ATE354562T1 - Cyclohexylsulfon-derivate als gamma-secretase- inhibitoren - Google Patents

Cyclohexylsulfon-derivate als gamma-secretase- inhibitoren

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Publication number
ATE354562T1
ATE354562T1 AT03748306T AT03748306T ATE354562T1 AT E354562 T1 ATE354562 T1 AT E354562T1 AT 03748306 T AT03748306 T AT 03748306T AT 03748306 T AT03748306 T AT 03748306T AT E354562 T1 ATE354562 T1 AT E354562T1
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Austria
Prior art keywords
sup
sub
cyclohexylsulfone
derivatives
gamma secretase
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AT03748306T
Other languages
German (de)
English (en)
Inventor
Ian Churcher
Timothy Harrison
Sonia Kerrad
Paul Joseph Oakley
Duncan Edward Shaw
Martin Richard Teall
Susannah Williams
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Merck Sharp & Dohme
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Publication of ATE354562T1 publication Critical patent/ATE354562T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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