DE60315296T2 - Zell-selektives Abgabe System - Google Patents
Zell-selektives Abgabe System Download PDFInfo
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- DE60315296T2 DE60315296T2 DE60315296T DE60315296T DE60315296T2 DE 60315296 T2 DE60315296 T2 DE 60315296T2 DE 60315296 T DE60315296 T DE 60315296T DE 60315296 T DE60315296 T DE 60315296T DE 60315296 T2 DE60315296 T2 DE 60315296T2
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Classifications
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Immunology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201863A SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cell penetrating peptides |
| SE0201863 | 2002-06-18 | ||
| US39178802P | 2002-06-25 | 2002-06-25 | |
| US391788P | 2002-06-25 | ||
| PCT/IB2003/003163 WO2003106491A2 (en) | 2002-06-18 | 2003-06-18 | Cell penetrating peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60315296D1 DE60315296D1 (de) | 2007-09-13 |
| DE60315296T2 true DE60315296T2 (de) | 2008-04-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315296T Expired - Lifetime DE60315296T2 (de) | 2002-06-18 | 2003-06-18 | Zell-selektives Abgabe System |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080234183A1 (https=) |
| EP (1) | EP1516184B1 (https=) |
| JP (1) | JP4503435B2 (https=) |
| AT (1) | ATE368853T1 (https=) |
| AU (1) | AU2003253125A1 (https=) |
| DE (1) | DE60315296T2 (https=) |
| SE (1) | SE0201863D0 (https=) |
| WO (1) | WO2003106491A2 (https=) |
Families Citing this family (193)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| US8003595B2 (en) | 2000-03-01 | 2011-08-23 | Cellectis | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
| US7696168B2 (en) | 2000-04-21 | 2010-04-13 | Tufts Medical Center, Inc. | G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same |
| AU2001257169C1 (en) * | 2000-04-21 | 2011-06-16 | Tufts Medical Center, Inc. | G-protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same |
| GB0313132D0 (en) * | 2003-06-06 | 2003-07-09 | Ich Productions Ltd | Peptide ligands |
| ES2330115T3 (es) | 2003-08-14 | 2009-12-04 | Cellectis | Composicion antibacteriana, mas particilarmente contra las bacterias gram-negativas, que comprende un peptido y un agente antibacteriano ventajosamente hidrofobo. |
| EP1512696A1 (en) * | 2003-08-14 | 2005-03-09 | Diatos | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
| EP1997828B1 (en) | 2003-11-05 | 2017-10-04 | Dana-Farber Cancer Institute, Inc. | Stabilized alpha helical peptides from BCL-2 and uses thereof |
| CA2565685A1 (en) * | 2004-05-04 | 2005-12-15 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| US20060040882A1 (en) | 2004-05-04 | 2006-02-23 | Lishan Chen | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| EP1809291A4 (en) * | 2004-11-03 | 2012-04-04 | Forhumantech Co Ltd | PHARMACEUTICAL COMPOSITIONS FOR TRANSDERMAL LEVY |
| EP1814911A2 (en) * | 2004-11-04 | 2007-08-08 | New England Medical Center Hospitals, Inc. | G protein coupled receptor agonists and antagonists and methods of use |
| FR2877946B1 (fr) | 2004-11-12 | 2011-02-11 | Commissariat Energie Atomique | Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet |
| WO2006067402A2 (en) | 2004-12-22 | 2006-06-29 | Lipopeptide Ab | Agents inibiting the cathelin-like protein cap18/ll-37 |
| WO2006078816A2 (en) | 2005-01-18 | 2006-07-27 | The Board Of Governors For Higher Education | Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally senstive transmembrane peptide |
| WO2007031098A1 (en) | 2005-09-12 | 2007-03-22 | Xigen S.A. | Cell-permeable peptide inhibitors of the jnk signal transduction pathway |
| LT2236608T (lt) | 2005-10-04 | 2017-03-27 | Soligenix, Inc. | Naujieji peptidai, skirti gydymui ir prevencijai su imunitetu susijusių sutrikimų, įskaitant infekcijų gydymą ir prevenciją, moduliuojant įgimtą imunitetą |
| CA2649261A1 (en) * | 2006-03-13 | 2007-09-20 | Keio University | Influenza infection-inhibiting peptide, influenza virus-infection inhibitor, liposome and influenza preventive/therapeutic agent |
| WO2008063315A2 (en) * | 2006-10-13 | 2008-05-29 | University Of Southern California | C-TERMINAL DOMAIN TRUNCATION OF MGLUR1α BY CALPAIN AND USES THEREOF |
| CA2670658A1 (en) * | 2006-12-28 | 2008-07-10 | International Institute Of Cancer Immunology, Inc. | Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same |
| KR20090103957A (ko) * | 2007-01-29 | 2009-10-01 | 주식회사 프로셀제약 | 신규한 거대분자 전달 도메인 및 이의 동정 방법 및 용도 |
| EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| DE102007008596B4 (de) * | 2007-02-15 | 2010-09-02 | Friedrich-Schiller-Universität Jena | Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| WO2009009441A2 (en) | 2007-07-06 | 2009-01-15 | Cedars-Sinai Medical Center | Self-assembling complex for targeting chemical agents to cells |
| AU2008295509A1 (en) * | 2007-08-29 | 2009-03-12 | Tufts University | Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits |
| WO2009041902A1 (en) * | 2007-09-25 | 2009-04-02 | Loefgren Kajsa | Prion protein derived cell penetrating peptides and their uses |
| TW200932260A (en) * | 2007-11-28 | 2009-08-01 | Oncotherapy Science Inc | STAT3 epitope peptides |
| KR20100126361A (ko) | 2008-02-08 | 2010-12-01 | 에일러론 테라퓨틱스 인코포레이티드 | 치료용 펩티드유사 거대고리 |
| DE102009043743B4 (de) | 2009-03-13 | 2016-10-13 | Friedrich-Schiller-Universität Jena | Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung |
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| JP7699588B2 (ja) * | 2019-11-22 | 2025-06-27 | アルカメナ・ステム・セル・セラピューティクス、エルエルシー | Ｒｅ１サイレンシング転写因子標的遺伝子を抑制解除する組成物 |
| US12139555B2 (en) | 2019-12-03 | 2024-11-12 | Rodan & Fields, Llc | Peptides and compositions for inhibiting hair growth |
| EP4086275A4 (en) | 2019-12-31 | 2024-04-17 | Xiamen University | Multimerization delivery system for intracellular delivery of molecule |
| EP3906935A1 (en) | 2020-05-06 | 2021-11-10 | Sorbonne Universite | Peptides for preventing or treating viral infections |
| CN113943778A (zh) * | 2020-07-17 | 2022-01-18 | 通用电气医疗集团股份有限公司 | 用于核酸检测的分子探针及其制备方法和用途 |
| US20250325469A1 (en) | 2021-01-24 | 2025-10-23 | Michael David FORREST | Inhibitors of atp synthase - cosmetic and therapeutic uses |
| US20240182526A1 (en) * | 2021-03-31 | 2024-06-06 | University Of Southern California | Compositions and methods for modulting inflammatory and degenerative disorder |
| JP2024513087A (ja) | 2021-04-07 | 2024-03-21 | アストラゼネカ・アクチエボラーグ | 部位特異的改変のための組成物及び方法 |
| CN115385987B (zh) * | 2021-05-19 | 2024-08-02 | 中山大学 | 一种抗鱼类神经坏死病毒的穿膜肽及其应用 |
| KR102504190B1 (ko) * | 2021-06-03 | 2023-02-28 | 주식회사 레메디 | 화물분자 수송 도메인 rmmr1, 이의 변이체, 이를 포함하는 재조합 화물분자 및 이를 이용한 화물분자 수송 방법 |
| KR102819567B1 (ko) * | 2021-11-24 | 2025-06-13 | 주식회사 윙스타바이오 | 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도 |
| KR102793149B1 (ko) * | 2021-11-24 | 2025-04-09 | 주식회사 윙스타바이오 | 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도 |
| CN114349846B (zh) * | 2022-01-07 | 2023-12-15 | 天津市泌尿外科研究所 | 一种人精子膜蛋白or1d2特异性多肽与抗体的制备方法 |
| EP4496800A4 (en) * | 2022-03-23 | 2026-04-01 | Council Scient Ind Res | ALPHA-SYNUCLEIN AMYLOID-BASED PEPTIDE FOR TREATING DISORDERS |
| CN116444678B (zh) * | 2022-10-18 | 2024-02-02 | 百葵锐(深圳)生物科技有限公司 | 一种具有真菌抗菌抑菌性能的新型多肽 |
| AU2023406926A1 (en) | 2022-12-01 | 2025-06-26 | Yale University | Stimuli-responsive traceless engineering platform for intracellular payload delivery |
| WO2025172421A1 (en) | 2024-02-14 | 2025-08-21 | Astrazeneca Ab | Compositions and methods for treatment of huntington's disease |
| WO2025228328A1 (zh) * | 2024-04-29 | 2025-11-06 | 苏州百迈生物医药有限公司 | 一种两性离子多肽载体及其在跨屏障药物递送中的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL132941A0 (en) * | 1997-05-21 | 2001-03-19 | Univ Leland Stanford Junior | Composition and method for enhancing transport across biological membranes |
| WO1999030727A1 (en) * | 1997-12-17 | 1999-06-24 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| JP2002531113A (ja) * | 1998-12-10 | 2002-09-24 | ワシントン大学 | 蛋白質の形質導入システムおよびその使用法 |
| AU2001268683A1 (en) * | 2000-06-22 | 2002-01-02 | Mount Sinai School Of Medicine | Modification of mdm2 activity |
| FR2810985B1 (fr) * | 2000-07-03 | 2004-12-24 | Synt Em | Peptides lineaires amphipathiques et les compositions les contenant |
| EP1360311B1 (en) * | 2000-08-25 | 2008-04-09 | Aventis Pharmaceuticals Inc. | Membrane penetrating peptides and uses thereof |
| ATE466069T1 (de) * | 2000-09-05 | 2010-05-15 | Biosight Ltd | Peptid-konjugierte antikrebs-prodrugs |
| FR2818981A1 (fr) * | 2001-01-03 | 2002-07-05 | Synt Em | Peptides amphipathiques et leur utilisation pour le transfert de substances d'interet dans les cellules |
| WO2002062823A2 (en) * | 2001-02-02 | 2002-08-15 | Yale University | Peptides for facilitating composite receptor expression and translocation of macromolecules |
| DE10390251D2 (de) * | 2002-01-27 | 2004-12-23 | Viromics Gmbh | Trojanische Inhibitoren, Verfahren zu ihrer Herstellung und ihre Verwendung |
-
2002
- 2002-06-18 SE SE0201863A patent/SE0201863D0/ unknown
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2003
- 2003-06-18 AT AT03760107T patent/ATE368853T1/de not_active IP Right Cessation
- 2003-06-18 US US10/517,079 patent/US20080234183A1/en not_active Abandoned
- 2003-06-18 DE DE60315296T patent/DE60315296T2/de not_active Expired - Lifetime
- 2003-06-18 WO PCT/IB2003/003163 patent/WO2003106491A2/en not_active Ceased
- 2003-06-18 JP JP2004513322A patent/JP4503435B2/ja not_active Expired - Fee Related
- 2003-06-18 EP EP03760107A patent/EP1516184B1/en not_active Expired - Lifetime
- 2003-06-18 AU AU2003253125A patent/AU2003253125A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE368853T1 (de) | 2007-08-15 |
| WO2003106491A2 (en) | 2003-12-24 |
| JP4503435B2 (ja) | 2010-07-14 |
| EP1516184B1 (en) | 2007-08-01 |
| DE60315296D1 (de) | 2007-09-13 |
| HK1078130A1 (en) | 2006-03-03 |
| EP1516184A2 (en) | 2005-03-23 |
| JP2006514602A (ja) | 2006-05-11 |
| WO2003106491A3 (en) | 2004-12-23 |
| AU2003253125A1 (en) | 2003-12-31 |
| US20080234183A1 (en) | 2008-09-25 |
| AU2003253125A8 (en) | 2003-12-31 |
| SE0201863D0 (en) | 2002-06-18 |
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| 8381 | Inventor (new situation) |
Inventor name: HAELLBRINK, MATTIAS, S-113 28 STOCKHOLM, SE Inventor name: POOGA, MARGUS, E-51010 TARTU, EE Inventor name: METSIS, MADIS TALLIN UNIVE, 12618 TALLINN, EE Inventor name: KOGERMAN, PRIIT, E-79601 TABASALU, EE Inventor name: VALKNA, ANDREAS, VIIMSI, EE Inventor name: MEIKAS, ANNE, SAKU ESTONIA, EE Inventor name: LINDGREN, MARIA, S-113 28 STOCKHOLM, SE Inventor name: GRAESLUND, ASTRID, S-191 44 SOLLENTUNA, SE Inventor name: ERIKSSON, GOERAN, S-116 43 STOCKHOLM, SE Inventor name: OESTENSSON, CLAES GOERAN, S-171 64 SOLNA, SE Inventor name: BUDIHNA, METKA, 1210 LJUBLJANA-SENTVID, SI Inventor name: ZORKO, MATJAZ, SKOFLJICA, SI Inventor name: ELMQUIST, ANNA, S-761 71 NORRTAELJE, SE Inventor name: SOOMETS, URSEL, TARTU, EE Inventor name: LUNDBERG, PONTUS, S-169 72 SOLNA, SE Inventor name: JAERVER, PETER, S-116 67 STOCKHOLM, SE Inventor name: SAAR, KUELLIKI, S-113 53 STOCKHOLM, SE Inventor name: EL-ANDALOUSSI, SAMIR, S-104 05 STOCKHOLM, SE Inventor name: KILK, KALLE, S-182 38 DANDERYD, SE Inventor name: LANGEL, UELO, S-124 32 BANDHAGEN, SE |
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| 8364 | No opposition during term of opposition |