DE60208450T2 - Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium - Google Patents
Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium Download PDFInfo
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- DE60208450T2 DE60208450T2 DE60208450T DE60208450T DE60208450T2 DE 60208450 T2 DE60208450 T2 DE 60208450T2 DE 60208450 T DE60208450 T DE 60208450T DE 60208450 T DE60208450 T DE 60208450T DE 60208450 T2 DE60208450 T2 DE 60208450T2
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- glutamine
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
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| JP2001028163 | 2001-02-05 | ||
| JP2001028163 | 2001-02-05 | ||
| JP2001162806 | 2001-05-30 | ||
| JP2001162806A JP4560998B2 (ja) | 2001-02-05 | 2001-05-30 | 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
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| DE60208450D1 DE60208450D1 (de) | 2006-03-30 |
| DE60208450T2 true DE60208450T2 (de) | 2006-08-24 |
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|---|---|---|---|
| DE60208450T Expired - Lifetime DE60208450T2 (de) | 2001-02-05 | 2002-02-05 | Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium |
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| US (2) | US7262035B2 (https=) |
| EP (2) | EP1229121B1 (https=) |
| JP (1) | JP4560998B2 (https=) |
| CN (1) | CN100457894C (https=) |
| BR (1) | BRPI0200320B1 (https=) |
| DE (1) | DE60208450T2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU756507B2 (en) * | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| JP4427878B2 (ja) | 1999-08-20 | 2010-03-10 | 味の素株式会社 | 析出を伴う発酵法によるｌ−グルタミン酸の製造法 |
| JP4560998B2 (ja) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| JP4599726B2 (ja) | 2001-02-20 | 2010-12-15 | 味の素株式会社 | Ｌ−グルタミン酸の製造法 |
| JP2004187684A (ja) * | 2002-11-26 | 2004-07-08 | Ajinomoto Co Inc | Ｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| DE60335774D1 (de) | 2002-11-26 | 2011-03-03 | Ajinomoto Kk | Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium |
| EP1460128B1 (en) * | 2003-03-03 | 2016-11-30 | Ajinomoto Co., Inc. | Method for producing L-arginine or L-lysine by fermentation |
| JP4576850B2 (ja) * | 2003-03-03 | 2010-11-10 | 味の素株式会社 | 発酵法によるｌ−アルギニン又はｌ−リジンの製造法 |
| EP1624069A4 (en) * | 2003-05-07 | 2011-06-29 | Ajinomoto Kk | PROCESS FOR THE PREPARATION OF L-GLUTAMINE ACID |
| DE10344739A1 (de) * | 2003-09-26 | 2005-04-14 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| ATE455845T1 (de) | 2004-06-25 | 2010-02-15 | Kyowa Hakko Bio Co Ltd | Verfahren zur herstellung von substanzen |
| JP5592059B2 (ja) * | 2005-12-27 | 2014-09-17 | 協和発酵バイオ株式会社 | Ｌ−グルタミンの製造法 |
| US8187843B2 (en) | 2006-09-01 | 2012-05-29 | Kyowa Hakko Bio Co., Ltd. | Method for production of L-glutamine |
| JP2010041920A (ja) | 2006-12-19 | 2010-02-25 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| JP2010110216A (ja) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | Ｌ−アミノ酸または核酸の製造方法 |
| JP2010130899A (ja) | 2007-03-14 | 2010-06-17 | Ajinomoto Co Inc | Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法 |
| WO2009103547A1 (en) * | 2008-02-21 | 2009-08-27 | Basf Se | Process for the production of gamma-aminobutyric acid |
| RU2418064C2 (ru) * | 2009-01-23 | 2011-05-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТЫ СЕМЕЙСТВА ГЛУТАМАТА ИЛИ L-ВАЛИНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ, ПРИНАДЛЕЖАЩЕЙ К РОДУ Escherichia |
| RU2420586C2 (ru) * | 2009-01-23 | 2011-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Способ получения l-аминокислоты семейства глутамата с использованием бактерии, принадлежащей к роду escherichia |
| JP2012223091A (ja) | 2009-08-25 | 2012-11-15 | Ajinomoto Co Inc | Ｌ−アミノ酸の製造法 |
| EP2522737B1 (en) | 2010-01-08 | 2020-03-04 | Kyowa Hakko Bio Co., Ltd | Process for production of l-amino acid |
| JP5827131B2 (ja) | 2010-01-08 | 2015-12-02 | 協和発酵バイオ株式会社 | Ｌ−グルタミンまたはｌ−グルタミン酸の製造法 |
| RU2496867C2 (ru) | 2011-04-25 | 2013-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | Способ получения l-аминокислоты семейства глутамата с использованием коринеформной бактерии |
| ES2599482T3 (es) | 2011-07-29 | 2017-02-01 | Mitsui Chemicals, Inc. | Microorganismo que tiene un ciclo de fijación de dióxido de carbono introducido en el mismo |
| BR112013016373B1 (pt) | 2011-11-11 | 2021-05-18 | Ajinomoto Co., Inc | método para produzir uma substância alvo |
| CN104718292B (zh) | 2013-01-24 | 2019-09-10 | 三井化学株式会社 | 导入了二氧化碳固定循环的微生物 |
| JP5831669B2 (ja) | 2013-05-13 | 2015-12-09 | 味の素株式会社 | Ｌ−アミノ酸の製造法 |
| JP2016165225A (ja) | 2013-07-09 | 2016-09-15 | 味の素株式会社 | 有用物質の製造方法 |
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| EP2886651B1 (en) | 2013-10-21 | 2018-08-22 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
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| CN103695491B (zh) * | 2013-12-24 | 2016-08-24 | 山东民强生物科技股份有限公司 | L-谷氨酰胺的精制方法 |
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| CN103667382B (zh) * | 2013-12-24 | 2015-09-02 | 山东民强生物科技股份有限公司 | 一种微生物发酵生产l-谷氨酰胺的方法 |
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| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Ｌ－アミノ酸の製造法 |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| CN113025542B (zh) * | 2019-12-25 | 2022-09-16 | 中国科学院微生物研究所 | 产l-谷氨酰胺的重组大肠杆菌及其构建方法与应用 |
| KR102198072B1 (ko) * | 2020-03-04 | 2021-01-04 | 씨제이제일제당 주식회사 | 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법 |
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| KR102216450B1 (ko) * | 2020-03-30 | 2021-02-17 | 대상 주식회사 | 글루타민 생산능을 향상시키는 형질전환용 재조합 벡터 및 이를 도입한 균주 |
| CN113201535B (zh) * | 2020-07-20 | 2022-02-08 | 中国科学院天津工业生物技术研究所 | 谷氨酸脱氢酶基因启动子的突变体及其应用 |
| EP4239070A4 (en) | 2020-10-28 | 2025-09-10 | Ajinomoto Kk | PROCESS FOR THE PRODUCTION OF L-AMINO ACID |
| WO2022108383A1 (ko) | 2020-11-20 | 2022-05-27 | 씨제이제일제당 (주) | L-글루타민 생산능이 향상된 미생물 및 이를 이용한 l-글루타민 생산 방법 |
| CN112646766B (zh) * | 2020-12-30 | 2023-08-18 | 内蒙古伊品生物科技有限公司 | 一种改造基因bbd29_04920的产l-谷氨酸的重组菌株及其构建方法与应用 |
| CN113817627B (zh) * | 2021-07-15 | 2023-04-28 | 大连医诺生物股份有限公司 | 一种嗜乙酰乙酸棒杆菌及以氨态氮浓度控制进行谷氨酰胺发酵的方法 |
| CN113684165B (zh) * | 2021-08-12 | 2023-07-25 | 江南大学 | 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用 |
| US20240117393A1 (en) | 2022-09-30 | 2024-04-11 | Ajinomoto Co., Inc. | Method for producing l-amino acid |
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| JPS5317675B2 (https=) * | 1972-12-16 | 1978-06-09 | ||
| US3888039A (en) * | 1974-01-11 | 1975-06-10 | Quaker Oats Co | Foldable toy building |
| GB9111872D0 (en) | 1991-06-03 | 1991-07-24 | Shell Int Research | Polymer process |
| CA2180202A1 (en) * | 1995-06-30 | 1996-12-31 | Mika Moriya | Method of amplifying gene using artificial transposon |
| AU756507B2 (en) * | 1998-03-18 | 2003-01-16 | Ajinomoto Co., Inc. | L-glutamic acid-producing bacterium and method for producing L-glutamic acid |
| AU761990B2 (en) * | 1998-10-19 | 2003-06-12 | Ajinomoto Co., Inc. | L-glutamic acid producing bacterium and process for producing L-glutamic acid |
| CN1067434C (zh) * | 1998-12-28 | 2001-06-20 | 山东大学 | 一种谷氨酰胺发酵生产工艺 |
| EP1257649B1 (en) * | 1999-06-25 | 2010-01-20 | Paik Kwang Industrial Co., Ltd. | Corynebacterium glutamicum genes encoding metabolic pathway proteins |
| JP4427878B2 (ja) * | 1999-08-20 | 2010-03-10 | 味の素株式会社 | 析出を伴う発酵法によるｌ−グルタミン酸の製造法 |
| JP4304837B2 (ja) * | 2000-07-05 | 2009-07-29 | 味の素株式会社 | Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造法 |
| JP4560998B2 (ja) * | 2001-02-05 | 2010-10-13 | 味の素株式会社 | 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌 |
| JP2002238592A (ja) * | 2001-02-20 | 2002-08-27 | Ajinomoto Co Inc | Ｌ−グルタミン酸の製造法 |
| RU2230114C2 (ru) * | 2001-11-30 | 2004-06-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот |
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- 2002-02-05 US US10/062,458 patent/US7262035B2/en not_active Expired - Lifetime
- 2002-02-05 CN CNB021205817A patent/CN100457894C/zh not_active Expired - Lifetime
- 2002-02-05 EP EP04000167A patent/EP1424398A3/en not_active Withdrawn
- 2002-02-05 DE DE60208450T patent/DE60208450T2/de not_active Expired - Lifetime
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| US20070092953A1 (en) | 2007-04-26 |
| EP1229121A2 (en) | 2002-08-07 |
| DE60208450D1 (de) | 2006-03-30 |
| US20030003550A1 (en) | 2003-01-02 |
| CN100457894C (zh) | 2009-02-04 |
| BRPI0200320B1 (pt) | 2016-07-26 |
| EP1229121A3 (en) | 2003-03-12 |
| EP1424398A2 (en) | 2004-06-02 |
| JP4560998B2 (ja) | 2010-10-13 |
| US7262035B2 (en) | 2007-08-28 |
| EP1229121B1 (en) | 2006-01-04 |
| JP2002300887A (ja) | 2002-10-15 |
| EP1424398A3 (en) | 2004-09-22 |
| CN1384190A (zh) | 2002-12-11 |
| BR0200320A (pt) | 2002-10-29 |
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Inventor name: NAKAMURA, JUN, C/O AJINOMOTO CO., KAWASAKI-SHI, KA Inventor name: IZUI, HIROSHI, C/O AJINOMOTO CO., KAWASAKI-SHI, KA Inventor name: MORIGUCHI, KAYO, C/O AJINOMOTO CO., KAWASAKI-SHI, Inventor name: KAWASHIMA, HIROKI, C/O AJINOMOTO CO., KAWASAKI-SHI Inventor name: NAKAMATSU, TSUYOSHI, C/O TOKYO DENKI UNIV. KANADA, Inventor name: KURAHASHI, OSAMU, C/O AJINOMOTO CO., KAWASAKI-SHI, |