DE60038567T2 - Modifiziertes gp100 und dessen verwendung - Google Patents

Modifiziertes gp100 und dessen verwendung Download PDF

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Publication number
DE60038567T2
DE60038567T2 DE60038567T DE60038567T DE60038567T2 DE 60038567 T2 DE60038567 T2 DE 60038567T2 DE 60038567 T DE60038567 T DE 60038567T DE 60038567 T DE60038567 T DE 60038567T DE 60038567 T2 DE60038567 T2 DE 60038567T2
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DE
Germany
Prior art keywords
alvac
nucleic acid
gp100m
modified
virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60038567T
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German (de)
English (en)
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DE60038567D1 (de
Inventor
Neil Toronto BERINSTEIN
James Schenectady TARTAGLIA
Philippe Moingeon
Brian Mississauga BARBER
John A. Scotia TINE
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Sanofi Pasteur Ltd
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Sanofi Pasteur Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001148—Regulators of development
    • A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
    • A61K39/001151—Apoptosis related proteins, e.g. survivin or livin p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/0011—Cancer antigens
    • A61K39/001169—Tumor associated carbohydrates
    • A61K39/00117—Mucins, e.g. MUC-1
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    • A61K39/0011—Cancer antigens
    • A61K39/00118—Cancer antigens from embryonic or fetal origin
    • A61K39/001182—Carcinoembryonic antigen [CEA]
    • A—HUMAN NECESSITIES
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001188—NY-ESO
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    • A61K39/0011—Cancer antigens
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6494—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral-endopeptidase 24.11
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    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24011—Neprilysin (3.4.24.11), i.e. enkephalinase or neutral endopeptidase 24.11
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
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    • C12N2710/24011—Poxviridae
    • C12N2710/24071—Demonstrated in vivo effect

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DE60038567T 1999-10-22 2000-10-20 Modifiziertes gp100 und dessen verwendung Expired - Lifetime DE60038567T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16087999P 1999-10-22 1999-10-22
US160879P 1999-10-22
US22332500P 2000-08-07 2000-08-07
US223325P 2000-08-07
PCT/CA2000/001254 WO2001030847A1 (en) 1999-10-22 2000-10-20 Modified gp100 and uses thereof

Publications (2)

Publication Number Publication Date
DE60038567D1 DE60038567D1 (de) 2008-05-21
DE60038567T2 true DE60038567T2 (de) 2009-05-14

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ID=26857297

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Application Number Title Priority Date Filing Date
DE60038567T Expired - Lifetime DE60038567T2 (de) 1999-10-22 2000-10-20 Modifiziertes gp100 und dessen verwendung
DE60038971T Expired - Lifetime DE60038971D1 (de) 1999-10-22 2000-10-20 Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE60038971T Expired - Lifetime DE60038971D1 (de) 1999-10-22 2000-10-20 Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene

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US (4) US8017590B1 (enExample)
EP (4) EP1227837B1 (enExample)
JP (2) JP4540033B2 (enExample)
AT (2) ATE395930T1 (enExample)
AU (2) AU1013601A (enExample)
CA (3) CA2721011A1 (enExample)
DE (2) DE60038567T2 (enExample)
DK (1) DK1227837T3 (enExample)
ES (1) ES2306670T3 (enExample)
WO (2) WO2001030382A1 (enExample)

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CA2388337A1 (en) 2001-05-03
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