LU90488I2 - Eptifibatide - Google Patents

Eptifibatide

Info

Publication number
LU90488I2
LU90488I2 LU90488C LU90488C LU90488I2 LU 90488 I2 LU90488 I2 LU 90488I2 LU 90488 C LU90488 C LU 90488C LU 90488 C LU90488 C LU 90488C LU 90488 I2 LU90488 I2 LU 90488I2
Authority
LU
Luxembourg
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
LU90488C
Other languages
English (en)
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90488(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of LU90488I2 publication Critical patent/LU90488I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
LU90488C 1989-06-16 1999-12-15 Eptifibatide LU90488I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (fr) 1989-06-16 1990-06-15 Inhibiteurs de l'agregation des plaquettes

Publications (1)

Publication Number Publication Date
LU90488I2 true LU90488I2 (fr) 2000-02-15

Family

ID=27408820

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90488C LU90488I2 (fr) 1989-06-16 1999-12-15 Eptifibatide

Country Status (16)

Country Link
US (4) US5318899A (fr)
EP (2) EP0751219A1 (fr)
JP (1) JP3281370B2 (fr)
KR (1) KR0180918B1 (fr)
AT (1) ATE146969T1 (fr)
CA (2) CA2388770A1 (fr)
DE (2) DE69029579T3 (fr)
DK (1) DK0477295T4 (fr)
ES (1) ES2097150T5 (fr)
FI (1) FI104364B (fr)
HU (1) HU216318B (fr)
LU (1) LU90488I2 (fr)
NL (1) NL990043I2 (fr)
NO (3) NO304267B1 (fr)
RU (1) RU2156468C2 (fr)
WO (1) WO1990015620A1 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
CA2027936C (fr) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Peptides cycliques anti-agregants
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
JPH05509294A (ja) * 1990-04-06 1993-12-22 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション 血栓症治療のための方法および組成物
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
EP0555328A1 (fr) * 1990-11-02 1993-08-18 Genentech, Inc. Inhibiteurs d'agregation de plaquettes
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
CA2106314A1 (fr) * 1991-04-05 1992-10-06 John P. Burnier Inhibiteurs de l'agregation plaquettaire hautement specifiques du gpiibiiia
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
EP0648224B1 (fr) * 1992-06-04 1998-07-15 Merrell Pharmaceuticals Inc. Analogues de peptides restreints quant a la conformation utilises comme agents antiagregants plaquettaires
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
WO1994022834A1 (fr) * 1993-03-29 1994-10-13 Zeneca Limited Derives heterocycliques utilises comme inhibiteurs d'agregation plaquettaire
AU692439B2 (en) * 1993-03-29 1998-06-11 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
WO1995000544A1 (fr) * 1993-06-18 1995-01-05 La Jolla Cancer Research Foundation Procede et composition de traitement de la thrombose
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
CN1186439A (zh) * 1995-06-07 1998-07-01 森特克公司 血小板特异性的嵌合性免疫球蛋白及其使用方法
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
EP0877620A4 (fr) * 1996-01-16 1999-04-14 Rensselaer Polytech Inst Peptides utilises pour la modification d'une adhesion osteoblastique
JP2001500875A (ja) * 1996-09-18 2001-01-23 メルク エンド カンパニー インコーポレーテッド 心臓血管系疾患関連の危険性を減らす併用治療法
EP0939900A4 (fr) * 1996-11-21 2003-01-08 Merck & Co Inc DETECTION D'ANTICORPS DE RECEPTEUR GPIIb/IIIa DEPENDANT D'ANTAGONISTES
FR2764389B1 (fr) * 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
WO1999013898A1 (fr) * 1997-08-15 1999-03-25 Stefan Niewiarowski Ec-3 en tant qu'inhibiteur des integrines alpha4 beta1 et alpha4 beta7
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
AU736951C (en) 1998-03-19 2003-02-20 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
WO2002022571A2 (fr) * 2000-09-11 2002-03-21 Temple University-Of The Commonwealth System Of Higher Education Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1
EP1451207B1 (fr) * 2001-11-05 2009-08-26 Irm Llc Reactif de marquage et ses procedes d'utilisation
AU2003227907A1 (en) * 2002-05-03 2003-11-17 Avecia Limited Process for the synthesis of peptides amides by side-chain attachement to a solid phase
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (fr) * 2003-07-15 2005-05-19 Washington University Methodes de traitement, prevention et inhibition des metastases cancereuses et de la formation de tumeurs
US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
MXPA06011904A (es) * 2004-04-08 2007-01-25 Millenium Pharmaceuticals Inc Procesos para preparar eptifibatido.
JP2008503597A (ja) * 2004-06-14 2008-02-07 ユーエスブイ・リミテッド ペプチドの製造方法
CA2578046A1 (fr) * 2004-09-07 2006-03-16 Archemix Corp. Chimie medicale utilisant des aptameres
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
CA2579374A1 (fr) * 2004-09-07 2006-03-30 Archemix Corp. Aptameres au facteur de von willebrand et leur utilisation en tant qu'agents therapeutiques pour des maladies thrombotiques
WO2007003010A1 (fr) * 2005-07-05 2007-01-11 Baker Medical Research Institute Agent anticoagulant et son utilisation
WO2008020743A2 (fr) * 2006-08-16 2008-02-21 Wisdom Asset Company Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
WO2008150495A2 (fr) * 2007-06-01 2008-12-11 Archemix Corp. Formulations d'aptamère vwf et procédés d'utilisation
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
EP2590634B1 (fr) 2010-07-09 2016-03-09 BHV Pharma, Inc. Système d'administration à libération immédiate/retardée en combinaison pour des médicaments à courte demi-vie comprenant de la rémogliflozine
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
ES2800027T3 (es) 2012-08-09 2020-12-23 Swimc Llc Estabilizador y composiciones de recubrimiento del mismo
US9944749B2 (en) 2012-08-09 2018-04-17 Swimc, Llc Polycarbonates
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US11643439B2 (en) 2015-08-05 2023-05-09 Shaanxi Micot Technology Limited Company Multi-target compound with anticoagulation and antiplatelet activity, preparation method therefor, and use thereof
AU2017426938B2 (en) * 2017-08-09 2020-08-27 Dcb-Usa Llc Disintegrin variants and uses thereof

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* Cited by examiner, † Cited by third party
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US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
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US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
FR2617170B1 (fr) * 1987-06-25 1989-12-22 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
EP0317053B1 (fr) * 1987-11-18 1993-12-08 Temple University of the Commonwealth System of Higher Education Trigramine, un polypeptide inhibant l'aggrégation des plaquettes
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
WO1989007609A1 (fr) * 1988-02-22 1989-08-24 The Upjohn Company Peptides a base d'homoarginine utilises comme inhibiteurs de l'agglomeration de plaquettes
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (fr) * 1989-02-07 1991-05-29 Merck & Co. Inc. Polypeptides issus du venin de vipère et leurs variantes
AU5939890A (en) * 1989-06-07 1991-01-07 Genentech Inc. Platelet aggregation inhibitors and related molecules
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
DE19975072I1 (de) 2000-03-09
JP3281370B2 (ja) 2002-05-13
DK0477295T4 (da) 2005-12-12
FI104364B (fi) 2000-01-14
EP0477295B2 (fr) 2005-11-16
DE19975072I2 (de) 2011-01-20
RU2156468C2 (ru) 2000-09-20
US5496724A (en) 1996-03-05
NO982249D0 (no) 1998-05-15
EP0751219A1 (fr) 1997-01-02
NO982249L (no) 1992-01-31
KR0180918B1 (ko) 1999-04-01
CA2388770A1 (fr) 1990-12-27
EP0477295B1 (fr) 1997-01-02
DE69029579T3 (de) 2006-06-22
NO304267B1 (no) 1998-11-23
NL990043I2 (nl) 2000-04-03
CA2059124C (fr) 2002-08-20
HUT59835A (en) 1992-07-28
DE69029579D1 (de) 1997-02-13
AU6036990A (en) 1991-01-08
US5318899A (en) 1994-06-07
ES2097150T5 (es) 2006-06-16
JPH05500750A (ja) 1993-02-18
NO312965B1 (no) 2002-07-22
NO914962D0 (no) 1991-12-16
DE69029579T2 (de) 1997-07-24
ATE146969T1 (de) 1997-01-15
HU905490D0 (en) 1992-03-30
HU216318B (hu) 1999-06-28
KR920702627A (ko) 1992-10-06
DK0477295T3 (da) 1997-07-07
WO1990015620A1 (fr) 1990-12-27
US5958732A (en) 1999-09-28
NO914962L (no) 1992-01-31
EP0477295A1 (fr) 1992-04-01
FI915919A0 (fi) 1991-12-16
ES2097150T3 (es) 1997-04-01
NL990043I1 (nl) 2000-02-01
EP0477295A4 (en) 1992-10-07
US5736339A (en) 1998-04-07
CA2059124A1 (fr) 1990-12-17
NO2000008I2 (no) 2006-01-16
AU636159B2 (en) 1993-04-22

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