DE69222183T2 - 22-oxacholecalziferol-derivate und ihre herstellung - Google Patents

22-oxacholecalziferol-derivate und ihre herstellung

Info

Publication number
DE69222183T2
DE69222183T2 DE69222183T DE69222183T DE69222183T2 DE 69222183 T2 DE69222183 T2 DE 69222183T2 DE 69222183 T DE69222183 T DE 69222183T DE 69222183 T DE69222183 T DE 69222183T DE 69222183 T2 DE69222183 T2 DE 69222183T2
Authority
DE
Germany
Prior art keywords
compound
formula
hydroxyl group
hydrogen atom
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222183T
Other languages
German (de)
English (en)
Other versions
DE69222183D1 (de
Inventor
Masahiro Chugai Seiyaku K Kato
Noboru Chugai Seiyaku Kubodera
Tetsuhiro Chugai Seiyak Mikami
Kiyoshige Chugai Seiyaku Ochi
Hiroyoshi Chugai Seiy Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE69222183D1 publication Critical patent/DE69222183D1/de
Application granted granted Critical
Publication of DE69222183T2 publication Critical patent/DE69222183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DE69222183T 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung Expired - Fee Related DE69222183T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP36105191 1991-12-18
PCT/JP1992/001662 WO1993012083A1 (fr) 1991-12-18 1992-12-18 Derive de 22-oxacholecalciferol et son procede de production

Publications (2)

Publication Number Publication Date
DE69222183D1 DE69222183D1 (de) 1997-10-16
DE69222183T2 true DE69222183T2 (de) 1998-01-22

Family

ID=18471985

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222183T Expired - Fee Related DE69222183T2 (de) 1991-12-18 1992-12-18 22-oxacholecalziferol-derivate und ihre herstellung

Country Status (12)

Country Link
US (1) US5436401A (enFirst)
EP (1) EP0619304B1 (enFirst)
JP (1) JP3493037B2 (enFirst)
KR (1) KR100247214B1 (enFirst)
AT (1) ATE157966T1 (enFirst)
DE (1) DE69222183T2 (enFirst)
DK (1) DK0619304T3 (enFirst)
ES (1) ES2107650T3 (enFirst)
GR (1) GR3025468T3 (enFirst)
SG (1) SG78265A1 (enFirst)
TW (1) TW222621B (enFirst)
WO (1) WO1993012083A1 (enFirst)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3563310D1 (en) * 1985-07-30 1988-07-21 Salzgitter Ind Method and device for the preparation of suspensions with constant indications from basic materials with variable properties
US6121469A (en) 1993-12-23 2000-09-19 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
ES2181773T3 (es) * 1994-04-19 2003-03-01 Chugai Pharmaceutical Co Ltd Productos destinados al tratamiento de la cquexia asociada con tumores.
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
JP3310301B2 (ja) * 1996-09-03 2002-08-05 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ビタミンｄおよびステロイド誘導体の合成用中間体およびその製造方法
GB9804861D0 (en) 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
CN1150973C (zh) 1998-07-03 2004-05-26 中外制药株式会社 光化学反应用紫外线照射装置以及使用它的维生素d衍生物的制备方法
DE60044090D1 (de) * 1999-08-27 2010-05-12 Hiroaki Takayama Vitamin-d-derivate mit substituenten an der 2-alpha-position
JP4803939B2 (ja) 2000-04-19 2011-10-26 中外製薬株式会社 ビタミンｄ誘導体
CN100469764C (zh) * 2000-06-15 2009-03-18 中外制药株式会社 维生素d衍生物
CN1449289A (zh) * 2000-08-30 2003-10-15 中外制药株式会社 Oct制剂
JP2014514274A (ja) 2011-03-09 2014-06-19 テバ ファーマシューティカル インダストリーズ リミティド マキサカルシトールの多形およびマキサカルシトールの調製方法
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103508999B (zh) 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN107286067A (zh) * 2016-04-05 2017-10-24 湖南华腾制药有限公司 一种马沙骨化醇的制备方法
CN114728874B (zh) 2019-11-27 2024-04-26 研成精密化学株式会社 用于制备马沙骨化醇的方法及用于其的中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61140560A (ja) * 1984-12-12 1986-06-27 Chugai Pharmaceut Co Ltd ２０−オキサ−２１−ノルビタミンｄ３誘導体
JPS61267550A (ja) * 1984-12-28 1986-11-27 Chugai Pharmaceut Co Ltd ９，１０−セコ−５，７，１０（１９）−プレグナトリエン誘導体
JP3050564B2 (ja) * 1989-12-15 2000-06-12 中外製薬株式会社 新規な２２―オキサビタミンｄ誘導体

Also Published As

Publication number Publication date
WO1993012083A1 (fr) 1993-06-24
DK0619304T3 (da) 1998-02-16
ATE157966T1 (de) 1997-09-15
TW222621B (enFirst) 1994-04-21
JP3493037B2 (ja) 2004-02-03
GR3025468T3 (en) 1998-02-27
DE69222183D1 (de) 1997-10-16
EP0619304A4 (en) 1995-03-29
EP0619304B1 (en) 1997-09-10
JPH0672994A (ja) 1994-03-15
HK1002729A1 (en) 1998-09-11
ES2107650T3 (es) 1997-12-01
KR100247214B1 (ko) 2000-03-15
SG78265A1 (en) 2001-02-20
EP0619304A1 (en) 1994-10-12
US5436401A (en) 1995-07-25
KR940703807A (ko) 1994-12-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee