LU90488I2 - Eptifibatide - Google Patents

Eptifibatide

Info

Publication number
LU90488I2
LU90488I2 LU90488C LU90488C LU90488I2 LU 90488 I2 LU90488 I2 LU 90488I2 LU 90488 C LU90488 C LU 90488C LU 90488 C LU90488 C LU 90488C LU 90488 I2 LU90488 I2 LU 90488I2
Authority
LU
Luxembourg
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
LU90488C
Other languages
English (en)
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90488(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of LU90488I2 publication Critical patent/LU90488I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
LU90488C 1989-06-16 1999-12-15 Eptifibatide LU90488I2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (fr) 1989-06-16 1990-06-15 Inhibiteurs de l'agregation des plaquettes

Publications (1)

Publication Number Publication Date
LU90488I2 true LU90488I2 (fr) 2000-02-15

Family

ID=27408820

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90488C LU90488I2 (fr) 1989-06-16 1999-12-15 Eptifibatide

Country Status (16)

Country Link
US (4) US5318899A (fr)
EP (2) EP0477295B2 (fr)
JP (1) JP3281370B2 (fr)
KR (1) KR0180918B1 (fr)
AT (1) ATE146969T1 (fr)
CA (2) CA2388770A1 (fr)
DE (2) DE69029579T3 (fr)
DK (1) DK0477295T4 (fr)
ES (1) ES2097150T5 (fr)
FI (1) FI104364B (fr)
HU (1) HU216318B (fr)
LU (1) LU90488I2 (fr)
NL (1) NL990043I2 (fr)
NO (3) NO304267B1 (fr)
RU (1) RU2156468C2 (fr)
WO (1) WO1990015620A1 (fr)

Families Citing this family (70)

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US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2027936C (fr) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Peptides cycliques anti-agregants
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
WO1991015515A1 (fr) * 1990-04-06 1991-10-17 La Jolla Cancer Research Foundation Procede et composition de traitement de la thrombose
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
CA2092315A1 (fr) * 1990-11-02 1992-05-03 John P. Burnier Inhibiteurs de l'agregation plaquettaire
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
CA2106314A1 (fr) * 1991-04-05 1992-10-06 John P. Burnier Inhibiteurs de l'agregation plaquettaire hautement specifiques du gpiibiiia
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
AU679913B2 (en) 1992-04-30 1997-07-17 Millennium Pharmaceuticals, Inc. Stable polypeptide composition
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
DE69319733T2 (de) * 1992-06-04 1999-01-14 Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
EP0691959B1 (fr) * 1993-03-29 1998-07-22 Zeneca Limited Derives heterocycliques utilises comme inhibiteurs d'agregation plaquettaire
EP0690847A1 (fr) * 1993-03-29 1996-01-10 Zeneca Limited Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
AU7112794A (en) * 1993-06-18 1995-01-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
JPH11511120A (ja) * 1995-06-07 1999-09-28 セントコー，インコーポレイテッド 血小板特異的キメラ免疫グロブリン及びその使用方法
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
AU1749497A (en) * 1996-01-16 1997-08-11 Rensselaer Polytechnic Institute Peptides for altering osteoblast adhesion
WO1998011896A1 (fr) * 1996-09-18 1998-03-26 Merck & Co., Inc. Traitement combine destine a reduire les risques de maladies cardio-vasculaires
WO1998022821A1 (fr) * 1996-11-21 1998-05-28 Merck & Co., Inc. DETECTION D'ANTICORPS DE RECEPTEUR GPIIa/IIIb DEPENDANT D'ANTAGONISTES
FR2764389B1 (fr) 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
WO1999013898A1 (fr) * 1997-08-15 1999-03-25 Stefan Niewiarowski Ec-3 en tant qu'inhibiteur des integrines alpha4 beta1 et alpha4 beta7
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
EP1063973B1 (fr) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
CA2421786A1 (fr) * 2000-09-11 2002-03-21 Temple University - Of The Commonwealth System Of Higher Education Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1
ATE441115T1 (de) * 2001-11-05 2009-09-15 Irm Llc Markierungsreagens und anwendungsverfahren
EP1504022B1 (fr) * 2002-05-03 2006-10-11 Avecia Limited Procede de synthese d'amides de peptides par fixation des chaines laterales sur une phase solide
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (fr) * 2003-07-15 2005-05-19 Washington University Methodes de traitement, prevention et inhibition des metastases cancereuses et de la formation de tumeurs
US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
WO2005100381A2 (fr) * 2004-04-08 2005-10-27 Millennium Pharmaceuticals, Inc. Procedes de preparation de l'eptifibatide
CN1968961A (zh) * 2004-06-14 2007-05-23 Usv有限公司 制备肽的方法
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101227A (ko) * 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
JP2008512097A (ja) * 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
EP1717588A1 (fr) * 2005-04-29 2006-11-02 Synapse B.V. Mesure de l'activité thrombique dans le sang total
CA2613691A1 (fr) 2005-07-05 2007-01-11 Baker Medical Research Institute Agent anticoagulant et son utilisation
WO2008020743A2 (fr) * 2006-08-16 2008-02-21 Wisdom Asset Company Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
CN103153288B (zh) 2010-07-09 2017-02-15 詹姆斯·特林卡·格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
CN104540874B (zh) 2012-08-09 2018-05-01 威士伯采购公司 聚碳酸酯
CN104583347B (zh) 2012-08-09 2016-11-16 威士伯采购公司 稳定剂和其涂料组合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
WO2017020282A1 (fr) 2015-08-05 2017-02-09 陕西麦科奥特科技有限公司 Composé multicible présentant une activité d'anticoagulation et antiplaquettaire, son procédé de préparation et son utilisation
JP7016945B2 (ja) * 2017-08-09 2022-02-07 国立台湾大学 ディスインテグリン変異体及びその使用法

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US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
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DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
FR2617170B1 (fr) * 1987-06-25 1989-12-22 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
ES2060654T3 (es) * 1987-11-18 1994-12-01 Univ Temple Trigramina - un polipeptido inhibidor de la agregacion plaquetaria.
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
WO1989007609A1 (fr) * 1988-02-22 1989-08-24 The Upjohn Company Peptides a base d'homoarginine utilises comme inhibiteurs de l'agglomeration de plaquettes
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
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Also Published As

Publication number Publication date
DE69029579T2 (de) 1997-07-24
KR0180918B1 (ko) 1999-04-01
EP0751219A1 (fr) 1997-01-02
NO982249L (no) 1992-01-31
CA2059124A1 (fr) 1990-12-17
EP0477295B1 (fr) 1997-01-02
NO914962L (no) 1992-01-31
EP0477295B2 (fr) 2005-11-16
NO914962D0 (no) 1991-12-16
ES2097150T3 (es) 1997-04-01
JP3281370B2 (ja) 2002-05-13
DE19975072I2 (de) 2011-01-20
HU216318B (hu) 1999-06-28
JPH05500750A (ja) 1993-02-18
KR920702627A (ko) 1992-10-06
DE19975072I1 (de) 2000-03-09
AU636159B2 (en) 1993-04-22
NO982249D0 (no) 1998-05-15
DK0477295T4 (da) 2005-12-12
US5958732A (en) 1999-09-28
AU6036990A (en) 1991-01-08
NO312965B1 (no) 2002-07-22
ATE146969T1 (de) 1997-01-15
RU2156468C2 (ru) 2000-09-20
FI915919A0 (fi) 1991-12-16
DE69029579D1 (de) 1997-02-13
NO2000008I2 (no) 2006-01-16
DE69029579T3 (de) 2006-06-22
WO1990015620A1 (fr) 1990-12-27
US5318899A (en) 1994-06-07
HU905490D0 (en) 1992-03-30
US5736339A (en) 1998-04-07
NL990043I1 (nl) 2000-02-01
CA2388770A1 (fr) 1990-12-27
NO304267B1 (no) 1998-11-23
DK0477295T3 (da) 1997-07-07
US5496724A (en) 1996-03-05
NL990043I2 (nl) 2000-04-03
CA2059124C (fr) 2002-08-20
EP0477295A1 (fr) 1992-04-01
ES2097150T5 (es) 2006-06-16
EP0477295A4 (en) 1992-10-07
FI104364B (fi) 2000-01-14
HUT59835A (en) 1992-07-28

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