DK1032579T3 - Carbohydratderivater - Google Patents

Carbohydratderivater

Info

Publication number
DK1032579T3
DK1032579T3 DK98958248T DK98958248T DK1032579T3 DK 1032579 T3 DK1032579 T3 DK 1032579T3 DK 98958248 T DK98958248 T DK 98958248T DK 98958248 T DK98958248 T DK 98958248T DK 1032579 T3 DK1032579 T3 DK 1032579T3
Authority
DK
Denmark
Prior art keywords
carbohydrate derivatives
carbohydrate
derivatives
Prior art date
Application number
DK98958248T
Other languages
English (en)
Inventor
Boeckel Constant Adriaan A Van
Maurice Petitou
Cornelia Maria Dreef-Tromp
Johannes Egbertus Maria Basten
Philippe Duchaussoy
Original Assignee
Akzo Nobel Nv
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv, Sanofi Synthelabo filed Critical Akzo Nobel Nv
Application granted granted Critical
Publication of DK1032579T3 publication Critical patent/DK1032579T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
DK98958248T 1997-11-19 1998-11-16 Carbohydratderivater DK1032579T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97203613 1997-11-19
PCT/EP1998/007518 WO1999025720A1 (en) 1997-11-19 1998-11-16 Carbohydrate derivatives

Publications (1)

Publication Number Publication Date
DK1032579T3 true DK1032579T3 (da) 2003-08-25

Family

ID=8228942

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98958248T DK1032579T3 (da) 1997-11-19 1998-11-16 Carbohydratderivater

Country Status (34)

Country Link
US (1) US6174863B1 (da)
EP (1) EP1032579B1 (da)
JP (1) JP4364959B2 (da)
KR (1) KR100518497B1 (da)
CN (1) CN1177855C (da)
AR (1) AR017640A1 (da)
AT (1) ATE239030T1 (da)
AU (1) AU746959B2 (da)
BR (1) BRPI9804699B1 (da)
CA (1) CA2253113C (da)
CO (1) CO4990974A1 (da)
CZ (1) CZ293639B6 (da)
DE (1) DE69814140T2 (da)
DK (1) DK1032579T3 (da)
EE (1) EE04348B1 (da)
ES (1) ES2198081T3 (da)
HK (1) HK1028406A1 (da)
HU (1) HU226685B1 (da)
ID (1) ID21287A (da)
IL (1) IL126893A (da)
IS (1) IS2527B (da)
NO (1) NO310723B1 (da)
NZ (1) NZ332834A (da)
PE (1) PE134799A1 (da)
PL (1) PL188229B1 (da)
PT (1) PT1032579E (da)
RU (1) RU2210573C2 (da)
SG (1) SG72889A1 (da)
SK (1) SK284134B6 (da)
TR (1) TR199802372A2 (da)
TW (1) TW448180B (da)
UA (1) UA49089C2 (da)
WO (1) WO1999025720A1 (da)
ZA (1) ZA9810559B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
EP1353556A4 (en) * 2001-01-23 2009-09-09 Massachusetts Inst Technology SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
TWI426080B (zh) * 2004-03-04 2014-02-11 Progen Pharmaceuticals Ltd 硫酸化寡醣衍生物
JP2011522805A (ja) 2008-05-30 2011-08-04 モメンタ ファーマシューティカルズ インコーポレイテッド 糖構造ならびにそのような構造を作製および使用する方法
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
EP2464668B1 (en) 2009-07-31 2022-12-07 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
EP2721044B1 (en) * 2011-06-17 2015-11-18 Carbomimetics Synthetic pentasaccharides having short half-life and high activity
EP2578594A1 (en) 2011-10-04 2013-04-10 Sanofi Process of preparation of L-iduronic acid comprising a decarboxylation/intramolecular cyclisation tandem reaction
US9873712B2 (en) 2014-10-03 2018-01-23 Amphastar Pharmaceuticals, Inc. Method of purifying idraparinux sodium
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
WO2021043631A1 (en) 2019-09-02 2021-03-11 Hepoligo Solutions Aps Intermediates useful for preparing iduronic acid containing di- and polysaccharides
WO2021211441A1 (en) * 2020-04-13 2021-10-21 The Board Of Regents Of The University Of Oklahoma Modified sugar polymers with low anticoagulant activity and therapeutic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
IE64378B1 (en) * 1990-04-23 1995-07-26 Akzo Nv Carbohydrate derivatives comprising a trisaccharide unit
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
IL126893A (en) 2003-05-29
NO985365L (no) 1999-05-20
DE69814140D1 (de) 2003-06-05
AU746959B2 (en) 2002-05-09
UA49089C2 (uk) 2002-09-16
IL126893A0 (en) 1999-09-22
SG72889A1 (en) 2000-05-23
TR199802372A2 (xx) 1999-06-21
TW448180B (en) 2001-08-01
CO4990974A1 (es) 2000-12-26
AR017640A1 (es) 2001-09-12
SK7362000A3 (en) 2000-10-09
HUP9802663A3 (en) 2000-04-28
KR19990045312A (ko) 1999-06-25
PE134799A1 (es) 2000-01-07
EE200000301A (et) 2001-12-17
ATE239030T1 (de) 2003-05-15
KR100518497B1 (ko) 2005-12-16
CN1222524A (zh) 1999-07-14
PL188229B1 (pl) 2004-12-31
EP1032579A1 (en) 2000-09-06
JP4364959B2 (ja) 2009-11-18
DE69814140T2 (de) 2004-04-08
HUP9802663A2 (hu) 1999-06-28
SK284134B6 (sk) 2004-09-08
EP1032579B1 (en) 2003-05-02
NO310723B1 (no) 2001-08-20
US6174863B1 (en) 2001-01-16
NZ332834A (en) 2000-01-28
PT1032579E (pt) 2003-08-29
CZ293639B6 (cs) 2004-06-16
CA2253113C (en) 2008-06-17
ES2198081T3 (es) 2004-01-16
EE04348B1 (et) 2004-08-16
CZ376198A3 (cs) 1999-06-16
RU2210573C2 (ru) 2003-08-20
HU226685B1 (en) 2009-06-29
PL329789A1 (en) 1999-05-24
HK1028406A1 (en) 2001-02-16
CA2253113A1 (en) 1999-05-19
CN1177855C (zh) 2004-12-01
IS5485A (is) 2000-05-09
NO985365D0 (no) 1998-11-18
IS2527B (is) 2009-07-15
AU9324298A (en) 1999-06-17
HU9802663D0 (en) 1999-01-28
JPH11217394A (ja) 1999-08-10
ZA9810559B (en) 1999-05-15
BRPI9804699B1 (pt) 2016-07-12
WO1999025720A1 (en) 1999-05-27
BR9804699A (pt) 2000-12-26
ID21287A (id) 1999-05-20

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