RU2307125C2 - Промежуточные соединения для синтеза антагониста рилизинг-фактора лютеинизирующего гормона (lhrh), способ их получения и способ получения антагониста lhrh - Google Patents

Промежуточные соединения для синтеза антагониста рилизинг-фактора лютеинизирующего гормона (lhrh), способ их получения и способ получения антагониста lhrh Download PDF

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Publication number
RU2307125C2
RU2307125C2 RU2004119964/04A RU2004119964A RU2307125C2 RU 2307125 C2 RU2307125 C2 RU 2307125C2 RU 2004119964/04 A RU2004119964/04 A RU 2004119964/04A RU 2004119964 A RU2004119964 A RU 2004119964A RU 2307125 C2 RU2307125 C2 RU 2307125C2
Authority
RU
Russia
Prior art keywords
heptapeptide
boc
lhrh
4clphe
general formula
Prior art date
Application number
RU2004119964/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2004119964A (ru
Inventor
Йон Х. РАСМУССЕН (DK)
Йон Х. РАСМУССЕН
Палле Х. РАСМУССЕН (DK)
Палле Х. РАСМУССЕН
Вольфганг О. ВАКС (DE)
Вольфганг О. ВАКС
Стефан ХАНСЕН (DK)
Стефан ХАНСЕН
Енс ФОМСГОР (DK)
Енс ФОМСГОР
Original Assignee
Полипептид Лэборэторис А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Полипептид Лэборэторис А/С filed Critical Полипептид Лэборэторис А/С
Publication of RU2004119964A publication Critical patent/RU2004119964A/ru
Application granted granted Critical
Publication of RU2307125C2 publication Critical patent/RU2307125C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2004119964/04A 2001-12-29 2002-12-23 Промежуточные соединения для синтеза антагониста рилизинг-фактора лютеинизирующего гормона (lhrh), способ их получения и способ получения антагониста lhrh RU2307125C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
SE0104463-5 2001-12-29

Publications (2)

Publication Number Publication Date
RU2004119964A RU2004119964A (ru) 2006-01-10
RU2307125C2 true RU2307125C2 (ru) 2007-09-27

Family

ID=20286557

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004119964/04A RU2307125C2 (ru) 2001-12-29 2002-12-23 Промежуточные соединения для синтеза антагониста рилизинг-фактора лютеинизирующего гормона (lhrh), способ их получения и способ получения антагониста lhrh

Country Status (21)

Country Link
US (2) US20050124788A1 (enExample)
EP (2) EP1465917B1 (enExample)
JP (1) JP4272529B2 (enExample)
KR (1) KR100844520B1 (enExample)
CN (1) CN1304417C (enExample)
AT (2) ATE342913T1 (enExample)
AU (1) AU2002348749B2 (enExample)
CA (1) CA2471723C (enExample)
CY (2) CY1107580T1 (enExample)
DE (2) DE60222189T2 (enExample)
DK (2) DK1465917T3 (enExample)
ES (2) ES2296050T3 (enExample)
IL (2) IL162788A0 (enExample)
NO (1) NO330129B1 (enExample)
NZ (1) NZ534245A (enExample)
PT (2) PT1465917E (enExample)
RU (1) RU2307125C2 (enExample)
SE (1) SE0104463D0 (enExample)
SI (1) SI1630169T1 (enExample)
WO (1) WO2003055902A1 (enExample)
ZA (1) ZA200405136B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促黄体生成素释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
HRP20161746T1 (hr) 2010-10-27 2017-02-10 Ferring B.V. Postupak za proizvodnju degareliksa i njegovih međuprodukata
EP2447276A1 (en) * 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
FI4512390T1 (fi) 2012-06-01 2025-08-01 Ferring Bv Degareliksin valmistaminen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
CA2086416A1 (en) * 1990-07-24 1992-01-25 John C. Hubbs Process for synthesizing peptides
AU4394897A (en) * 1996-10-30 1998-05-22 Pfizer Inc. Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and the ir use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1623166A1 (ru) * 1989-04-03 1994-02-15 Институт биоорганической химии АН БССР Нейтропептиды, обладающие поведенческой активностью
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists

Also Published As

Publication number Publication date
AU2002348749B2 (en) 2008-09-04
EP1630169A3 (en) 2006-03-15
US20080306242A1 (en) 2008-12-11
ATE371666T1 (de) 2007-09-15
AU2002348749A1 (en) 2003-07-15
SI1630169T1 (sl) 2008-04-30
HK1075052A1 (en) 2005-12-02
CY1107025T1 (el) 2012-09-26
EP1630169B1 (en) 2007-08-29
ZA200405136B (en) 2005-07-27
WO2003055902A1 (en) 2003-07-10
US20050124788A1 (en) 2005-06-09
ATE342913T1 (de) 2006-11-15
DE60215544T2 (de) 2007-08-30
DK1630169T3 (da) 2008-01-02
NO20043047L (no) 2004-08-30
IL162788A0 (en) 2005-11-20
US8173770B2 (en) 2012-05-08
CN1622954A (zh) 2005-06-01
ES2296050T3 (es) 2008-04-16
EP1630169A2 (en) 2006-03-01
DE60222189T2 (de) 2008-06-19
JP4272529B2 (ja) 2009-06-03
CN1304417C (zh) 2007-03-14
IL162788A (en) 2010-12-30
CA2471723C (en) 2011-02-15
DE60215544D1 (de) 2006-11-30
SE0104463D0 (sv) 2001-12-29
CA2471723A1 (en) 2003-07-10
NO330129B1 (no) 2011-02-21
EP1465917B1 (en) 2006-10-18
PT1630169E (pt) 2007-12-06
NZ534245A (en) 2007-05-31
RU2004119964A (ru) 2006-01-10
KR100844520B1 (ko) 2008-07-08
EP1465917A1 (en) 2004-10-13
ES2275012T3 (es) 2007-06-01
DE60222189D1 (de) 2007-10-11
PT1465917E (pt) 2007-01-31
JP2005516962A (ja) 2005-06-09
CY1107580T1 (el) 2013-03-13
KR20040090965A (ko) 2004-10-27
DK1465917T3 (da) 2007-02-19

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Legal Events

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TK4A Correction to the publication in the bulletin (patent)

Free format text: AMENDMENT TO CHAPTER -FG4A- IN JOURNAL: 27-2007 FOR TAG: (57)

MM4A The patent is invalid due to non-payment of fees

Effective date: 20191224