CY1107025T1 - Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh - Google Patents

Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh

Info

Publication number
CY1107025T1
CY1107025T1 CY20071101513T CY071101513T CY1107025T1 CY 1107025 T1 CY1107025 T1 CY 1107025T1 CY 20071101513 T CY20071101513 T CY 20071101513T CY 071101513 T CY071101513 T CY 071101513T CY 1107025 T1 CY1107025 T1 CY 1107025T1
Authority
CY
Cyprus
Prior art keywords
preparing
lhrh
component
boc
4clphe
Prior art date
Application number
CY20071101513T
Other languages
English (en)
Inventor
Jon H Rasmussen
Palle H Rasmussen
Wolfgang O Wachs
Stefan Hansen
Jens Fomsgaard
Original Assignee
Polypeptide Laboratories A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polypeptide Laboratories A/S filed Critical Polypeptide Laboratories A/S
Publication of CY1107025T1 publication Critical patent/CY1107025T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση αφορά μία μέθοδο παρασκευής ενός τριπεπτιδίου, που συμπεριλαμβάνει άλας αυτού, του τύπου (IX) Boc-D-2Nal-D-4CIPhe-D-3Pal-OH (IX), που περιλαμβάνει τα ακόλουθα διαδοχικά στάδια:
CY20071101513T 2001-12-29 2007-11-27 Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh CY1107025T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
EP05025717A EP1630169B1 (en) 2001-12-29 2002-12-23 Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production

Publications (1)

Publication Number Publication Date
CY1107025T1 true CY1107025T1 (el) 2012-09-26

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071100070T CY1107580T1 (el) 2001-12-29 2007-01-18 Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh
CY20071101513T CY1107025T1 (el) 2001-12-29 2007-11-27 Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20071100070T CY1107580T1 (el) 2001-12-29 2007-01-18 Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh

Country Status (22)

Country Link
US (2) US20050124788A1 (el)
EP (2) EP1630169B1 (el)
JP (1) JP4272529B2 (el)
KR (1) KR100844520B1 (el)
CN (1) CN1304417C (el)
AT (2) ATE371666T1 (el)
AU (1) AU2002348749B2 (el)
CA (1) CA2471723C (el)
CY (2) CY1107580T1 (el)
DE (2) DE60215544T2 (el)
DK (2) DK1630169T3 (el)
ES (2) ES2296050T3 (el)
HK (1) HK1075052A1 (el)
IL (2) IL162788A0 (el)
NO (1) NO330129B1 (el)
NZ (1) NZ534245A (el)
PT (2) PT1630169E (el)
RU (1) RU2307125C2 (el)
SE (1) SE0104463D0 (el)
SI (1) SI1630169T1 (el)
WO (1) WO2003055902A1 (el)
ZA (1) ZA200405136B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
PT2632934T (pt) * 2010-10-27 2017-01-06 Ferring Bv Processo para o fabrico de degarelix e seus intermediários
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
EP0540626A1 (en) * 1990-07-24 1993-05-12 Eastman Chemical Company Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
ES2264169T3 (es) * 1996-10-30 2006-12-16 Pfizer Inc. Derivados azabiciclicos de piridona fusionada o de citisina, su preparacion y su uso en la terapia de adiccion.
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
IL162788A (en) 2010-12-30
KR100844520B1 (ko) 2008-07-08
JP2005516962A (ja) 2005-06-09
DK1630169T3 (da) 2008-01-02
US20050124788A1 (en) 2005-06-09
EP1630169B1 (en) 2007-08-29
IL162788A0 (en) 2005-11-20
DE60215544D1 (de) 2006-11-30
US20080306242A1 (en) 2008-12-11
CY1107580T1 (el) 2013-03-13
KR20040090965A (ko) 2004-10-27
EP1630169A2 (en) 2006-03-01
RU2004119964A (ru) 2006-01-10
ATE342913T1 (de) 2006-11-15
HK1075052A1 (en) 2005-12-02
CA2471723C (en) 2011-02-15
US8173770B2 (en) 2012-05-08
EP1630169A3 (en) 2006-03-15
NO20043047L (no) 2004-08-30
NZ534245A (en) 2007-05-31
ES2296050T3 (es) 2008-04-16
SE0104463D0 (sv) 2001-12-29
ATE371666T1 (de) 2007-09-15
EP1465917B1 (en) 2006-10-18
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
JP4272529B2 (ja) 2009-06-03
CA2471723A1 (en) 2003-07-10
DE60215544T2 (de) 2007-08-30
DE60222189D1 (de) 2007-10-11
ZA200405136B (en) 2005-07-27
DE60222189T2 (de) 2008-06-19
WO2003055902A1 (en) 2003-07-10
CN1622954A (zh) 2005-06-01
DK1465917T3 (da) 2007-02-19
CN1304417C (zh) 2007-03-14
PT1465917E (pt) 2007-01-31
NO330129B1 (no) 2011-02-21
AU2002348749B2 (en) 2008-09-04
PT1630169E (pt) 2007-12-06
SI1630169T1 (sl) 2008-04-30
AU2002348749A1 (en) 2003-07-15
RU2307125C2 (ru) 2007-09-27

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