US5080891A
(en)
*
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
US5324844A
(en)
*
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
US5122614A
(en)
*
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
CA2101918A1
(en)
*
|
1991-03-18 |
1992-09-19 |
Samuel Zalipsky |
Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
GB9116610D0
(en)
*
|
1991-08-01 |
1991-09-18 |
Danbiosyst Uk |
Preparation of microparticles
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
CA2101361A1
(en)
*
|
1992-08-27 |
1994-02-28 |
Robert A. Snow |
Low diol polyalkylene oxide biologically active proteinaceous substances
|
US5349001A
(en)
*
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
US5359030A
(en)
*
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
US5643575A
(en)
*
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
US5583114A
(en)
*
|
1994-07-27 |
1996-12-10 |
Minnesota Mining And Manufacturing Company |
Adhesive sealant composition
|
WO1996040792A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Novo Nordisk A/S |
Modification of polypeptides
|
WO1996040791A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Novo Nordisk A/S |
Modification of polypeptides
|
US6818018B1
(en)
|
1998-08-14 |
2004-11-16 |
Incept Llc |
In situ polymerizable hydrogels
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
WO2001051510A2
(en)
|
2000-01-10 |
2001-07-19 |
Maxygen Holdings Ltd |
G-csf conjugates
|
WO2001058935A2
(en)
|
2000-02-11 |
2001-08-16 |
Maxygen Aps |
FACTOR VII OR VIIa-LIKE MOLECULES
|
WO2001060335A2
(en)
|
2000-02-17 |
2001-08-23 |
3M Innovative Properties Company |
Delivery systems using preformed biodegradable polymer compositions and methods
|
US7118737B2
(en)
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
YU48703A
(sh)
|
2001-02-27 |
2006-05-25 |
Maxygen Aps |
Novi interferonu beta-slični molekuli
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
EP2322229B1
(de)
|
2001-10-10 |
2016-12-21 |
Novo Nordisk A/S |
Neumodulierung und Glykokonjugation von Faktor IX
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
DK1578771T3
(da)
|
2001-10-10 |
2013-06-10 |
Novo Nordisk As |
Remodellering og glycokonjugering af peptider
|
NZ536340A
(en)
|
2002-04-30 |
2006-09-29 |
Maxygen Holdings Ltd |
Factor VII or VIIa polypeptide variants with N-glycosylation
|
ES2363205T3
(es)
|
2002-06-21 |
2011-07-26 |
Novo Nordisk Health Care Ag |
Glicoformas del factor vii pegilado.
|
US8034900B2
(en)
|
2002-12-30 |
2011-10-11 |
Amylin Pharmaceuticals, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
NZ542094A
(en)
|
2003-03-14 |
2008-12-24 |
Neose Technologies Inc |
Branched polymer conjugates comprising a peptide and water-soluble polymer chains
|
SG155777A1
(en)
|
2003-04-09 |
2009-10-29 |
Neose Technologies Inc |
Glycopegylation methods and proteins/peptides produced by the methods
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
WO2006127896A2
(en)
|
2005-05-25 |
2006-11-30 |
Neose Technologies, Inc. |
Glycopegylated factor ix
|
EP1624847B1
(de)
|
2003-05-09 |
2012-01-04 |
BioGeneriX AG |
Zusammensetzungen und Verfahren zur Herstellung von Glykosylierungsmutanten des menschlichen Wachstumshormons
|
GB0314472D0
(en)
*
|
2003-06-20 |
2003-07-23 |
Warwick Effect Polymers Ltd |
Polymer
|
GB0316294D0
(en)
|
2003-07-11 |
2003-08-13 |
Polytherics Ltd |
Conjugated biological molecules and their preparation
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
CA2542179A1
(en)
|
2003-10-10 |
2005-04-21 |
Novo Nordisk A/S |
Il-21 derivatives
|
EP2633866A3
(de)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Kombinationstherapie
|
US7842661B2
(en)
|
2003-11-24 |
2010-11-30 |
Novo Nordisk A/S |
Glycopegylated erythropoietin formulations
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
US7956032B2
(en)
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
EP1765853B1
(de)
|
2004-01-08 |
2015-10-28 |
ratiopharm GmbH |
O-Glykosylierung von G-CSF Peptiden
|
US8778880B2
(en)
|
2004-02-02 |
2014-07-15 |
Ambrx, Inc. |
Human growth hormone modified at position 35
|
ZA200609638B
(en)
*
|
2004-04-21 |
2008-02-27 |
Alza Corp |
Polymer conjugate releasable under mild thiolytic conditions
|
ZA200609930B
(en)
|
2004-06-08 |
2009-01-28 |
Alza Corp |
Macromolecular peg conjucates by four-component condensation
|
CA2568952C
(en)
|
2004-06-18 |
2019-05-21 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
WO2006031811A2
(en)
|
2004-09-10 |
2006-03-23 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
EP3061461A1
(de)
|
2004-10-29 |
2016-08-31 |
ratiopharm GmbH |
Remodellierung und glykopegylierung von fibroblasten-wachstumsfaktor (fgf)
|
KR20070090023A
(ko)
|
2004-12-22 |
2007-09-04 |
암브룩스, 인코포레이티드 |
변형 인간 성장 호르몬
|
SG161210A1
(en)
|
2004-12-22 |
2010-05-27 |
Ambrx Inc |
Methods for expression and purification of recombinant human growth hormone
|
AU2005322019B2
(en)
|
2004-12-22 |
2010-08-26 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid
|
ATE541934T1
(de)
|
2004-12-22 |
2012-02-15 |
Ambrx Inc |
Zusammensetzungen von aminoacyl-trna-synthetase und verwendungen davon
|
DK2399893T3
(en)
|
2004-12-22 |
2018-10-08 |
Ambrx Inc |
COMPOSITIONS CONTAINING, INVOLVING PROCEDURES, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES
|
ES2449195T3
(es)
|
2005-01-10 |
2014-03-18 |
Ratiopharm Gmbh |
Factor estimulante de colonias de granulocitos glicopegilado
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
JP2008534640A
(ja)
|
2005-04-05 |
2008-08-28 |
イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー |
タンパク質の機能部位またはエピトープの遮蔽方法
|
WO2006121569A2
(en)
|
2005-04-08 |
2006-11-16 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
EP1893229B1
(de)
|
2005-06-03 |
2011-10-19 |
Ambrx, Inc. |
Verbesserte humane interferon-moleküle und ihre verwendungen
|
JP5335422B2
(ja)
|
2005-06-17 |
2013-11-06 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
EP1797901A1
(de)
|
2005-12-16 |
2007-06-20 |
Diatos |
Zelldurchlässige Peptidkonjugate zum Transfer von Nukleinsäuren in Zellen
|
RU2470940C2
(ru)
|
2006-03-13 |
2012-12-27 |
Лиат МИНТЦ |
Применение варианта сплайсинга грелина для лечения кахексии, и/или анорексии, и/или анорексии-кахексии, и/или нарушения питания, и/или липодистрофии, и/или мышечного истощения, и/или стимуляции аппетита
|
EP2029738A2
(de)
|
2006-05-24 |
2009-03-04 |
Novo Nordisk Health Care AG |
Faktor-ix-analoge mit verlängerter in-vivo-halbwertszeit
|
US20080274958A1
(en)
|
2006-07-21 |
2008-11-06 |
Neose Technologies, Inc. |
Glycosylation of peptides via o-linked glycosylation sequences
|
JP5840345B2
(ja)
|
2006-09-08 |
2016-01-06 |
アンブルックス, インコーポレイテッドAmbrx, Inc. |
修飾ヒト血漿ポリペプチドまたは修飾ヒトFc足場タンパク質ならびにこれらの利用
|
KR20090051227A
(ko)
|
2006-09-08 |
2009-05-21 |
암브룩스, 인코포레이티드 |
척추동물 세포를 위한 하이브리드 서프레서 tRNA
|
AU2007292893B2
(en)
|
2006-09-08 |
2012-03-01 |
Ambrx, Inc. |
Suppressor tRNA transcription in vertebrate cells
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
MX2009003470A
(es)
|
2006-10-04 |
2009-04-14 |
Novo Nordisk As |
Azucares y glicopeptidos pegilados enlazados a glicerol.
|
US8012931B2
(en)
|
2007-03-30 |
2011-09-06 |
Ambrx, Inc. |
Modified FGF-21 polypeptides and their uses
|
NZ580030A
(en)
|
2007-04-03 |
2012-06-29 |
Biogenerix Ag |
Methods of treatment using glycopegylated g-csf
|
CA2685596A1
(en)
|
2007-05-02 |
2008-11-13 |
Ambrx, Inc. |
Modified interferon beta polypeptides and their uses
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
JP5547083B2
(ja)
|
2007-11-20 |
2014-07-09 |
アンブルックス,インコーポレイテッド |
修飾されたインスリンポリペプチドおよびそれらの使用
|
NZ620606A
(en)
|
2008-02-08 |
2015-08-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
KR101582841B1
(ko)
|
2008-02-27 |
2016-01-11 |
노보 노르디스크 에이/에스 |
콘쥬게이트된 인자 viii 분자
|
US9040723B2
(en)
*
|
2008-07-14 |
2015-05-26 |
Biocon Limited |
Method of synthesizing a substantially monodispersed mixture of oligomers
|
PE20110426A1
(es)
|
2008-07-23 |
2011-07-01 |
Ambrx Inc |
Polipeptidos g-csf bovinos modificados
|
MX357314B
(es)
|
2008-09-26 |
2018-07-04 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
|
KR101647164B1
(ko)
|
2008-09-26 |
2016-08-09 |
암브룩스, 인코포레이티드 |
변형된 동물 에리트로포이에틴 폴리펩티드 및 이의 용도
|
TWI496582B
(zh)
|
2008-11-24 |
2015-08-21 |
必治妥美雅史谷比公司 |
雙重專一性之egfr/igfir結合分子
|
LT2440239T
(lt)
|
2009-06-09 |
2017-12-11 |
Prolong Pharmaceuticals, LLC |
Hemoglobino kompozicijos
|
SG181769A1
(en)
|
2009-12-21 |
2012-07-30 |
Ambrx Inc |
Modified porcine somatotropin polypeptides and their uses
|
CA2784793A1
(en)
|
2009-12-21 |
2011-07-21 |
Ambrx, Inc. |
Modified bovine somatotropin polypeptides and their uses
|
JP6148013B2
(ja)
|
2010-03-05 |
2017-06-14 |
リグショスピタレト |
補体活性化のキメラ抑制分子
|
US20120135912A1
(en)
|
2010-05-10 |
2012-05-31 |
Perseid Therapeutics Llc |
Polypeptide inhibitors of vla4
|
EP2605789B1
(de)
|
2010-08-17 |
2019-06-05 |
Ambrx, Inc. |
Modifizierte relaxinpolypeptide und ihre verwendungen
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
CN103429256B
(zh)
|
2011-03-02 |
2022-09-13 |
诺和诺德保健股份有限公司 |
凝血因子向活化的血小板上的tlt-1的靶向
|
US9051562B2
(en)
|
2011-06-15 |
2015-06-09 |
Institut National De La Santé Et De La Recherche Médicale (Inserm) |
Polypeptides isolated from brevibacterium aurantiacum and their use for the treatment of cancer
|
CA2840552A1
(en)
|
2011-07-01 |
2013-01-10 |
Bayer Intellectual Property Gmbh |
Relaxin fusion polypeptides and uses thereof
|
EP3088005B1
(de)
|
2011-07-05 |
2019-01-02 |
biOasis Technologies Inc |
P97-antikörperkonjugate
|
JP6262206B2
(ja)
|
2012-05-01 |
2018-01-17 |
ノヴォ ノルディスク アー/エス |
医薬組成物
|
PL2859017T3
(pl)
|
2012-06-08 |
2019-07-31 |
Sutro Biopharma, Inc. |
Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania
|
EP3135690A1
(de)
|
2012-06-26 |
2017-03-01 |
Sutro Biopharma, Inc. |
Modifizierte fc-proteine mit stellenspezifischen nichtnatürlichen aminosäureresten, konjugate daraus, verfahren zu deren herstellung und verfahren zu deren verwendung
|
WO2014022515A1
(en)
|
2012-07-31 |
2014-02-06 |
Bioasis Technologies, Inc. |
Dephosphorylated lysosomal storage disease proteins and methods of use thereof
|
CN104981254B
(zh)
|
2012-08-31 |
2018-05-22 |
苏特罗生物制药公司 |
含有叠氮基的经修饰的氨基酸
|
EP2916835A4
(de)
|
2012-11-12 |
2016-07-27 |
Redwood Bioscience Inc |
Verbindungen und verfahren zur herstellung eines konjugats
|
JP2016505528A
(ja)
|
2012-11-16 |
2016-02-25 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
タンパク質の化学修飾のためのピクテ−スペングラーライゲーション
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
EP2970433B1
(de)
|
2013-03-13 |
2019-09-18 |
Bioasis Technologies Inc. |
Fragmente von p97 und verwendungen davon
|
JP6586016B2
(ja)
|
2013-03-15 |
2019-10-02 |
ノヴォ ノルディスク アー/エス |
組織因子系凝固インヒビター上の2つのエピトープに特異的に結合することが可能な抗体
|
ES2865473T3
(es)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
WO2015031673A2
(en)
|
2013-08-28 |
2015-03-05 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
CN105744935B
(zh)
|
2013-11-27 |
2022-09-30 |
雷德伍德生物科技股份有限公司 |
肼基-吡咯并化合物及用于生成缀合物的方法
|
CN114805532A
(zh)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
WO2017029391A1
(en)
|
2015-08-20 |
2017-02-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
New method for treating cancer
|
EP4019007A1
(de)
|
2016-06-01 |
2022-06-29 |
Servier IP UK Limited |
Formulierungen von polyalkylen-oxid-asparaginase und verfahren zur herstellung und verwendung davon
|
MA46568A
(fr)
|
2016-10-24 |
2019-08-28 |
Novo Nordisk As |
Dosage biologique de formulations d'insuline
|
AU2018219283B2
(en)
|
2017-02-08 |
2022-05-19 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
WO2019038420A1
(en)
|
2017-08-25 |
2019-02-28 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF OSTEOCLAST DISEASES
|
WO2019133399A1
(en)
|
2017-12-26 |
2019-07-04 |
Becton, Dickinson And Company |
Deep ultraviolet-excitable water-solvated polymeric dyes
|
JP2021519841A
(ja)
|
2018-03-30 |
2021-08-12 |
ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company |
ペンダントクロモフォアを有する水溶性ポリマー色素
|
WO2020023300A1
(en)
|
2018-07-22 |
2020-01-30 |
Bioasis Technologies, Inc. |
Treatment of lymmphatic metastases
|
FI3849614T3
(fi)
|
2018-09-11 |
2024-02-08 |
Ambrx Inc |
Interleukiini-2-polypeptidikonjugaatteja ja niiden käyttöjä
|
WO2020089743A1
(en)
|
2018-11-02 |
2020-05-07 |
Cadila Healthcare Limited |
Pharmaceutical composition of pegylated l-asparaginase
|
WO2021048171A1
(en)
|
2019-09-10 |
2021-03-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Method to improve phagocytosis
|
AU2021233909A1
(en)
|
2020-03-11 |
2022-09-29 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
US11739166B2
(en)
|
2020-07-02 |
2023-08-29 |
Davol Inc. |
Reactive polysaccharide-based hemostatic agent
|
CA3177039A1
(en)
|
2020-12-28 |
2022-07-07 |
Davol Inc. |
Reactive dry powdered hemostatic materials comprising a protein and a multifunctionalized modified polyethylene glycol based crosslinking agent
|
WO2022152698A1
(en)
|
2021-01-12 |
2022-07-21 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of npdk-d to evaluate cancer prognosis
|
WO2022200469A1
(en)
|
2021-03-24 |
2022-09-29 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
A dominant negative protein of rad51 for treating cancer
|
EP4155349A1
(de)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Wasserlösliche gelbe grünabsorbierende farbstoffe
|
WO2024007016A2
(en)
|
2022-07-01 |
2024-01-04 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|