DK0477295T4 - Blodpladeaggregationsinhibitorer - Google Patents

Blodpladeaggregationsinhibitorer

Info

Publication number
DK0477295T4
DK0477295T4 DK90911002T DK90911002T DK0477295T4 DK 0477295 T4 DK0477295 T4 DK 0477295T4 DK 90911002 T DK90911002 T DK 90911002T DK 90911002 T DK90911002 T DK 90911002T DK 0477295 T4 DK0477295 T4 DK 0477295T4
Authority
DK
Denmark
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
DK90911002T
Other languages
Danish (da)
English (en)
Other versions
DK0477295T3 (da
Inventor
Israel F Charo
Robert M Scarborough
David Lawrence Wolf
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0477295(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of DK0477295T3 publication Critical patent/DK0477295T3/da
Application granted granted Critical
Publication of DK0477295T4 publication Critical patent/DK0477295T4/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
DK90911002T 1989-06-16 1990-06-15 Blodpladeaggregationsinhibitorer DK0477295T4 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors

Publications (2)

Publication Number Publication Date
DK0477295T3 DK0477295T3 (da) 1997-07-07
DK0477295T4 true DK0477295T4 (da) 2005-12-12

Family

ID=27408820

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90911002T DK0477295T4 (da) 1989-06-16 1990-06-15 Blodpladeaggregationsinhibitorer

Country Status (16)

Country Link
US (4) US5318899A (fr)
EP (2) EP0477295B2 (fr)
JP (1) JP3281370B2 (fr)
KR (1) KR0180918B1 (fr)
AT (1) ATE146969T1 (fr)
CA (2) CA2059124C (fr)
DE (2) DE19975072I2 (fr)
DK (1) DK0477295T4 (fr)
ES (1) ES2097150T5 (fr)
FI (1) FI104364B (fr)
HU (1) HU216318B (fr)
LU (1) LU90488I2 (fr)
NL (1) NL990043I2 (fr)
NO (3) NO304267B1 (fr)
RU (1) RU2156468C2 (fr)
WO (1) WO1990015620A1 (fr)

Families Citing this family (67)

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EP0394326B1 (fr) * 1987-12-10 1996-07-31 La Jolla Cancer Research Foundation Methodes pour la production des peptides d'adhesion cellulaire a stabilisation conformationnelle
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
CA2092315A1 (fr) * 1990-11-02 1992-05-03 John P. Burnier Inhibiteurs de l'agregation plaquettaire
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
WO1992017492A1 (fr) * 1991-04-05 1992-10-15 Genentech, Inc. INHIBITEURS DE L'AGREGATION PLAQUETTAIRE PRESENTANT UNE SPECIFICITE ELEVEE POUR GP IIbIII¿a?
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5663166A (en) * 1991-10-18 1997-09-02 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
WO1993024520A1 (fr) * 1992-06-04 1993-12-09 Merrell Dow Pharmaceuticals Inc. Analogues de peptides restreints quant a la conformation utilises comme agents antiagregants plaquettaires
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
ZW4194A1 (en) * 1993-03-29 1994-12-21 Zeneca Ltd Heterocyclic compounds
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
DE69411900T2 (de) * 1993-03-29 1998-12-10 Zeneca Ltd., London Heterozyklische derivate als plätchenaggregationsinhibitoren
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
JPH09501910A (ja) * 1993-06-18 1997-02-25 ラ ホヤ キャンサー リサーチ ファウンデイション 血栓症処置のための方法および組成物
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
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US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
WO1997025999A1 (fr) * 1996-01-16 1997-07-24 Rensselaer Polytechnic Institute Peptides utilises pour la modification d'une adhesion osteoblastique
CA2265827A1 (fr) * 1996-09-18 1998-03-26 Merck & Co., Inc. Traitement combine destine a reduire les risques de maladies cardio-vasculaires
EP0939900A4 (fr) * 1996-11-21 2003-01-08 Merck & Co Inc DETECTION D'ANTICORPS DE RECEPTEUR GPIIb/IIIa DEPENDANT D'ANTAGONISTES
FR2764389B1 (fr) 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
WO1999013898A1 (fr) * 1997-08-15 1999-03-25 Stefan Niewiarowski Ec-3 en tant qu'inhibiteur des integrines alpha4 beta1 et alpha4 beta7
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
CN1203846C (zh) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 高溶解性药物的双相控释递送系统和方法
EP1322322A4 (fr) * 2000-09-11 2005-04-06 Univ Temple Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1
JP4328625B2 (ja) * 2001-11-05 2009-09-09 アイアールエム エルエルシー 標識試薬とその使用方法
US7691968B2 (en) * 2002-05-03 2010-04-06 Avecia Biologics Limited Process for the synthesis of peptides amides by side-chain attachment to a solid phase
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
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US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
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KR20080031383A (ko) 2005-07-05 2008-04-08 베이커 메디컬 리서치 인스티튜트 항응고제 및 그의 용도
WO2008020743A2 (fr) * 2006-08-16 2008-02-21 Wisdom Asset Company Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
WO2008150495A2 (fr) * 2007-06-01 2008-12-11 Archemix Corp. Formulations d'aptamère vwf et procédés d'utilisation
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CA2804926C (fr) 2010-07-09 2019-01-08 James Trinca Green Systeme d'administration a liberation immediate/retardee en combinaison pour des medicaments a courte demi-vie comprenant de la remogliflozine
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
US9944749B2 (en) 2012-08-09 2018-04-17 Swimc, Llc Polycarbonates
CN104583347B (zh) 2012-08-09 2016-11-16 威士伯采购公司 稳定剂和其涂料组合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
CN113201048B (zh) 2015-08-05 2022-10-04 陕西麦科奥特科技有限公司 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
JP7016945B2 (ja) * 2017-08-09 2022-02-07 国立台湾大学 ディスインテグリン変異体及びその使用法

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Also Published As

Publication number Publication date
ATE146969T1 (de) 1997-01-15
DE69029579D1 (de) 1997-02-13
DK0477295T3 (da) 1997-07-07
NO982249L (no) 1992-01-31
NO312965B1 (no) 2002-07-22
WO1990015620A1 (fr) 1990-12-27
NO982249D0 (no) 1998-05-15
ES2097150T3 (es) 1997-04-01
NO304267B1 (no) 1998-11-23
AU636159B2 (en) 1993-04-22
EP0477295B1 (fr) 1997-01-02
NO914962L (no) 1992-01-31
LU90488I2 (fr) 2000-02-15
CA2059124C (fr) 2002-08-20
FI104364B (fi) 2000-01-14
DE69029579T3 (de) 2006-06-22
EP0477295A1 (fr) 1992-04-01
NL990043I1 (nl) 2000-02-01
AU6036990A (en) 1991-01-08
DE69029579T2 (de) 1997-07-24
US5318899A (en) 1994-06-07
US5958732A (en) 1999-09-28
HU216318B (hu) 1999-06-28
US5496724A (en) 1996-03-05
KR0180918B1 (ko) 1999-04-01
CA2388770A1 (fr) 1990-12-27
NL990043I2 (nl) 2000-04-03
HU905490D0 (en) 1992-03-30
RU2156468C2 (ru) 2000-09-20
HUT59835A (en) 1992-07-28
KR920702627A (ko) 1992-10-06
DE19975072I2 (de) 2011-01-20
JP3281370B2 (ja) 2002-05-13
NO914962D0 (no) 1991-12-16
CA2059124A1 (fr) 1990-12-17
NO2000008I2 (no) 2006-01-16
EP0477295A4 (en) 1992-10-07
FI915919A0 (fi) 1991-12-16
EP0751219A1 (fr) 1997-01-02
EP0477295B2 (fr) 2005-11-16
DE19975072I1 (de) 2000-03-09
JPH05500750A (ja) 1993-02-18
ES2097150T5 (es) 2006-06-16
US5736339A (en) 1998-04-07

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