DE60222189T2 - Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten - Google Patents

Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten Download PDF

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Publication number
DE60222189T2
DE60222189T2 DE60222189T DE60222189T DE60222189T2 DE 60222189 T2 DE60222189 T2 DE 60222189T2 DE 60222189 T DE60222189 T DE 60222189T DE 60222189 T DE60222189 T DE 60222189T DE 60222189 T2 DE60222189 T2 DE 60222189T2
Authority
DE
Germany
Prior art keywords
boc
4clphe
3pal
2nal
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60222189T
Other languages
German (de)
English (en)
Other versions
DE60222189D1 (de
Inventor
Jon H. Rasmussen
Palle H. Rasmussen
Wolfgang O. Wachs
Stefan Hansen
Jens Fomsgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARLBIOTECH Ltd AS
Polypeptide Laboratories AS
Original Assignee
CARLBIOTECH Ltd AS
Polypeptide Laboratories AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARLBIOTECH Ltd AS, Polypeptide Laboratories AS filed Critical CARLBIOTECH Ltd AS
Application granted granted Critical
Publication of DE60222189D1 publication Critical patent/DE60222189D1/de
Publication of DE60222189T2 publication Critical patent/DE60222189T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60222189T 2001-12-29 2002-12-23 Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten Expired - Lifetime DE60222189T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
SE0104463 2001-12-29

Publications (2)

Publication Number Publication Date
DE60222189D1 DE60222189D1 (de) 2007-10-11
DE60222189T2 true DE60222189T2 (de) 2008-06-19

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60222189T Expired - Lifetime DE60222189T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die Synthese von LHRH-Antagonisten, Verfahren zu deren Herstellung und Verfahren zur Herstellung von LHRH-Antagonisten
DE60215544T Expired - Lifetime DE60215544T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60215544T Expired - Lifetime DE60215544T2 (de) 2001-12-29 2002-12-23 Zwischenprodukte für die synthese von lhrh-antagonisten, verfahren zu deren herstellung und verfahren zur herstellung von lhrh-antagonisten

Country Status (21)

Country Link
US (2) US20050124788A1 (enExample)
EP (2) EP1465917B1 (enExample)
JP (1) JP4272529B2 (enExample)
KR (1) KR100844520B1 (enExample)
CN (1) CN1304417C (enExample)
AT (2) ATE342913T1 (enExample)
AU (1) AU2002348749B2 (enExample)
CA (1) CA2471723C (enExample)
CY (2) CY1107580T1 (enExample)
DE (2) DE60222189T2 (enExample)
DK (2) DK1465917T3 (enExample)
ES (2) ES2296050T3 (enExample)
IL (2) IL162788A0 (enExample)
NO (1) NO330129B1 (enExample)
NZ (1) NZ534245A (enExample)
PT (2) PT1465917E (enExample)
RU (1) RU2307125C2 (enExample)
SE (1) SE0104463D0 (enExample)
SI (1) SI1630169T1 (enExample)
WO (1) WO2003055902A1 (enExample)
ZA (1) ZA200405136B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
HRP20161746T1 (hr) 2010-10-27 2017-02-10 Ferring B.V. Postupak za proizvodnju degareliksa i njegovih međuprodukata
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
FI4512390T1 (fi) 2012-06-01 2025-08-01 Ferring Bv Degareliksin valmistaminen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
CA2086416A1 (en) * 1990-07-24 1992-01-25 John C. Hubbs Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
AU4394897A (en) * 1996-10-30 1998-05-22 Pfizer Inc. Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and the ir use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
AU2002348749B2 (en) 2008-09-04
EP1630169A3 (en) 2006-03-15
US20080306242A1 (en) 2008-12-11
ATE371666T1 (de) 2007-09-15
AU2002348749A1 (en) 2003-07-15
SI1630169T1 (sl) 2008-04-30
HK1075052A1 (en) 2005-12-02
CY1107025T1 (el) 2012-09-26
EP1630169B1 (en) 2007-08-29
ZA200405136B (en) 2005-07-27
WO2003055902A1 (en) 2003-07-10
US20050124788A1 (en) 2005-06-09
ATE342913T1 (de) 2006-11-15
DE60215544T2 (de) 2007-08-30
DK1630169T3 (da) 2008-01-02
NO20043047L (no) 2004-08-30
RU2307125C2 (ru) 2007-09-27
IL162788A0 (en) 2005-11-20
US8173770B2 (en) 2012-05-08
CN1622954A (zh) 2005-06-01
ES2296050T3 (es) 2008-04-16
EP1630169A2 (en) 2006-03-01
JP4272529B2 (ja) 2009-06-03
CN1304417C (zh) 2007-03-14
IL162788A (en) 2010-12-30
CA2471723C (en) 2011-02-15
DE60215544D1 (de) 2006-11-30
SE0104463D0 (sv) 2001-12-29
CA2471723A1 (en) 2003-07-10
NO330129B1 (no) 2011-02-21
EP1465917B1 (en) 2006-10-18
PT1630169E (pt) 2007-12-06
NZ534245A (en) 2007-05-31
RU2004119964A (ru) 2006-01-10
KR100844520B1 (ko) 2008-07-08
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
DE60222189D1 (de) 2007-10-11
PT1465917E (pt) 2007-01-31
JP2005516962A (ja) 2005-06-09
CY1107580T1 (el) 2013-03-13
KR20040090965A (ko) 2004-10-27
DK1465917T3 (da) 2007-02-19

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