DE3886175T2 - Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt. - Google Patents

Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.

Info

Publication number
DE3886175T2
DE3886175T2 DE88307818T DE3886175T DE3886175T2 DE 3886175 T2 DE3886175 T2 DE 3886175T2 DE 88307818 T DE88307818 T DE 88307818T DE 3886175 T DE3886175 T DE 3886175T DE 3886175 T2 DE3886175 T2 DE 3886175T2
Authority
DE
Germany
Prior art keywords
trigramin
polypeptide
platelet aggregation
inhibits platelet
inhibits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88307818T
Other languages
English (en)
Other versions
DE3886175D1 (de
Inventor
Tur-Fu Huang
Stefan Niewiarowski
John C Holt
Hanna Lukasiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education filed Critical Temple University of Commonwealth System of Higher Education
Publication of DE3886175D1 publication Critical patent/DE3886175D1/de
Application granted granted Critical
Publication of DE3886175T2 publication Critical patent/DE3886175T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE88307818T 1987-11-18 1988-08-24 Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt. Expired - Fee Related DE3886175T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12197287A 1987-11-18 1987-11-18
US16566188A 1988-03-08 1988-03-08

Publications (2)

Publication Number Publication Date
DE3886175D1 DE3886175D1 (de) 1994-01-20
DE3886175T2 true DE3886175T2 (de) 1994-04-07

Family

ID=26820025

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88307818T Expired - Fee Related DE3886175T2 (de) 1987-11-18 1988-08-24 Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.

Country Status (4)

Country Link
EP (1) EP0317053B1 (de)
JP (1) JPH0631317B2 (de)
DE (1) DE3886175T2 (de)
ES (1) ES2060654T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
EP0731110A1 (de) * 1987-12-10 1996-09-11 La Jolla Cancer Research Foundation Verfahren zur Herstellung von konformationell stabilisierten Zelladhäsionspeptiden
NZ228710A (en) * 1988-04-22 1992-10-28 Merck & Co Inc Modified "echistatin" and anti-clotting pharmaceutical composition
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
EP0382451A3 (de) * 1989-02-07 1991-05-29 Merck & Co. Inc. Polypeptide und deren Varianten aus dem Gift von Schlangen
EP0382538A3 (de) * 1989-02-09 1991-10-23 Merck & Co. Inc. Synthese von Polypeptiden
US5795868A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5843897A (en) * 1989-06-16 1998-12-01 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
ES2104702T3 (es) * 1990-04-06 1997-10-16 Jolla Cancer Res Found Metodo y composicion para el tratamiento de la trombosis.
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
DE69226077T2 (de) * 1991-04-05 1998-12-03 Genentech Inc PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

Also Published As

Publication number Publication date
JPH0631317B2 (ja) 1994-04-27
EP0317053B1 (de) 1993-12-08
DE3886175D1 (de) 1994-01-20
JPH01250399A (ja) 1989-10-05
EP0317053A3 (en) 1990-07-25
ES2060654T3 (es) 1994-12-01
EP0317053A2 (de) 1989-05-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee