CA2471723C - Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production - Google Patents

Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production Download PDF

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Publication number
CA2471723C
CA2471723C CA2471723A CA2471723A CA2471723C CA 2471723 C CA2471723 C CA 2471723C CA 2471723 A CA2471723 A CA 2471723A CA 2471723 A CA2471723 A CA 2471723A CA 2471723 C CA2471723 C CA 2471723C
Authority
CA
Canada
Prior art keywords
boc
4clphe
3pal
2nal
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2471723A
Other languages
English (en)
French (fr)
Other versions
CA2471723A1 (en
Inventor
Jon H. Rasmussen
Palle H. Rasmussen
Wolfgang O. Wachs
Stefan Hansen
Jens Fomsgaard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polypeptide Laboratories AS
Original Assignee
Polypeptide Laboratories AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polypeptide Laboratories AS filed Critical Polypeptide Laboratories AS
Publication of CA2471723A1 publication Critical patent/CA2471723A1/en
Application granted granted Critical
Publication of CA2471723C publication Critical patent/CA2471723C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2471723A 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production Expired - Fee Related CA2471723C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
SE0104463-5 2001-12-29
PCT/IB2002/005583 WO2003055902A1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (2)

Publication Number Publication Date
CA2471723A1 CA2471723A1 (en) 2003-07-10
CA2471723C true CA2471723C (en) 2011-02-15

Family

ID=20286557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2471723A Expired - Fee Related CA2471723C (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Country Status (21)

Country Link
US (2) US20050124788A1 (enExample)
EP (2) EP1630169B1 (enExample)
JP (1) JP4272529B2 (enExample)
KR (1) KR100844520B1 (enExample)
CN (1) CN1304417C (enExample)
AT (2) ATE342913T1 (enExample)
AU (1) AU2002348749B2 (enExample)
CA (1) CA2471723C (enExample)
CY (2) CY1107580T1 (enExample)
DE (2) DE60215544T2 (enExample)
DK (2) DK1465917T3 (enExample)
ES (2) ES2296050T3 (enExample)
IL (2) IL162788A0 (enExample)
NO (1) NO330129B1 (enExample)
NZ (1) NZ534245A (enExample)
PT (2) PT1630169E (enExample)
RU (1) RU2307125C2 (enExample)
SE (1) SE0104463D0 (enExample)
SI (1) SI1630169T1 (enExample)
WO (1) WO2003055902A1 (enExample)
ZA (1) ZA200405136B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI539959B (zh) 2008-02-11 2016-07-01 菲瑞茵國際中心股份有限公司 治療轉移階段攝護腺癌的方法
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
WO2012055903A1 (en) * 2010-10-27 2012-05-03 Ferring B.V. Process for the manufacture of degarelix and its intermediates
NZ727679A (en) 2012-06-01 2018-05-25 Ferring Bv Manufacture of degarelix

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
JPH05508859A (ja) * 1990-07-24 1993-12-09 イーストマン コダック カンパニー ペプチド合成方法
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
EP0937077B1 (en) * 1996-10-30 2006-05-17 Pfizer Inc. Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
AU2002348749A1 (en) 2003-07-15
DE60215544D1 (de) 2006-11-30
EP1630169A3 (en) 2006-03-15
CN1622954A (zh) 2005-06-01
NO20043047L (no) 2004-08-30
ES2296050T3 (es) 2008-04-16
ATE371666T1 (de) 2007-09-15
NO330129B1 (no) 2011-02-21
EP1630169B1 (en) 2007-08-29
US8173770B2 (en) 2012-05-08
JP4272529B2 (ja) 2009-06-03
JP2005516962A (ja) 2005-06-09
DE60222189T2 (de) 2008-06-19
SE0104463D0 (sv) 2001-12-29
US20050124788A1 (en) 2005-06-09
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
PT1465917E (pt) 2007-01-31
DK1630169T3 (da) 2008-01-02
DE60222189D1 (de) 2007-10-11
PT1630169E (pt) 2007-12-06
KR100844520B1 (ko) 2008-07-08
SI1630169T1 (sl) 2008-04-30
US20080306242A1 (en) 2008-12-11
IL162788A0 (en) 2005-11-20
DE60215544T2 (de) 2007-08-30
ZA200405136B (en) 2005-07-27
IL162788A (en) 2010-12-30
CA2471723A1 (en) 2003-07-10
EP1465917B1 (en) 2006-10-18
CN1304417C (zh) 2007-03-14
ATE342913T1 (de) 2006-11-15
CY1107025T1 (el) 2012-09-26
WO2003055902A1 (en) 2003-07-10
HK1075052A1 (en) 2005-12-02
RU2004119964A (ru) 2006-01-10
CY1107580T1 (el) 2013-03-13
AU2002348749B2 (en) 2008-09-04
EP1630169A2 (en) 2006-03-01
NZ534245A (en) 2007-05-31
DK1465917T3 (da) 2007-02-19
RU2307125C2 (ru) 2007-09-27
KR20040090965A (ko) 2004-10-27

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MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20191223