DE60312523T2 - Orale, pharmazeutische Darreichungsformen von flüssigen Medikamenten mit verbesserter Bioverfügbarkeit - Google Patents
Orale, pharmazeutische Darreichungsformen von flüssigen Medikamenten mit verbesserter Bioverfügbarkeit Download PDFInfo
- Publication number
- DE60312523T2 DE60312523T2 DE60312523T DE60312523T DE60312523T2 DE 60312523 T2 DE60312523 T2 DE 60312523T2 DE 60312523 T DE60312523 T DE 60312523T DE 60312523 T DE60312523 T DE 60312523T DE 60312523 T2 DE60312523 T2 DE 60312523T2
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- Germany
- Prior art keywords
- nitrooxy
- methyl
- acid
- ester
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003814 drug Substances 0.000 title abstract description 6
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- -1 nitrooxymethyl Chemical group 0.000 claims description 43
- 125000001893 nitrooxy group Chemical group [O-][N+](=O)O* 0.000 claims description 30
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Landscapes
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- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| IT2002MI001392A ITMI20021392A1 (it) | 2002-06-25 | 2002-06-25 | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| ITMI20021392 | 2002-06-25 | ||
| PCT/EP2003/006496 WO2004000273A1 (en) | 2002-06-25 | 2003-06-20 | Oral pharmaceutical forms of liquid drugs having improved bioavailability |
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| US20030148818A1 (en) * | 2002-01-18 | 2003-08-07 | Myrhum Mark C. | Golf club woods with wood club head having a selectable center of gravity and a selectable shaft |
| SE0200895D0 (sv) * | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
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| CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| FR2873923B1 (fr) * | 2004-08-05 | 2007-01-12 | Gattefosse Holding Sa | Particule solide anhydre contenant une composition lipidique liquide et composition pharmaceutique contenant lesdites particules |
| WO2006085217A2 (en) * | 2005-02-08 | 2006-08-17 | Pfizer Products Inc. | Solid adsorbates of hydrophobic drugs |
| PL1879466T5 (pl) * | 2005-03-04 | 2016-07-29 | Dsm Ip Assets Bv | Spożywcza cząsteczkowa kompozycja lipidowa |
| US20080260816A1 (en) * | 2005-09-16 | 2008-10-23 | Bengt Herslof | Particulate Lipid Pharmaceutical Composition |
| US20080293781A1 (en) | 2005-11-23 | 2008-11-27 | Alberto Gasco | Salicylic Acid Derivatives |
| EP2786749A1 (en) * | 2006-02-03 | 2014-10-08 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| MX2009011493A (es) * | 2007-04-25 | 2009-11-09 | Teva Pharma | Complejo de excipiente farmaceutico. |
| WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| CN102964250A (zh) * | 2012-11-19 | 2013-03-13 | 吉林大学 | 氟比洛芬丁香酚酯药用化合物及其制剂和制备方法 |
| US9180104B2 (en) | 2013-03-13 | 2015-11-10 | Tris Pharma, Inc. | Benzonatate modified release solid tablets and capsules |
| CN105188677A (zh) | 2013-03-13 | 2015-12-23 | 特瑞斯制药股份有限公司 | 苯佐那酯调释固体片剂和胶囊剂 |
| EP4072516A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Oral product comprising a cannabinoid |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
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| MX2023015529A (es) | 2021-06-25 | 2024-03-05 | Nicoventures Trading Ltd | Productos orales y metodo de fabricacion. |
| IL312564A (en) | 2021-11-05 | 2024-07-01 | Cinclus Pharma Holding Ab Publ | Polymorphs of the hydrochloride salt of linfarezan glurate |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5266615A (en) * | 1975-11-29 | 1977-06-02 | Sawai Seiyaku Kk | Manufacturing of solidified oily liquid substance |
| JPS56169622A (en) * | 1980-06-03 | 1981-12-26 | Kissei Pharmaceut Co Ltd | Method of making solid preparation from oily substance |
| JPS58213073A (ja) * | 1982-06-07 | 1983-12-10 | Masatoshi Yamada | 油状物質の固形化法 |
| US6054136A (en) * | 1993-09-30 | 2000-04-25 | Gattefosse S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
| US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| BRPI9810945B8 (pt) * | 1997-06-27 | 2021-05-25 | Abraxis Bioscience Inc | formulações de agentes farmacológicos, métodos para sua preparação e métodos para uso das mesmas |
| JP2000016934A (ja) * | 1998-06-30 | 2000-01-18 | Eisai Co Ltd | テプレノンを含有した錠剤 |
| EP2127642A3 (en) * | 1998-08-13 | 2010-02-24 | Cima Labs, Inc. | Microemulsions as solid dosage forms for oral administration |
| EP1140027B1 (en) * | 1998-12-23 | 2005-10-12 | Alza Corporation | Dosage forms comprising porous particles |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| US6793934B1 (en) * | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0000774D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0200895D0 (sv) * | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
-
2002
- 2002-06-25 IT IT2002MI001392A patent/ITMI20021392A1/it unknown
-
2003
- 2003-06-20 CN CNB038151812A patent/CN1319518C/zh not_active Expired - Fee Related
- 2003-06-20 CA CA002491152A patent/CA2491152A1/en not_active Abandoned
- 2003-06-20 DE DE60312523T patent/DE60312523T2/de not_active Expired - Lifetime
- 2003-06-20 AU AU2003246564A patent/AU2003246564B2/en not_active Ceased
- 2003-06-20 NZ NZ537204A patent/NZ537204A/en not_active IP Right Cessation
- 2003-06-20 PT PT03760660T patent/PT1526839E/pt unknown
- 2003-06-20 MX MXPA04012852A patent/MXPA04012852A/es active IP Right Grant
- 2003-06-20 PL PL374388A patent/PL206599B1/pl not_active IP Right Cessation
- 2003-06-20 AT AT03760660T patent/ATE356612T1/de not_active IP Right Cessation
- 2003-06-20 EP EP03760660A patent/EP1526839B1/en not_active Expired - Lifetime
- 2003-06-20 IL IL16560103A patent/IL165601A0/xx not_active IP Right Cessation
- 2003-06-20 RU RU2004138554/15A patent/RU2323003C2/ru not_active IP Right Cessation
- 2003-06-20 WO PCT/EP2003/006496 patent/WO2004000273A1/en not_active Ceased
- 2003-06-20 ES ES03760660T patent/ES2285182T3/es not_active Expired - Lifetime
- 2003-06-20 DK DK03760660T patent/DK1526839T3/da active
- 2003-06-20 HK HK06100214.4A patent/HK1080364B/zh not_active IP Right Cessation
- 2003-06-20 KR KR1020047021307A patent/KR20060076136A/ko not_active Ceased
- 2003-06-20 JP JP2004514802A patent/JP2005530835A/ja active Pending
- 2003-06-20 SI SI200330822T patent/SI1526839T1/sl unknown
- 2003-06-20 US US10/515,621 patent/US20060171969A1/en not_active Abandoned
-
2004
- 2004-12-14 ZA ZA200410109A patent/ZA200410109B/xx unknown
-
2005
- 2005-01-21 NO NO20050347A patent/NO20050347L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004000273A1 (en) | 2003-12-31 |
| HK1080364A1 (en) | 2006-04-28 |
| ATE356612T1 (de) | 2007-04-15 |
| MXPA04012852A (es) | 2005-06-08 |
| RU2323003C2 (ru) | 2008-04-27 |
| EP1526839B1 (en) | 2007-03-14 |
| JP2005530835A (ja) | 2005-10-13 |
| ITMI20021392A1 (it) | 2003-12-29 |
| KR20060076136A (ko) | 2006-07-04 |
| PL206599B1 (pl) | 2010-08-31 |
| SI1526839T1 (sl) | 2007-08-31 |
| NZ537204A (en) | 2006-07-28 |
| EP1526839A1 (en) | 2005-05-04 |
| PL374388A1 (en) | 2005-10-17 |
| CN1665486A (zh) | 2005-09-07 |
| HK1080364B (zh) | 2008-02-01 |
| US20060171969A1 (en) | 2006-08-03 |
| NO20050347L (no) | 2005-01-21 |
| ITMI20021392A0 (it) | 2002-06-25 |
| AU2003246564B2 (en) | 2008-06-12 |
| IL165601A0 (en) | 2006-01-15 |
| CN1319518C (zh) | 2007-06-06 |
| PT1526839E (pt) | 2007-06-06 |
| RU2004138554A (ru) | 2005-08-27 |
| ES2285182T3 (es) | 2007-11-16 |
| CA2491152A1 (en) | 2003-12-31 |
| DE60312523D1 (de) | 2007-04-26 |
| AU2003246564A1 (en) | 2004-01-06 |
| ZA200410109B (en) | 2005-09-02 |
| DK1526839T3 (da) | 2007-05-21 |
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