CA2491152A1 - Oral pharmaceutical forms of liquid drugs having improved bioavailability - Google Patents
Oral pharmaceutical forms of liquid drugs having improved bioavailability Download PDFInfo
- Publication number
- CA2491152A1 CA2491152A1 CA002491152A CA2491152A CA2491152A1 CA 2491152 A1 CA2491152 A1 CA 2491152A1 CA 002491152 A CA002491152 A CA 002491152A CA 2491152 A CA2491152 A CA 2491152A CA 2491152 A1 CA2491152 A1 CA 2491152A1
- Authority
- CA
- Canada
- Prior art keywords
- nitrooxy
- acid
- ester
- methyl
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2002A001392 | 2002-06-25 | ||
| IT2002MI001392A ITMI20021392A1 (it) | 2002-06-25 | 2002-06-25 | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| PCT/EP2003/006496 WO2004000273A1 (en) | 2002-06-25 | 2003-06-20 | Oral pharmaceutical forms of liquid drugs having improved bioavailability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2491152A1 true CA2491152A1 (en) | 2003-12-31 |
Family
ID=11450079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002491152A Abandoned CA2491152A1 (en) | 2002-06-25 | 2003-06-20 | Oral pharmaceutical forms of liquid drugs having improved bioavailability |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20060171969A1 (https=) |
| EP (1) | EP1526839B1 (https=) |
| JP (1) | JP2005530835A (https=) |
| KR (1) | KR20060076136A (https=) |
| CN (1) | CN1319518C (https=) |
| AT (1) | ATE356612T1 (https=) |
| AU (1) | AU2003246564B2 (https=) |
| CA (1) | CA2491152A1 (https=) |
| DE (1) | DE60312523T2 (https=) |
| DK (1) | DK1526839T3 (https=) |
| ES (1) | ES2285182T3 (https=) |
| HK (1) | HK1080364B (https=) |
| IL (1) | IL165601A0 (https=) |
| IT (1) | ITMI20021392A1 (https=) |
| MX (1) | MXPA04012852A (https=) |
| NO (1) | NO20050347L (https=) |
| NZ (1) | NZ537204A (https=) |
| PL (1) | PL206599B1 (https=) |
| PT (1) | PT1526839E (https=) |
| RU (1) | RU2323003C2 (https=) |
| SI (1) | SI1526839T1 (https=) |
| WO (1) | WO2004000273A1 (https=) |
| ZA (1) | ZA200410109B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| US20030148818A1 (en) * | 2002-01-18 | 2003-08-07 | Myrhum Mark C. | Golf club woods with wood club head having a selectable center of gravity and a selectable shaft |
| SE0200895D0 (sv) * | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
| WO2003103602A2 (en) | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| ES2285233T3 (es) | 2002-12-20 | 2007-11-16 | Niconovum Ab | Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable. |
| FR2873923B1 (fr) * | 2004-08-05 | 2007-01-12 | Gattefosse Holding Sa | Particule solide anhydre contenant une composition lipidique liquide et composition pharmaceutique contenant lesdites particules |
| WO2006085217A2 (en) * | 2005-02-08 | 2006-08-17 | Pfizer Products Inc. | Solid adsorbates of hydrophobic drugs |
| PL1879466T5 (pl) * | 2005-03-04 | 2016-07-29 | Dsm Ip Assets Bv | Spożywcza cząsteczkowa kompozycja lipidowa |
| US20080260816A1 (en) * | 2005-09-16 | 2008-10-23 | Bengt Herslof | Particulate Lipid Pharmaceutical Composition |
| US20080293781A1 (en) | 2005-11-23 | 2008-11-27 | Alberto Gasco | Salicylic Acid Derivatives |
| EP2786749A1 (en) * | 2006-02-03 | 2014-10-08 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US9402809B2 (en) | 2006-03-16 | 2016-08-02 | Niconovum Usa, Inc. | Snuff composition |
| MX2009011493A (es) * | 2007-04-25 | 2009-11-09 | Teva Pharma | Complejo de excipiente farmaceutico. |
| WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
| US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| ES2821528T3 (es) | 2012-11-14 | 2021-04-26 | Grace W R & Co | Composiciones que contienen un material biológicamente activo y un óxido inorgánico no ordenado |
| CN102964250A (zh) * | 2012-11-19 | 2013-03-13 | 吉林大学 | 氟比洛芬丁香酚酯药用化合物及其制剂和制备方法 |
| US9180104B2 (en) | 2013-03-13 | 2015-11-10 | Tris Pharma, Inc. | Benzonatate modified release solid tablets and capsules |
| CN105188677A (zh) | 2013-03-13 | 2015-12-23 | 特瑞斯制药股份有限公司 | 苯佐那酯调释固体片剂和胶囊剂 |
| EP4072516A1 (en) | 2019-12-09 | 2022-10-19 | Nicoventures Trading Limited | Oral product comprising a cannabinoid |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US12520867B2 (en) | 2019-12-09 | 2026-01-13 | Nicoventures Trading Limited | Buffered oral compositions |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| MX2022007085A (es) * | 2019-12-09 | 2022-08-19 | Nicoventures Trading Ltd | Nanoemulsion para uso oral. |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| MX2023015529A (es) | 2021-06-25 | 2024-03-05 | Nicoventures Trading Ltd | Productos orales y metodo de fabricacion. |
| IL312564A (en) | 2021-11-05 | 2024-07-01 | Cinclus Pharma Holding Ab Publ | Polymorphs of the hydrochloride salt of linfarezan glurate |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5266615A (en) * | 1975-11-29 | 1977-06-02 | Sawai Seiyaku Kk | Manufacturing of solidified oily liquid substance |
| JPS56169622A (en) * | 1980-06-03 | 1981-12-26 | Kissei Pharmaceut Co Ltd | Method of making solid preparation from oily substance |
| JPS58213073A (ja) * | 1982-06-07 | 1983-12-10 | Masatoshi Yamada | 油状物質の固形化法 |
| US6054136A (en) * | 1993-09-30 | 2000-04-25 | Gattefosse S.A. | Orally administrable composition capable of providing enhanced bioavailability when ingested |
| US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| BRPI9810945B8 (pt) * | 1997-06-27 | 2021-05-25 | Abraxis Bioscience Inc | formulações de agentes farmacológicos, métodos para sua preparação e métodos para uso das mesmas |
| JP2000016934A (ja) * | 1998-06-30 | 2000-01-18 | Eisai Co Ltd | テプレノンを含有した錠剤 |
| EP2127642A3 (en) * | 1998-08-13 | 2010-02-24 | Cima Labs, Inc. | Microemulsions as solid dosage forms for oral administration |
| EP1140027B1 (en) * | 1998-12-23 | 2005-10-12 | Alza Corporation | Dosage forms comprising porous particles |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| US6793934B1 (en) * | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
| SE0000773D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0000774D0 (sv) * | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | New formulation |
| SE0200895D0 (sv) * | 2002-03-22 | 2002-03-22 | Astrazeneca Ab | New pharmaceutical composition |
-
2002
- 2002-06-25 IT IT2002MI001392A patent/ITMI20021392A1/it unknown
-
2003
- 2003-06-20 CN CNB038151812A patent/CN1319518C/zh not_active Expired - Fee Related
- 2003-06-20 CA CA002491152A patent/CA2491152A1/en not_active Abandoned
- 2003-06-20 DE DE60312523T patent/DE60312523T2/de not_active Expired - Lifetime
- 2003-06-20 AU AU2003246564A patent/AU2003246564B2/en not_active Ceased
- 2003-06-20 NZ NZ537204A patent/NZ537204A/en not_active IP Right Cessation
- 2003-06-20 PT PT03760660T patent/PT1526839E/pt unknown
- 2003-06-20 MX MXPA04012852A patent/MXPA04012852A/es active IP Right Grant
- 2003-06-20 PL PL374388A patent/PL206599B1/pl not_active IP Right Cessation
- 2003-06-20 AT AT03760660T patent/ATE356612T1/de not_active IP Right Cessation
- 2003-06-20 EP EP03760660A patent/EP1526839B1/en not_active Expired - Lifetime
- 2003-06-20 IL IL16560103A patent/IL165601A0/xx not_active IP Right Cessation
- 2003-06-20 RU RU2004138554/15A patent/RU2323003C2/ru not_active IP Right Cessation
- 2003-06-20 WO PCT/EP2003/006496 patent/WO2004000273A1/en not_active Ceased
- 2003-06-20 ES ES03760660T patent/ES2285182T3/es not_active Expired - Lifetime
- 2003-06-20 DK DK03760660T patent/DK1526839T3/da active
- 2003-06-20 HK HK06100214.4A patent/HK1080364B/zh not_active IP Right Cessation
- 2003-06-20 KR KR1020047021307A patent/KR20060076136A/ko not_active Ceased
- 2003-06-20 JP JP2004514802A patent/JP2005530835A/ja active Pending
- 2003-06-20 SI SI200330822T patent/SI1526839T1/sl unknown
- 2003-06-20 US US10/515,621 patent/US20060171969A1/en not_active Abandoned
-
2004
- 2004-12-14 ZA ZA200410109A patent/ZA200410109B/xx unknown
-
2005
- 2005-01-21 NO NO20050347A patent/NO20050347L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004000273A1 (en) | 2003-12-31 |
| HK1080364A1 (en) | 2006-04-28 |
| ATE356612T1 (de) | 2007-04-15 |
| MXPA04012852A (es) | 2005-06-08 |
| RU2323003C2 (ru) | 2008-04-27 |
| EP1526839B1 (en) | 2007-03-14 |
| JP2005530835A (ja) | 2005-10-13 |
| ITMI20021392A1 (it) | 2003-12-29 |
| KR20060076136A (ko) | 2006-07-04 |
| PL206599B1 (pl) | 2010-08-31 |
| SI1526839T1 (sl) | 2007-08-31 |
| NZ537204A (en) | 2006-07-28 |
| EP1526839A1 (en) | 2005-05-04 |
| PL374388A1 (en) | 2005-10-17 |
| CN1665486A (zh) | 2005-09-07 |
| HK1080364B (zh) | 2008-02-01 |
| US20060171969A1 (en) | 2006-08-03 |
| NO20050347L (no) | 2005-01-21 |
| ITMI20021392A0 (it) | 2002-06-25 |
| AU2003246564B2 (en) | 2008-06-12 |
| IL165601A0 (en) | 2006-01-15 |
| CN1319518C (zh) | 2007-06-06 |
| PT1526839E (pt) | 2007-06-06 |
| RU2004138554A (ru) | 2005-08-27 |
| ES2285182T3 (es) | 2007-11-16 |
| DE60312523D1 (de) | 2007-04-26 |
| AU2003246564A1 (en) | 2004-01-06 |
| DE60312523T2 (de) | 2008-01-10 |
| ZA200410109B (en) | 2005-09-02 |
| DK1526839T3 (da) | 2007-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2003246564B2 (en) | Oral pharmaceutical forms of liquid drugs having improved bioavailability | |
| CA2294033C (en) | Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation | |
| WO2010124525A1 (zh) | 亲水性药物之自微乳化医药组合物及其制备 | |
| CA2490341A1 (fr) | Composition pharmaceutique solide contenant un principe actif lipophile, son procede de preparation | |
| FR2775188A1 (fr) | Forme galenique a liberation immediate ou liberation prolongee administrable par voie orale comprenant un agent promoteur d'absorption et utilisation de cet agent promoteur d'absorption | |
| JP2005530835A5 (https=) | ||
| CN1261790A (zh) | 亲脂性化合物的自体乳化剂 | |
| JP5225084B2 (ja) | ７−［（ｅ）−ｔ−ブチルオキシミノメチル］カンプトテシンの改良された経口吸収のための即効型治療システム | |
| EP1648440B1 (en) | Semi-solid formulations for the oral administration of taxoids | |
| CA2817310A1 (fr) | Composition pharmaceutique et forme galenique a base de dronedarone et son procede de preparation | |
| JP3048602B2 (ja) | ポリプレニル系化合物を含有する医薬組成物およびその製造方法 | |
| EA007153B1 (ru) | Твердая дисперсная композиция | |
| US20080125477A1 (en) | 7-(acryloyl) indole compositions and methods of making and using same | |
| Renugopal et al. | An emerging trend in solid self micro emulsifying drug delivery system | |
| WO2005041956A1 (fr) | Compositions pharmaceutiques a base de sel d’idazoxan ou l’un de ses polymorphes | |
| JP2008526896A (ja) | 医薬製剤に適したグロピドグレル塩基及びその調製 | |
| WO2025071429A1 (ru) | Фармацевтическая композиция на основе ментилового эфира индометацина | |
| FR2511680A1 (fr) | Nouveau sel de n-methyl-d-glucamine et medicament le contenant | |
| KR20250052834A (ko) | 프란루카스트의 생체이용률이 개선된 약제학적 조성물 및 그 제조방법 | |
| JPH0977663A (ja) | フルタミド組成物 | |
| KR100986531B1 (ko) | 액상의 아세클로페낙을 함유하는 캡슐제 | |
| Thawabtah et al. | Evaluation and Optimization of a Lipid-Based Drug Delivery System with Enhanced Dissolution/Solubility Properties | |
| HK1080717B (en) | Pharmaceutical compositions with improved dissolution | |
| HK1080717A1 (zh) | 具有提高的溶出度的药物组合物 | |
| JPH029816A (ja) | スパガリン類製剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130620 |