DK1630169T3 - Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister - Google Patents

Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister

Info

Publication number
DK1630169T3
DK1630169T3 DK05025717T DK05025717T DK1630169T3 DK 1630169 T3 DK1630169 T3 DK 1630169T3 DK 05025717 T DK05025717 T DK 05025717T DK 05025717 T DK05025717 T DK 05025717T DK 1630169 T3 DK1630169 T3 DK 1630169T3
Authority
DK
Denmark
Prior art keywords
preparation
boc
lhrh
4clphe
3pal
Prior art date
Application number
DK05025717T
Other languages
English (en)
Inventor
Wolfgang O Wachs
Stefan Hansen
Jens Fomsgaard
Jon H Rasmussen
Palle H Rasmussen
Original Assignee
Carlbiotech Ltd As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlbiotech Ltd As filed Critical Carlbiotech Ltd As
Application granted granted Critical
Publication of DK1630169T3 publication Critical patent/DK1630169T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK05025717T 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister DK1630169T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (1)

Publication Number Publication Date
DK1630169T3 true DK1630169T3 (da) 2008-01-02

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05025717T DK1630169T3 (da) 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister
DK02781699T DK1465917T3 (da) 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonister

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK02781699T DK1465917T3 (da) 2001-12-29 2002-12-23 Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonister

Country Status (22)

Country Link
US (2) US20050124788A1 (da)
EP (2) EP1630169B1 (da)
JP (1) JP4272529B2 (da)
KR (1) KR100844520B1 (da)
CN (1) CN1304417C (da)
AT (2) ATE342913T1 (da)
AU (1) AU2002348749B2 (da)
CA (1) CA2471723C (da)
CY (2) CY1107580T1 (da)
DE (2) DE60222189T2 (da)
DK (2) DK1630169T3 (da)
ES (2) ES2296050T3 (da)
HK (1) HK1075052A1 (da)
IL (2) IL162788A0 (da)
NO (1) NO330129B1 (da)
NZ (1) NZ534245A (da)
PT (2) PT1465917E (da)
RU (1) RU2307125C2 (da)
SE (1) SE0104463D0 (da)
SI (1) SI1630169T1 (da)
WO (1) WO2003055902A1 (da)
ZA (1) ZA200405136B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
PT2632934T (pt) * 2010-10-27 2017-01-06 Ferring Bv Processo para o fabrico de degarelix e seus intermediários
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
CN107569456A (zh) 2012-06-01 2018-01-12 辉凌公司 制造地加瑞克

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
WO1992001709A1 (en) * 1990-07-24 1992-02-06 Eastman Kodak Company Process for synthesizing peptides
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
ES2264169T3 (es) * 1996-10-30 2006-12-16 Pfizer Inc. Derivados azabiciclicos de piridona fusionada o de citisina, su preparacion y su uso en la terapia de adiccion.
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
SI1630169T1 (sl) 2008-04-30
EP1465917B1 (en) 2006-10-18
JP4272529B2 (ja) 2009-06-03
US8173770B2 (en) 2012-05-08
NZ534245A (en) 2007-05-31
DE60215544T2 (de) 2007-08-30
ES2296050T3 (es) 2008-04-16
ATE371666T1 (de) 2007-09-15
KR20040090965A (ko) 2004-10-27
IL162788A0 (en) 2005-11-20
RU2307125C2 (ru) 2007-09-27
KR100844520B1 (ko) 2008-07-08
NO330129B1 (no) 2011-02-21
RU2004119964A (ru) 2006-01-10
HK1075052A1 (en) 2005-12-02
JP2005516962A (ja) 2005-06-09
EP1630169A2 (en) 2006-03-01
CA2471723A1 (en) 2003-07-10
US20080306242A1 (en) 2008-12-11
US20050124788A1 (en) 2005-06-09
IL162788A (en) 2010-12-30
EP1630169B1 (en) 2007-08-29
ATE342913T1 (de) 2006-11-15
CY1107025T1 (el) 2012-09-26
EP1630169A3 (en) 2006-03-15
SE0104463D0 (sv) 2001-12-29
NO20043047L (no) 2004-08-30
DE60215544D1 (de) 2006-11-30
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
AU2002348749A1 (en) 2003-07-15
AU2002348749B2 (en) 2008-09-04
CY1107580T1 (el) 2013-03-13
DE60222189T2 (de) 2008-06-19
CN1622954A (zh) 2005-06-01
PT1465917E (pt) 2007-01-31
WO2003055902A1 (en) 2003-07-10
DE60222189D1 (de) 2007-10-11
CA2471723C (en) 2011-02-15
CN1304417C (zh) 2007-03-14
DK1465917T3 (da) 2007-02-19
PT1630169E (pt) 2007-12-06
ZA200405136B (en) 2005-07-27

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