ATE441115T1 - Markierungsreagens und anwendungsverfahren - Google Patents

Markierungsreagens und anwendungsverfahren

Info

Publication number
ATE441115T1
ATE441115T1 AT02803304T AT02803304T ATE441115T1 AT E441115 T1 ATE441115 T1 AT E441115T1 AT 02803304 T AT02803304 T AT 02803304T AT 02803304 T AT02803304 T AT 02803304T AT E441115 T1 ATE441115 T1 AT E441115T1
Authority
AT
Austria
Prior art keywords
lysine
labels
present
polypeptide
terminal
Prior art date
Application number
AT02803304T
Other languages
English (en)
Inventor
Eric Peters
Ansgar Brock
Christer Ericson
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Application granted granted Critical
Publication of ATE441115T1 publication Critical patent/ATE441115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/36—Radio frequency spectrometers, e.g. Bennett-type spectrometers, Redhead-type spectrometers
    • H01J49/38—Omegatrons ; using ion cyclotron resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Evolutionary Biology (AREA)
  • Microbiology (AREA)
  • Theoretical Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medical Informatics (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02803304T 2001-11-05 2002-11-05 Markierungsreagens und anwendungsverfahren ATE441115T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33298801P 2001-11-05 2001-11-05
US38583502P 2002-06-03 2002-06-03
US41038202P 2002-09-12 2002-09-12
PCT/US2002/035581 WO2003056299A2 (en) 2001-11-05 2002-11-05 Labeling reagent and methods of use

Publications (1)

Publication Number Publication Date
ATE441115T1 true ATE441115T1 (de) 2009-09-15

Family

ID=27406887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02803304T ATE441115T1 (de) 2001-11-05 2002-11-05 Markierungsreagens und anwendungsverfahren

Country Status (7)

Country Link
US (2) US20030228700A1 (de)
EP (1) EP1451207B1 (de)
JP (1) JP4328625B2 (de)
AT (1) ATE441115T1 (de)
AU (1) AU2002365152A1 (de)
DE (1) DE60233520D1 (de)
WO (1) WO2003056299A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977370B1 (en) * 2003-04-07 2005-12-20 Ciphergen Biosystems, Inc. Off-resonance mid-IR laser desorption ionization
WO2005050226A1 (en) * 2003-11-14 2005-06-02 Irm Llc Fluorous labeling for selective processing of biologically-derived samples
US20070054345A1 (en) 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
EP1776588A1 (de) * 2004-07-12 2007-04-25 Applera Corporation Massen-tags für quantitative analysen
US7371514B2 (en) * 2004-07-16 2008-05-13 Agilent Technologies, Inc. Serial derivatization of peptides for de novo sequencing using tandem mass spectrometry
US20060014293A1 (en) * 2004-07-16 2006-01-19 Joyce Timothy H Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
WO2009023946A1 (en) * 2007-08-21 2009-02-26 Mds Analytical Technologies, A Business Unit Of Mds Inc., Doing Business Through Its Sciex Division Method for enhancing mass assignment accuracy
KR101081053B1 (ko) 2008-07-18 2011-11-07 포항공과대학교 산학협력단 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법
WO2010109022A1 (en) 2009-03-27 2010-09-30 Universitetet I Oslo Quantitative proteomics method
US9625469B2 (en) 2011-06-23 2017-04-18 Board Of Regents, The University Of Texas System Identifying peptides at the single molecule level
US11435358B2 (en) 2011-06-23 2022-09-06 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
JP6281349B2 (ja) * 2014-03-19 2018-02-21 株式会社島津製作所 質量分析用ペプチド混合物試料の調製方法
US10545153B2 (en) 2014-09-15 2020-01-28 Board Of Regents, The University Of Texas System Single molecule peptide sequencing
JP2018538511A (ja) * 2015-10-14 2018-12-27 ウイスコンシン アラムナイ リサーチ ファウンデーシヨンＷｉｓｃｏｎｓｉｎ Ａｌｕｍｎｉ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 高スループット定量的プロテオミクス及びペプチドミクスのための質量欠損ベースの多重化ジメチルピリミジニルオルニチン（ｄｉｐｙｒｏ）タグ
JP6857569B2 (ja) * 2017-07-26 2021-04-14 日本電子株式会社 質量分析システム及び質量スペクトル表示方法
CN116813693B (zh) * 2023-08-29 2023-12-01 苏州金顶生物有限公司 一种用于多肽合成的标签化合物及其在多肽合成中的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB869977A (en) * 1957-12-26 1961-06-07 Pfizer & Co C Diazacycloalkenes and the preparation thereof
FI832053L (fi) * 1982-06-10 1983-12-11 Syntex Inc Nonapeptid- och dekapeptidanaloger av lhrh anvaendbara som lhrh-antagonister samt deras framstaellningsfoerfarande
US4530920A (en) * 1983-11-07 1985-07-23 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH agonist
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
AU685055B2 (en) * 1992-05-29 1998-01-15 Rockefeller University, The Method and product for the sequence determination of peptides using a mass spectrometer
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
CA2303761C (en) * 1999-04-06 2005-12-20 Micromass Limited A method of determining peptide sequences by mass spectrometry

Also Published As

Publication number Publication date
EP1451207A2 (de) 2004-09-01
JP2005514404A (ja) 2005-05-19
US20080242838A1 (en) 2008-10-02
US20030228700A1 (en) 2003-12-11
AU2002365152A8 (en) 2003-07-15
WO2003056299A2 (en) 2003-07-10
DE60233520D1 (de) 2009-10-08
WO2003056299A3 (en) 2004-02-26
EP1451207B1 (de) 2009-08-26
AU2002365152A1 (en) 2003-07-15
JP4328625B2 (ja) 2009-09-09
EP1451207A4 (de) 2005-08-24

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