CA2421786A1 - Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1 - Google Patents
Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1 Download PDFInfo
- Publication number
- CA2421786A1 CA2421786A1 CA002421786A CA2421786A CA2421786A1 CA 2421786 A1 CA2421786 A1 CA 2421786A1 CA 002421786 A CA002421786 A CA 002421786A CA 2421786 A CA2421786 A CA 2421786A CA 2421786 A1 CA2421786 A1 CA 2421786A1
- Authority
- CA
- Canada
- Prior art keywords
- integrin
- xaa
- cys
- beta
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne l'obtustatine, une disintégrine courte indéprendante de la séquence RGD (arginine-glycine-acide aspartique), qui a une action inhibitrice puissante et sélective sur la liaison de l'intégrine .alpha.1.beta.1 avec son ligand d'adhésion. On peut utiliser l'obtustatine, y compris ses fragments, dérives, homologues et analogues, pour le traitement des maladies et pour moduler les états biologiques associés à l'intégrine .alpha.1.beta.1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23159100P | 2000-09-11 | 2000-09-11 | |
US60/231,591 | 2000-09-11 | ||
PCT/US2001/028522 WO2002022571A2 (fr) | 2000-09-11 | 2001-09-12 | Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2421786A1 true CA2421786A1 (fr) | 2002-03-21 |
Family
ID=22869882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002421786A Abandoned CA2421786A1 (fr) | 2000-09-11 | 2001-09-12 | Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1322322A4 (fr) |
AU (1) | AU2001294552A1 (fr) |
CA (1) | CA2421786A1 (fr) |
WO (1) | WO2002022571A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005016883A2 (fr) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Derives d'acrylamide servant d'antagonistes de l'integrine vla-1, et leurs utilisations |
WO2015087334A1 (fr) | 2013-12-15 | 2015-06-18 | Yissum Research Develoment Company Of The Hebrew University Of Jerusalem Ltd. | Peptides dérivés de vipéristatine et leurs utilisations |
MA49645A (fr) * | 2017-07-20 | 2021-03-31 | Univ Virginia Patent Foundation | Procédés de traitement ou de prévention d'un trouble neurologique du système immunitaire |
CN110974938A (zh) * | 2019-12-02 | 2020-04-10 | 上海长海医院 | 整合素α1β1抑制剂在制备预防或治疗主动脉疾病药物中的应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
-
2001
- 2001-09-12 WO PCT/US2001/028522 patent/WO2002022571A2/fr not_active Application Discontinuation
- 2001-09-12 AU AU2001294552A patent/AU2001294552A1/en not_active Abandoned
- 2001-09-12 EP EP01975200A patent/EP1322322A4/fr not_active Withdrawn
- 2001-09-12 CA CA002421786A patent/CA2421786A1/fr not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002022571A3 (fr) | 2002-06-20 |
WO2002022571A2 (fr) | 2002-03-21 |
AU2001294552A1 (en) | 2002-03-26 |
EP1322322A4 (fr) | 2005-04-06 |
EP1322322A2 (fr) | 2003-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20060912 |