KR100844520B1 - Ｌｈｒｈ 길항제 합성용 중간체, 그 제조 방법 및ｌｈｒｈ 길항제의 제조 방법 - Google Patents

Ｌｈｒｈ 길항제 합성용 중간체, 그 제조 방법 및ｌｈｒｈ 길항제의 제조 방법 Download PDF

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Publication number
KR100844520B1
KR100844520B1 KR1020047010267A KR20047010267A KR100844520B1 KR 100844520 B1 KR100844520 B1 KR 100844520B1 KR 1020047010267 A KR1020047010267 A KR 1020047010267A KR 20047010267 A KR20047010267 A KR 20047010267A KR 100844520 B1 KR100844520 B1 KR 100844520B1
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South Korea
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boc
4clphe
3pal
2nal
mixture
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Expired - Fee Related
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KR1020047010267A
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English (en)
Korean (ko)
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KR20040090965A (ko
Inventor
라스무센욘에이취.
라스무센팔레에이취.
박스볼프강오.
한센슈테판
폼스가드옌스
Original Assignee
폴리펩타이드 라보라토리즈 에이/에스
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Publication of KR20040090965A publication Critical patent/KR20040090965A/ko
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Publication of KR100844520B1 publication Critical patent/KR100844520B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020047010267A 2001-12-29 2002-12-23 Ｌｈｒｈ 길항제 합성용 중간체, 그 제조 방법 및ｌｈｒｈ 길항제의 제조 방법 Expired - Fee Related KR100844520B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0104463-5 2001-12-29
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (2)

Publication Number Publication Date
KR20040090965A KR20040090965A (ko) 2004-10-27
KR100844520B1 true KR100844520B1 (ko) 2008-07-08

Family

ID=20286557

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047010267A Expired - Fee Related KR100844520B1 (ko) 2001-12-29 2002-12-23 Ｌｈｒｈ 길항제 합성용 중간체, 그 제조 방법 및ｌｈｒｈ 길항제의 제조 방법

Country Status (21)

Country Link
US (2) US20050124788A1 (enExample)
EP (2) EP1630169B1 (enExample)
JP (1) JP4272529B2 (enExample)
KR (1) KR100844520B1 (enExample)
CN (1) CN1304417C (enExample)
AT (2) ATE342913T1 (enExample)
AU (1) AU2002348749B2 (enExample)
CA (1) CA2471723C (enExample)
CY (2) CY1107580T1 (enExample)
DE (2) DE60215544T2 (enExample)
DK (2) DK1465917T3 (enExample)
ES (2) ES2296050T3 (enExample)
IL (2) IL162788A0 (enExample)
NO (1) NO330129B1 (enExample)
NZ (1) NZ534245A (enExample)
PT (2) PT1630169E (enExample)
RU (1) RU2307125C2 (enExample)
SE (1) SE0104463D0 (enExample)
SI (1) SI1630169T1 (enExample)
WO (1) WO2003055902A1 (enExample)
ZA (1) ZA200405136B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
RS55457B1 (sr) 2010-10-27 2017-04-28 Ferring Bv Postupak za proizvodnju degareliksa i njegovih intermedijara
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
JPH05508859A (ja) * 1990-07-24 1993-12-09 イーストマン コダック カンパニー ペプチド合成方法
US6235734B1 (en) * 1996-10-30 2001-05-22 Pfizer Inc Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists

Also Published As

Publication number Publication date
DE60215544T2 (de) 2007-08-30
CA2471723C (en) 2011-02-15
ATE342913T1 (de) 2006-11-15
DE60215544D1 (de) 2006-11-30
IL162788A (en) 2010-12-30
RU2004119964A (ru) 2006-01-10
JP4272529B2 (ja) 2009-06-03
US20080306242A1 (en) 2008-12-11
DK1630169T3 (da) 2008-01-02
PT1465917E (pt) 2007-01-31
EP1630169A2 (en) 2006-03-01
AU2002348749B2 (en) 2008-09-04
AU2002348749A1 (en) 2003-07-15
HK1075052A1 (en) 2005-12-02
EP1630169A3 (en) 2006-03-15
SI1630169T1 (sl) 2008-04-30
CY1107025T1 (el) 2012-09-26
NZ534245A (en) 2007-05-31
ES2296050T3 (es) 2008-04-16
DK1465917T3 (da) 2007-02-19
CN1304417C (zh) 2007-03-14
NO330129B1 (no) 2011-02-21
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
CN1622954A (zh) 2005-06-01
SE0104463D0 (sv) 2001-12-29
IL162788A0 (en) 2005-11-20
EP1630169B1 (en) 2007-08-29
RU2307125C2 (ru) 2007-09-27
DE60222189D1 (de) 2007-10-11
DE60222189T2 (de) 2008-06-19
WO2003055902A1 (en) 2003-07-10
CY1107580T1 (el) 2013-03-13
PT1630169E (pt) 2007-12-06
US8173770B2 (en) 2012-05-08
US20050124788A1 (en) 2005-06-09
CA2471723A1 (en) 2003-07-10
EP1465917B1 (en) 2006-10-18
ZA200405136B (en) 2005-07-27
KR20040090965A (ko) 2004-10-27
NO20043047L (no) 2004-08-30
ATE371666T1 (de) 2007-09-15
JP2005516962A (ja) 2005-06-09

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