DE3991505B4 - Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen - Google Patents

Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen Download PDF

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Publication number
DE3991505B4
DE3991505B4 DE3991505A DE3991505A DE3991505B4 DE 3991505 B4 DE3991505 B4 DE 3991505B4 DE 3991505 A DE3991505 A DE 3991505A DE 3991505 A DE3991505 A DE 3991505A DE 3991505 B4 DE3991505 B4 DE 3991505B4
Authority
DE
Germany
Prior art keywords
group
somatostatin
peptide
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3991505A
Other languages
German (de)
English (en)
Other versions
DE3991505T1 (de
Inventor
Rainer Dr. Albert
Eric P Dr. Krenning
Steven W. J. Prof.Dr. Lamberts
Janos Dr. Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888828364A external-priority patent/GB8828364D0/en
Priority claimed from GB898916115A external-priority patent/GB8916115D0/en
Priority claimed from GB898916761A external-priority patent/GB8916761D0/en
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE3991505B4 publication Critical patent/DE3991505B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE3991505A 1988-12-05 1989-11-30 Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen Expired - Lifetime DE3991505B4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB8828364.3 1988-12-05
GB888828364A GB8828364D0 (en) 1988-12-05 1988-12-05 Improvements in/relating to organic compounds
GB898916115A GB8916115D0 (en) 1989-07-13 1989-07-13 Improvements in or relating to organic compounds
GB8916115.2 1989-07-13
GB8916761.3 1989-07-21
GB898916761A GB8916761D0 (en) 1989-07-21 1989-07-21 Improvements in or relating to organic compounds
PCT/EP1989/001448 WO1990006949A2 (en) 1988-12-05 1989-11-30 Peptide derivatives

Publications (1)

Publication Number Publication Date
DE3991505B4 true DE3991505B4 (de) 2006-04-20

Family

ID=27264222

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3991505A Expired - Lifetime DE3991505B4 (de) 1988-12-05 1989-11-30 Somatostatinpeptide, deren Analoga oder Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Country Status (24)

Country Link
JP (2) JP2726320B2 (sv)
KR (1) KR0156541B1 (sv)
AT (1) AT403476B (sv)
AU (1) AU633859B2 (sv)
BE (1) BE1002296A5 (sv)
CA (1) CA2004532C (sv)
CH (1) CH678329A5 (sv)
DE (1) DE3991505B4 (sv)
DK (1) DK175338B1 (sv)
ES (1) ES2023533A6 (sv)
FI (1) FI102540B1 (sv)
FR (1) FR2639947B1 (sv)
GB (1) GB2225579B (sv)
HK (1) HK189995A (sv)
HU (2) HUT53375A (sv)
IE (1) IE62091B1 (sv)
IL (1) IL92534A (sv)
LU (1) LU87633A1 (sv)
MY (1) MY106120A (sv)
NL (1) NL194828C (sv)
PT (1) PT92487B (sv)
SA (1) SA96160495B1 (sv)
SE (1) SE508799C2 (sv)
WO (1) WO1990006949A2 (sv)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639371B2 (en) * 1987-07-10 1993-07-22 Novartis Ag Method of treating breast cancer
DE3845000C2 (de) * 1987-07-10 1998-11-19 Novartis Ag Anwendung von Octreotid zur Behandlung von Brustkrebs
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US7238340B1 (en) 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
ATE181240T1 (de) * 1991-02-08 1999-07-15 Biomeasure Inc Verwendung von somatostatinanalogen zur behandlung von melanomen
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
CA2102633A1 (en) * 1991-06-03 1992-12-04 Peter H. Cox Radiolabelled somatostatin derivatives, their preparation and use
ES2150916T3 (es) * 1991-08-29 2000-12-16 Mallinckrodt Medical Inc Utilizacion del acido gentisico o del alcohol gentisilico para estabilizar peptidos y proteinas radiomarcados.
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
ES2155447T3 (es) * 1992-01-03 2001-05-16 Rhomed Inc Aplicaciones farmaceuticas de peptidos-iones metalicos.
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
ATE203417T1 (de) * 1992-02-05 2001-08-15 Mallinckrodt Inc Radioaktiv markierte somatostatin
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
EP0636032A1 (en) * 1992-03-25 1995-02-01 Mallinckrodt Medical, Inc. Method of intraoperatively detecting and locating tumoral tissues
US5871711A (en) * 1992-06-23 1999-02-16 Diatide, Inc. Radioactively-labeled somatostatin-derived peptides for imaging and therapeutic uses
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
EP0607103A3 (en) * 1993-01-12 1997-07-09 Sandoz Ltd Somatostatin analogs containing chelating groups and their radiolabeled compositions.
US5650134A (en) * 1993-01-12 1997-07-22 Novartis Ag (Formerly Sandoz Ltd.) Peptides
EP0683676A4 (en) * 1993-02-02 1998-09-30 Neorx Corp BIODISTRIBUTION DIRECTED FROM SMALL MOLECULES.
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
EP1099707A3 (en) * 1993-06-23 2002-01-09 Diatide, Inc. Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
GB9417873D0 (en) 1994-09-06 1994-10-26 Sandoz Ltd Organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
FI965181A (sv) 1996-12-20 1998-06-21 Map Medical Technologies Oy Polyalkohol-peptidderivat
US7175953B2 (en) 1999-04-09 2007-02-13 Institute Fuer Diagnostik Forschung Short-warp peptide-dye conjugate as contrast agent for optical diagnostic
DE19917713A1 (de) * 1999-04-09 2000-10-19 Diagnostikforschung Inst Kurzkettige Peptid-Farbstoffkonjugate als Konstrastmittel für die optische Diagnostik
US6630570B1 (en) 1999-04-09 2003-10-07 Insitut für Diagnostikforschung GmbH Short-chain peptide-dye conjugates as contrast media for optical diagnosis
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
CA2443273C (en) * 2001-04-23 2011-09-27 Mallinckrodt Inc. Tc and re labeled radioactive glycosylated octreotide derivatives
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
BRPI0414512B8 (pt) * 2003-09-17 2021-05-25 Board Of Regentes The Univ Of Texas System composição para reproduzir imagens de um pâncreas e uso desta
EP2067786A1 (en) 2007-12-07 2009-06-10 ITALFARMACO S.p.A. Novel non selective analogs of somatostatin
WO2014081655A1 (en) 2012-11-21 2014-05-30 Serene Oncology, Llc Tin-1 17m comprising somatostatin receptor binding compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083129B1 (en) * 1981-12-29 1986-02-05 Mallinckrodt Diagnostica (Holland) B.V. Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4707352A (en) * 1984-01-30 1987-11-17 Enzo Biochem, Inc. Method of radioactively labeling diagnostic and therapeutic agents containing a chelating group
DE3511206A1 (de) * 1985-03-28 1986-10-09 Sandoz-Patent-GmbH, 7850 Lörrach Neue polypeptidderivate, ihre herstellung und pharmazeutische praeparate, welche diese polypeptidderivate enthalten
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
DE3522638A1 (de) * 1985-06-25 1987-01-08 Diamalt Ag Neue somatostatin-derivate
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4732974A (en) * 1986-03-05 1988-03-22 Mallinckrodt, Inc. Metal ion labeling of carrier molecules
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
CH679045A5 (sv) * 1987-06-29 1991-12-13 Sandoz Ag
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
FR2638968B1 (fr) * 1988-11-11 1994-10-07 Sandoz Sa Nouvelle utilisation therapeutique de la somatostatine et de ses analogues et derives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0083129B1 (en) * 1981-12-29 1986-02-05 Mallinckrodt Diagnostica (Holland) B.V. Method of preparing radionuclide-labelled proteins, in particular antibodies or antibody fragments
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents

Also Published As

Publication number Publication date
FR2639947B1 (fr) 1995-04-21
KR0156541B1 (ko) 1998-10-15
NL194828B (nl) 2002-12-02
DK612689A (da) 1990-06-06
GB2225579B (en) 1993-03-17
GB2225579A (en) 1990-06-06
WO1990006949A2 (en) 1990-06-28
MY106120A (en) 1995-03-31
SE8904087D0 (sv) 1989-12-04
FR2639947A1 (fr) 1990-06-08
HU211468A9 (en) 1995-11-28
AT403476B (de) 1998-02-25
IL92534A (en) 1994-06-24
HK189995A (en) 1995-12-29
KR900009697A (ko) 1990-07-05
SE508799C2 (sv) 1998-11-09
AU4587189A (en) 1990-06-14
JP2726320B2 (ja) 1998-03-11
CA2004532C (en) 2000-02-22
CH678329A5 (sv) 1991-08-30
BE1002296A5 (fr) 1990-11-20
IE62091B1 (en) 1994-12-14
DK612689D0 (da) 1989-12-05
GB8927255D0 (en) 1990-01-31
JPH02184698A (ja) 1990-07-19
ES2023533A6 (es) 1992-01-16
ATA901789A (de) 1997-07-15
PT92487A (pt) 1990-06-29
WO1990006949A3 (en) 1990-07-26
NL194828C (nl) 2003-04-03
HU896359D0 (en) 1990-02-28
FI102540B (sv) 1998-12-31
FI102540B1 (sv) 1998-12-31
SE8904087L (sv) 1991-06-05
JPH1095737A (ja) 1998-04-14
FI895809A0 (fi) 1989-12-04
HUT53375A (en) 1990-10-28
AU633859B2 (en) 1993-02-11
JP3686503B2 (ja) 2005-08-24
NL8902981A (nl) 1990-07-02
IE893866L (en) 1990-06-05
SA96160495B1 (ar) 2006-08-23
DK175338B1 (da) 2004-08-30
CA2004532A1 (en) 1990-06-05
LU87633A1 (fr) 1991-09-18
PT92487B (pt) 1996-01-31

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8364 No opposition during term of opposition