) | HRP980315A2 (sh) |
HU (1) | HUP0004076A3 (sh) |
ID (1) | ID24530A (sh) |
IL (1) | IL132808A (sh) |
IS (1) | IS1979B (sh) |
MA (1) | MA24563A1 (sh) |
MY (1) | MY133027A (sh) |
NO (1) | NO315560B1 (sh) |
NZ (1) | NZ500652A (sh) |
OA (1) | OA11226A (sh) |
PA (1) | PA8452001A1 (sh) |
PE (1) | PE79999A1 (sh) |
PL (1) | PL337497A1 (sh) |
SK (1) | SK168299A3 (sh) |
TN (1) | TNSN98084A1 (sh) |
TW (2) | TWI224106B (sh) |
UA (1) | UA70298A (sh) |
UY (1) | UY25041A1 (sh) |
WO (1) | WO1998056801A1 (sh) |
YU (1) | YU62999A (sh) |
ZA (1) | ZA985016B (sh) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6339063B1 (en) | 1997-09-10 | 2002-01-15 | Merck & Co., Inc. | 9a-azalides as veterinary antimicrobial agents |
EP1779853A3 (en) * | 1997-09-10 | 2010-01-27 | Merial Ltd. | 9a-azalides as veterinary antimicrobial agents |
DE69837007T2 (de) * | 1997-09-10 | 2007-11-22 | Merial Ltd. | Verwendung von 9a-azaliden als antimikrobielle mittel für tiere |
AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
EP1437360A3 (en) * | 1998-08-19 | 2005-04-06 | Pfizer Products Inc. | C11 Carbamates of macrolide antibacterials |
US6043227A (en) * | 1998-08-19 | 2000-03-28 | Pfizer Inc. | C11 carbamates of macrolide antibacterials |
US6100240A (en) * | 1998-10-09 | 2000-08-08 | Pfizer Inc | Macrolide derivatives |
HUP0104192A3 (en) | 1998-11-03 | 2003-12-29 | Pfizer Prod Inc | Novel macrolide antibiotics |
CA2292359C (en) * | 1999-01-28 | 2004-09-28 | Pfizer Products Inc. | Novel azalides and methods of making same |
DK1206476T3 (da) * | 1999-08-24 | 2006-05-15 | Abbott Lab | 9a-azalider med antibakteriel virkning |
US6764996B1 (en) | 1999-08-24 | 2004-07-20 | Abbott Laboratories | 9a-azalides with antibacterial activity |
PT1250343E (pt) | 2000-01-27 | 2003-11-28 | Pfizer Prod Inc | Composicoes de antibioticos de azalida |
CA2445306C (en) * | 2001-04-27 | 2008-02-12 | Pfizer Products Inc. | Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives |
JP2003040782A (ja) * | 2001-05-31 | 2003-02-13 | Pfizer Prod Inc | アザリド抗生物質組成物 |
WO2004005313A2 (en) | 2002-07-08 | 2004-01-15 | Pliva - Istrazivacki Institut D.O.O. | Hybrid molecules of macrolides with steroid/non-steroid anti-inflammatory, antineoplastic and antiviral active molecules |
EP1521763A2 (en) * | 2002-07-08 | 2005-04-13 | Pliva - Istrazivacki Institut d.o.o. | Novel nonsteroidal anti-inflammatory substances, compositions and methods for their use |
WO2004005310A2 (en) | 2002-07-08 | 2004-01-15 | Pliva-Istrazivacki Institut D.O.O. | New compounds, compositions and methods for treatment of inflammatory diseases and conditions |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
US7601695B2 (en) * | 2003-03-10 | 2009-10-13 | Optimer Pharmaceuticals, Inc. | Antibacterial agents |
US7276487B2 (en) | 2003-09-23 | 2007-10-02 | Enanta Pharmaceuticals, Inc. | 9a, 11-3C-bicyclic 9a-azalide derivatives |
CN102816194A (zh) | 2004-02-27 | 2012-12-12 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
JPWO2009019868A1 (ja) | 2007-08-06 | 2010-10-28 | 大正製薬株式会社 | 10a、12位架橋型10a−アザライド化合物 |
CA2703475A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
US8299035B2 (en) | 2008-05-15 | 2012-10-30 | Taisho Pharmaceutucal Co., Ltd. | 10a-azalide compound having 4-membered ring structure |
CN102245195B (zh) | 2008-10-24 | 2016-01-13 | 森普拉制药公司 | 使用含三唑的大环内酯的生物防御 |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
JP5908479B2 (ja) * | 2010-09-20 | 2016-04-26 | ノバルティス ティーアゲズントハイト アーゲー | クラジノース環のC−4”をエポキシド基で修飾した9−デオキソ−9a−アザ−9a−ホモエリスロマイシンAの新規製造方法 |
AR085286A1 (es) | 2011-02-21 | 2013-09-18 | Taisho Pharmaceutical Co Ltd | Derivado de macrolido sustituido en la posicion c-4 |
EP2830632A4 (en) | 2012-03-27 | 2015-10-21 | Cempra Pharmaceuticals Inc | PARENTERAL FORMULATIONS FOR THE ADMINISTRATION OF MACROLIDE ANTIBIOTICS |
JP5857008B2 (ja) * | 2012-08-20 | 2016-02-10 | 大正製薬株式会社 | C−4”位置換マクロライド誘導体を含有する医薬 |
CN105246334A (zh) | 2013-04-04 | 2016-01-13 | 哈佛大学的校长及成员们 | 大环内酯及其制备和使用方法 |
CN105669798B (zh) * | 2013-08-23 | 2019-07-26 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
CN103965273B (zh) | 2013-08-23 | 2016-05-25 | 普莱柯生物工程股份有限公司 | 一种大环内酯类化合物 |
AR102810A1 (es) | 2014-08-18 | 2017-03-29 | Taisho Pharmaceutical Co Ltd | Derivado de macrólido sustituido en la posición c-4 |
US10633407B2 (en) | 2014-10-08 | 2020-04-28 | President And Fellows Of Harvard College | 14-membered ketolides and methods of their preparation and use |
JP2018509452A (ja) | 2015-03-25 | 2018-04-05 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 修飾デソサミン糖をもつマクロライドおよびその使用 |
CN108003207B (zh) | 2017-12-19 | 2019-05-10 | 海门慧聚药业有限公司 | 制备泰拉霉素的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE445223B (sv) * | 1977-02-04 | 1986-06-09 | Pfizer | Sett att framstella 4"-amino-erytomylin-a-derivat |
US4150220A (en) * | 1977-02-04 | 1979-04-17 | Pfizer Inc. | Semi-synthetic 4"-erythromycin A derivatives |
YU43006B (en) * | 1981-03-06 | 1989-02-28 | Pliva Pharm & Chem Works | Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
GR80277B (en) * | 1983-09-06 | 1985-01-04 | Pfizer | Azahomoerythromycin b derivatives and intermediates therefor |
US4512982A (en) * | 1984-04-13 | 1985-04-23 | Pfizer Inc. | 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method |
CA2064634C (en) * | 1991-04-04 | 1998-08-04 | James V. Heck | 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions |
US5441939A (en) * | 1994-03-04 | 1995-08-15 | Pfizer Inc. | 3"-desmethoxy derivatives of erythromycin and azithromycin |
US5412982A (en) * | 1994-03-10 | 1995-05-09 | Potts; James K. | Windsock support |
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1998
- 1998-05-20 HN HN1998000074A patent/HN1998000074A/es unknown
- 1998-05-22 PA PA19988452001A patent/PA8452001A1/es unknown
- 1998-05-25 HU HU0004076A patent/HUP0004076A3/hu unknown
- 1998-05-25 PL PL98337497A patent/PL337497A1/xx unknown
- 1998-05-25 EP EP98919414A patent/EP0988309B1/en not_active Expired - Lifetime
- 1998-05-25 ES ES98919414T patent/ES2251081T3/es not_active Expired - Lifetime
- 1998-05-25 JP JP50192999A patent/JP3262806B2/ja not_active Expired - Fee Related
- 1998-05-25 NZ NZ500652A patent/NZ500652A/en unknown
- 1998-05-25 BR BR9810097-1A patent/BR9810097A/pt not_active IP Right Cessation
- 1998-05-25 CA CA002293397A patent/CA2293397C/en not_active Expired - Fee Related
- 1998-05-25 ID IDW991565A patent/ID24530A/id unknown
- 1998-05-25 SK SK1682-99A patent/SK168299A3/sk unknown
- 1998-05-25 DE DE69832486T patent/DE69832486T2/de not_active Expired - Fee Related
- 1998-05-25 AT AT98919414T patent/ATE310742T1/de not_active IP Right Cessation
- 1998-05-25 AU AU72281/98A patent/AU745006C/en not_active Ceased
- 1998-05-25 CN CNB988060493A patent/CN1145636C/zh not_active Expired - Fee Related
- 1998-05-25 UA UA99126737A patent/UA70298A/uk unknown
- 1998-05-25 YU YU62999A patent/YU62999A/sh unknown
- 1998-05-25 EA EA199901014A patent/EA002440B1/ru not_active IP Right Cessation
- 1998-05-25 IL IL13280898A patent/IL132808A/en not_active IP Right Cessation
- 1998-05-25 KR KR10-1999-7011643A patent/KR100369959B1/ko not_active IP Right Cessation
- 1998-05-25 WO PCT/IB1998/000799 patent/WO1998056801A1/en not_active Application Discontinuation
- 1998-06-04 AP APAP/P/1998/001254A patent/AP1189A/en active
- 1998-06-08 GT GT199800075A patent/GT199800075A/es unknown
- 1998-06-08 TW TW087109085A patent/TWI224106B/zh active
- 1998-06-08 TW TW093111859A patent/TW200418871A/zh unknown
- 1998-06-08 PE PE1998000469A patent/PE79999A1/es not_active Application Discontinuation
- 1998-06-09 AR ARP980102704A patent/AR013085A1/es active IP Right Grant
- 1998-06-09 MY MYPI98002563A patent/MY133027A/en unknown
- 1998-06-10 CO CO98033231A patent/CO4950584A1/es unknown
- 1998-06-10 MA MA25106A patent/MA24563A1/fr unknown
- 1998-06-10 DZ DZ980125A patent/DZ2515A1/xx active
- 1998-06-10 ZA ZA9805016A patent/ZA985016B/xx unknown
- 1998-06-10 TN TNTNSN98084A patent/TNSN98084A1/fr unknown
- 1998-06-11 HR HR60/049,980A patent/HRP980315A2/hr not_active Application Discontinuation
- 1998-06-11 UY UY25041A patent/UY25041A1/es not_active IP Right Cessation
-
1999
- 1999-11-16 IS IS5250A patent/IS1979B/is unknown
- 1999-12-03 OA OA9900270A patent/OA11226A/en unknown
- 1999-12-08 BG BG103969A patent/BG64357B1/bg unknown
- 1999-12-10 NO NO19996107A patent/NO315560B1/no unknown
-
2000
- 2000-08-28 HK HK00105362A patent/HK1025974A1/xx not_active IP Right Cessation
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