DE3689191T2 - Gereinigtes protein mit angiogenischer wirkung und dessen herstellung. - Google Patents

Gereinigtes protein mit angiogenischer wirkung und dessen herstellung.

Info

Publication number
DE3689191T2
DE3689191T2 DE86902741T DE3689191T DE3689191T2 DE 3689191 T2 DE3689191 T2 DE 3689191T2 DE 86902741 T DE86902741 T DE 86902741T DE 3689191 T DE3689191 T DE 3689191T DE 3689191 T2 DE3689191 T2 DE 3689191T2
Authority
DE
Germany
Prior art keywords
production
purified protein
angiogenic effect
angiogenic
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE86902741T
Other languages
English (en)
Other versions
DE3689191D1 (de
Inventor
Bert Vallee
James Fett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvard College
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of DE3689191D1 publication Critical patent/DE3689191D1/de
Application granted granted Critical
Publication of DE3689191T2 publication Critical patent/DE3689191T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
DE86902741T 1985-04-17 1986-04-16 Gereinigtes protein mit angiogenischer wirkung und dessen herstellung. Expired - Lifetime DE3689191T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72408885A 1985-04-17 1985-04-17
US06/778,387 US4727137A (en) 1985-04-17 1985-09-20 Purified protein having angiogenic activity and methods of preparation

Publications (2)

Publication Number Publication Date
DE3689191D1 DE3689191D1 (de) 1993-11-25
DE3689191T2 true DE3689191T2 (de) 1994-03-10

Family

ID=27110921

Family Applications (1)

Application Number Title Priority Date Filing Date
DE86902741T Expired - Lifetime DE3689191T2 (de) 1985-04-17 1986-04-16 Gereinigtes protein mit angiogenischer wirkung und dessen herstellung.

Country Status (6)

Country Link
US (1) US4727137A (de)
EP (1) EP0220241B1 (de)
JP (1) JPH0662677B2 (de)
CA (1) CA1338453C (de)
DE (1) DE3689191T2 (de)
WO (1) WO1986006079A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4966849A (en) * 1985-09-20 1990-10-30 President And Fellows Of Harvard College CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression
IL81650A0 (en) * 1986-02-24 1987-09-16 Robapharm Ag Purified human angiogenic factor,method for its preparation and pharmaceutical preparations
US5019556A (en) * 1987-04-14 1991-05-28 President And Fellows Of Harvard College Inhibitors of angiogenin
CA1313818C (en) * 1987-06-03 1993-02-23 Ross Leon Coppel Nuclear antigen la
US4952403A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Implants for the promotion of healing of meniscal tissue
US4952404A (en) * 1987-06-19 1990-08-28 President And Fellows Of Harvard College Promotion of healing of meniscal tissue
US4853219A (en) * 1987-08-06 1989-08-01 President And Fellows Of Harvard College Antibodies to angiogenin: immunotherapeutic agents
US5520914A (en) * 1987-08-06 1996-05-28 President And Fellows Of Harvard College Antibodies to angiogenin: immunotherapeutic agents
AU3863689A (en) * 1988-06-22 1990-01-12 Synergen, Inc. Angiogenic potentiating peptides which potentiate angiogenic factors
ZA909633B (en) * 1990-02-15 1991-10-30 Harvard College Covalent angiogenin/rnase hybrids
US5270204A (en) * 1990-02-15 1993-12-14 The President And Fellows Of Harvard College Covalent angiogenin/RNase hybrids
DE4309391C2 (de) * 1993-03-23 1996-10-24 Harald Prof Dr Tschesche Verwendung von Angiogenin und/oder dessen Fragmenten als Wirkstoff zur Verhinderung oder Begrenzung der Sekretion von Proteinen aus Leukozyten
JP2572931B2 (ja) * 1993-04-28 1997-01-16 雪印乳業株式会社 美白剤
US7745106B2 (en) 1997-06-24 2010-06-29 Cascade Medical Enterprises, Llc Methods and devices for separating liquid components
US6979307B2 (en) * 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US20080199513A1 (en) * 1997-06-24 2008-08-21 Cascade Medical Enterprises, Llc Systems and methods for preparing autologous fibrin glue
MXPA00000009A (es) 1998-06-22 2005-09-08 Autologous Wound Therapy Inc Solicitud para patente de utilidad para curativo de heridas mejorado enriquecido con plaquetas.
EP1890820A4 (de) * 2005-03-22 2012-04-11 Cascade Medical Entpr Llc Systeme und verfahren zur herstellung von membranen
WO2007092827A2 (en) 2006-02-08 2007-08-16 Waters Investments Limited Improved separation method
US8500857B2 (en) 2007-05-21 2013-08-06 Peter Eisenberger Carbon dioxide capture/regeneration method using gas mixture
US20080289495A1 (en) 2007-05-21 2008-11-27 Peter Eisenberger System and Method for Removing Carbon Dioxide From an Atmosphere and Global Thermostat Using the Same
US9028592B2 (en) 2010-04-30 2015-05-12 Peter Eisenberger System and method for carbon dioxide capture and sequestration from relatively high concentration CO2 mixtures

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4229531A (en) * 1978-12-29 1980-10-21 Monsanto Company Production of tumor angiogenesis factor by cell culture
US4209587A (en) * 1978-12-29 1980-06-24 Monsanto Company Production of tumor angiogenesis factor by cell culture
US4268629A (en) * 1980-03-03 1981-05-19 Monsanto Company Production of angiogenic factor by cell culture
DE3110560A1 (de) * 1981-03-18 1982-10-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben"
US4529590A (en) * 1982-12-27 1985-07-16 Leveen Robert F Production of angiogenetic factor
US4503038A (en) * 1983-02-25 1985-03-05 The Regents Of The University Of California Extracellular nonmitogenic angiogenesis factor and method of isolation thereof from wound fluid

Also Published As

Publication number Publication date
EP0220241A1 (de) 1987-05-06
EP0220241B1 (de) 1993-10-20
JPH0662677B2 (ja) 1994-08-17
DE3689191D1 (de) 1993-11-25
JPS62502544A (ja) 1987-10-01
CA1338453C (en) 1996-07-09
WO1986006079A1 (en) 1986-10-23
EP0220241A4 (de) 1988-09-28
US4727137A (en) 1988-02-23

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