DE69127485T2 - Verfahren zur selektiven Herstellung von Hydratkristallen - Google Patents

Verfahren zur selektiven Herstellung von Hydratkristallen

Info

Publication number
DE69127485T2
DE69127485T2 DE69127485T DE69127485T DE69127485T2 DE 69127485 T2 DE69127485 T2 DE 69127485T2 DE 69127485 T DE69127485 T DE 69127485T DE 69127485 T DE69127485 T DE 69127485T DE 69127485 T2 DE69127485 T2 DE 69127485T2
Authority
DE
Germany
Prior art keywords
methyl
selective production
hydrate crystals
benzoxazine
pyrido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69127485T
Other languages
English (en)
Other versions
DE69127485D1 (de
Inventor
Yukio Sato
Atsushi Sato
Tatsuro Sumikawa
Tazuo Uemura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69127485D1 publication Critical patent/DE69127485D1/de
Publication of DE69127485T2 publication Critical patent/DE69127485T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69127485T 1990-03-01 1991-02-28 Verfahren zur selektiven Herstellung von Hydratkristallen Expired - Lifetime DE69127485T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5045490 1990-03-01

Publications (2)

Publication Number Publication Date
DE69127485D1 DE69127485D1 (de) 1997-10-09
DE69127485T2 true DE69127485T2 (de) 1998-04-02

Family

ID=12859314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69127485T Expired - Lifetime DE69127485T2 (de) 1990-03-01 1991-02-28 Verfahren zur selektiven Herstellung von Hydratkristallen

Country Status (13)

Country Link
US (1) US5545737A (de)
EP (1) EP0444678B1 (de)
KR (1) KR970000045B1 (de)
AT (1) ATE157666T1 (de)
DE (1) DE69127485T2 (de)
ES (1) ES2106739T3 (de)
GR (1) GR3025276T3 (de)
HK (1) HK1002730A1 (de)
IE (1) IE910692A1 (de)
IN (1) IN172207B (de)
PT (1) PT96917B (de)
TW (1) TW208013B (de)
YU (1) YU48328B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA946853B (en) * 1993-09-10 1995-04-24 Daiichi Seiyaku Co Crystals of antimicrobial compound.
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
IL161164A0 (en) † 2001-10-03 2004-08-31 Teva Pharma Preparation of levofloxacin and forms thereof
IL162172A0 (en) * 2001-11-29 2005-11-20 Teva Pharma Methods for the purification of levofloxacin
WO2004055025A1 (en) * 2002-12-16 2004-07-01 Ranbaxy Laboratories Limited Pure levofloxacin hemihydrate and processes for preparation thereof
KR100704641B1 (ko) * 2004-07-21 2007-04-06 주식회사유한양행 고순도의 레보플록사신 제조방법
WO2006030452A1 (en) * 2004-09-17 2006-03-23 Matrix Laboratories Ltd An improved process for the preparation of levofloxacin hemihydrate
US20070244318A1 (en) * 2004-11-08 2007-10-18 Rao Davuluri R Process for the Preparation of Levofloxacin Hemihydrate
ES2255871B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la obtencion de levofloxacino exento de sales.
CN1321121C (zh) * 2005-04-21 2007-06-13 浙江医药股份有限公司新昌制药厂 左氧氟沙星制备及后处理方法
US7964723B2 (en) * 2008-08-02 2011-06-21 Apeloa-Kangyu And practical process for exclusively producing (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3,de][1,4]benzoxazine-6-carboxylic acid hemihydrate
CN101863904A (zh) * 2010-07-08 2010-10-20 浙江东亚药业有限公司 一种高纯度左氧氟沙星半水合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE203719C (de) * 1907-11-02 1908-10-20
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS57131769A (en) * 1981-02-10 1982-08-14 Kissei Pharmaceut Co Ltd 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate, its preparation and drug containing the same
JPS5843977A (ja) * 1981-09-09 1983-03-14 Dai Ichi Seiyaku Co Ltd ピリドベンズオキサジン誘導体の製法
JPS60226855A (ja) * 1984-04-26 1985-11-12 Nippon Kayaku Co Ltd Ｎ−ベンジルオキシカルボニル−ｌ−スレオニンアミド・１／２水和物およびその製造法
ZA864518B (en) * 1985-06-20 1987-03-25 Daiichi Seiyaku Co Optically active pyridobenzoxazine derivatives and intermediates thereof
DK170473B1 (da) * 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
FI82240C (fi) * 1988-10-20 1991-02-11 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt vaerdefullt s-timolol-hemihydrat.
MTP1076B (en) * 1990-01-12 1991-09-30 Ciba Geigy Ag Hemihydrate

Also Published As

Publication number Publication date
GR3025276T3 (en) 1998-02-27
ES2106739T3 (es) 1997-11-16
KR970000045B1 (ko) 1997-01-04
ATE157666T1 (de) 1997-09-15
KR910016748A (ko) 1991-11-05
IE910692A1 (en) 1991-09-11
PT96917B (pt) 1998-07-31
PT96917A (pt) 1991-10-31
TW208013B (de) 1993-06-21
HK1002730A1 (en) 1998-09-11
EP0444678B1 (de) 1997-09-03
IN172207B (de) 1993-05-01
EP0444678A1 (de) 1991-09-04
YU48328B (sh) 1998-05-15
DE69127485D1 (de) 1997-10-09
YU35491A (sh) 1994-04-05
US5545737A (en) 1996-08-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAIICHI SANKYO CO., LTD., TOKYO, JP