DE60007306T2 - Verwendung von mikrofluidischen systemen zur elektrochemischen detektion von zielanalyten - Google Patents

Verwendung von mikrofluidischen systemen zur elektrochemischen detektion von zielanalyten Download PDF

Info

Publication number
DE60007306T2
DE60007306T2 DE60007306T DE60007306T DE60007306T2 DE 60007306 T2 DE60007306 T2 DE 60007306T2 DE 60007306 T DE60007306 T DE 60007306T DE 60007306 T DE60007306 T DE 60007306T DE 60007306 T2 DE60007306 T2 DE 60007306T2
Authority
DE
Germany
Prior art keywords
sample
nucleic acid
preferred
probe
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60007306T
Other languages
German (de)
English (en)
Other versions
DE60007306D1 (de
Inventor
Faiz Jon KAYYEM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Clinical Micro Sensors Inc
Original Assignee
Clinical Micro Sensors Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clinical Micro Sensors Inc filed Critical Clinical Micro Sensors Inc
Publication of DE60007306D1 publication Critical patent/DE60007306D1/de
Application granted granted Critical
Publication of DE60007306T2 publication Critical patent/DE60007306T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/4473—Arrangements for investigating the separated zones, e.g. localising zones by electric means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54386—Analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0418—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electro-osmotic flow [EOF]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B01L2400/0611—Valves, specific forms thereof check valves duck bill valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y35/00—Methods or apparatus for measurement or analysis of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2610/00—Assays involving self-assembled monolayers [SAMs]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44752—Controlling the zeta potential, e.g. by wall coatings
DE60007306T 1999-04-21 2000-04-21 Verwendung von mikrofluidischen systemen zur elektrochemischen detektion von zielanalyten Expired - Lifetime DE60007306T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/295,691 US6942771B1 (en) 1999-04-21 1999-04-21 Microfluidic systems in the electrochemical detection of target analytes
US295691 1999-04-21
PCT/US2000/010903 WO2000062931A1 (en) 1999-04-21 2000-04-21 The use of microfluidic systems in the electrochemical detection of target analytes

Publications (2)

Publication Number Publication Date
DE60007306D1 DE60007306D1 (de) 2004-01-29
DE60007306T2 true DE60007306T2 (de) 2004-09-16

Family

ID=23138824

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60007306T Expired - Lifetime DE60007306T2 (de) 1999-04-21 2000-04-21 Verwendung von mikrofluidischen systemen zur elektrochemischen detektion von zielanalyten

Country Status (11)

Country Link
US (11) US6942771B1 (US07534331-20090519-C00024.png)
EP (2) EP1183102B1 (US07534331-20090519-C00024.png)
JP (1) JP2002542461A (US07534331-20090519-C00024.png)
AT (1) ATE256500T1 (US07534331-20090519-C00024.png)
AU (1) AU771571B2 (US07534331-20090519-C00024.png)
CA (1) CA2370879A1 (US07534331-20090519-C00024.png)
DE (1) DE60007306T2 (US07534331-20090519-C00024.png)
DK (1) DK1183102T3 (US07534331-20090519-C00024.png)
ES (1) ES2213009T3 (US07534331-20090519-C00024.png)
PT (1) PT1183102E (US07534331-20090519-C00024.png)
WO (1) WO2000062931A1 (US07534331-20090519-C00024.png)

Families Citing this family (342)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
EP0988534B1 (en) 1997-06-12 2011-02-16 Clinical Micro Sensors, Inc. Electronic methods and apparatus for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
US6541617B1 (en) * 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US7312087B2 (en) * 2000-01-11 2007-12-25 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
DE60125713T2 (de) * 2000-01-11 2007-11-08 Clinical Micro Sensors, Inc., Pasadena Patrone, die einen Biochip enthält
US6602400B1 (en) 2000-06-15 2003-08-05 Motorola, Inc. Method for enhanced bio-conjugation events
AU2001288249A1 (en) * 2000-08-14 2002-02-25 The Regents Of The University Of California Biosensors and methods for their use
US6787339B1 (en) 2000-10-02 2004-09-07 Motorola, Inc. Microfluidic devices having embedded metal conductors and methods of fabricating said devices
CA2427669A1 (en) * 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US6767194B2 (en) 2001-01-08 2004-07-27 President And Fellows Of Harvard College Valves and pumps for microfluidic systems and method for making microfluidic systems
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
CA2441206A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
DE10117772C2 (de) * 2001-04-09 2003-04-03 Advalytix Ag Mischvorrichtung und Mischverfahren für die Durchmischung kleiner Flüssigkeitsmengen
DE10123803C1 (de) * 2001-05-16 2002-10-31 Roche Diagnostics Gmbh Elektrochemische Messzelle
US7338760B2 (en) 2001-10-26 2008-03-04 Ntu Ventures Private Limited Sample preparation integrated chip
US7691244B2 (en) * 2001-12-18 2010-04-06 Massachusetts Institute Of Technology Microfluidic pumps and mixers driven by induced-charge electro-osmosis
US6532997B1 (en) 2001-12-28 2003-03-18 3M Innovative Properties Company Sample processing device with integral electrophoresis channels
JP3740528B2 (ja) * 2002-02-05 2006-02-01 独立行政法人産業技術総合研究所 微細粒子製造方法
WO2003068906A1 (en) * 2002-02-12 2003-08-21 Cellectricon Ab Systems and methods for rapidly changing the solution environment around sensors
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
DE10224567B4 (de) * 2002-06-03 2014-10-23 Boehringer Ingelheim Vetmedica Gmbh Sensor-Anordnung und Verfahren zum Betreiben einer Sensor-Anordnung
JP4106977B2 (ja) 2002-06-21 2008-06-25 株式会社日立製作所 分析チップ及び分析装置
US20040018577A1 (en) * 2002-07-29 2004-01-29 Emerson Campbell John Lewis Multiple hybrid immunoassay
US20040099531A1 (en) * 2002-08-15 2004-05-27 Rengaswamy Srinivasan Methods and apparatus for electrochemically testing samples for constituents
US7250602B2 (en) * 2002-08-26 2007-07-31 Osaka University Probe device
WO2004029221A2 (en) * 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
AU2003278461A1 (en) 2002-10-16 2004-05-04 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
GB0227765D0 (en) * 2002-11-28 2003-01-08 Secr Defence Apparatus for processing a fluid sample
WO2004067444A1 (en) * 2003-01-30 2004-08-12 Gyros Ab Inner walls of microfluidic devices
DE10305050A1 (de) 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
CA2526946A1 (en) 2003-05-14 2005-04-07 Nantero, Inc. Sensor platform using a non-horizontally oriented nanotube element
US7238269B2 (en) 2003-07-01 2007-07-03 3M Innovative Properties Company Sample processing device with unvented channel
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
GB2404739B (en) * 2003-08-05 2006-04-12 E2V Tech Uk Ltd Sensor
US7396677B2 (en) * 2003-11-07 2008-07-08 Nanosphere, Inc. Method of preparing nucleic acids for detection
US7250775B1 (en) * 2003-11-12 2007-07-31 The Regents Of The University Of California Microfluidic devices and methods based on measurements of electrical admittance
WO2005052578A1 (ja) * 2003-11-28 2005-06-09 Olympus Corporation 生体関連物質の検査装置とその反応ステージ
US8293471B2 (en) * 2004-01-28 2012-10-23 Marshall University Research Corporation Apparatus and method for a continuous rapid thermal cycle system
GB2416030B (en) * 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA2994321C (en) 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
US7402616B2 (en) 2004-09-30 2008-07-22 Lifescan, Inc. Fusible conductive ink for use in manufacturing microfluidic analytical systems
US8883487B2 (en) 2004-12-23 2014-11-11 Abbott Point Of Care Inc. Molecular diagnostics system and methods
US20090035800A1 (en) * 2004-12-24 2009-02-05 Aartsma T J Novel Use of Fluorescence Resonance Energy Transfer
JP4583937B2 (ja) * 2005-01-07 2010-11-17 積水化学工業株式会社 砒素イオンの電気化学測定方法
US20060166223A1 (en) * 2005-01-26 2006-07-27 Reed Michael W DNA purification and analysis on nanoengineered surfaces
DE102005013762C5 (de) * 2005-03-22 2012-12-20 Sew-Eurodrive Gmbh & Co. Kg Elektronisches Gerät und Verfahren zur Bestimmung der Temperatur eines Leistungshalbleiters
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
GB0508983D0 (en) 2005-05-03 2005-06-08 Oxford Gene Tech Ip Ltd Cell analyser
US20060286549A1 (en) * 2005-05-06 2006-12-21 The Regents Of The University Of California Microfluidic system for identifying or sizing individual particles passing through a channel
US7635594B2 (en) 2005-05-09 2009-12-22 Theranos, Inc. Point-of-care fluidic systems and uses thereof
US20070072287A1 (en) * 2005-05-23 2007-03-29 Biovitesse, Inc. Biomems cartridges
WO2006132666A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
JP4660662B2 (ja) * 2005-09-06 2011-03-30 アークレイ株式会社 カートリッジ
CN101258397B (zh) * 2005-07-14 2012-07-04 毫微创新科技公司 微流装置和制备及使用方法
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
JP4699840B2 (ja) * 2005-08-31 2011-06-15 ローム株式会社 バイオチップ及び免疫分析方法
KR100697292B1 (ko) * 2005-10-04 2007-03-20 삼성전자주식회사 반도체 장치 및 그 형성 방법
CN101317086B (zh) * 2005-10-04 2013-08-14 海德威技术公司 分析物的微观流体检测
WO2008042003A2 (en) * 2006-01-12 2008-04-10 Biosense Technologies, Inc. Method and composition for rapid viability testing of cells
US20070170056A1 (en) * 2006-01-26 2007-07-26 Arnold Don W Microscale electrochemical cell and methods incorporating the cell
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7909928B2 (en) * 2006-03-24 2011-03-22 The Regents Of The University Of Michigan Reactive coatings for regioselective surface modification
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
GB2436616A (en) * 2006-03-29 2007-10-03 Inverness Medical Switzerland Assay device and method
JP4664846B2 (ja) * 2006-03-29 2011-04-06 株式会社東芝 核酸検出用デバイス
ITTO20060273A1 (it) * 2006-04-12 2007-10-13 Silicon Biosystem S P A Metodi ed apparati per la selezione e/o il processamento di particellle, in particolare per la lisi selettiva e/o ottimizzata di cellule
ITTO20060278A1 (it) 2006-04-13 2007-10-14 Silicon Biosystem S P A Metodo per la selezione e/o il processamento di particelle, in particolare cellule
JP4167697B2 (ja) * 2006-04-13 2008-10-15 株式会社東芝 核酸検出用デバイス
US7851184B2 (en) 2006-04-18 2010-12-14 Advanced Liquid Logic, Inc. Droplet-based nucleic acid amplification method and apparatus
EP2021514A2 (en) 2006-05-10 2009-02-11 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
US20100216657A1 (en) * 2006-05-16 2010-08-26 Arcxis Biotechnologies, Inc. Pcr-free sample preparation and detection systems for high speed biologic analysis and identification
CA2652626A1 (en) * 2006-05-19 2008-01-03 The Governors Of The University Of Alberta Microfluidic methods for nucleic acid monitoring
US10741034B2 (en) 2006-05-19 2020-08-11 Apdn (B.V.I.) Inc. Security system and method of marking an inventory item and/or person in the vicinity
US7947148B2 (en) 2006-06-01 2011-05-24 The Regents Of The University Of Michigan Dry adhesion bonding
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8349604B2 (en) * 2006-06-15 2013-01-08 University Of South Florida Nano-based device for detection of disease biomarkers and other target molecules
US20080100279A1 (en) * 2006-06-15 2008-05-01 University Of South Florida Nano-Based Device for Detection of Disease Biomarkers and Other Target Molecules
US7608399B2 (en) * 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20080032311A1 (en) * 2006-08-04 2008-02-07 Zhenghua Ji Low volume mixing of sample
US7516658B2 (en) 2006-09-29 2009-04-14 Rosemount Inc. Electro-kinetic pressure/flow sensor
CN101589157B (zh) 2006-10-06 2014-04-02 万达利亚研究公司 用于连续快速热循环系统的方法
EP2089410A4 (en) * 2006-10-11 2011-08-03 Arcxis Biotechnologies Inc DISPOSABLE MICRO-PURIFICATION CARDS, METHODS AND SYSTEMS THEREOF
EP2091647A2 (en) 2006-11-14 2009-08-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
JP4884180B2 (ja) * 2006-11-21 2012-02-29 東京エレクトロン株式会社 基板処理装置および基板処理方法
JP5240945B2 (ja) * 2006-11-28 2013-07-17 ピクター リミテッド アッセイ膜およびその使用法
WO2008090557A2 (en) * 2007-01-23 2008-07-31 Yeda Research And Development Co. Ltd. Microfluidic devices and methods of generating and using same
US20080182136A1 (en) * 2007-01-26 2008-07-31 Arnold Don W Microscale Electrochemical Cell And Methods Incorporating The Cell
US20090107335A1 (en) 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
EP2136716A2 (en) * 2007-03-14 2009-12-30 Ogeno Gmbh Biopsy device for the in vivo enrichment of tissue, cells, or analytes
US8399047B2 (en) * 2007-03-22 2013-03-19 The Regents Of The Univeristy Of Michigan Multifunctional CVD coatings
US20100151465A1 (en) 2008-03-27 2010-06-17 Jingyue Ju Selective Capture and Release of Analytes
WO2008131048A2 (en) * 2007-04-16 2008-10-30 Cellpoint Diagnotics, Inc. Devices and methods for diagnosing, prognosing, or theranosing a condition by enriching rare cells
CN101038284B (zh) 2007-04-25 2011-04-27 博奥生物有限公司 一种提高电阻抗检测装置的电阻抗检测灵敏度的方法
EP2803992B1 (en) * 2007-04-27 2021-02-17 ARKRAY, Inc. Sample analyzing method by capillary electrophoresis method
US8431090B2 (en) 2007-06-29 2013-04-30 The Trustees Of Columbia University In The City Of New York Microfluidic device for counting biological particles
US8921121B2 (en) * 2007-06-29 2014-12-30 The Trustees Of Columbia University In The City Of New York Methods, devices, and systems for chemiluminescence-based microfluidic cell counting
US8324372B2 (en) 2007-07-13 2012-12-04 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
AU2008276308A1 (en) * 2007-07-13 2009-01-22 The Board Of Trustees Of The Leland Stanford Junior University Method and apparatus using electric field for improved biological assays
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
EP2178640A1 (en) * 2007-08-03 2010-04-28 Enigma Diagnostics Limited Reaction vessel
GB0715170D0 (en) * 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Reaction vessel
US8308926B2 (en) 2007-08-20 2012-11-13 Purdue Research Foundation Microfluidic pumping based on dielectrophoresis
EP2201136B1 (en) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment
US8789536B2 (en) 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
WO2009049675A1 (en) * 2007-10-17 2009-04-23 Agilent Technologies, Inc. Measurement device with motion-triggered data exchange
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8303573B2 (en) 2007-10-17 2012-11-06 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808271B2 (en) 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8109920B2 (en) * 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
JP4516107B2 (ja) * 2007-12-19 2010-08-04 株式会社東芝 塩基配列判定方法、塩基配列判定システム及び塩基配列判定プログラム
WO2009117167A1 (en) * 2008-01-02 2009-09-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US20090227476A1 (en) * 2008-03-07 2009-09-10 Applied Microarrays, Inc. Amplification and microarray detection apparatus and methods of making
CN101556273B (zh) * 2008-04-08 2013-03-20 博奥生物有限公司 利用电阻抗传感技术分析细胞迁移的方法及其专用装置
US20090269746A1 (en) * 2008-04-25 2009-10-29 Gil Atzmon Microsequencer-whole genome sequencer
WO2009139898A2 (en) 2008-05-16 2009-11-19 President And Fellows Of Harvard College Valves and other flow control in fluidic systems including microfluidic systems
US9879360B2 (en) * 2008-06-20 2018-01-30 International Business Machines Corporation Microfluidic selection of library elements
CN101614729B (zh) * 2008-06-27 2013-04-24 博奥生物有限公司 用于细胞操作及电生理信号检测的微电极阵列器件及专用装置
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
WO2010026488A2 (en) * 2008-09-03 2010-03-11 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
JP5717634B2 (ja) 2008-09-03 2015-05-13 ナブシス， インコーポレイテッド 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
CA3069081C (en) 2008-09-20 2023-05-23 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
AU2009313556A1 (en) * 2008-11-04 2010-05-14 Blood Cell Storage, Inc. Nucleic acid extraction on curved glass surfaces
US8608926B2 (en) * 2008-11-20 2013-12-17 Neroxis Sa Amperometric in-pipe electrochemical sensing probe
WO2010091406A2 (en) * 2009-02-09 2010-08-12 Forensic Science Service Limited Improvements in and relating to devices
US8357279B2 (en) * 2009-02-23 2013-01-22 Carnegie Mellon University Methods, apparatus and systems for concentration, separation and removal of particles at/from the surface of drops
DK2414544T3 (da) * 2009-04-01 2014-06-16 Dxterity Diagnostics Inc Probe-amplifikations-afhængig kemisk ligering
US9114395B2 (en) 2009-04-15 2015-08-25 Koninklijke Philips N.V. Cartridge for an amplification process
US9090663B2 (en) * 2009-04-21 2015-07-28 The Trustees Of Columbia University In The City Of New York Systems and methods for the capture and separation of microparticles
TW201039872A (en) * 2009-05-01 2010-11-16 Top Vision Medical Equipment Consultant Co Ltd Gas delivery mask with features of detection and adjustment of temperature and humidity
US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
TWI425207B (zh) * 2009-06-11 2014-02-01 Eps Bio Technology Corp 生化感測試片
US9182411B2 (en) * 2009-07-14 2015-11-10 Colen Innovations, L.L.C. Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample
RU2012104780A (ru) 2009-07-20 2013-08-27 Сайлоам Байосайенсиз, Инк. Микрожидкостные аналитические платформы
EP2456894A4 (en) 2009-07-23 2013-09-25 Chromatin Inc CENTROMER SEQUENCES AND SORGHUM MINI-CHROMOSOMES
CA2770071C (en) 2009-08-07 2014-07-15 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immunoassay
US9250234B2 (en) 2011-01-19 2016-02-02 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-TRACE) immunoassay
GB0914762D0 (en) 2009-08-24 2009-09-30 Univ Glasgow Fluidics apparatus and fluidics substrate
WO2011036650A2 (en) 2009-09-28 2011-03-31 Koninklijke Philips Electronics N.V. Sensor device with imaging optics
FR2950699A1 (fr) * 2009-09-29 2011-04-01 Centre Nat Rech Scient Dispositif a usage unique pour la detection de particules d'interet, telles que des entites biologiques, systeme de detection comprenant ledit dispositif et procede de mise en oeuvre
WO2011044116A2 (en) * 2009-10-05 2011-04-14 The Charles Stark Draper Laboratory, Inc. Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US10001476B2 (en) 2009-10-28 2018-06-19 Genmark Diagnostics, Inc. Capture ligand controls, blocking probes, masking probes and methods of using the same
TWI421495B (zh) * 2009-10-30 2014-01-01 Univ Nat Cheng Kung 微流體晶片
WO2011051718A2 (en) * 2009-11-02 2011-05-05 Ffei Limited Micro-channel structure method and apparatus
JP5792181B2 (ja) 2009-11-23 2015-10-07 ブリマン、ミカイル 炭素系電極の制御された電気化学的活性化
US20110127034A1 (en) * 2009-11-30 2011-06-02 Schlumberger Technology Corporation Preparation of setting slurries
ES2588703T3 (es) * 2009-12-07 2016-11-04 Meso Scale Technologies, Llc. Un cartucho de ensayo
EP2536818B1 (en) * 2010-02-18 2018-10-03 Bima Limited Immobilised-bead immunomultiplex assay
US8596354B2 (en) 2010-04-02 2013-12-03 Schlumberger Technology Corporation Detection of tracers used in hydrocarbon wells
US8452037B2 (en) 2010-05-05 2013-05-28 Apple Inc. Speaker clip
US20120034638A1 (en) 2010-05-21 2012-02-09 Michael Ahrens Electrochemical assay for the detection of enzymatically active PSA
US8715933B2 (en) * 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
TWI495727B (zh) * 2010-10-08 2015-08-11 Nat Applied Res Laboratories 微型電化學多重即時定量聚合酶連鎖反應(ｐｃｒ)系統
EP2632593B1 (en) 2010-10-27 2021-09-29 Illumina, Inc. Flow cells for biological or chemical analysis
US9387476B2 (en) 2010-10-27 2016-07-12 Illumina, Inc. Flow cells for biological or chemical analysis
DE102010064391A1 (de) 2010-10-29 2012-05-03 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Verfahren zur Bestimmung eines Analytgehalts einer Flüssigkeitsprobe mittels eines Bioanalysators
US8859201B2 (en) 2010-11-16 2014-10-14 Nabsys, Inc. Methods for sequencing a biomolecule by detecting relative positions of hybridized probes
US9052309B2 (en) 2010-12-03 2015-06-09 Abbott Point Of Care Inc. Ratiometric immunoassay method and blood testing device
CN103282125B (zh) * 2010-12-03 2015-05-20 雅培医护站股份有限公司 具有整合的样品稀释的样品计量装置和测定装置
US9057702B2 (en) * 2010-12-21 2015-06-16 The Regents Of The University Of California Compact wide-field fluorescent imaging on a mobile device
US20120225491A1 (en) * 2010-12-30 2012-09-06 Ayal Ram Portable detection devices and methods for detection of biomarkers and other analytes
KR101226655B1 (ko) * 2011-01-28 2013-01-25 서강대학교산학협력단 전기화학적 방법을 기반으로 한 세포 주기 측정 방법
WO2012109574A2 (en) 2011-02-11 2012-08-16 Nabsys, Inc. Assay methods using dna binding proteins
US8922860B2 (en) * 2011-02-22 2014-12-30 Corning Incorporated Motion control systems and methods for biosensor scanning
GB201103211D0 (en) 2011-02-24 2011-04-13 Univ Glasgow Fluidics apparatus, use of fluidics apparatus and process for the manufacture of fluidics apparatus
WO2012122564A2 (en) * 2011-03-10 2012-09-13 Xagenic, Inc. Diagnostic and sample preparation devices and methods
US8399262B2 (en) 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
BR112013026451B1 (pt) 2011-04-15 2021-02-09 Becton, Dickinson And Company sistema e método para realizar ensaios de diagnóstico molecular em várias amostras em paralelo e simultaneamente amplificação em tempo real em pluralidade de câmaras de reação de amplificação
EP2710145B1 (en) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Methods and compositions for detecting target nucleic acids
WO2012159063A2 (en) 2011-05-19 2012-11-22 Blood Cell Strorage, Inc. Gravity flow fluidic device for nucleic acid extraction
US8447443B1 (en) 2011-06-21 2013-05-21 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Systems and methods for peak-seeking control
US20130087467A1 (en) * 2011-06-24 2013-04-11 Hongjun Yang High-performance analytical instrument and method
US10080526B2 (en) * 2011-07-13 2018-09-25 Leidos Innovations Technology, Inc. Three dimensional microfluidic multiplexed diagnostic system
US9638663B2 (en) 2011-07-25 2017-05-02 Proxim Diagnostics Corporation Cartridge for diagnostic testing
WO2013019714A1 (en) 2011-07-29 2013-02-07 The Trustees Of Columbia University In The City Of New York Mems affinity sensor for continuous monitoring of analytes
WO2013044217A1 (en) * 2011-09-23 2013-03-28 The Trustees Of Columbia University In The City Of New York Isolation and enrichment of nucleic acids on microchip
JP6117217B2 (ja) 2011-09-30 2017-04-19 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ ユニット化された試薬ストリップ
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
JP6203183B2 (ja) 2011-10-17 2017-09-27 オームクス コーポレイション 酵素誘発レドックス変化化学的脱離（ｅ−ｔｒａｃｅ）イムノアッセイを使用する、ヘモグロビンａ１ｃのパーセンテージの単回直接検出
EP2773892B1 (en) 2011-11-04 2020-10-07 Handylab, Inc. Polynucleotide sample preparation device
CA2854459A1 (en) 2011-11-04 2013-05-10 Ohmx Corporation Novel chemistry used in biosensors
US9873119B2 (en) * 2011-12-28 2018-01-23 Ibis Biosciences, Inc. Multiple- analyte assay device and system
EP2802669A1 (en) 2012-01-09 2014-11-19 Ohmx Corporation Enzyme cascade methods for e-trace assay signal amplification
US10822644B2 (en) 2012-02-03 2020-11-03 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9409175B2 (en) * 2012-02-28 2016-08-09 Arkray, Inc. Mixing apparatus
JP6013519B2 (ja) 2012-03-13 2016-10-25 ピラマル エンタープライズィズ リミテッドＰｉｒａｍａｌ Ｅｎｔｅｒｐｒｉｓｅｓ Ｌｉｍｉｔｅｄ 統合された電気化学的免疫測定に基づくマイクロ流体デバイス、及びその基板
DK2825309T3 (en) 2012-03-16 2018-07-30 Stat Diagnostica & Innovation Sl Sample cartridge with integrated transfer module
ES2485377T3 (es) * 2012-05-15 2014-08-13 Omicron Electronics Gmbh Dispositivo de prueba, sistema de prueba y procedimiento de prueba de un objeto de prueba de ingeniería eléctrica
US20140299468A1 (en) * 2012-06-25 2014-10-09 Hongjun Yang High-Performance Analytical Instrument and Method
WO2014004563A1 (en) * 2012-06-25 2014-01-03 The Arizona Board Of Regents On Behalf Of The University Of Arizona Electrokinetic polymerase chain reaction (pcr) devices and methods
EP2877851A1 (en) 2012-07-27 2015-06-03 Ohmx Corporation Electric measurement of monolayers following pro-cleave detection of presence and activity of enzymes and other target analytes
US9404883B2 (en) 2012-07-27 2016-08-02 Ohmx Corporation Electronic measurements of monolayers following homogeneous reactions of their components
WO2014022700A2 (en) * 2012-08-01 2014-02-06 Prakash Ranjit A Functionally integrated device for multiplex genetic identification and method for separation and detection of dna fragments
US20140200167A1 (en) 2012-08-01 2014-07-17 Nanomdx, Inc. Functionally integrated device for multiplex genetic identification
EP2890497B1 (en) 2012-08-30 2018-07-04 Life Technologies Corporation Vertical clamp device
MX2015003431A (es) * 2012-09-19 2015-06-22 Universal Biosensors Pty Ltd Sistemas y metodos para la deteccion de enzimas.
US9820033B2 (en) 2012-09-28 2017-11-14 Apple Inc. Speaker assembly
EP3427830B1 (en) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrated multiplex target analysis
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
WO2014078521A1 (en) * 2012-11-14 2014-05-22 The Trustees Of Columbia University In The City Of New York Isolation and enrichment of nucleic acids on microchip
WO2014081460A1 (en) * 2012-11-20 2014-05-30 Kisner Mark Chemical sequencing and control to expand and enhance detection capabilities utilizing a colorimetric test
WO2014085926A1 (en) * 2012-12-03 2014-06-12 Vladimir Evtodienko Pressure assisted lateral flow diagnostic device
US8872328B2 (en) * 2012-12-19 2014-10-28 General Electric Company Integrated power module package
US9914966B1 (en) 2012-12-20 2018-03-13 Nabsys 2.0 Llc Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
AU2014203992B2 (en) * 2013-01-04 2018-03-22 Meso Scale Technologies, Llc. Assay apparatuses, methods and reagents
US10294516B2 (en) 2013-01-18 2019-05-21 Nabsys 2.0 Llc Enhanced probe binding
WO2014127409A1 (en) * 2013-02-19 2014-08-28 The University Of Queensland Device and method for the detection of target entities
US10309947B2 (en) 2013-02-27 2019-06-04 Trace-Ability, Inc. System and method for radiosynthesis, quality control and dose dispensing
US9963740B2 (en) 2013-03-07 2018-05-08 APDN (B.V.I.), Inc. Method and device for marking articles
WO2014164654A1 (en) * 2013-03-11 2014-10-09 The University Of Toledo A biosensor device to target analytes in situ, in vivo, and/or in real time, and methods of making and using the same
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
IL297030B2 (en) 2013-03-11 2024-03-01 Cue Health Inc A method for activating fluid flow within a microfluidic cartridge
US9222623B2 (en) 2013-03-15 2015-12-29 Genmark Diagnostics, Inc. Devices and methods for manipulating deformable fluid vessels
WO2015019194A2 (en) * 2013-08-07 2015-02-12 Xagenic Inc. Systems, methods and devices for electrochemical detection using helper oligonucleotides
WO2015042493A2 (en) 2013-09-20 2015-03-26 Ohmx Corporation Psa enzymatic activity: a new biomarker for assessing prostate cancer aggressiveness
CA2926436A1 (en) 2013-10-07 2015-04-16 Judith Murrah Multimode image and spectral reader
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
KR101562865B1 (ko) * 2014-01-24 2015-10-26 한국과학기술연구원 신경 영양인자를 감지하기 위한 초소형 센서 시스템
KR101618113B1 (ko) * 2014-02-10 2016-05-09 나노바이오시스 주식회사 일 방향 슬라이딩 구동 수단을 구비하는 pcr 장치 및 이를 이용하는 pcr 방법
US10895563B2 (en) 2014-02-26 2021-01-19 Trace-Ability, Inc. Palette-based systems for analyte characterization
US11002717B2 (en) 2014-02-26 2021-05-11 Trace-Ability, Inc. Systems and methods for characterizing radioactive analytes
US10309921B2 (en) * 2014-03-03 2019-06-04 The Florida International University Board Of Trustees Label-free electrochemical biosensor
US10745825B2 (en) 2014-03-18 2020-08-18 Apdn (B.V.I.) Inc. Encrypted optical markers for security applications
WO2015142990A1 (en) 2014-03-18 2015-09-24 Apdn (B.V.I.) Inc. Encryped optical markers for security applications
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
US9451354B2 (en) 2014-05-12 2016-09-20 Apple Inc. Liquid expulsion from an orifice
CN106879252B (zh) 2014-06-10 2020-07-17 德克斯特里蒂诊断公司 用于收集和稳定生物样品的装置及方法
WO2016012870A1 (en) * 2014-07-22 2016-01-28 Bhat, Shama System for the characterization of nucleic acid and detection of dna amplification using electrical method
US10137423B2 (en) * 2014-07-30 2018-11-27 Schlumberger Technology Corporation Devices and methods for measuring analyte concentration
WO2016022696A1 (en) 2014-08-05 2016-02-11 The Trustees Of Columbia University In The City Of New York Method of isolating aptamers for minimal residual disease detection
WO2016019428A1 (en) * 2014-08-08 2016-02-11 Kimiya Pty. Ltd. Diagnostic, prognostic, and analytical system
WO2016020775A1 (en) * 2014-08-08 2016-02-11 Kimiya Pty. Ltd. Diagnostic, prognostic, and analytical system
WO2016025539A1 (en) 2014-08-11 2016-02-18 Ohmx Corporation Enzyme triggered redox altering chemical elimination (-trace) assay with multiplexing capabilities
US10913973B2 (en) 2014-09-17 2021-02-09 Board Of Regents, The University Texas System Methods and devices related to toehold-based strand displacement with loop-mediated isothermal amplification
DK3198284T3 (da) * 2014-09-27 2022-05-09 Trace Ability Inc Paletbaserede systemer til analytkarakterisering
AU2015346527A1 (en) 2014-11-11 2017-06-29 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
GB201420061D0 (en) 2014-11-11 2014-12-24 Univ Glasgow Nebulisation of liquids
US20160178562A1 (en) 2014-12-19 2016-06-23 Ohmx Corporation Competitive enzymatic assay
KR102336308B1 (ko) * 2014-12-26 2021-12-09 주식회사 미코바이오메드 반복 슬라이딩 구동 수단을 구비하는 pcr 장치 및 이를 이용하는 pcr 방법
CN107614421B (zh) * 2015-01-30 2021-04-30 惠普发展公司，有限责任合伙企业 微流体传输
TWI534426B (zh) * 2015-03-27 2016-05-21 國立清華大學 生物檢測方法
WO2016200922A1 (en) 2015-06-12 2016-12-15 Cytochip Inc. Fluidic units and cartridges for multi-analyte analysis
US10634602B2 (en) 2015-06-12 2020-04-28 Cytochip Inc. Fluidic cartridge for cytometry and additional analysis
US10077999B2 (en) 2015-07-14 2018-09-18 Cytochip Inc. Volume sensing in fluidic cartridge
EP3307885B1 (en) * 2015-06-15 2020-10-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
US9900698B2 (en) 2015-06-30 2018-02-20 Apple Inc. Graphene composite acoustic diaphragm
CN117310193A (zh) 2015-07-17 2023-12-29 克忧健康公司 用于增强检测和分析物定量的系统及方法
WO2017018977A1 (en) 2015-07-24 2017-02-02 Hewlett-Packard Development Company, L.P. Light guide for fluid testing cells
KR101691508B1 (ko) * 2015-09-03 2016-12-30 한국과학기술연구원 유체 전달 채널이 형성된 커버 부재를 포함하는 신경 탐침 구조체
EP3138920B1 (en) * 2015-09-07 2018-06-13 Miltenyi Biotec GmbH Disposable cartridge for electroporation
US10859563B2 (en) * 2015-12-01 2020-12-08 General Electric Company Erythrocyte aggregation and leukocyte isolation
WO2017180302A1 (en) 2016-04-11 2017-10-19 Apdn (B.V.I.) Inc. Method of marking cellulosic products
DE102016209904A1 (de) * 2016-06-06 2017-12-07 Robert Bosch Gmbh Verfahren und mikrofluidische Vorrichtung zum Verarbeiten einer Probe biologischen Materials
WO2018027107A1 (en) 2016-08-05 2018-02-08 Trustees Of Boston University Method and device for antibiotic susceptibility testing based on fluctuations of electrical resistance in a microchannel
US11300578B2 (en) 2016-09-19 2022-04-12 Roche Molecular Systems, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
CN109790571A (zh) 2016-10-07 2019-05-21 勃林格殷格翰维特梅迪卡有限公司 用于检测样品的方法及分析系统
JP2019536441A (ja) * 2016-10-07 2019-12-19 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ サンプルを検査するための分析システム及び方法
BR112019006655A2 (pt) 2016-10-07 2019-07-02 Boehringer Ingelheim Vetmedica Gmbh método e sistema de análise para testagem de uma amostra
US10995371B2 (en) 2016-10-13 2021-05-04 Apdn (B.V.I.) Inc. Composition and method of DNA marking elastomeric material
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
WO2018156352A1 (en) 2017-02-21 2018-08-30 Apdn (B.V.I) Inc. Nucleic acid coated submicron particles for authentication
US10648955B2 (en) * 2017-02-24 2020-05-12 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Online chemical derivatization using a cooled programmed temperature vaporization inlet
US11299776B2 (en) 2017-05-10 2022-04-12 Board Of Regents, The University Of Texas System Methods and devices related to amplifying nucleic acid at a variety of temperatures
WO2019013825A1 (en) * 2017-07-14 2019-01-17 Hewlett-Packard Development Company, L.P. MICROFLUIDIC VALVE
EP3655160A4 (en) * 2017-07-19 2021-04-07 Evanostics, LLC ORAL FLUID ANALYSIS CARTRIDGES AND METHODS OF USE
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
WO2019040769A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) ELECTROCHEMICAL DETECTION OF BACTERIAL AND / OR FUNGAL INFECTIONS
EP3655158A1 (en) * 2017-09-07 2020-05-27 Sony Corporation Particle capturing chamber, particle capturing chip, particle capturing method, apparatus, and particle analysis system
US11307661B2 (en) 2017-09-25 2022-04-19 Apple Inc. Electronic device with actuators for producing haptic and audio output along a device housing
US11491487B2 (en) 2017-10-23 2022-11-08 Cytochip Inc. Devices and methods for measuring analytes and target particles
US11009480B2 (en) * 2017-11-07 2021-05-18 Amrita Vishwa Vidyapeetham Lab on a chip device for multi-analyte detection and a method of fabrication thereof
EP4140396A1 (en) 2017-11-21 2023-03-01 MX3 Diagnostics, Inc. Saliva testing system and method
EP3724636A4 (en) 2017-12-15 2021-08-18 Evanostics, LLC OPTICAL READER FOR ANALYTE TEST
US10935561B2 (en) 2018-06-01 2021-03-02 Genmark Diagnostics, Inc. Integrated diagnostic instrument
US10757491B1 (en) 2018-06-11 2020-08-25 Apple Inc. Wearable interactive audio device
US10873798B1 (en) 2018-06-11 2020-12-22 Apple Inc. Detecting through-body inputs at a wearable audio device
EP3807628A4 (en) * 2018-06-14 2022-03-16 Coastal Genomics Inc. DEVICE FOR CAPTURING MACROMOLECULES AND METHOD OF PRODUCTION AND USE THEREOF
US10948450B2 (en) 2018-07-23 2021-03-16 Genmark Diagnostics, Inc. Electrochemical measurements of components in coatings
US11334032B2 (en) 2018-08-30 2022-05-17 Apple Inc. Electronic watch with barometric vent
KR102401909B1 (ko) * 2018-08-30 2022-05-24 주식회사 엘지화학 반응 최적화를 위한 고속 스크리닝 분석 시스템
US11198128B2 (en) 2018-09-05 2021-12-14 International Business Machines Corporation Microfluidic device with array of chambers for encoding detectable information
US11561144B1 (en) 2018-09-27 2023-01-24 Apple Inc. Wearable electronic device with fluid-based pressure sensing
WO2020122922A1 (en) * 2018-12-13 2020-06-18 Hewlett-Packard Development Company, L.P. Multiplex nucleic acid detection
WO2020159545A1 (en) 2019-02-01 2020-08-06 Hewlett-Packard Development Company, L.P. Chemical lysis systems
CN114399014A (zh) 2019-04-17 2022-04-26 苹果公司 无线可定位标签
US20200333286A1 (en) * 2019-04-18 2020-10-22 University Of Florida Research Foundation, Inc. Modularized inexpensive detection of cerebral spinal fluid for medical applications
US11701036B2 (en) * 2019-07-10 2023-07-18 MX3 Diagnostics, Inc. Saliva test strip and method
CN110346579B (zh) * 2019-07-24 2023-07-07 中国科学院重庆绿色智能技术研究院 基于纳米孔的体外hiv蛋白酶检测仪器及方法
WO2021086954A1 (en) * 2019-10-29 2021-05-06 Quantum-Si Incorporated Methods and devices using cartridges for sequencing
MX2022005186A (es) * 2019-10-29 2022-08-08 Quantum Si Inc Sistemas y metodos para preparacion de muestras.
CN110975948A (zh) * 2019-11-06 2020-04-10 佛山市铬维科技有限公司 微流控细胞计数仪
CN115003827A (zh) * 2020-01-29 2022-09-02 密歇根大学董事会 分析物检测
AU2021212727A1 (en) 2020-01-30 2022-09-22 MX3 Diagnostics, Inc. Biological fluid sample assessment
US20230287479A1 (en) * 2020-07-21 2023-09-14 Hewlett-Packard Development Company, L.P. Identifying target nucleic acids using immobilized nuclease
CN116547537A (zh) 2020-07-29 2023-08-04 皮克托有限公司 SARS-CoV-2抗体免疫测定
TW202223378A (zh) * 2020-12-14 2022-06-16 國立中央大學 複合式細胞成像與生化檢測晶片及其使用方法
WO2022221618A1 (en) * 2021-04-16 2022-10-20 New York University Bone marrow on a chip
CN113893892B (zh) * 2021-11-10 2023-02-10 大连海事大学 一种基于微流控芯片的纳米孔及其制备方法
US20230302445A1 (en) * 2022-03-22 2023-09-28 Perkinelmer Health Sciences, Inc. Microfluidic chip and electrical interface for microchip electrophoresis

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171912A (en) 1981-04-14 1982-10-22 Sumitomo Chem Co Ltd Cream
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1219824A (en) 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US5241060A (en) 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US5509410A (en) 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
DE3479522D1 (en) 1983-12-16 1989-09-28 Medisense Inc Assay for nucleic acids
US4849513A (en) 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
US5175269A (en) 1984-01-30 1992-12-29 Enzo Diagnostics, Inc. Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group
US4707352A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
US5002885A (en) 1984-01-30 1991-03-26 Enzo Biochem, Inc. Detectable molecules, method preparation and use
US4707440A (en) 1984-01-30 1987-11-17 Enzo Biochem, Inc. Nucleic acid hybridization assay and detectable molecules useful in such assay
US4943523A (en) 1984-01-30 1990-07-24 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US4952685A (en) 1984-01-30 1990-08-28 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
US5013831A (en) 1984-01-30 1991-05-07 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
CA1260372A (en) 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4755458A (en) 1984-08-30 1988-07-05 Enzo Biochem, Inc. Composition and method for the detection of the presence of a polynucleotide sequence of interest
US5112974A (en) 1985-01-18 1992-05-12 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents to DNA
US4965188A (en) * 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5595908A (en) 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1254945A (en) 1986-02-27 1989-05-30 Marco F. Cardosi Application of tetrathiafulvalenes in bioelectrochemical processes
US4822746A (en) 1986-06-25 1989-04-18 Trustees Of Tufts College Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5114864A (en) 1986-06-25 1992-05-19 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using fluid erodible controlled release polymers for delivery of reagent formulations
JPS63238166A (ja) 1987-03-26 1988-10-04 Mitsubishi Electric Corp 有機電子素子材料
US5192507A (en) 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
GB8720470D0 (en) 1987-08-29 1987-10-07 Emi Plc Thorn Sensor arrangements
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US4908319A (en) * 1988-03-16 1990-03-13 Smyczek Peter J Laboratory apparatus
US5320808A (en) * 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
US5106751A (en) * 1988-09-15 1992-04-21 Biotronic Systems Corporation Apparatus for supporting a biochemical sensor responsive to bubbles
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5200051A (en) * 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
US5071531A (en) 1989-05-01 1991-12-10 Soane Technologies, Inc. Casting of gradient gels
US5061336A (en) 1989-05-01 1991-10-29 Soane Technologies, Inc. Gel casting method and apparatus
US5110745A (en) 1989-06-01 1992-05-05 The Trustees Of The University Of Pennsylvania Methods of detecting glycated proteins
AU642444B2 (en) * 1989-11-30 1993-10-21 Mochida Pharmaceutical Co., Ltd. Reaction vessel
CA2033692A1 (en) 1990-01-25 1991-07-26 Wilhelm Bannwarth Energy transfer systems
US5750015A (en) 1990-02-28 1998-05-12 Soane Biosciences Method and device for moving molecules by the application of a plurality of electrical fields
US5126022A (en) 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
GB2244135B (en) * 1990-05-04 1994-07-13 Gen Electric Co Plc Sensor devices
US5108573A (en) * 1990-06-05 1992-04-28 The United States Of America As Represented By The United States Department Of Energy Morphology in electrochemically grown conducting polymer films
US5776672A (en) 1990-09-28 1998-07-07 Kabushiki Kaisha Toshiba Gene detection method
US5135627A (en) 1990-10-15 1992-08-04 Soane Technologies, Inc. Mosaic microcolumns, slabs, and separation media for electrophoresis and chromatography
US5294369A (en) * 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
DE4039677A1 (de) 1990-12-12 1992-06-17 Boehringer Mannheim Gmbh Universalbindefilm
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
RU1794088C (ru) 1991-03-18 1993-02-07 Институт Молекулярной Биологии Ан@ Ссср Способ определени нуклеотидной последовательности ДНК и устройство дл его осуществлени
ES2178636T3 (es) * 1991-03-27 2003-01-01 Ambri Ltd Deposito ionico en la supeerficie de un electrodo.
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
CA2123133C (en) 1991-11-07 2005-01-04 Michael J. Heller Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
DK0567635T3 (da) 1991-11-15 2000-09-25 Igen Int Inc Hurtige assays for amplifikationsprodukter
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5565552A (en) 1992-01-21 1996-10-15 Pharmacyclics, Inc. Method of expanded porphyrin-oligonucleotide conjugate synthesis
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
EP0566751B1 (en) 1992-03-23 1996-01-10 F. Hoffmann-La Roche Ag DNA detection method
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
DE69319427T2 (de) 1992-05-01 1998-12-10 Univ Pennsylvania Analyse bei messung des durchflusswiderstandes
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5296375A (en) 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5486335A (en) 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) * 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
CA2094785A1 (en) 1992-05-08 1993-11-09 Jean Gariepy Metal chelating peptide
JP3094183B2 (ja) * 1992-05-11 2000-10-03 セイコーインスツルメンツ株式会社 誘電率測定装置
JPH0641183A (ja) 1992-07-23 1994-02-15 Mitsubishi Kasei Corp オリゴヌクレオチド単分子膜
US5312527A (en) 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US5569364A (en) 1992-11-05 1996-10-29 Soane Biosciences, Inc. Separation media for electrophoresis
US5472881A (en) 1992-11-12 1995-12-05 University Of Utah Research Foundation Thiol labeling of DNA for attachment to gold surfaces
DE69333991T2 (de) 1992-11-27 2006-12-14 Canon K.K. Verfahren und Sonde zum Nachweis von Nukleinsäuren
CH685458A5 (de) 1993-03-01 1995-07-14 Disetronic Ag Sensorarray zur selektiven Feststellung oder Messung mindestens einer Stoffkomponente in einer wässerigen Lösung.
EP0690983A4 (en) 1993-03-05 1998-01-28 Univ Wollongong PULSE ELECTROCHEMICAL DETECTION BY ELECTRODES WITH ELECTROACTIVE POLYMER
US5785789A (en) * 1993-03-18 1998-07-28 Digital Equipment Corporation Low dielectric constant microsphere filled layers for multilayer electrical structures
RU2041261C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ изготовления матрицы для детектирования мисматчей
RU2041262C1 (ru) 1993-08-11 1995-08-09 Институт молекулярной биологии им.В.А.Энгельгардта РАН Способ иммобилизации водорастворимых биоорганических соединений на капиллярно-пористый носитель
RU2041263C1 (ru) 1993-08-11 1995-08-09 Геннадий Моисеевич Ершов Способ микродозирования водных растворов веществ на носитель и устройство для его осуществления
JP2948069B2 (ja) 1993-09-20 1999-09-13 株式会社日立製作所 化学分析装置
GB9320286D0 (en) * 1993-10-01 1993-11-17 Drew Scient Ltd Electro-chemical detector
US5512131A (en) * 1993-10-04 1996-04-30 President And Fellows Of Harvard College Formation of microstamped patterns on surfaces and derivative articles
US6068818A (en) * 1993-11-01 2000-05-30 Nanogen, Inc. Multicomponent devices for molecular biological analysis and diagnostics
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US20040077074A1 (en) * 1993-11-01 2004-04-22 Nanogen, Inc. Multi-chambered analysis device
US5505321A (en) 1994-12-05 1996-04-09 Teledyne Industries, Inc. Fabrication multilayer combined rigid/flex printed circuit board
US5952172A (en) 1993-12-10 1999-09-14 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5595712A (en) * 1994-07-25 1997-01-21 E. I. Du Pont De Nemours And Company Chemical mixing and reaction apparatus
CA2198489A1 (en) 1994-08-26 1996-03-07 Igen International, Inc. Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5500071A (en) * 1994-10-19 1996-03-19 Hewlett-Packard Company Miniaturized planar columns in novel support media for liquid phase analysis
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5985119A (en) 1994-11-10 1999-11-16 Sarnoff Corporation Electrokinetic pumping
DE69533554T2 (de) 1994-11-10 2005-01-27 Orchid Biosciences, Inc. Flüssigkeitsverteilungssystem
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5601982A (en) 1995-02-07 1997-02-11 Sargent; Jeannine P. Method and apparatus for determining the sequence of polynucleotides
CN1192097C (zh) 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验
US6207369B1 (en) * 1995-03-10 2001-03-27 Meso Scale Technologies, Llc Multi-array, multi-specific electrochemiluminescence testing
GB9506312D0 (en) * 1995-03-28 1995-05-17 Medical Res Council Improvements in or relating to sample processing
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
KR19990022394A (ko) 1995-06-06 1999-03-25 윌리암 제이. 버크 동전기 펌프
CA2225935A1 (en) 1995-06-27 1997-01-16 The University Of North Carolina At Chapel Hill Electrochemical detection of nucleic acid hybridization
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US20020022261A1 (en) * 1995-06-29 2002-02-21 Anderson Rolfe C. Miniaturized genetic analysis systems and methods
US5657208A (en) * 1995-07-28 1997-08-12 Hewlett-Packard Company Surface mount attachments of daughterboards to motherboards
CA2228485A1 (en) * 1995-08-03 1997-02-20 Akzo Nobel Nv Diagnostic device
JPH0961312A (ja) 1995-08-30 1997-03-07 Mochida Pharmaceut Co Ltd 簡易測定装置
US5650061A (en) * 1995-09-18 1997-07-22 The Regents Of The University Of California Large amplitude sinusoidal voltammetry
WO1997017302A1 (en) 1995-11-09 1997-05-15 David Sarnoff Research Center, Inc. Field-assisted sealing
AU704863B2 (en) * 1995-11-15 1999-05-06 Arkray, Inc. Device and method for assaying biological components in sample
US5631337A (en) 1996-01-19 1997-05-20 Soane Bioscience Thermoreversible hydrogels comprising linear copolymers and their use in electrophoresis
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US5861247A (en) 1996-01-26 1999-01-19 University Of Chicago Rapid method to detect duplex formation in sequencing by hybridization methods
US5851772A (en) 1996-01-29 1998-12-22 University Of Chicago Microchip method for the enrichment of specific DNA sequences
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
CA2250212C (en) * 1996-04-03 2010-02-09 The Perkin-Elmer Corporation Device and method for multiple analyte detection
WO1997037755A1 (en) 1996-04-09 1997-10-16 Sarnoff Corporation Plate for reaction system
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
WO1997044651A1 (en) 1996-05-22 1997-11-27 Australian Membrane And Biotechnology Research Institute Nucleic acid sensor
US5728532A (en) 1996-05-31 1998-03-17 Ackley; Donald E. Electrode configuration for matrix addressing of a molecular detection device
US6020047A (en) * 1996-09-04 2000-02-01 Kimberly-Clark Worldwide, Inc. Polymer films having a printed self-assembling monolayer
US5874046A (en) * 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
US7393645B2 (en) * 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) * 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
US7014992B1 (en) * 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7045285B1 (en) * 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
CA2270633A1 (en) 1996-11-05 1998-05-14 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7160678B1 (en) * 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US5971355A (en) * 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
US5905024A (en) 1996-12-17 1999-05-18 University Of Chicago Method for performing site-specific affinity fractionation for use in DNA sequencing
EP0951569A2 (en) 1996-12-23 1999-10-27 University Of Chicago Customized oligonucleotide microchips as multiple biosensors
US6306584B1 (en) * 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
WO1998035232A2 (en) 1997-02-06 1998-08-13 The University Of North Carolina At Chapel Hill Electrochemical detection of specific binding
US6100045A (en) 1997-02-10 2000-08-08 Dsm N.V. Detection of analytes using electrochemistry
SI20346A (sl) 1997-02-28 2001-02-28 Burstein Laboratories, Inc. Laboratorij na disku
EP0988534B1 (en) * 1997-06-12 2011-02-16 Clinical Micro Sensors, Inc. Electronic methods and apparatus for the detection of analytes
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
SE9703314D0 (sv) 1997-09-15 1997-09-15 Sangtec Medical Ab Capacity affinity sensor
US6048692A (en) * 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5945286A (en) * 1997-10-23 1999-08-31 Motorola, Inc. Electrochemical-based molecular detection apparatus and method
ES2309022T3 (es) 1997-12-24 2008-12-16 Cepheid Dispositivo y procedimiento para lisis.
US6686150B1 (en) * 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US20050053962A1 (en) * 1998-01-27 2005-03-10 Gary Blackburn Amplification of nucleic acids with electronic detection
CA2319170A1 (en) * 1998-01-27 1999-07-29 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6063573A (en) * 1998-01-27 2000-05-16 Clinical Micro Sensors, Inc. Cycling probe technology using electron transfer detection
ES2322859T3 (es) * 1998-05-01 2009-06-30 Gen-Probe Incorporated Analizador de diagnostico automatizado.
US20030087228A1 (en) * 1998-05-06 2003-05-08 Cynthia Bamdad Electronic detection of nucleic acids using monolayers
CA2331189A1 (en) 1998-05-06 1999-11-11 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
US7087148B1 (en) * 1998-06-23 2006-08-08 Clinical Micro Sensors, Inc. Binding acceleration techniques for the detection of analytes
US6761816B1 (en) 1998-06-23 2004-07-13 Clinical Micro Systems, Inc. Printed circuit boards with monolayers and capture ligands
AU4833899A (en) * 1998-06-24 2000-01-10 Therasense, Inc. Multi-sensor array for electrochemical recognition of nucleotide sequences and methods
US6132685A (en) * 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6740518B1 (en) * 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
US6541617B1 (en) * 1998-10-27 2003-04-01 Clinical Micro Sensors, Inc. Detection of target analytes using particles and electrodes
WO2000052457A1 (en) * 1999-03-02 2000-09-08 Helix Biopharma Corporation Card-based biosensor device
US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
US20040053290A1 (en) * 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
US20020177135A1 (en) * 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
EP1077264B1 (en) * 1999-06-07 2005-04-20 Fuji Photo Film Co., Ltd. DNA chip, PNA chip, and their preparation methods
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US6258593B1 (en) 1999-06-30 2001-07-10 Agilent Technologies Inc. Apparatus for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber
ES2225264T3 (es) 1999-11-12 2005-03-16 Clinical Micro Sensors, Inc. Tecnicas de aceleracion de union para la deteccion de analitos.
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
DE60125713T2 (de) 2000-01-11 2007-11-08 Clinical Micro Sensors, Inc., Pasadena Patrone, die einen Biochip enthält
CA2427669A1 (en) 2000-11-03 2002-06-06 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US20030175947A1 (en) * 2001-11-05 2003-09-18 Liu Robin Hui Enhanced mixing in microfluidic devices

Also Published As

Publication number Publication date
WO2000062931A1 (en) 2000-10-26
US20090057147A1 (en) 2009-03-05
PT1183102E (pt) 2004-05-31
US9557295B2 (en) 2017-01-31
US20120132527A1 (en) 2012-05-31
DK1183102T3 (da) 2004-04-19
US20080242553A1 (en) 2008-10-02
JP2002542461A (ja) 2002-12-10
US20090166196A1 (en) 2009-07-02
ATE256500T1 (de) 2004-01-15
US20160054261A1 (en) 2016-02-25
EP1183102B1 (en) 2003-12-17
US20070098600A1 (en) 2007-05-03
DE60007306D1 (de) 2004-01-29
AU771571B2 (en) 2004-03-25
US20050211559A1 (en) 2005-09-29
ES2213009T3 (es) 2004-08-16
EP1183102A1 (en) 2002-03-06
US8486247B2 (en) 2013-07-16
US20110180425A1 (en) 2011-07-28
WO2000062931A9 (en) 2001-11-01
EP1391241A1 (en) 2004-02-25
US20100285981A1 (en) 2010-11-11
US6942771B1 (en) 2005-09-13
CA2370879A1 (en) 2000-10-26
US7534331B2 (en) 2009-05-19
US20140087374A1 (en) 2014-03-27
US9151746B2 (en) 2015-10-06
AU4368000A (en) 2000-11-02

Similar Documents

Publication Publication Date Title
DE60007306T2 (de) Verwendung von mikrofluidischen systemen zur elektrochemischen detektion von zielanalyten
DE60125713T2 (de) Patrone, die einen Biochip enthält
DE60012511T2 (de) Mikrofluidische systeme mit mikrokugelmatrizen zum nachweis von zielanalyten
US20020090649A1 (en) High density column and row addressable electrode arrays
JP2004515231A (ja) バイオチップを多重化するための装置および方法
US20020121314A1 (en) Target analyte detection using asymmetrical self-assembled monolayers
DE60011821T2 (de) Bindungsbeschleunigungsverfahren zum nachweis von analyten
WO2002031463A9 (en) High density column and row addressable electrode arrays
US20020177135A1 (en) Devices and methods for biochip multiplexing
AU2907201A (en) Methods and compositions relating to electrical detection of nucleic acid reactions
US20070259359A1 (en) Nanoelectronic Detection of Biomolecules Employing Analyte Amplification and Reporters
DE112011106056T5 (de) Nanogap-Wandler mit selektiven Oberflächenimmobilisierungsorten
US20030209432A1 (en) Methods and compositions relating to electrical detection of nucleic acid reactions
JP2002525577A (ja) 被検体検出のためのシグナル検出法
JP2003530822A (ja) 電子的核酸検出の増幅
EP2007379A2 (en) Nanoelectronic detection of biomolecules employing analyte amplification and reporters
AU2004202695A1 (en) The use of microfluidic systems in the electrochemical detection of target analytes
WO2004099430A2 (de) Substrat als träger von ligaten
Yeung Development of electrochemistry-based DNA assay in a silicon/glass bio-device for point-of-care applications
Lee Sequence-specific electrochemical DNA detection and its implementation in integrated PCR-electrochemical microdevices
Kawde Novel bioelectrochemical assays for the detection of DNA hybridization

Legal Events

Date Code Title Description
8364 No opposition during term of opposition