DE3886175D1 - Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt. - Google Patents

Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.

Info

Publication number
DE3886175D1
DE3886175D1 DE88307818T DE3886175T DE3886175D1 DE 3886175 D1 DE3886175 D1 DE 3886175D1 DE 88307818 T DE88307818 T DE 88307818T DE 3886175 T DE3886175 T DE 3886175T DE 3886175 D1 DE3886175 D1 DE 3886175D1
Authority
DE
Germany
Prior art keywords
trigramin
polypeptide
platelet aggregation
inhibits platelet
inhibits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88307818T
Other languages
English (en)
Other versions
DE3886175T2 (de
Inventor
Tur-Fu Huang
Stefan Niewiarowski
John C Holt
Hanna Lukasiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education filed Critical Temple University of Commonwealth System of Higher Education
Publication of DE3886175D1 publication Critical patent/DE3886175D1/de
Application granted granted Critical
Publication of DE3886175T2 publication Critical patent/DE3886175T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DE88307818T 1987-11-18 1988-08-24 Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt. Expired - Fee Related DE3886175T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12197287A 1987-11-18 1987-11-18
US16566188A 1988-03-08 1988-03-08

Publications (2)

Publication Number Publication Date
DE3886175D1 true DE3886175D1 (de) 1994-01-20
DE3886175T2 DE3886175T2 (de) 1994-04-07

Family

ID=26820025

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88307818T Expired - Fee Related DE3886175T2 (de) 1987-11-18 1988-08-24 Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.

Country Status (4)

Country Link
EP (1) EP0317053B1 (de)
JP (1) JPH0631317B2 (de)
DE (1) DE3886175T2 (de)
ES (1) ES2060654T3 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2547263B2 (ja) * 1987-12-10 1996-10-23 ラ・ジョラ・キャンサー・リサーチ・ファウンデーション 立体配座的に安定化された細胞付着ペプチド
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
NZ228710A (en) * 1988-04-22 1992-10-28 Merck & Co Inc Modified "echistatin" and anti-clotting pharmaceutical composition
US5196403A (en) * 1989-01-27 1993-03-23 Biogen, Inc. Method of inhibiting platelet activation
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (de) * 1989-02-07 1991-05-29 Merck & Co. Inc. Polypeptide und deren Varianten aus dem Gift von Schlangen
JPH02275899A (ja) * 1989-02-09 1990-11-09 Merck & Co Inc ポリペプチド合成
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686568A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregration inhibitors
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5672585A (en) * 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
WO1992017492A1 (en) * 1991-04-05 1992-10-15 Genentech, Inc. PLATELET AGGREGATION INHIBITORS HAVING HIGH SPECIFICITY FOR GP IIbIII¿a?
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

Also Published As

Publication number Publication date
EP0317053B1 (de) 1993-12-08
JPH0631317B2 (ja) 1994-04-27
ES2060654T3 (es) 1994-12-01
EP0317053A3 (en) 1990-07-25
DE3886175T2 (de) 1994-04-07
EP0317053A2 (de) 1989-05-24
JPH01250399A (ja) 1989-10-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee