DE60315296T2 - Zell-selektives Abgabe System - Google Patents
Zell-selektives Abgabe System Download PDFInfo
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- DE60315296T2 DE60315296T2 DE60315296T DE60315296T DE60315296T2 DE 60315296 T2 DE60315296 T2 DE 60315296T2 DE 60315296 T DE60315296 T DE 60315296T DE 60315296 T DE60315296 T DE 60315296T DE 60315296 T2 DE60315296 T2 DE 60315296T2
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Classifications
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201863 | 2002-06-18 | ||
| SE0201863A SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cell penetrating peptides |
| US39178802P | 2002-06-25 | 2002-06-25 | |
| US391788P | 2002-06-25 | ||
| PCT/IB2003/003163 WO2003106491A2 (en) | 2002-06-18 | 2003-06-18 | Cell penetrating peptides |
Publications (2)
| Publication Number | Publication Date |
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| DE60315296D1 DE60315296D1 (de) | 2007-09-13 |
| DE60315296T2 true DE60315296T2 (de) | 2008-04-17 |
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| DE60315296T Expired - Lifetime DE60315296T2 (de) | 2002-06-18 | 2003-06-18 | Zell-selektives Abgabe System |
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| US (1) | US20080234183A1 (https=) |
| EP (1) | EP1516184B1 (https=) |
| JP (1) | JP4503435B2 (https=) |
| AT (1) | ATE368853T1 (https=) |
| AU (1) | AU2003253125A1 (https=) |
| DE (1) | DE60315296T2 (https=) |
| SE (1) | SE0201863D0 (https=) |
| WO (1) | WO2003106491A2 (https=) |
Families Citing this family (193)
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| US8003595B2 (en) | 2000-03-01 | 2011-08-23 | Cellectis | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
| US7696168B2 (en) | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
| EP2348047A1 (en) * | 2000-04-21 | 2011-07-27 | New England Medical Center | G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same |
| GB0313132D0 (en) * | 2003-06-06 | 2003-07-09 | Ich Productions Ltd | Peptide ligands |
| EP1512696A1 (en) * | 2003-08-14 | 2005-03-09 | Diatos | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
| DE602004022056D1 (de) | 2003-08-14 | 2009-08-27 | Diatos | Antibakterielle zusammensetzung, vor allem zur bekämpfung gramnegativer bakterien, umfassend ein peptid und ein vorteilhafterweise hydrophobes antibakterielles agens |
| ES2586387T3 (es) | 2003-11-05 | 2016-10-14 | Dana-Farber Cancer Institute, Inc. | Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular |
| US20060040882A1 (en) | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| JP2007536253A (ja) * | 2004-05-04 | 2007-12-13 | ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド | 細胞内への核酸の送達を増強し、細胞中の標的遺伝子の発現を修飾するための組成物及び方法 |
| KR100897915B1 (ko) * | 2004-11-03 | 2009-05-18 | 포휴먼텍(주) | 경피전달을 위한 약제 조성물 |
| JP2008519039A (ja) * | 2004-11-04 | 2008-06-05 | ニュー イングランド メデカル センター ホスピタルズ インク | Ｇタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法 |
| FR2877946B1 (fr) | 2004-11-12 | 2011-02-11 | Commissariat Energie Atomique | Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet |
| CN101142233A (zh) | 2004-12-22 | 2008-03-12 | 利波佩普蒂德有限公司 | 抑制cathelin样蛋白hCAP18/LL-17的试剂 |
| WO2006078816A2 (en) | 2005-01-18 | 2006-07-27 | The Board Of Governors For Higher Education | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally senstive transmembrane peptide |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| PT2236608T (pt) | 2005-10-04 | 2017-03-01 | Soligenix Inc | Péptidos novos para tratar e prevenir distúrbios relacionados com a imunidade, incluindo tratar e prevenir infecção por modulação da imunidade inata |
| EP2003198A2 (en) * | 2006-03-13 | 2008-12-17 | Keio University | Peptide for inhibition of influenza infection, inhibitor of influenza infection, liposome, and prophylactic/therapeutic agent for influenza |
| US8642559B2 (en) * | 2006-10-13 | 2014-02-04 | University Of Southern California | C-terminal domain truncation of mGluR1α by calpain and uses thereof |
| EP2341142B8 (en) | 2006-12-28 | 2015-01-14 | International Institute of Cancer Immunology, Inc. | HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising same |
| EP2837636B1 (en) * | 2007-01-29 | 2018-04-11 | Procell Therapeutics Inc. | Novel macromolecule transduction domains and methods for identification and uses thereof |
| DK2118123T3 (en) | 2007-01-31 | 2016-01-25 | Dana Farber Cancer Inst Inc | Stabilized p53 peptides and uses thereof |
| DE102007008596B4 (de) * | 2007-02-15 | 2010-09-02 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung |
| US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2009009441A2 (en) | 2007-07-06 | 2009-01-15 | Cedars-Sinai Medical Center | Self-assembling complex for targeting chemical agents to cells |
| AU2008295509A1 (en) | 2007-08-29 | 2009-03-12 | Tufts University | Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits |
| WO2009041902A1 (en) * | 2007-09-25 | 2009-04-02 | Loefgren Kajsa | Prion protein derived cell penetrating peptides and their uses |
| TW200932260A (en) * | 2007-11-28 | 2009-08-01 | Oncotherapy Science Inc | STAT3 epitope peptides |
| DE112009000300T5 (de) | 2008-02-08 | 2011-01-20 | Aileron Therapeutics, Inc., Cambridge | Therapeutische Peptidomimetische Makrocyclen |
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| WO2021113434A1 (en) | 2019-12-03 | 2021-06-10 | Rodan & Fields, Llc | Peptides and compositions for inhibiting hair growth |
| US20230054711A1 (en) | 2019-12-31 | 2023-02-23 | Xiamen University | Multimerization delivery system for intracellular delivery of molecule |
| EP3906935A1 (en) | 2020-05-06 | 2021-11-10 | Sorbonne Universite | Peptides for preventing or treating viral infections |
| CN113943778A (zh) * | 2020-07-17 | 2022-01-18 | 通用电气医疗集团股份有限公司 | 用于核酸检测的分子探针及其制备方法和用途 |
| MX2023007788A (es) | 2021-01-24 | 2023-11-17 | Michael David Forrest | Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos. |
| WO2022212513A1 (en) * | 2021-03-31 | 2022-10-06 | University Of Southern California | Compositions and methods for modulating inflammatory and degenerative disorder |
| WO2022214522A2 (en) | 2021-04-07 | 2022-10-13 | Astrazeneca Ab | Compositions and methods for site-specific modification |
| CN115385987B (zh) * | 2021-05-19 | 2024-08-02 | 中山大学 | 一种抗鱼类神经坏死病毒的穿膜肽及其应用 |
| KR102504190B1 (ko) * | 2021-06-03 | 2023-02-28 | 주식회사 레메디 | 화물분자 수송 도메인 rmmr1, 이의 변이체, 이를 포함하는 재조합 화물분자 및 이를 이용한 화물분자 수송 방법 |
| KR102793149B1 (ko) * | 2021-11-24 | 2025-04-09 | 주식회사 윙스타바이오 | 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도 |
| KR102819567B1 (ko) * | 2021-11-24 | 2025-06-13 | 주식회사 윙스타바이오 | 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도 |
| CN114349846B (zh) * | 2022-01-07 | 2023-12-15 | 天津市泌尿外科研究所 | 一种人精子膜蛋白or1d2特异性多肽与抗体的制备方法 |
| JP2025510046A (ja) * | 2022-03-23 | 2025-04-14 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | α－シヌクレインアミロイドベースの障害を処置するためのペプチド |
| CN116444678B (zh) * | 2022-10-18 | 2024-02-02 | 百葵锐(深圳)生物科技有限公司 | 一种具有真菌抗菌抑菌性能的新型多肽 |
| JP2025540052A (ja) | 2022-12-01 | 2025-12-11 | イェール ユニバーシティー | 細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム |
| WO2025172421A1 (en) | 2024-02-14 | 2025-08-21 | Astrazeneca Ab | Compositions and methods for treatment of huntington's disease |
| WO2025228328A1 (zh) * | 2024-04-29 | 2025-11-06 | 苏州百迈生物医药有限公司 | 一种两性离子多肽载体及其在跨屏障药物递送中的应用 |
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| CN1263473A (zh) * | 1997-05-21 | 2000-08-16 | 利兰·斯坦福青年大学托管委员会 | 增加跨生物膜转运的组合物和方法 |
| WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| JP2002531113A (ja) * | 1998-12-10 | 2002-09-24 | ワシントン大学 | 蛋白質の形質導入システムおよびその使用法 |
| AU2001268683A1 (en) * | 2000-06-22 | 2002-01-02 | Mount Sinai School Of Medicine | Modification of mdm2 activity |
| FR2810985B1 (fr) * | 2000-07-03 | 2004-12-24 | Synt Em | Peptides lineaires amphipathiques et les compositions les contenant |
| IL154589A0 (en) * | 2000-08-25 | 2003-09-17 | Aventis Pharma Inc | Membrane penetrating peptides and uses thereof |
| EP2272947B1 (en) * | 2000-09-05 | 2016-08-10 | Biosight Ltd | Peptide conjugated anti-cancer prodrugs |
| FR2818981A1 (fr) * | 2001-01-03 | 2002-07-05 | Synt Em | Peptides amphipathiques et leur utilisation pour le transfert de substances d'interet dans les cellules |
| AU2002240201A1 (en) * | 2001-02-02 | 2002-08-19 | Yale University | Peptides for facilitating composite receptor expression and translocation of macromolecules |
| AU2003208275A1 (en) * | 2002-01-27 | 2003-09-02 | Viromics Gmbh | Trojan inhibitors, method for the production and use thereof |
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2002
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- 2003-06-18 US US10/517,079 patent/US20080234183A1/en not_active Abandoned
- 2003-06-18 AU AU2003253125A patent/AU2003253125A1/en not_active Abandoned
- 2003-06-18 AT AT03760107T patent/ATE368853T1/de not_active IP Right Cessation
- 2003-06-18 WO PCT/IB2003/003163 patent/WO2003106491A2/en not_active Ceased
- 2003-06-18 DE DE60315296T patent/DE60315296T2/de not_active Expired - Lifetime
- 2003-06-18 JP JP2004513322A patent/JP4503435B2/ja not_active Expired - Fee Related
- 2003-06-18 EP EP03760107A patent/EP1516184B1/en not_active Expired - Lifetime
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|---|---|
| AU2003253125A1 (en) | 2003-12-31 |
| ATE368853T1 (de) | 2007-08-15 |
| EP1516184B1 (en) | 2007-08-01 |
| AU2003253125A8 (en) | 2003-12-31 |
| JP2006514602A (ja) | 2006-05-11 |
| JP4503435B2 (ja) | 2010-07-14 |
| WO2003106491A2 (en) | 2003-12-24 |
| EP1516184A2 (en) | 2005-03-23 |
| US20080234183A1 (en) | 2008-09-25 |
| WO2003106491A3 (en) | 2004-12-23 |
| HK1078130A1 (en) | 2006-03-03 |
| DE60315296D1 (de) | 2007-09-13 |
| SE0201863D0 (en) | 2002-06-18 |
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| Date | Code | Title | Description |
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| 8381 | Inventor (new situation) |
Inventor name: HAELLBRINK, MATTIAS, S-113 28 STOCKHOLM, SE Inventor name: POOGA, MARGUS, E-51010 TARTU, EE Inventor name: METSIS, MADIS TALLIN UNIVE, 12618 TALLINN, EE Inventor name: KOGERMAN, PRIIT, E-79601 TABASALU, EE Inventor name: VALKNA, ANDREAS, VIIMSI, EE Inventor name: MEIKAS, ANNE, SAKU ESTONIA, EE Inventor name: LINDGREN, MARIA, S-113 28 STOCKHOLM, SE Inventor name: GRAESLUND, ASTRID, S-191 44 SOLLENTUNA, SE Inventor name: ERIKSSON, GOERAN, S-116 43 STOCKHOLM, SE Inventor name: OESTENSSON, CLAES GOERAN, S-171 64 SOLNA, SE Inventor name: BUDIHNA, METKA, 1210 LJUBLJANA-SENTVID, SI Inventor name: ZORKO, MATJAZ, SKOFLJICA, SI Inventor name: ELMQUIST, ANNA, S-761 71 NORRTAELJE, SE Inventor name: SOOMETS, URSEL, TARTU, EE Inventor name: LUNDBERG, PONTUS, S-169 72 SOLNA, SE Inventor name: JAERVER, PETER, S-116 67 STOCKHOLM, SE Inventor name: SAAR, KUELLIKI, S-113 53 STOCKHOLM, SE Inventor name: EL-ANDALOUSSI, SAMIR, S-104 05 STOCKHOLM, SE Inventor name: KILK, KALLE, S-182 38 DANDERYD, SE Inventor name: LANGEL, UELO, S-124 32 BANDHAGEN, SE |
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| 8364 | No opposition during term of opposition |