DE69814140D1 - Kohlenhydrat-derivate - Google Patents

Kohlenhydrat-derivate

Info

Publication number
DE69814140D1
DE69814140D1 DE69814140T DE69814140T DE69814140D1 DE 69814140 D1 DE69814140 D1 DE 69814140D1 DE 69814140 T DE69814140 T DE 69814140T DE 69814140 T DE69814140 T DE 69814140T DE 69814140 D1 DE69814140 D1 DE 69814140D1
Authority
DE
Germany
Prior art keywords
carbohydrate derivatives
carbohydrate
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69814140T
Other languages
English (en)
Other versions
DE69814140T2 (de
Inventor
Boeckel Adriaan Van
Maurice Petitou
Philippe Duchaussoy
Maria Dreef-Tromp
Egbertus Basten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA, Akzo Nobel NV filed Critical Sanofi Synthelabo SA
Publication of DE69814140D1 publication Critical patent/DE69814140D1/de
Application granted granted Critical
Publication of DE69814140T2 publication Critical patent/DE69814140T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69814140T 1997-11-19 1998-11-16 Kohlenhydrat-derivate Expired - Lifetime DE69814140T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97203613 1997-11-19
EP97203613 1997-11-19
PCT/EP1998/007518 WO1999025720A1 (en) 1997-11-19 1998-11-16 Carbohydrate derivatives

Publications (2)

Publication Number Publication Date
DE69814140D1 true DE69814140D1 (de) 2003-06-05
DE69814140T2 DE69814140T2 (de) 2004-04-08

Family

ID=8228942

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69814140T Expired - Lifetime DE69814140T2 (de) 1997-11-19 1998-11-16 Kohlenhydrat-derivate

Country Status (34)

Country Link
US (1) US6174863B1 (de)
EP (1) EP1032579B1 (de)
JP (1) JP4364959B2 (de)
KR (1) KR100518497B1 (de)
CN (1) CN1177855C (de)
AR (1) AR017640A1 (de)
AT (1) ATE239030T1 (de)
AU (1) AU746959B2 (de)
BR (1) BRPI9804699B1 (de)
CA (1) CA2253113C (de)
CO (1) CO4990974A1 (de)
CZ (1) CZ293639B6 (de)
DE (1) DE69814140T2 (de)
DK (1) DK1032579T3 (de)
EE (1) EE04348B1 (de)
ES (1) ES2198081T3 (de)
HK (1) HK1028406A1 (de)
HU (1) HU226685B1 (de)
ID (1) ID21287A (de)
IL (1) IL126893A (de)
IS (1) IS2527B (de)
NO (1) NO310723B1 (de)
NZ (1) NZ332834A (de)
PE (1) PE134799A1 (de)
PL (1) PL188229B1 (de)
PT (1) PT1032579E (de)
RU (1) RU2210573C2 (de)
SG (1) SG72889A1 (de)
SK (1) SK284134B6 (de)
TR (1) TR199802372A2 (de)
TW (1) TW448180B (de)
UA (1) UA49089C2 (de)
WO (1) WO1999025720A1 (de)
ZA (1) ZA9810559B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI289566B (en) * 1999-12-07 2007-11-11 N.V.Organon Antithrombotic compound
CA2435637A1 (en) * 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
CN1317287C (zh) * 2003-04-18 2007-05-23 山东大学 一种多硫酸寡糖及其制备方法
CA2557989C (en) * 2004-03-04 2013-04-23 Progen Industries Limited Sulfated oligosaccharide derivatives
WO2009155108A1 (en) 2008-05-30 2009-12-23 Momenta Pharmaceuticals, Inc. Saccharide structures and methods of making and using such structures
EP2323605A4 (de) * 2008-09-10 2014-02-05 Syneron Medical Ltd Transdermale verabreichung von oligosacchariden
WO2011014793A2 (en) 2009-07-31 2011-02-03 Reliable Biopharmaceutical Corporation Process for preparing fondaparinux sodium and intermediates useful in the synthesis thereof
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
EP2721044B1 (de) * 2011-06-17 2015-11-18 Carbomimetics Synthetische pentasaccharide mit kurzer halbwertszeit und hoher aktivität
EP2578594A1 (de) 2011-10-04 2013-04-10 Sanofi Verfahren zur Herstellung von L-Iduronsäure mittels einer Decarboxylierung/intramolekulare Zyklisierungs-Tandemreaktion
US9873712B2 (en) * 2014-10-03 2018-01-23 Amphastar Pharmaceuticals, Inc. Method of purifying idraparinux sodium
CN109134554B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134555B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
CN109134553B (zh) * 2017-06-15 2021-09-28 南京正大天晴制药有限公司 抗凝血的五糖类化合物及其制备方法和医药用途
WO2021043631A1 (en) 2019-09-02 2021-03-11 Hepoligo Solutions Aps Intermediates useful for preparing iduronic acid containing di- and polysaccharides
WO2021211441A1 (en) * 2020-04-13 2021-10-21 The Board Of Regents Of The University Of Oklahoma Modified sugar polymers with low anticoagulant activity and therapeutic activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (de) * 1987-07-20 1989-01-25 Akzo N.V. Pentasaccharide
DK0454220T3 (da) * 1990-04-23 1993-11-22 Sanofi Elf Carbohydratderivater omfattende en trisaccharidenhed
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
PT1032579E (pt) 2003-08-29
WO1999025720A1 (en) 1999-05-27
HK1028406A1 (en) 2001-02-16
CA2253113A1 (en) 1999-05-19
RU2210573C2 (ru) 2003-08-20
TR199802372A2 (xx) 1999-06-21
IL126893A0 (en) 1999-09-22
HU9802663D0 (en) 1999-01-28
HUP9802663A2 (hu) 1999-06-28
EP1032579B1 (de) 2003-05-02
PE134799A1 (es) 2000-01-07
AU746959B2 (en) 2002-05-09
EP1032579A1 (de) 2000-09-06
PL329789A1 (en) 1999-05-24
CN1177855C (zh) 2004-12-01
UA49089C2 (uk) 2002-09-16
AR017640A1 (es) 2001-09-12
HUP9802663A3 (en) 2000-04-28
CA2253113C (en) 2008-06-17
PL188229B1 (pl) 2004-12-31
SK284134B6 (sk) 2004-09-08
NO310723B1 (no) 2001-08-20
SK7362000A3 (en) 2000-10-09
CZ376198A3 (cs) 1999-06-16
BR9804699A (pt) 2000-12-26
CO4990974A1 (es) 2000-12-26
IL126893A (en) 2003-05-29
JPH11217394A (ja) 1999-08-10
ES2198081T3 (es) 2004-01-16
IS2527B (is) 2009-07-15
NO985365D0 (no) 1998-11-18
IS5485A (is) 2000-05-09
HU226685B1 (en) 2009-06-29
JP4364959B2 (ja) 2009-11-18
NZ332834A (en) 2000-01-28
ZA9810559B (en) 1999-05-15
ID21287A (id) 1999-05-20
CZ293639B6 (cs) 2004-06-16
US6174863B1 (en) 2001-01-16
TW448180B (en) 2001-08-01
DK1032579T3 (da) 2003-08-25
DE69814140T2 (de) 2004-04-08
EE200000301A (et) 2001-12-17
NO985365L (no) 1999-05-20
AU9324298A (en) 1999-06-17
SG72889A1 (en) 2000-05-23
BRPI9804699B1 (pt) 2016-07-12
KR100518497B1 (ko) 2005-12-16
EE04348B1 (et) 2004-08-16
ATE239030T1 (de) 2003-05-15
CN1222524A (zh) 1999-07-14
KR19990045312A (ko) 1999-06-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-SYNTHELABO, PARIS, FR

8327 Change in the person/name/address of the patent owner

Owner name: SANOFI-AVENTIS, PARIS, FR

R082 Change of representative

Ref document number: 1032579

Country of ref document: EP

Representative=s name: WUESTHOFF & WUESTHOFF PATENT- UND RECHTSANWAEL, DE