PT98332A - Metodo para a producao de uma proteina biologicamente activa por processamento in vitro de proteinas de fusao - Google Patents

Metodo para a producao de uma proteina biologicamente activa por processamento in vitro de proteinas de fusao

Info

Publication number
PT98332A
PT98332A PT98332A PT9833291A PT98332A PT 98332 A PT98332 A PT 98332A PT 98332 A PT98332 A PT 98332A PT 9833291 A PT9833291 A PT 9833291A PT 98332 A PT98332 A PT 98332A
Authority
PT
Portugal
Prior art keywords
biologically active
active protein
protein
production
fusao
Prior art date
Application number
PT98332A
Other languages
English (en)
Other versions
PT98332B (pt
Inventor
Jutta Heim
Kenji Takabayashi
Peter Seeboth
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of PT98332A publication Critical patent/PT98332A/pt
Publication of PT98332B publication Critical patent/PT98332B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
PT98332A 1990-07-18 1991-07-16 Metodo para a producao de uma proteina biologicamente activa por processamento in vitro de proteinas de fusao PT98332B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909015825A GB9015825D0 (en) 1990-07-18 1990-07-18 In vitro processing of fusion proteins

Publications (2)

Publication Number Publication Date
PT98332A true PT98332A (pt) 1992-05-29
PT98332B PT98332B (pt) 1999-01-29

Family

ID=10679295

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98332A PT98332B (pt) 1990-07-18 1991-07-16 Metodo para a producao de uma proteina biologicamente activa por processamento in vitro de proteinas de fusao

Country Status (19)

Country Link
EP (1) EP0467839B1 (pt)
JP (1) JP3140488B2 (pt)
AT (1) ATE141645T1 (pt)
AU (1) AU651830B2 (pt)
CA (1) CA2047119C (pt)
DE (1) DE69121489T2 (pt)
DK (1) DK0467839T3 (pt)
ES (1) ES2091897T3 (pt)
FI (1) FI106720B (pt)
GB (1) GB9015825D0 (pt)
GR (1) GR3020840T3 (pt)
HU (1) HU216104B (pt)
IE (1) IE73209B1 (pt)
NO (1) NO303132B1 (pt)
NZ (1) NZ238989A (pt)
PT (1) PT98332B (pt)
SG (1) SG49863A1 (pt)
TW (1) TW209247B (pt)
ZA (1) ZA915579B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525491A (en) * 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
WO1997023639A1 (fr) * 1995-12-22 1997-07-03 Toray Industries, Inc. Procede de production de proteines fusionnees biologiquement actives
US6800726B1 (en) 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
GB9716790D0 (en) 1997-08-07 1997-10-15 Creative Peptides Sweden Ab Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
SG11201504771RA (en) 2013-03-06 2015-09-29 Glaxosmithkline Llc Host cells and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
US5010182A (en) * 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid

Also Published As

Publication number Publication date
ES2091897T3 (es) 1996-11-16
GB9015825D0 (en) 1990-09-05
HU216104B (hu) 1999-04-28
DE69121489D1 (de) 1996-09-26
NO912803D0 (no) 1991-07-17
DK0467839T3 (da) 1996-09-16
NO912803L (no) 1992-01-20
AU651830B2 (en) 1994-08-04
EP0467839B1 (en) 1996-08-21
AU8046391A (en) 1992-01-23
FI913405A (fi) 1992-01-19
JPH04229188A (ja) 1992-08-18
ATE141645T1 (de) 1996-09-15
NZ238989A (en) 1992-09-25
TW209247B (pt) 1993-07-11
HU912398D0 (en) 1991-12-30
HUT58369A (en) 1992-02-28
IE912501A1 (en) 1992-01-29
GR3020840T3 (en) 1996-11-30
NO303132B1 (no) 1998-06-02
PT98332B (pt) 1999-01-29
FI913405A0 (fi) 1991-07-15
SG49863A1 (en) 2002-03-19
CA2047119A1 (en) 1992-01-19
DE69121489T2 (de) 1997-02-27
CA2047119C (en) 2002-10-08
EP0467839A1 (en) 1992-01-22
FI106720B (fi) 2001-03-30
JP3140488B2 (ja) 2001-03-05
IE73209B1 (en) 1997-05-07
ZA915579B (en) 1992-03-25

Similar Documents

Publication Publication Date Title
ES2124685T3 (es) Variantes del inhibidor de la tripsina pancreatica bovina, su produccion y uso.
DK105489D0 (da) Polypeptid
FI102075B1 (fi) Menetelmä valmistaa glykosyloitu tai glykosyloimaton polypeptidi, rekombinanttinukleiinihappo ja vektorit
DK0815245T3 (da) Bioaktive IL 12 fusionsproteiner
ES2059356T3 (es) Inhibidor de la tripsina pancreatico secretor, preparado mediante tecnologia genetica y sus variantes.
SE8801701D0 (sv) Production technology based on enzymic method
ES2101716T3 (es) Vectores y compuestos para la expresion de mutantes de glicosilacion de la proteina c humana.
PT98332A (pt) Metodo para a producao de uma proteina biologicamente activa por processamento in vitro de proteinas de fusao
DE69233245D1 (de) Verfahren zur Herstellung von Peptiden
MX167236B (es) Peptidos sinteticos de timosina -1 y metodo para su obtencion
BR8907452A (pt) Peptideo e polipeptideo antifilicos,processo e composicao para sua utilizacao
CA2032167A1 (en) Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
DE69014541D1 (de) Chemisch modifizierte Allergene und Verfahren zu ihrer Herstellung.
YU69691A (sh) Postupak za pripremu stranih proteina u streptomicetama
DE59108261D1 (de) Peptide des HIV-gag Proteins, ihre Herstellung und Verwendung
KR880701073A (ko) 제조합 dna 기법에 의해 생성된 민악티빈
DE3680524D1 (de) Verfahren zur stabilisierung von proteinen.
DK53290A (da) Syntetiske gaer-leader-peptider

Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920114

FG3A Patent granted, date of granting

Effective date: 19981009

MM4A Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20110411