ES2124685T3 - Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso. - Google Patents
Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.Info
- Publication number
- ES2124685T3 ES2124685T3 ES88112130T ES88112130T ES2124685T3 ES 2124685 T3 ES2124685 T3 ES 2124685T3 ES 88112130 T ES88112130 T ES 88112130T ES 88112130 T ES88112130 T ES 88112130T ES 2124685 T3 ES2124685 T3 ES 2124685T3
- Authority
- ES
- Spain
- Prior art keywords
- variants
- trypsin inhibitor
- production
- bovine pancreatic
- pancreatic trypsin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBEN PEPTIDOS CON LA SECUENCIA ESENCIAL DE LOS INHIBIDORES DE TRIPSINA PANCREATICA BOBINA (APROTIMA), DONDE SE SUSTITUYEN UNO O MAS AMINOACIDOS EN POSICION 15, 16, 17, 18, 34, 39 Y 52 POR UN AMINOACIDO QUE SE ENCUENTRA NATURALMENTE. LA PRODUCCION DE LOS MISMOS RESULTA POR TECNOLOGIA DEL DNA RECOMBINANTE, ADEMAS SE DESCRIBEN PROCEDIMIENTOS, VECTORES DE EXPRESION Y RECOMBINANTES ASI COMO LA UTILIZACION FARMACEUTICA DE LAS VARIANTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8718777A GB2208511A (en) | 1987-08-07 | 1987-08-07 | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2124685T3 true ES2124685T3 (es) | 1999-02-16 |
Family
ID=10621986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88112130T Expired - Lifetime ES2124685T3 (es) | 1987-08-07 | 1988-07-27 | Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5118668A (es) |
EP (1) | EP0307592B1 (es) |
JP (1) | JP2894354B2 (es) |
KR (1) | KR890003802A (es) |
AT (1) | ATE173478T1 (es) |
AU (1) | AU604953B2 (es) |
DE (1) | DE3856265D1 (es) |
ES (1) | ES2124685T3 (es) |
GB (1) | GB2208511A (es) |
IL (1) | IL87332A (es) |
ZA (1) | ZA885764B (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5223482A (en) * | 1986-11-17 | 1993-06-29 | Scios Nova Inc. | Recombinant Alzheimer's protease inhibitory amyloid protein and method of use |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
US7078383B2 (en) * | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
US20060134087A1 (en) * | 1988-09-02 | 2006-06-22 | Dyax Corp. | ITI-D1 Kunitz domain mutants as hNE inhibitors |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5866413A (en) * | 1989-03-06 | 1999-02-02 | Board Of Regents Of The University Of Texas System | Pai-1 mutants |
EP0462207B1 (en) * | 1989-03-06 | 2001-02-07 | Board Of Regents, The University Of Texas System | T-pa mutants resistant to inhibition by their cognate inhibitors |
US7413537B2 (en) | 1989-09-01 | 2008-08-19 | Dyax Corp. | Directed evolution of disulfide-bonded micro-proteins |
US5231010A (en) * | 1989-09-13 | 1993-07-27 | Bayer Aktiengesellschaft | Recombinant aprotinin variants genetically engineered process for the microbial preparation of homogeneously processed aprotinin variants and the therapeutic use thereof |
DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
AU1581692A (en) * | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Inhibitors of human neutrophil elastase and human cathepsin g |
EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
US20030223977A1 (en) * | 1991-03-01 | 2003-12-04 | Ley Arthur Charles | Kunitz domain mutants as cathepsin G inhibitors |
JPH07509229A (ja) * | 1992-07-13 | 1995-10-12 | コルバス・インターナショナル、インコーポレイテッド | ウシ膵トリプシン阻害因子から誘導される因子Xaの阻害因子 |
EP0671944A4 (en) * | 1992-09-25 | 1996-07-24 | Corvas Int Inc | TISSUE VIA-THROMBOPLASTIN FACTOR COMPLEX INHIBITORS DERIVED FROM A BOVINE PANCREATIC TRYPSIN INHIBITOR. |
US5650394A (en) * | 1993-11-04 | 1997-07-22 | Adeza Biomedical | Use of urinastatin-like compounds to prevent premature delivery |
PT1489097E (pt) | 1994-01-11 | 2012-01-04 | Dyax Corp | Inibidores de plasmina humana derivados de domínios kunitz e ácidos nucleicos codificando os mesmos |
US6057287A (en) * | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
DE4417353A1 (de) * | 1994-05-18 | 1996-01-25 | Bayer Ag | Verfahren zur Herstellung von rekombinantem Aprotinin und rekombinanten Aprotinin Varianten mit der natürlichen N-terminlaen Sequenz |
US5786328A (en) * | 1995-06-05 | 1998-07-28 | Genentech, Inc. | Use of kunitz type plasma kallikrein inhibitors |
US5780265A (en) * | 1995-06-05 | 1998-07-14 | Genentech, Inc. | Kunitz type plasma kallikrein inhibitors |
DE19629982A1 (de) * | 1996-07-25 | 1998-01-29 | Bayer Ag | Aprotinin-Varianten mit verbesserten Eigenschaften |
DE19725014A1 (de) * | 1997-06-13 | 1998-12-17 | Bayer Ag | Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten |
US6731695B2 (en) * | 2001-03-27 | 2004-05-04 | Aware, Inc. | Systems and methods for implementing receiver transparent Q-mode |
DK1941867T3 (da) * | 2002-06-07 | 2012-01-02 | Dyax Corp | Polypeptid med modificeret Kunitz domæne |
US7153829B2 (en) * | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
SI2386310T1 (sl) * | 2002-08-28 | 2019-03-29 | Dyax Corp. | Metode za ohranjanje organov in tkiv |
DK1583562T3 (da) * | 2003-01-06 | 2011-09-19 | Angiochem Inc | Angiopep-1, beslægtede forbindelser og anvendelser deraf |
US20040209243A1 (en) * | 2003-01-07 | 2004-10-21 | Andrew Nixon | Kunitz domain library |
US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
US7235530B2 (en) * | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
US20060218667A1 (en) * | 2004-10-12 | 2006-09-28 | Vojdani Fakhrieh S | Plant-produced recombinant aprotinin and aprotinin variants |
EP1674870B1 (en) * | 2004-11-15 | 2008-06-11 | Roche Diagnostics GmbH | High-throughput prion assays |
US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
ES2383901T5 (es) | 2005-02-18 | 2015-02-25 | Angiochem Inc. | Polipéptidos de aprotinina para transportar un compuesto a través de la barrera sangre-cerebro |
TW200716611A (en) * | 2005-04-29 | 2007-05-01 | Wyeth Corp | Process for preparing isatins with control of side-product formation |
ES2424242T3 (es) | 2005-07-15 | 2013-09-30 | Angiochem Inc. | Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos |
JP2009529542A (ja) * | 2006-03-10 | 2009-08-20 | ダイアックス コーポレーション | エカランチドに関する配合物 |
WO2008060362A2 (en) | 2006-09-27 | 2008-05-22 | The Regents Of The University Of California | Methods and compositions for the treatment of skin diseases and disorders |
WO2008110301A1 (de) * | 2007-03-13 | 2008-09-18 | Bayer Schering Pharma Aktiengesellschaft | Aprotinin-varianten mit verbesserten eigenschaften |
PL2164866T3 (pl) | 2007-05-29 | 2014-10-31 | Angiochem Inc | Polipeptydy podobne do aprotyniny do dostarczania skoniugowanych z nimi środków do tkanek |
US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
DE102007056231A1 (de) | 2007-09-08 | 2009-03-12 | Bayer Healthcare Ag | Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI) |
EP2205623B1 (en) * | 2007-10-29 | 2016-03-16 | Helix Biomedix Inc. | Protective skin care tetrapeptides |
JP5860698B2 (ja) * | 2008-04-18 | 2016-02-16 | アンジオケム,インコーポレーテッド | パクリタキセル、パクリタキセル類似体またはパクリタキセルコンジュゲートの医薬組成物ならびに関連する調製方法および使用方法 |
RU2531591C2 (ru) | 2008-10-15 | 2014-10-20 | Ангиокем Инк. | Конъюгаты этопозида и доксорубицина для доставки лекарственных средств |
BRPI0920209A2 (pt) | 2008-10-15 | 2015-12-22 | Angiochem Inc | conjugados de agonistas de glp-1 e usos dos mesmos |
US9914754B2 (en) * | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
MX2011006685A (es) | 2008-12-17 | 2011-09-27 | Angiochem Inc | Inhibidores de metaloproteinas de matriz de membrana tipo-1 y sus usos. |
WO2010080833A1 (en) * | 2009-01-06 | 2010-07-15 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
ES2729261T3 (es) | 2009-04-20 | 2019-10-31 | Angiochem Inc | Tratamiento del cáncer de ovario utilizando un agente anticancerígeno conjugado con un análogo de Angiopep-2 |
IN2012DN00248A (es) | 2009-07-02 | 2015-05-01 | Angiochem Inc | |
CA3168591A1 (en) | 2010-01-06 | 2011-07-14 | Takeda Pharmaceutical Company Limited | Plasma kallikrein binding proteins |
WO2011153642A1 (en) * | 2010-06-10 | 2011-12-15 | Angiochem Inc. | Leptin and leptin analog conjugates and fusion proteins and uses thereof |
KR102502293B1 (ko) | 2011-01-06 | 2023-02-21 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
IL295414A (en) | 2014-03-27 | 2022-10-01 | Takeda Pharmaceuticals Co | Compositions and methods for treating macular edema as a result of diabetes |
ES2826827T3 (es) | 2015-06-15 | 2021-05-19 | Angiochem Inc | Métodos para el tratamiento de carcinomatosis leptomeníngea |
NZ744233A (en) | 2015-12-11 | 2023-11-24 | Takeda Pharmaceuticals Co | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
KR20200083435A (ko) | 2017-08-31 | 2020-07-08 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 피부 효소 활성을 제어하기 위한 분자 박테리아요법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
JPH0616716B2 (ja) * | 1986-10-14 | 1994-03-09 | 塩野義製薬株式会社 | 酵母におけるヒトpstiの製造法 |
SE8604600L (sv) * | 1986-10-29 | 1988-04-30 | Nixflu Ab | Anordning for att kontrollera kontokort |
GB2199582A (en) * | 1987-01-07 | 1988-07-13 | Bayer Ag | Analogues of pancreatic secretory trypsin inhibitor |
US5032573A (en) * | 1987-03-23 | 1991-07-16 | Bayer Aktiengesellschaft | Homologs of aprotinin produced from a recombinant host, process, expression vector and recombinant host therefor and pharmaceutical use thereof |
DE3724570A1 (de) * | 1987-06-27 | 1989-01-05 | Bayer Ag | Human-aprotinin, dessen lys-rest in position 15 gegen einen anderen protogenen aminosaeurerest ausgetauscht ist |
GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
US5591603A (en) * | 1987-08-28 | 1997-01-07 | Novo Nordisk A/S | Process for preparing aprotinin and aprotinin analogs in yeast cells |
DK225488D0 (da) * | 1988-04-26 | 1988-04-26 | Novo Industri As | Polypeptid |
DE3930522A1 (de) * | 1989-09-13 | 1991-03-21 | Bayer Ag | Rekombinante aprotinin-varianten - gentechnisches verfahren zur mikrobiellen herstellung von homogen prozessierten aprotinin-varianten sowie die therapeutische anwendung derselben |
-
1987
- 1987-08-07 GB GB8718777A patent/GB2208511A/en not_active Withdrawn
-
1988
- 1988-07-20 US US07/221,835 patent/US5118668A/en not_active Expired - Fee Related
- 1988-07-27 DE DE3856265T patent/DE3856265D1/de not_active Expired - Fee Related
- 1988-07-27 EP EP88112130A patent/EP0307592B1/de not_active Expired - Lifetime
- 1988-07-27 AT AT88112130T patent/ATE173478T1/de not_active IP Right Cessation
- 1988-07-27 ES ES88112130T patent/ES2124685T3/es not_active Expired - Lifetime
- 1988-08-04 IL IL87332A patent/IL87332A/xx not_active IP Right Cessation
- 1988-08-05 ZA ZA885764A patent/ZA885764B/xx unknown
- 1988-08-06 JP JP63195323A patent/JP2894354B2/ja not_active Expired - Fee Related
- 1988-08-06 KR KR1019880010059A patent/KR890003802A/ko not_active Application Discontinuation
- 1988-08-08 AU AU20588/88A patent/AU604953B2/en not_active Ceased
-
1995
- 1995-01-09 US US08/369,987 patent/US5770568A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU604953B2 (en) | 1991-01-03 |
KR890003802A (ko) | 1989-04-18 |
IL87332A (en) | 1993-01-14 |
ATE173478T1 (de) | 1998-12-15 |
JPH02480A (ja) | 1990-01-05 |
US5118668A (en) | 1992-06-02 |
EP0307592B1 (de) | 1998-11-18 |
ZA885764B (en) | 1989-04-26 |
JP2894354B2 (ja) | 1999-05-24 |
GB2208511A (en) | 1989-04-05 |
EP0307592A3 (de) | 1990-06-06 |
GB8718777D0 (en) | 1987-09-16 |
EP0307592A2 (de) | 1989-03-22 |
IL87332A0 (en) | 1989-01-31 |
AU2058888A (en) | 1989-04-20 |
US5770568A (en) | 1998-06-23 |
DE3856265D1 (de) | 1998-12-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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