DE60208450D1 - Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium - Google Patents

Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium

Info

Publication number
DE60208450D1
DE60208450D1 DE60208450T DE60208450T DE60208450D1 DE 60208450 D1 DE60208450 D1 DE 60208450D1 DE 60208450 T DE60208450 T DE 60208450T DE 60208450 T DE60208450 T DE 60208450T DE 60208450 D1 DE60208450 D1 DE 60208450D1
Authority
DE
Germany
Prior art keywords
glutamine
fermentation
production
producing bacterium
bacterium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60208450T
Other languages
English (en)
Other versions
DE60208450T2 (de
Inventor
C O Ajinomoto Co Nakamura
C O Ajinomoto Co Izui
C O Ajinomoto Co Moriguchi
Ajinomoto Co Kawashima
C O Tokyo Denki Univ Nakamatsu
C O Ajinomoto Co Kurahashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE60208450D1 publication Critical patent/DE60208450D1/de
Application granted granted Critical
Publication of DE60208450T2 publication Critical patent/DE60208450T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE60208450T 2001-02-05 2002-02-05 Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium Expired - Lifetime DE60208450T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001028163 2001-02-05
JP2001028163 2001-02-05
JP2001162806A JP4560998B2 (ja) 2001-02-05 2001-05-30 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP2001162806 2001-05-30

Publications (2)

Publication Number Publication Date
DE60208450D1 true DE60208450D1 (de) 2006-03-30
DE60208450T2 DE60208450T2 (de) 2006-08-24

Family

ID=26608914

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60208450T Expired - Lifetime DE60208450T2 (de) 2001-02-05 2002-02-05 Verfahren zur Herstellung von L-Glutamin mittels Fermentation und ein L-Glutamin produzierendes Bakterium

Country Status (6)

Country Link
US (2) US7262035B2 (de)
EP (2) EP1229121B1 (de)
JP (1) JP4560998B2 (de)
CN (1) CN100457894C (de)
BR (1) BRPI0200320B1 (de)
DE (1) DE60208450T2 (de)

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AU756507B2 (en) * 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
JP4427878B2 (ja) 1999-08-20 2010-03-10 味の素株式会社 析出を伴う発酵法によるｌ−グルタミン酸の製造法
JP4560998B2 (ja) * 2001-02-05 2010-10-13 味の素株式会社 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP4599726B2 (ja) 2001-02-20 2010-12-15 味の素株式会社 Ｌ−グルタミン酸の製造法
EP1424397B1 (de) * 2002-11-26 2011-01-19 Ajinomoto Co., Inc. Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium
JP2004187684A (ja) * 2002-11-26 2004-07-08 Ajinomoto Co Inc Ｌ−グルタミンの製造法及びｌ−グルタミン生産菌
EP1460128B1 (de) * 2003-03-03 2016-11-30 Ajinomoto Co., Inc. Verfahren zur Herstellung von L-Arginin oder L-Lysin mittels Fermentation
JP4576850B2 (ja) * 2003-03-03 2010-11-10 味の素株式会社 発酵法によるｌ−アルギニン又はｌ−リジンの製造法
AU2004236516A1 (en) * 2003-05-07 2004-11-18 Ajinomoto Co., Inc. Process for producing L-glutamic acid
DE10344739A1 (de) * 2003-09-26 2005-04-14 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP4898441B2 (ja) * 2004-06-25 2012-03-14 協和発酵バイオ株式会社 物質の製造法
CN101336292B (zh) * 2005-12-27 2013-09-11 协和发酵生化株式会社 用于生产l-谷氨酰胺的方法
JP5064396B2 (ja) 2006-09-01 2012-10-31 協和発酵バイオ株式会社 Ｌ‐グルタミンの製造法
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010130899A (ja) 2007-03-14 2010-06-17 Ajinomoto Co Inc Ｌ−グルタミン酸系アミノ酸生産微生物及びアミノ酸の製造法
US8771998B2 (en) * 2008-02-21 2014-07-08 Basf Se Process for the production of gamma-aminobutyric acid
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
WO2011083860A1 (ja) 2010-01-08 2011-07-14 協和発酵バイオ株式会社 Ｌ－アミノ酸の製造法
EP2522738B1 (de) 2010-01-08 2022-03-16 Kyowa Hakko Bio Co., Ltd. Verfahren zur herstellung von l-glutamin oder l-glutaminsäure
RU2496867C2 (ru) 2011-04-25 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты семейства глутамата с использованием коринеформной бактерии
US9822387B2 (en) 2011-07-29 2017-11-21 Mitsui Chemicals, Inc. Microorganism having carbon dioxide fixation pathway introduced thereinto
PE20141569A1 (es) 2011-11-11 2014-11-08 Ajinomoto Kk Metodo para producir una sustancia diana mediante fermentacion
MY172023A (en) 2013-01-24 2019-11-12 Mitsui Chemicals Inc Microorganism having carbon dioxide fixation cycle introduced thereinto
KR101773755B1 (ko) 2013-05-13 2017-09-01 아지노모토 가부시키가이샤 Ｌ-아미노산의 제조법
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
CN104736707B (zh) 2013-10-21 2017-08-25 味之素株式会社 生产l‑氨基酸的方法
EP3061828B1 (de) 2013-10-23 2024-08-28 Ajinomoto Co., Inc. Verfahren zur herstellung einer zielsubstanz
CN103695491B (zh) * 2013-12-24 2016-08-24 山东民强生物科技股份有限公司 L-谷氨酰胺的精制方法
CN103695492B (zh) * 2013-12-24 2016-04-06 山东民强生物科技股份有限公司 一种提高l-谷氨酰胺收率的方法
CN103667382B (zh) * 2013-12-24 2015-09-02 山东民强生物科技股份有限公司 一种微生物发酵生产l-谷氨酰胺的方法
CN105054068A (zh) * 2014-01-25 2015-11-18 北京凯因科技股份有限公司 一种酵母谷胱甘肽营养配制品
JP6623690B2 (ja) 2015-10-30 2019-12-25 味の素株式会社 グルタミン酸系ｌ−アミノ酸の製造法
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
EP3861109A1 (de) 2018-10-05 2021-08-11 Ajinomoto Co., Inc. Verfahren zur herstellung einer zielsubstanz durch bakterielle fermentation
CN113025542B (zh) * 2019-12-25 2022-09-16 中国科学院微生物研究所 产l-谷氨酰胺的重组大肠杆菌及其构建方法与应用
KR102198072B1 (ko) * 2020-03-04 2021-01-04 씨제이제일제당 주식회사 글루타민 신테타아제 변이형 폴리펩티드 및 이를 이용한 l-글루타민 생산 방법
CN113444655B (zh) * 2020-03-26 2023-05-16 吉林中粮生化有限公司 谷氨酸棒状杆菌、高谷氨酸产量的温度敏感型菌株及其获得方法、应用以及谷氨酸发酵方法
KR102216450B1 (ko) * 2020-03-30 2021-02-17 대상 주식회사 글루타민 생산능을 향상시키는 형질전환용 재조합 벡터 및 이를 도입한 균주
CN113201535B (zh) * 2020-07-20 2022-02-08 中国科学院天津工业生物技术研究所 谷氨酸脱氢酶基因启动子的突变体及其应用
JPWO2022092018A1 (de) 2020-10-28 2022-05-05
CN116761884A (zh) 2020-11-20 2023-09-15 Cj第一制糖株式会社 具有增强的l-谷氨酰胺生产能力的微生物，以及使用该微生物的l-谷氨酰胺生产方法
CN112646766B (zh) * 2020-12-30 2023-08-18 内蒙古伊品生物科技有限公司 一种改造基因bbd29_04920的产l-谷氨酸的重组菌株及其构建方法与应用
CN113817627B (zh) * 2021-07-15 2023-04-28 大连医诺生物股份有限公司 一种嗜乙酰乙酸棒杆菌及以氨态氮浓度控制进行谷氨酰胺发酵的方法
CN113684165B (zh) * 2021-08-12 2023-07-25 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid

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AU756507B2 (en) * 1998-03-18 2003-01-16 Ajinomoto Co., Inc. L-glutamic acid-producing bacterium and method for producing L-glutamic acid
PE20001128A1 (es) * 1998-10-19 2000-11-14 Ajinomoto Kk Bacteria productora del acido l-glutamico y procedimiento para obtener el acido l-glutamico
CN1067434C (zh) 1998-12-28 2001-06-20 山东大学 一种谷氨酰胺发酵生产工艺
ES2177475T1 (es) * 1999-06-25 2002-12-16 Basf Ag Genes de corynebacterium glutamicum que codifican proteinas de una ruta metabolica.
JP4427878B2 (ja) * 1999-08-20 2010-03-10 味の素株式会社 析出を伴う発酵法によるｌ−グルタミン酸の製造法
JP4304837B2 (ja) * 2000-07-05 2009-07-29 味の素株式会社 Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造法
JP4560998B2 (ja) * 2001-02-05 2010-10-13 味の素株式会社 発酵法によるｌ−グルタミンの製造法及びｌ−グルタミン生産菌
JP2002238592A (ja) * 2001-02-20 2002-08-27 Ajinomoto Co Inc Ｌ−グルタミン酸の製造法
RU2230114C2 (ru) * 2001-11-30 2004-06-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" Мутантная глутаминсинтетаза, фрагмент днк, штамм escherichia coli - продуцент l-глутамина и способ получения l-аминокислот

Also Published As

Publication number Publication date
US20030003550A1 (en) 2003-01-02
JP4560998B2 (ja) 2010-10-13
BRPI0200320B1 (pt) 2016-07-26
EP1229121A3 (de) 2003-03-12
CN1384190A (zh) 2002-12-11
EP1424398A3 (de) 2004-09-22
EP1229121A2 (de) 2002-08-07
DE60208450T2 (de) 2006-08-24
US7262035B2 (en) 2007-08-28
EP1424398A2 (de) 2004-06-02
BR0200320A (pt) 2002-10-29
CN100457894C (zh) 2009-02-04
EP1229121B1 (de) 2006-01-04
JP2002300887A (ja) 2002-10-15
US20070092953A1 (en) 2007-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8381 Inventor (new situation)

Inventor name: NAKAMURA, JUN, C/O AJINOMOTO CO., KAWASAKI-SHI, KA

Inventor name: IZUI, HIROSHI, C/O AJINOMOTO CO., KAWASAKI-SHI, KA

Inventor name: MORIGUCHI, KAYO, C/O AJINOMOTO CO., KAWASAKI-SHI,

Inventor name: KAWASHIMA, HIROKI, C/O AJINOMOTO CO., KAWASAKI-SHI

Inventor name: NAKAMATSU, TSUYOSHI, C/O TOKYO DENKI UNIV. KANADA,

Inventor name: KURAHASHI, OSAMU, C/O AJINOMOTO CO., KAWASAKI-SHI,