DK1465917T3 - Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonister - Google Patents
Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonisterInfo
- Publication number
- DK1465917T3 DK1465917T3 DK02781699T DK02781699T DK1465917T3 DK 1465917 T3 DK1465917 T3 DK 1465917T3 DK 02781699 T DK02781699 T DK 02781699T DK 02781699 T DK02781699 T DK 02781699T DK 1465917 T3 DK1465917 T3 DK 1465917T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- methods
- boc
- lhrh
- 4clphe
- Prior art date
Links
- 229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 title 2
- 238000000034 method Methods 0.000 title 2
- 238000002360 preparation method Methods 0.000 title 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000002474 gonadorelin antagonist Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- URKWHOVNPHQQTM-OAHLLOKOSA-N (2r)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-naphthalen-2-ylpropanoic acid Chemical compound C1=CC=CC2=CC(C[C@@H](NC(=O)OC(C)(C)C)C(O)=O)=CC=C21 URKWHOVNPHQQTM-OAHLLOKOSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0104463A SE0104463D0 (sv) | 2001-12-29 | 2001-12-29 | Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister |
| PCT/IB2002/005583 WO2003055902A1 (en) | 2001-12-29 | 2002-12-23 | Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1465917T3 true DK1465917T3 (da) | 2007-02-19 |
Family
ID=20286557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02781699T DK1465917T3 (da) | 2001-12-29 | 2002-12-23 | Mellemprodukter for LHRH-antagonistsyntesen, fremgangsmåder til deres fremstilling samt fremgangsmåder til fremstilling af LHRH-antagonister |
| DK05025717T DK1630169T3 (da) | 2001-12-29 | 2002-12-23 | Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05025717T DK1630169T3 (da) | 2001-12-29 | 2002-12-23 | Mellemprodukter for LHRH-antagonist-synthesen, fremgangsmåde til deres fremstilling og fremgangsmåde til fremstilling af LHRH-antagonister |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20050124788A1 (enExample) |
| EP (2) | EP1630169B1 (enExample) |
| JP (1) | JP4272529B2 (enExample) |
| KR (1) | KR100844520B1 (enExample) |
| CN (1) | CN1304417C (enExample) |
| AT (2) | ATE342913T1 (enExample) |
| AU (1) | AU2002348749B2 (enExample) |
| CA (1) | CA2471723C (enExample) |
| CY (2) | CY1107580T1 (enExample) |
| DE (2) | DE60215544T2 (enExample) |
| DK (2) | DK1465917T3 (enExample) |
| ES (2) | ES2296050T3 (enExample) |
| IL (2) | IL162788A0 (enExample) |
| NO (1) | NO330129B1 (enExample) |
| NZ (1) | NZ534245A (enExample) |
| PT (2) | PT1630169E (enExample) |
| RU (1) | RU2307125C2 (enExample) |
| SE (1) | SE0104463D0 (enExample) |
| SI (1) | SI1630169T1 (enExample) |
| WO (1) | WO2003055902A1 (enExample) |
| ZA (1) | ZA200405136B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4407322B2 (ja) * | 2004-03-09 | 2010-02-03 | 味の素株式会社 | ペプチドの製造方法 |
| CN101037472B (zh) * | 2006-03-14 | 2013-03-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 具有低组胺释放作用的促黄体生成素释放激素拮抗剂 |
| TWI442932B (zh) | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法 |
| EP2447276A1 (en) * | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| RS55457B1 (sr) | 2010-10-27 | 2017-04-28 | Ferring Bv | Postupak za proizvodnju degareliksa i njegovih intermedijara |
| AR092840A1 (es) | 2012-06-01 | 2015-05-06 | Ferring Bv | Elaboracion de degarelix |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4098777A (en) * | 1977-03-14 | 1978-07-04 | Merck & Co., Inc. | Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn |
| SU1623166A1 (ru) * | 1989-04-03 | 1994-02-15 | Институт биоорганической химии АН БССР | Нейтропептиды, обладающие поведенческой активностью |
| US5225598A (en) * | 1990-03-30 | 1993-07-06 | Union Carbide Chemicals & Plastics Technology Corporation | Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine |
| JPH05508859A (ja) * | 1990-07-24 | 1993-12-09 | イーストマン コダック カンパニー | ペプチド合成方法 |
| US5710246A (en) * | 1996-03-19 | 1998-01-20 | Abbott Laboratories | Process for intermediates for the synthesis of LHRH antagonists |
| US6235734B1 (en) * | 1996-10-30 | 2001-05-22 | Pfizer Inc | Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy |
| US5968895A (en) * | 1996-12-11 | 1999-10-19 | Praecis Pharmaceuticals, Inc. | Pharmaceutical formulations for sustained drug delivery |
| DE19941248A1 (de) | 1998-09-01 | 2000-03-02 | Asta Medica Ag | Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore |
-
2001
- 2001-12-29 SE SE0104463A patent/SE0104463D0/xx unknown
-
2002
- 2002-12-23 JP JP2003556432A patent/JP4272529B2/ja not_active Expired - Fee Related
- 2002-12-23 EP EP05025717A patent/EP1630169B1/en not_active Expired - Lifetime
- 2002-12-23 NZ NZ534245A patent/NZ534245A/en not_active IP Right Cessation
- 2002-12-23 SI SI200230642T patent/SI1630169T1/sl unknown
- 2002-12-23 ES ES05025717T patent/ES2296050T3/es not_active Expired - Lifetime
- 2002-12-23 KR KR1020047010267A patent/KR100844520B1/ko not_active Expired - Fee Related
- 2002-12-23 DK DK02781699T patent/DK1465917T3/da active
- 2002-12-23 US US10/500,047 patent/US20050124788A1/en not_active Abandoned
- 2002-12-23 AU AU2002348749A patent/AU2002348749B2/en not_active Ceased
- 2002-12-23 ES ES02781699T patent/ES2275012T3/es not_active Expired - Lifetime
- 2002-12-23 PT PT05025717T patent/PT1630169E/pt unknown
- 2002-12-23 DK DK05025717T patent/DK1630169T3/da active
- 2002-12-23 WO PCT/IB2002/005583 patent/WO2003055902A1/en not_active Ceased
- 2002-12-23 EP EP02781699A patent/EP1465917B1/en not_active Expired - Lifetime
- 2002-12-23 IL IL16278802A patent/IL162788A0/xx unknown
- 2002-12-23 AT AT02781699T patent/ATE342913T1/de active
- 2002-12-23 RU RU2004119964/04A patent/RU2307125C2/ru not_active IP Right Cessation
- 2002-12-23 PT PT02781699T patent/PT1465917E/pt unknown
- 2002-12-23 AT AT05025717T patent/ATE371666T1/de active
- 2002-12-23 DE DE60215544T patent/DE60215544T2/de not_active Expired - Lifetime
- 2002-12-23 CN CNB028283813A patent/CN1304417C/zh not_active Expired - Fee Related
- 2002-12-23 CA CA2471723A patent/CA2471723C/en not_active Expired - Fee Related
- 2002-12-23 DE DE60222189T patent/DE60222189T2/de not_active Expired - Lifetime
-
2004
- 2004-06-28 ZA ZA2004/05136A patent/ZA200405136B/en unknown
- 2004-06-29 IL IL162788A patent/IL162788A/en not_active IP Right Cessation
- 2004-07-16 NO NO20043047A patent/NO330129B1/no not_active IP Right Cessation
-
2007
- 2007-01-18 CY CY20071100070T patent/CY1107580T1/el unknown
- 2007-11-27 CY CY20071101513T patent/CY1107025T1/el unknown
-
2008
- 2008-08-12 US US12/189,925 patent/US8173770B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200300428A1 (ru) | Антагонисты метаботропных рецепторов глутамата | |
| EA200401533A1 (ru) | Способ получения росувастатина | |
| CY1112011T1 (el) | Παραγωγα αζαδικυκλο (3.1.0) εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης | |
| DK1838677T3 (da) | Krystallinske former af (R)-8-chlor-1.methyl-2,3,4,5-tetrahydro-1H-3-benzazepinhydrochlorid | |
| CY1108295T1 (el) | Παραγωγα μονοσακχαριτη αβερμεκτινης τα οποια εχουν παρασιτοκτονες ιδιοτητες | |
| CY1109998T1 (el) | Ενδυναμωτες υποδοχεων γλουταμινικου | |
| ATE356119T1 (de) | Pyrimidinone als melanin concentrating hormone receptor 1 | |
| CY1113657T1 (el) | Νεα παραγωγα βενζοφαινονης ή αλατα αυτων | |
| DZ3482A1 (fr) | Secretagogues de l'hormone de croissance | |
| SI1781683T1 (sl) | Postopek za pripravo 17-vinil-triflatov kot intermediatov | |
| MXPA05013474A (es) | Derivados de quinolilamida como antagonistas de ccr-5. | |
| DK1483246T3 (da) | 5-Substituerede alkylaminopyrazolderivater som pesticider | |
| MY136824A (en) | Substituted benzoxazinones and uses thereof | |
| EA200301317A1 (ru) | Производные аминохинолина и его применение в качестве лигандов аденозина a3 | |
| CY1107580T1 (el) | Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh | |
| DE60228724D1 (de) | Verfahren zur herstellung von beraprost und dessen salzen | |
| MX2007007725A (es) | Derivados de n-[(4,5-difenil-3-alquil-2-tienil)metil]amina (amida, sulfonamida, carbamato y urea), como antagonistas de los receptores cb1 de los cannabinoides. | |
| BR0307156A (pt) | Derivado de pirimidina bicìclica fundida, composto, antagonistas de receptores e agentes profiláticos e terapêuticos | |
| MXPA04005988A (es) | 3,4-dihidro-1h-isoquinolin-2-il-derivados. | |
| DE60101784D1 (de) | Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii | |
| DK1347960T3 (da) | Fremgangsmåde til fremstilling af (+/-) trans-4-p-fluorphenyl-3-hydromethyl-1-methylpiperidin | |
| DK1272480T3 (da) | Fremgangsmåde til fremstilling af spirocycliske tetronsyrederivater | |
| BRPI0417300A (pt) | métodos para a preparação de compostos de tiazolpirimidina | |
| DK1105392T3 (da) | Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin | |
| ATE370140T1 (de) | Kondensierte bicyclische pyrimidinderivate |