DE60312016T2 - Cyclohexylsulfon-derivate als gamma-secretase-inhibitoren - Google Patents
Cyclohexylsulfon-derivate als gamma-secretase-inhibitoren Download PDFInfo
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- DE60312016T2 DE60312016T2 DE60312016T DE60312016T DE60312016T2 DE 60312016 T2 DE60312016 T2 DE 60312016T2 DE 60312016 T DE60312016 T DE 60312016T DE 60312016 T DE60312016 T DE 60312016T DE 60312016 T2 DE60312016 T2 DE 60312016T2
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- 0 Cc(cc1)cc([C@]2(CC[C@](CC*)CC2)[N+](c(cc2)ccc2N)[O-])c1N Chemical compound Cc(cc1)cc([C@]2(CC[C@](CC*)CC2)[N+](c(cc2)ccc2N)[O-])c1N 0.000 description 4
- PYQLLIPYNDWNOP-XVDXERDNSA-N NC[C@H](CC1)CC[C@@]1(c(cc(cc1)F)c1F)S(c(cc1)ccc1Cl)(=O)=O Chemical compound NC[C@H](CC1)CC[C@@]1(c(cc(cc1)F)c1F)S(c(cc1)ccc1Cl)(=O)=O PYQLLIPYNDWNOP-XVDXERDNSA-N 0.000 description 1
- NMVZTPCISWKJSA-UJKQEGAGSA-N N[C@H](CC1)CC[C@@]1(c(cc(cc1)F)c1F)S(c1ccc(C(F)(F)F)cc1)(=O)=O Chemical compound N[C@H](CC1)CC[C@@]1(c(cc(cc1)F)c1F)S(c1ccc(C(F)(F)F)cc1)(=O)=O NMVZTPCISWKJSA-UJKQEGAGSA-N 0.000 description 1
- XZEPSDLURQRKPV-GMDFKXTESA-N O=S([C@H](C1)[C@]1(CCCCC1)CC[C@@H]1c1cc(F)ccc1F)c1ccccc1 Chemical compound O=S([C@H](C1)[C@]1(CCCCC1)CC[C@@H]1c1cc(F)ccc1F)c1ccccc1 XZEPSDLURQRKPV-GMDFKXTESA-N 0.000 description 1
- CDTZUJGFZYMVPG-LDTOLXSISA-N O=S([C@]1(CC[C@@H](CCI)CC1)c(cc(cc1)F)c1F)(c(cc1)ccc1Cl)=O Chemical compound O=S([C@]1(CC[C@@H](CCI)CC1)c(cc(cc1)F)c1F)(c(cc1)ccc1Cl)=O CDTZUJGFZYMVPG-LDTOLXSISA-N 0.000 description 1
- RDOJEKIVHJOBBF-XVDXERDNSA-N O=S([C@]1(CC[C@@H](CI)CC1)c(cc(cc1)F)c1F)(c(cc1)ccc1Cl)=O Chemical compound O=S([C@]1(CC[C@@H](CI)CC1)c(cc(cc1)F)c1F)(c(cc1)ccc1Cl)=O RDOJEKIVHJOBBF-XVDXERDNSA-N 0.000 description 1
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/62—Oxygen or sulfur atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Furan Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0223039 | 2002-10-04 | ||
| GBGB0223039.9A GB0223039D0 (en) | 2002-10-04 | 2002-10-04 | Therapeutic compounds |
| PCT/GB2003/004102 WO2004031137A1 (en) | 2002-10-04 | 2003-09-25 | Cyclohexyl sulphone derivatives as gamma-secretase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60312016D1 DE60312016D1 (en) | 2007-04-05 |
| DE60312016T2 true DE60312016T2 (de) | 2007-10-31 |
Family
ID=9945313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60312016T Expired - Lifetime DE60312016T2 (de) | 2002-10-04 | 2003-09-25 | Cyclohexylsulfon-derivate als gamma-secretase-inhibitoren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7101895B2 (enExample) |
| EP (1) | EP1551797B1 (enExample) |
| JP (1) | JP4653485B2 (enExample) |
| AT (1) | ATE354562T1 (enExample) |
| AU (1) | AU2003267614B2 (enExample) |
| CA (1) | CA2500964C (enExample) |
| DE (1) | DE60312016T2 (enExample) |
| ES (1) | ES2280774T3 (enExample) |
| GB (1) | GB0223039D0 (enExample) |
| WO (1) | WO2004031137A1 (enExample) |
Families Citing this family (73)
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|---|---|---|---|---|
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0120347D0 (en) | 2001-08-21 | 2001-10-17 | Merck Sharp & Dohme | Therapeutic agents |
| US7399775B2 (en) | 2001-12-27 | 2008-07-15 | Daiichi Pharmaceutical Co., Ltd. | β-amyloid protein production/secretion inhibitor |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| PL379466A1 (pl) | 2003-06-30 | 2006-09-18 | Daiichi Sankyo Company , Limited | Heterocykliczne pochodne metylosulfonu |
| AR047666A1 (es) * | 2004-02-20 | 2006-02-01 | Merck Sharp & Dohme | Sintesis estereoselectiva del acido ciclohexanopropanoico 4,4-disubstituido |
| ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
| WO2006123184A2 (en) * | 2005-05-17 | 2006-11-23 | Merck Sharp & Dohme Limited | Sulphonamido-substituted cyclohexyl sulphones for treatment of cancer |
| JP5281395B2 (ja) * | 2005-06-06 | 2013-09-04 | メルク シャープ エンド ドーム リミテッド | 統合失調症の治療用のglyt1阻害剤としてのシクロヘキサンスルホニル誘導体 |
| GB0513747D0 (en) * | 2005-07-06 | 2005-08-10 | Merck Sharp & Dohme | Therapeutic compounds |
| AR059075A1 (es) | 2006-01-20 | 2008-03-12 | Schering Corp | Bencesulfonil - cromano , tiocromano tetrahidronaftaleno e inhibidores de gamma secretasa relacionados |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008076556A2 (en) | 2006-11-15 | 2008-06-26 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| CA2676715A1 (en) | 2007-02-12 | 2008-08-21 | Merck & Co., Inc. | Piperazine derivatives for treatment of ad and related conditions |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| WO2008128985A1 (en) | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| EP2435416B1 (en) * | 2007-07-05 | 2016-03-30 | Merck Sharp & Dohme Corp. | Tetrahydropyranochromene gamma secretase inhibitors |
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| US8377886B2 (en) * | 2007-09-14 | 2013-02-19 | Albert Einstein College Of Medicine Of Yeshiva University | Use of gamma secretase inhibitors and notch pathway inhibitors for treatment and prevention of renal disease |
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| EP2686313B1 (en) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazole derivatives as inhibitors of glutaminyl cyclase |
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| CA2884309A1 (en) | 2012-09-07 | 2014-03-13 | Massachusetts Eye And Ear Infirmary | Methods and compositions for regenerating hair cells and/or supporting cells from differentiated cochlear cells or differentiated utricular cells by modulation of notch and cmyc activity |
| CA2882950A1 (en) | 2012-09-28 | 2014-04-03 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
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| EP3166627A1 (en) | 2014-07-11 | 2017-05-17 | Genentech, Inc. | Notch pathway inhibition |
| WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| EP3324965A4 (en) | 2015-07-24 | 2019-07-03 | Oncotracker, Inc. | Gamma secretase modulators for the treatment of immune system dysfunction |
| WO2017096233A1 (en) | 2015-12-04 | 2017-06-08 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
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| US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
| EP3554502A4 (en) | 2016-12-16 | 2021-01-06 | Pipeline Therapeutics, Inc. | METHOD FOR TREATMENT OF COCHLEA SYNAPTOPATHY |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| PL3461819T3 (pl) | 2017-09-29 | 2020-11-30 | Probiodrug Ag | Inhibitory cyklazy glutaminylowej |
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| EP3706742B1 (en) | 2017-11-08 | 2023-03-15 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
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| EP3833667B1 (en) | 2018-08-07 | 2024-03-13 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| ES3074517T3 (en) | 2019-12-17 | 2026-07-21 | Merck Sharp & Dohme Llc | 4-(3,4-dihydroisoquinolin-2(1h)-yl)-3-hydroxypiperidine derivatives as prmt5 inhibitors for the treatment of cancer and sickle cell disease |
| EP4076460B1 (en) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer |
| EP4076459B1 (en) | 2019-12-17 | 2026-04-29 | Merck Sharp & Dohme LLC | Prmt5 inhibitors |
| ES3022307T3 (en) | 2019-12-17 | 2025-05-28 | Merck Sharp & Dohme Llc | Prmt5 inhibitors |
| CN111205264A (zh) * | 2020-02-25 | 2020-05-29 | 成都睿智化学研究有限公司 | 一种合成同位羟基和甲磺酰甲基化合物的新方法 |
| WO2021195362A1 (en) | 2020-03-26 | 2021-09-30 | Seagen Inc. | Methods of treating multiple myeloma |
| CN120225528A (zh) | 2022-09-02 | 2025-06-27 | 默沙东有限责任公司 | 依喜替康衍生的拓扑异构酶-1抑制剂药物组合物及其用途 |
| KR20250079227A (ko) | 2022-10-25 | 2025-06-04 | 머크 샤프 앤드 돔 엘엘씨 | 엑사테칸-유래 adc 링커-페이로드, 제약 조성물, 및 그의 용도 |
| KR20250116773A (ko) | 2022-12-14 | 2025-08-01 | 머크 샤프 앤드 돔 엘엘씨 | 아우리스타틴 링커-페이로드, 제약 조성물, 및 그의 용도 |
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| US2802013A (en) | 1954-02-12 | 1957-08-06 | Searle & Co | 2-(oxo and imino)-3-(phenyl and halophenyl)-tetrahydrofuransulfones and processes for the manufacture thereof |
| US2812330A (en) | 1956-05-02 | 1957-11-05 | Searle & Co | Sulfone derivatives of 2, 6-piperidinedione |
| JPS5625149A (en) | 1979-08-08 | 1981-03-10 | Sagami Chem Res Center | Keto ester derivative and its preparation |
| JPS5626847A (en) | 1979-08-13 | 1981-03-16 | Sagami Chem Res Center | Preparation of substituted salicylic acid derivative |
| JPS5626866A (en) | 1979-08-13 | 1981-03-16 | Sagami Chem Res Center | Unsaturated ketoester derivative and its preparation |
| CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
| EP0863134A1 (en) | 1997-03-07 | 1998-09-09 | Merck Frosst Canada Inc. | 2-(3,5-difluorophenyl)-3-(4-(methyl-sulfonyl)phenyl)-2-cyclopenten-1-one useful as an inhibitor of cyclooxygenase-2 |
| HRP990246A2 (en) * | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
| CN1348442A (zh) | 1999-02-26 | 2002-05-08 | 默克公司 | 新的磺胺化合物及其应用 |
| JP2003528076A (ja) * | 2000-03-20 | 2003-09-24 | メルク シャープ エンド ドーム リミテッド | スルホンアミド置換架橋ビシクロアルキル誘導体 |
| GB0108592D0 (en) | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| GB0108591D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| US7122675B2 (en) * | 2001-08-03 | 2006-10-17 | Schering Corporation | Gamma secretase inhibitors |
| JP3711131B2 (ja) | 2001-08-21 | 2005-10-26 | メルク シャープ エンド ドーム リミテッド | 新規のシクロヘキシルスルホン |
| US7399775B2 (en) | 2001-12-27 | 2008-07-15 | Daiichi Pharmaceutical Co., Ltd. | β-amyloid protein production/secretion inhibitor |
| DE10201392A1 (de) | 2002-01-16 | 2003-07-31 | Bayer Ag | Phenylsulfoxide und-sulfone |
| GB0218041D0 (en) | 2002-08-02 | 2002-09-11 | Merck Sharp & Dohme | Chemical process |
| JP3092689U (ja) | 2002-09-10 | 2003-03-20 | 船井電機株式会社 | 光ピックアップ |
| GB0223040D0 (en) | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| GB0223038D0 (en) * | 2002-10-04 | 2002-11-13 | Merck Sharp & Dohme | Therapeutic compounds |
| DE10254875A1 (de) | 2002-11-25 | 2004-06-03 | Bayer Healthcare Ag | Phenylsulfoxid und -sulfon-Derivate |
| GB0304524D0 (en) | 2003-02-27 | 2003-04-02 | Merck Sharp & Dohme | Therapeutic agents |
| KR20060013404A (ko) | 2003-05-16 | 2006-02-09 | 머크 샤프 앤드 돔 리미티드 | γ-세크레타제 억제용 사이클릭 설폰아미드 |
| PL379466A1 (pl) | 2003-06-30 | 2006-09-18 | Daiichi Sankyo Company , Limited | Heterocykliczne pochodne metylosulfonu |
| GB0323258D0 (en) | 2003-10-04 | 2003-11-05 | Merck Sharp & Dohme | Therapeutic compounds |
-
2002
- 2002-10-04 GB GBGB0223039.9A patent/GB0223039D0/en not_active Ceased
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2003
- 2003-09-25 CA CA2500964A patent/CA2500964C/en not_active Expired - Fee Related
- 2003-09-25 DE DE60312016T patent/DE60312016T2/de not_active Expired - Lifetime
- 2003-09-25 JP JP2004540927A patent/JP4653485B2/ja not_active Expired - Fee Related
- 2003-09-25 AT AT03748306T patent/ATE354562T1/de not_active IP Right Cessation
- 2003-09-25 AU AU2003267614A patent/AU2003267614B2/en not_active Ceased
- 2003-09-25 EP EP03748306A patent/EP1551797B1/en not_active Expired - Lifetime
- 2003-09-25 ES ES03748306T patent/ES2280774T3/es not_active Expired - Lifetime
- 2003-09-25 WO PCT/GB2003/004102 patent/WO2004031137A1/en not_active Ceased
- 2003-10-06 US US10/679,557 patent/US7101895B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4653485B2 (ja) | 2011-03-16 |
| US20040122050A1 (en) | 2004-06-24 |
| EP1551797A1 (en) | 2005-07-13 |
| US7101895B2 (en) | 2006-09-05 |
| JP2006501292A (ja) | 2006-01-12 |
| ES2280774T3 (es) | 2007-09-16 |
| CA2500964C (en) | 2011-01-18 |
| WO2004031137A1 (en) | 2004-04-15 |
| EP1551797B1 (en) | 2007-02-21 |
| CA2500964A1 (en) | 2004-04-15 |
| DE60312016D1 (en) | 2007-04-05 |
| GB0223039D0 (en) | 2002-11-13 |
| ATE354562T1 (de) | 2007-03-15 |
| AU2003267614A1 (en) | 2004-04-23 |
| AU2003267614B2 (en) | 2010-02-18 |
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