DE60224039T2 - Stickstoffhaltige, bicyclische heterocyclen zur verwendung als antibakterielle mittel - Google Patents
Stickstoffhaltige, bicyclische heterocyclen zur verwendung als antibakterielle mittel Download PDFInfo
- Publication number
- DE60224039T2 DE60224039T2 DE60224039T DE60224039T DE60224039T2 DE 60224039 T2 DE60224039 T2 DE 60224039T2 DE 60224039 T DE60224039 T DE 60224039T DE 60224039 T DE60224039 T DE 60224039T DE 60224039 T2 DE60224039 T2 DE 60224039T2
- Authority
- DE
- Germany
- Prior art keywords
- amino
- alkyl
- oxo
- amide
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CCC*(*)(*C=C)*(*)*(C)(C)N Chemical compound CCC*(*)(*C=C)*(*)*(C)(C)N 0.000 description 3
- OSVVTVLREDJKKV-WGSAOQKQSA-N COc(cc1)cc2c1nccc2NC([C@H](CC1)CC[C@@H]1NCc(cc1)cc2c1OCCO2)=O Chemical compound COc(cc1)cc2c1nccc2NC([C@H](CC1)CC[C@@H]1NCc(cc1)cc2c1OCCO2)=O OSVVTVLREDJKKV-WGSAOQKQSA-N 0.000 description 1
- WYUMOJZSXWEIPU-WKILWMFISA-N COc(cc1)nc2c1nccc2NC([C@H](CC1)CC[C@@H]1NCc(cn1)cc2c1[s]cn2)=O Chemical compound COc(cc1)nc2c1nccc2NC([C@H](CC1)CC[C@@H]1NCc(cn1)cc2c1[s]cn2)=O WYUMOJZSXWEIPU-WKILWMFISA-N 0.000 description 1
- DQAOVLVVHPRDAI-RVZJWNSFSA-N COc(nc12)ccc1nccc2NC([C@H](CC[C@H]1NCc(nn2)cc(N3)c2SCC3=O)C[C@H]1O)=O Chemical compound COc(nc12)ccc1nccc2NC([C@H](CC[C@H]1NCc(nn2)cc(N3)c2SCC3=O)C[C@H]1O)=O DQAOVLVVHPRDAI-RVZJWNSFSA-N 0.000 description 1
- IUZLOVGIGVXBEB-XCNUYCIISA-N NOc(cc1)cc2c1nccc2NC([C@](CC1)(CC[C@@H]1NCc(cc1)nc(N2)c1SCC2=O)O)=O Chemical compound NOc(cc1)cc2c1nccc2NC([C@](CC1)(CC[C@@H]1NCc(cc1)nc(N2)c1SCC2=O)O)=O IUZLOVGIGVXBEB-XCNUYCIISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0112834.7A GB0112834D0 (en) | 2001-05-25 | 2001-05-25 | Medicaments |
| GB0112834 | 2001-05-25 | ||
| PCT/EP2002/005708 WO2003087098A1 (en) | 2001-05-25 | 2002-05-24 | Nitrogen-containing bicyclic heterocycles for use as antibacterials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60224039D1 DE60224039D1 (de) | 2008-01-24 |
| DE60224039T2 true DE60224039T2 (de) | 2008-11-27 |
Family
ID=9915342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60224039T Expired - Lifetime DE60224039T2 (de) | 2001-05-25 | 2002-05-24 | Stickstoffhaltige, bicyclische heterocyclen zur verwendung als antibakterielle mittel |
Country Status (23)
Families Citing this family (72)
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| SE9703377D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| US6803369B1 (en) | 2000-07-25 | 2004-10-12 | Smithkline Beecham Corporation | Compounds and methods for the treatment of neoplastic disease |
| CN1452619A (zh) | 2000-07-26 | 2003-10-29 | 史密斯克莱·比奇曼公司 | 具有抗细菌活性的氨基哌啶喹啉和它们的氮杂等排的类似物 |
| EP1320529B1 (en) * | 2000-09-21 | 2006-05-24 | Smithkline Beecham Plc | Quinoline derivatives as antibacterials |
| GB0031088D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0031086D0 (en) * | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| GB0112836D0 (en) * | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
| US7109213B2 (en) | 2002-01-29 | 2006-09-19 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| US7312212B2 (en) * | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| TW200406413A (en) * | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| TW200409637A (en) * | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| AU2003303956A1 (en) * | 2002-11-05 | 2004-11-23 | Smithkline Beecham Corporation | Antibacterial agents |
| US7618959B2 (en) | 2002-11-05 | 2009-11-17 | Smithklinebeecham Corp | Antibacterial agents |
| ES2312839T3 (es) * | 2002-12-04 | 2009-03-01 | Glaxo Group Limited | Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos. |
| US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
| TW200427688A (en) * | 2002-12-18 | 2004-12-16 | Glaxo Group Ltd | Antibacterial agents |
| DE102004023635A1 (de) * | 2004-05-10 | 2006-04-13 | Grünenthal GmbH | Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate |
| DE102004041163A1 (de) * | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| US7648980B2 (en) * | 2005-01-25 | 2010-01-19 | Glaxo Group Limited | Antibacterial agents |
| WO2006081289A2 (en) * | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
| US7605169B2 (en) | 2005-01-25 | 2009-10-20 | Glaxo Group Limited | Antibacterial agents |
| EP1846418A4 (en) | 2005-01-25 | 2009-12-23 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| US7709472B2 (en) | 2005-01-25 | 2010-05-04 | Glaxo Group Limited | Antibacterial agents |
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| CA2635126A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
| WO2007093963A1 (en) * | 2006-02-15 | 2007-08-23 | Actelion Pharmaceuticals Ltd | Ethanol or 1,2-ethanediol cyclohexyl antibiotic derivatives |
| JP2009527562A (ja) * | 2006-02-21 | 2009-07-30 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体 |
| JP2009528365A (ja) * | 2006-02-28 | 2009-08-06 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン及びキナゾリン誘導体 |
| AU2007223801A1 (en) * | 2006-03-08 | 2007-09-13 | Amgen Inc. | Quinoline and isoquinoline derivatives as phosphodiesterase 10 inhibitors |
| JP2009532504A (ja) | 2006-04-06 | 2009-09-10 | グラクソ グループ リミテッド | 抗菌薬 |
| ATE481406T1 (de) | 2006-04-06 | 2010-10-15 | Glaxo Group Ltd | Pyrrolochinoxalinonderivate als antibakterielle mittel |
| GB0613208D0 (en) | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
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| CL2008001002A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| KR101567096B1 (ko) | 2007-04-20 | 2015-11-06 | 글락소 그룹 리미티드 | 항균제로서의 트리시클릭 질소 함유 화합물 |
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| EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
| KR101592046B1 (ko) | 2008-02-22 | 2016-02-05 | 액테리온 파마슈티칼 리미티드 | 옥사졸리디논 유도체 |
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| JP2012505866A (ja) | 2008-10-17 | 2012-03-08 | グラクソ グループ リミテッド | 抗菌剤として使用される三環式窒素化合物 |
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| EP2346819B1 (en) | 2008-11-17 | 2013-04-10 | F. Hoffmann-La Roche AG | Naphthylacetic acids |
| PT2376497E (pt) | 2008-12-12 | 2013-11-21 | Actelion Pharmaceuticals Ltd | Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano |
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| CN104470898B (zh) | 2013-05-13 | 2016-04-06 | 上海恒瑞医药有限公司 | 环烷基甲酸类衍生物、其制备方法及其在医药上的应用 |
| BR112017003705B1 (pt) | 2014-08-22 | 2022-07-12 | Glaxosmithkline Intellectual Property Development Limited | Compostos contendo nitrogênio tricíclicos para o tratamento de infecção por neisseria gonorrhoea |
| SI3209655T1 (sl) | 2014-10-24 | 2020-11-30 | Landos Biopharma, Inc. | Terapevtiki na osnovi C-podobne lantionin sintetaze 2 |
| UY36851A (es) * | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| EP3601267A1 (en) | 2017-03-21 | 2020-02-05 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| CA3083442A1 (en) | 2017-11-30 | 2019-06-06 | Landos Biopharma, Inc. | Therapies with lanthionine c-like protein 2 ligands and cells prepared therewith |
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| WO2021076886A1 (en) | 2019-10-18 | 2021-04-22 | The Regents Of The University Of California | 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders |
| AU2020407645B2 (en) | 2019-12-20 | 2022-10-06 | Nimmune Biopharma, Inc. | Lanthionine C-like protein 2 ligands, cells prepared therewith, and therapies using same |
| WO2022058344A1 (en) | 2020-09-18 | 2022-03-24 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| CN116102537B (zh) * | 2021-11-10 | 2024-10-01 | 四川大学 | 一种喹啉酮类衍生物及其制备方法和用途 |
| CN117568087B (zh) * | 2024-01-16 | 2024-04-05 | 洛阳轻捷润滑油科技有限公司 | 一种长寿命汽车无极变速器油及其制备方法 |
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-
2001
- 2001-05-25 GB GBGB0112834.7A patent/GB0112834D0/en not_active Ceased
-
2002
- 2002-05-23 AR ARP020101914A patent/AR038172A1/es not_active Application Discontinuation
- 2002-05-23 TW TW091110839A patent/TWI232219B/zh not_active IP Right Cessation
- 2002-05-24 CA CA002448525A patent/CA2448525A1/en not_active Abandoned
- 2002-05-24 US US10/478,154 patent/US7141564B2/en not_active Expired - Fee Related
- 2002-05-24 CZ CZ20033202A patent/CZ20033202A3/cs unknown
- 2002-05-24 KR KR10-2003-7015379A patent/KR20040010654A/ko not_active Withdrawn
- 2002-05-24 WO PCT/EP2002/005708 patent/WO2003087098A1/en not_active Ceased
- 2002-05-24 ES ES02807202T patent/ES2298439T3/es not_active Expired - Lifetime
- 2002-05-24 DE DE60224039T patent/DE60224039T2/de not_active Expired - Lifetime
- 2002-05-24 EP EP02807202A patent/EP1399443B1/en not_active Expired - Lifetime
- 2002-05-24 CN CNA028146689A patent/CN1535272A/zh active Pending
- 2002-05-24 IL IL15886902A patent/IL158869A0/xx unknown
- 2002-05-24 AT AT02807202T patent/ATE380812T1/de not_active IP Right Cessation
- 2002-05-24 JP JP2003584054A patent/JP4463565B2/ja not_active Expired - Fee Related
- 2002-05-24 AU AU2002367697A patent/AU2002367697A1/en not_active Abandoned
- 2002-05-24 HU HU0400017A patent/HUP0400017A2/hu unknown
- 2002-05-24 PL PL02367079A patent/PL367079A1/xx not_active Application Discontinuation
- 2002-05-24 MX MXPA03010790A patent/MXPA03010790A/es unknown
- 2002-05-24 BR BR0210016-9A patent/BR0210016A/pt not_active IP Right Cessation
-
2003
- 2003-11-07 ZA ZA200308696A patent/ZA200308696B/en unknown
- 2003-11-18 CO CO03101671A patent/CO5540344A2/es not_active Application Discontinuation
- 2003-11-21 NO NO20035190A patent/NO20035190D0/no not_active Application Discontinuation
-
2006
- 2006-11-22 US US11/604,045 patent/US20070135422A1/en not_active Abandoned
-
2009
- 2009-11-13 JP JP2009259981A patent/JP2010031057A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA03010790A (es) | 2004-03-02 |
| US20040171620A1 (en) | 2004-09-02 |
| AR038172A1 (es) | 2005-01-05 |
| CN1535272A (zh) | 2004-10-06 |
| GB0112834D0 (en) | 2001-07-18 |
| CO5540344A2 (es) | 2005-07-29 |
| BR0210016A (pt) | 2004-06-15 |
| JP2010031057A (ja) | 2010-02-12 |
| TWI232219B (en) | 2005-05-11 |
| JP4463565B2 (ja) | 2010-05-19 |
| EP1399443B1 (en) | 2007-12-12 |
| ZA200308696B (en) | 2004-05-21 |
| ES2298439T3 (es) | 2008-05-16 |
| NO20035190D0 (no) | 2003-11-21 |
| AU2002367697A1 (en) | 2003-10-27 |
| JP2005519981A (ja) | 2005-07-07 |
| PL367079A1 (en) | 2005-02-21 |
| WO2003087098A1 (en) | 2003-10-23 |
| ATE380812T1 (de) | 2007-12-15 |
| CZ20033202A3 (cs) | 2004-08-18 |
| HUP0400017A2 (hu) | 2004-06-28 |
| EP1399443A1 (en) | 2004-03-24 |
| IL158869A0 (en) | 2004-05-12 |
| CA2448525A1 (en) | 2003-10-23 |
| US20070135422A1 (en) | 2007-06-14 |
| US7141564B2 (en) | 2006-11-28 |
| DE60224039D1 (de) | 2008-01-24 |
| KR20040010654A (ko) | 2004-01-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8381 | Inventor (new situation) |
Inventor name: BROOKS, GERALD, HARLOW, ESSEX CM19 5AW, GB Inventor name: DAVIES, DAVID THOMAS, HARLOW, ESSEX CM19 5AW, GB Inventor name: JONES, GRAHAM ELGIN, HARLOW, ESSEX CM19 5AW, GB Inventor name: MARKWELL, ROGER EDWARD, HARLOW, ESSEXCM19 5AW, GB Inventor name: PEARSON, NEIL DAVID, HARLOW, ESSEX CM19 5AW, GB |
|
| 8364 | No opposition during term of opposition |