DE69029579D1 - Inhibitoren der plättchen-aggregation - Google Patents

Inhibitoren der plättchen-aggregation

Info

Publication number
DE69029579D1
DE69029579D1 DE69029579T DE69029579T DE69029579D1 DE 69029579 D1 DE69029579 D1 DE 69029579D1 DE 69029579 T DE69029579 T DE 69029579T DE 69029579 T DE69029579 T DE 69029579T DE 69029579 D1 DE69029579 D1 DE 69029579D1
Authority
DE
Germany
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69029579T
Other languages
English (en)
Other versions
DE69029579T3 (de
DE69029579T2 (de
Inventor
Robert Scarborough
David Wolf
Israel Charo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COR Therapeutics Inc
Original Assignee
COR Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69029579(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by COR Therapeutics Inc filed Critical COR Therapeutics Inc
Application granted granted Critical
Publication of DE69029579D1 publication Critical patent/DE69029579D1/de
Publication of DE69029579T2 publication Critical patent/DE69029579T2/de
Publication of DE69029579T3 publication Critical patent/DE69029579T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE69029579T 1989-06-16 1990-06-15 Blutplättchen-Aggregationsinhibitoren Expired - Lifetime DE69029579T3 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US367509 1989-06-16
US41802889A 1989-10-06 1989-10-06
US418028 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
US483229 1990-02-20
PCT/US1990/003417 WO1990015620A1 (en) 1989-06-16 1990-06-15 Platelet aggregation inhibitors

Publications (3)

Publication Number Publication Date
DE69029579D1 true DE69029579D1 (de) 1997-02-13
DE69029579T2 DE69029579T2 (de) 1997-07-24
DE69029579T3 DE69029579T3 (de) 2006-06-22

Family

ID=27408820

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69029579T Expired - Lifetime DE69029579T3 (de) 1989-06-16 1990-06-15 Blutplättchen-Aggregationsinhibitoren
DE19975072C Active DE19975072I2 (de) 1989-06-16 1990-06-15 Blutplättchen-Aggregationsinhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19975072C Active DE19975072I2 (de) 1989-06-16 1990-06-15 Blutplättchen-Aggregationsinhibitoren

Country Status (16)

Country Link
US (4) US5318899A (de)
EP (2) EP0477295B2 (de)
JP (1) JP3281370B2 (de)
KR (1) KR0180918B1 (de)
AT (1) ATE146969T1 (de)
CA (2) CA2059124C (de)
DE (2) DE69029579T3 (de)
DK (1) DK0477295T4 (de)
ES (1) ES2097150T5 (de)
FI (1) FI104364B (de)
HU (1) HU216318B (de)
LU (1) LU90488I2 (de)
NL (1) NL990043I2 (de)
NO (3) NO304267B1 (de)
RU (1) RU2156468C2 (de)
WO (1) WO1990015620A1 (de)

Families Citing this family (67)

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AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
AU660926B2 (en) * 1990-04-06 1995-07-13 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
JPH06502407A (ja) * 1990-11-02 1994-03-17 ジェネンテク，インコーポレイテッド 血小板凝集阻害剤
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
AU666853B2 (en) * 1991-04-05 1996-02-29 Genentech Inc. Platelet aggregation inhibitors having high specificity for GP IIbIIIa
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
KR100297184B1 (ko) * 1992-06-04 2001-10-22 슈테펜엘.네스비트 항혈소판제로서의입체배좌적으로억제된펩타이드동족체및이를포함하는약제학적조성물
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
AU692439B2 (en) * 1993-03-29 1998-06-11 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
ATE202345T1 (de) * 1993-03-29 2001-07-15 Astrazeneca Ab Heterozyklische derivate als plätchenaggregationsinhibitoren
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
ATE195949T1 (de) * 1993-06-18 2000-09-15 Jolla Cancer Res Found Verfahren und zusammensetzungen zur behandlung der thrombose
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
EP0835135A2 (de) * 1995-06-07 1998-04-15 Centocor, Inc. Plättchen-spezifisches, chimäres immunglobulin und verfahren zu seiner verwendung
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
AU1749497A (en) * 1996-01-16 1997-08-11 Rensselaer Polytechnic Institute Peptides for altering osteoblast adhesion
JP2001500875A (ja) * 1996-09-18 2001-01-23 メルク エンド カンパニー インコーポレーテッド 心臓血管系疾患関連の危険性を減らす併用治療法
CA2271684A1 (en) * 1996-11-21 1998-05-28 Merck & Co., Inc. Detection of antagonist-dependent gpiib/iiia receptor antibodies
FR2764389B1 (fr) * 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
WO1999013898A1 (en) * 1997-08-15 1999-03-25 Stefan Niewiarowski EC-3, AN INHIBITOR OF α4β1 AND α4β7 INTEGRINS
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
CA2320900C (en) 1998-03-19 2009-10-27 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
WO2002022571A2 (en) * 2000-09-11 2002-03-21 Temple University-Of The Commonwealth System Of Higher Education Compounds and methods for inhibiting alpha-1 beta-1 integrins
DE60233520D1 (de) * 2001-11-05 2009-10-08 Irm Llc Markierungsreagens und anwendungsverfahren
EP1504022B1 (de) * 2002-05-03 2006-10-11 Avecia Limited Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
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US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
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US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
EP1906990B1 (de) * 2005-07-05 2013-12-11 Baker Medical Research Institute Antikoagulationsmittel
WO2008020743A2 (fr) * 2006-08-16 2008-02-21 Wisdom Asset Company Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
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MX342120B (es) 2010-07-09 2016-09-14 William Owen Wilkison Combinación de sistema de liberación prolongada/inmediata para productos farmacéuticos de vida media corta como el remogliflozin.
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
EP2882792A4 (de) 2012-08-09 2016-04-13 Valspar Sourcing Inc Polycarbonate
CN104583347B (zh) 2012-08-09 2016-11-16 威士伯采购公司 稳定剂和其涂料组合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
CN108137653B (zh) 2015-08-05 2021-07-13 陕西麦科奥特科技有限公司 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN111601816B (zh) * 2017-08-09 2023-12-22 黄德富 去整合蛋白变异体及其用途

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DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
FR2617170B1 (fr) * 1987-06-25 1989-12-22 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
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US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (de) * 1989-02-07 1991-05-29 Merck & Co. Inc. Polypeptide und deren Varianten aus dem Gift von Schlangen
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Also Published As

Publication number Publication date
DE19975072I1 (de) 2000-03-09
AU636159B2 (en) 1993-04-22
US5318899A (en) 1994-06-07
LU90488I2 (fr) 2000-02-15
CA2059124A1 (en) 1990-12-17
US5958732A (en) 1999-09-28
KR920702627A (ko) 1992-10-06
NO982249L (no) 1992-01-31
NL990043I2 (nl) 2000-04-03
JPH05500750A (ja) 1993-02-18
EP0751219A1 (de) 1997-01-02
RU2156468C2 (ru) 2000-09-20
AU6036990A (en) 1991-01-08
CA2388770A1 (en) 1990-12-27
FI104364B (fi) 2000-01-14
DE69029579T3 (de) 2006-06-22
DE19975072I2 (de) 2011-01-20
ES2097150T3 (es) 1997-04-01
NO914962D0 (no) 1991-12-16
EP0477295A1 (de) 1992-04-01
US5496724A (en) 1996-03-05
NO914962L (no) 1992-01-31
DE69029579T2 (de) 1997-07-24
HU905490D0 (en) 1992-03-30
EP0477295B1 (de) 1997-01-02
CA2059124C (en) 2002-08-20
NO982249D0 (no) 1998-05-15
NL990043I1 (nl) 2000-02-01
US5736339A (en) 1998-04-07
ES2097150T5 (es) 2006-06-16
KR0180918B1 (ko) 1999-04-01
ATE146969T1 (de) 1997-01-15
EP0477295A4 (en) 1992-10-07
HUT59835A (en) 1992-07-28
NO304267B1 (no) 1998-11-23
DK0477295T4 (da) 2005-12-12
FI915919A0 (fi) 1991-12-16
HU216318B (hu) 1999-06-28
EP0477295B2 (de) 2005-11-16
NO2000008I2 (no) 2006-01-16
WO1990015620A1 (en) 1990-12-27
JP3281370B2 (ja) 2002-05-13
DK0477295T3 (da) 1997-07-07
NO312965B1 (no) 2002-07-22

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