DE3876401D1 - N-terminale fragmente von menschlichem serumalbumin. - Google Patents

N-terminale fragmente von menschlichem serumalbumin.

Info

Publication number
DE3876401D1
DE3876401D1 DE8888310000T DE3876401T DE3876401D1 DE 3876401 D1 DE3876401 D1 DE 3876401D1 DE 8888310000 T DE8888310000 T DE 8888310000T DE 3876401 T DE3876401 T DE 3876401T DE 3876401 D1 DE3876401 D1 DE 3876401D1
Authority
DE
Germany
Prior art keywords
serum albumin
human serum
terminal fragments
hsa
polypeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8888310000T
Other languages
English (en)
Other versions
DE3876401T2 (de
Inventor
Peter James Senior
Michael John Geisow
Edward Hinchliffe
David James Ballance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albumedix Ltd
Original Assignee
Delta Biotechnology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delta Biotechnology Ltd filed Critical Delta Biotechnology Ltd
Application granted granted Critical
Publication of DE3876401D1 publication Critical patent/DE3876401D1/de
Publication of DE3876401T2 publication Critical patent/DE3876401T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
DE8888310000T 1987-10-30 1988-10-25 N-terminale fragmente von menschlichem serumalbumin. Expired - Lifetime DE3876401T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878725529A GB8725529D0 (en) 1987-10-30 1987-10-30 Polypeptides

Publications (2)

Publication Number Publication Date
DE3876401D1 true DE3876401D1 (de) 1993-01-14
DE3876401T2 DE3876401T2 (de) 1993-04-22

Family

ID=10626211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888310000T Expired - Lifetime DE3876401T2 (de) 1987-10-30 1988-10-25 N-terminale fragmente von menschlichem serumalbumin.

Country Status (17)

Country Link
US (1) US5380712A (de)
EP (1) EP0322094B1 (de)
JP (1) JPH02194A (de)
KR (1) KR0153516B1 (de)
AT (1) ATE82858T1 (de)
AU (1) AU619768B2 (de)
CA (1) CA1341298C (de)
DE (1) DE3876401T2 (de)
DK (1) DK175046B1 (de)
ES (1) ES2053758T3 (de)
FI (1) FI101381B1 (de)
GB (1) GB8725529D0 (de)
GR (1) GR3007162T3 (de)
HU (1) HU209145B (de)
IE (1) IE61050B1 (de)
IL (1) IL88223A (de)
ZA (1) ZA888118B (de)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
GB8909916D0 (en) * 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
US5766883A (en) * 1989-04-29 1998-06-16 Delta Biotechnology Limited Polypeptides
ATE92107T1 (de) * 1989-04-29 1993-08-15 Delta Biotechnology Ltd N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
GB8927480D0 (en) * 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5698517A (en) * 1994-03-21 1997-12-16 University Of Hawaii, Office Of Technology Transfer And Economic Development Thyroxin-binding HSA fragments
US5674842A (en) * 1994-10-26 1997-10-07 Health Research, Incorporated Growth inhibitory peptide
US7820798B2 (en) 1994-11-07 2010-10-26 Human Genome Sciences, Inc. Tumor necrosis factor-gamma
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
EP0947581A4 (de) * 1996-08-08 2004-07-28 Mitsubishi Pharma Corp Kulturmedium und seine verwendung.
US6274305B1 (en) 1996-12-19 2001-08-14 Tufts University Inhibiting proliferation of cancer cells
GB9815909D0 (en) 1998-07-21 1998-09-16 Btg Int Ltd Antibody preparation
US20030190740A1 (en) * 1998-10-13 2003-10-09 The University Of Georgia Research Foundation, Inc Stabilized bioactive peptides and methods of identification, synthesis, and use
DE69926009D1 (de) * 1998-10-13 2005-08-04 Univ Georgia Res Found Stabilisierte bioaktive peptide und methoden zu ihrer identifikation, synthese und verwendung
EP2267026A1 (de) 2000-04-12 2010-12-29 Human Genome Sciences, Inc. Albuminfusionsproteine
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050100991A1 (en) * 2001-04-12 2005-05-12 Human Genome Sciences, Inc. Albumin fusion proteins
US20030031675A1 (en) 2000-06-06 2003-02-13 Mikesell Glen E. B7-related nucleic acids and polypeptides useful for immunomodulation
AU6842701A (en) 2000-06-16 2002-01-14 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
DE60140461D1 (de) * 2000-09-11 2009-12-24 Genzyme Corp Muc1 extrazelluläre domäne und zusammensetzungen für krebsbehandlung, und davon abgeleitete verfahren
ES2311560T3 (es) 2000-12-07 2009-02-16 Eli Lilly And Company Proteinas de fusion glp-1.
EP1958642A1 (de) * 2000-12-22 2008-08-20 Dana-Farber Cancer Institute Regulierung des Zellwachstums durch MUC1
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
US20050054051A1 (en) * 2001-04-12 2005-03-10 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
DE60236646D1 (de) 2001-04-13 2010-07-22 Human Genome Sciences Inc Anti-VEGF-2 Antikörper
JP4309758B2 (ja) 2001-05-25 2009-08-05 ヒューマン ジノーム サイエンシーズ, インコーポレイテッド Trailレセプターに免疫特異的に結合する抗体
WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
EP2279755B1 (de) 2001-10-10 2014-02-26 ratiopharm GmbH Neumodulierung und Glykokonjugation von Fibroblasten-Wachstumsfaktor (FGF)
WO2004099231A2 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
EP2305314B1 (de) 2001-10-10 2015-12-23 ratiopharm GmbH Neumodulierung und Glykokonjugation von Antikörpern
PT1463751E (pt) * 2001-12-21 2013-08-26 Human Genome Sciences Inc Proteínas de fusão de albumina
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003066078A1 (en) 2002-02-07 2003-08-14 Delta Biotechnology Limited Hiv inhibiting proteins
US20060002935A1 (en) 2002-06-28 2006-01-05 Domantis Limited Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
WO2004041865A2 (en) 2002-11-08 2004-05-21 Ablynx N.V. Stabilized single domain antibodies
WO2004092339A2 (en) * 2003-04-11 2004-10-28 Ilex Products, Inc. Modulation of muc1 mediated signal transduction
US8129506B2 (en) * 2003-10-24 2012-03-06 Genzyme Corporation Modulation of the interaction of MUC1 with MUC1 ligands
PL1729795T3 (pl) 2004-02-09 2016-08-31 Human Genome Sciences Inc Białka fuzyjne albuminy
EP1718367A1 (de) * 2004-02-23 2006-11-08 Genzyme Corporation Muc1-antagonisten-verstärkung von durch todes-rezeptor-ligand ausgelöster apoptose
EP1786463A4 (de) 2004-03-26 2009-05-20 Human Genome Sciences Inc Antikörper gegen nogo-rezeptor
EP2301963A1 (de) 2004-09-23 2011-03-30 Vasgene Therapeutics, Inc. Polypeptidverbindungen zur Hemmung von Angiogenese und Tumorwachstum
CN101724071A (zh) 2004-10-08 2010-06-09 杜门蒂斯有限公司 抗肿瘤坏死因子受体1的单域抗体及其使用方法
AU2006344395B2 (en) 2005-10-13 2013-05-02 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive diseases
JP5256199B2 (ja) 2006-08-07 2013-08-07 テヴァ バイオファーマシューティカルズ ユーエスエー,インコーポレーティッド アルブミン−インスリン融合タンパク質
DK2615108T3 (en) 2006-09-08 2017-01-30 Ambrx Inc Modified human plasma polypeptide or fc scaffolds and their applications
EP2423221B1 (de) 2007-01-30 2015-04-29 Epivax, Inc. Regulatorische t-zellen-epitope sowie zusammensetzungen damit und anwendungen davon
WO2008097844A2 (en) * 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
US7972870B2 (en) 2007-02-02 2011-07-05 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3
EP2251035A3 (de) 2007-04-12 2011-03-16 Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre Neue Virulenzfaktoren von Pneumokokken
AU2008237632B2 (en) 2007-04-17 2014-01-16 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
CN103965347B (zh) 2007-05-02 2017-07-18 Ambrx公司 经修饰干扰素β多肽和其用途
KR20100018040A (ko) 2007-06-06 2010-02-16 도만티스 리미티드 프로테아제 내성 폴리펩티드를 선택하는 방법
AR068767A1 (es) 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
AU2008326324B9 (en) 2007-11-20 2012-11-15 Ambrx, Inc. Modified insulin polypeptides and their uses
UA118536C2 (uk) 2008-07-23 2019-02-11 Амбркс, Інк. Модифікований поліпептид бичачого гранулоцитарного колонієстимулювального фактора та його застосування
EP2174664A1 (de) 2008-10-07 2010-04-14 Stichting Katholieke Universiteit, more particularly the Radboud University Nijmegen Medical Centre Neue Virulenzfaktoren von Pneumokokken
IT1392551B1 (it) * 2008-11-25 2012-03-09 Bioindustry Park Del Canavese S P A Biomarcatori per la diagnosi e per rilevare la progressione di malattie neurodegenerative, in particolare della sclerosi laterale amiotrofica
WO2010063818A2 (en) 2008-12-05 2010-06-10 Glaxo Group Limited Methods for selecting protease resistant polypeptides
US9493545B2 (en) 2009-02-11 2016-11-15 Albumedix A/S Albumin variants and conjugates
JP2012517818A (ja) 2009-02-19 2012-08-09 グラクソ グループ リミテッド 改善された抗tnfr1ポリペプチド、抗体可変ドメインおよびアンタゴニスト
MA33279B1 (fr) 2009-04-27 2012-05-02 Novartis Ag Compositions et procédés pour l'augmentation de la croissance des muscles
EA201101572A1 (ru) 2009-04-27 2012-05-30 Новартис Аг Композиции и способы применения терапевтических антител, специфичных в отношении субъединицы бета1 рецептора il-12
CA2768460A1 (en) 2009-07-16 2011-01-20 Glaxo Group Limited Antagonists, uses & methods for partially inhibiting tnfr1
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
TW201125877A (en) 2009-10-27 2011-08-01 Glaxo Group Ltd Stable anti-TNFR1 polypeptides, antibody variable domains & and antagonists
GB0919054D0 (en) 2009-10-30 2009-12-16 Isis Innovation Treatment of obesity
EP3421491A3 (de) 2009-10-30 2019-03-27 Albumedix Ltd Albuminvarianten
GB0919837D0 (en) 2009-11-13 2009-12-30 Isis Innovation Method of treatment and screening method
CN102753573A (zh) 2009-12-21 2012-10-24 Ambrx公司 经过修饰的牛促生长素多肽和其用途
NZ600363A (en) 2009-12-21 2014-07-25 Ambrx Inc Modified porcine somatotropin polypeptides and their uses
US9290550B2 (en) 2010-02-23 2016-03-22 Stitchting Katholieke Universiteit Combination vaccine for Streptococcus
JP5969458B2 (ja) 2010-04-09 2016-08-17 アルブミディクス アクティーゼルスカブ アルブミン誘導体及び変異体
BR112013003522B1 (pt) 2010-08-17 2021-05-25 Ambrx, Inc. polipeptídeos relaxina modificados compreendendo um aminoácido não codificado naturalmente, seu método de preparação e seu uso, bem como ácido nucleico e célula hospedeira
CN103154037A (zh) 2010-10-05 2013-06-12 诺瓦提斯公司 抗IL12Rβ1抗体及它们在治疗自身免疫病和炎性疾病中的用途
WO2012075340A2 (en) 2010-12-01 2012-06-07 Alderbio Holdings Llc Anti-ngf compositions and use thereof
CN103732628B (zh) 2011-03-03 2017-06-23 酵活有限公司 多价杂多聚体骨架设计和构建体
DK2707391T3 (en) 2011-05-13 2018-02-05 Gamamabs Pharma ANTIBODIES AGAINST HER3
KR101965461B1 (ko) 2011-05-20 2019-04-04 앨더바이오 홀딩스 엘엘씨 필요한 대상체, 특히 편두통 환자의 광선공포증 또는 광선 혐오증을 예방 또는 억제하기 위한 항-cgrp 항체 및 항체 단편의 용도
LT3495392T (lt) 2011-05-20 2021-09-27 H. Lundbeck A/S Anti-cgrp kompozicijos ir jų panaudojimas
NZ732875A (en) 2011-05-20 2022-08-26 H Lundbeck As Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
BR112013032899A2 (pt) 2011-06-22 2017-01-24 Inserm Inst Nat De La Santé Et De La Rech Médicale anticorpos anti-axl e utilizações dos mesmos
CA2839508A1 (en) 2011-06-22 2012-12-27 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-axl antibodies and uses thereof
BR112014000055A2 (pt) 2011-07-01 2017-06-13 Bayer Ip Gmbh polipeptídeos de fusão de relaxina e usos dos mesmos
HUE040276T2 (hu) 2011-07-01 2019-02-28 Novartis Ag Eljárás metabolikus rendellenességek kezelésére
BR112014000474A2 (pt) 2011-07-08 2017-02-21 Bayer Ip Gmbh proteínas de fusão libertadoras de relaxina e suas utilizações
US20140187744A1 (en) * 2011-08-10 2014-07-03 Nipro Corporation Bilirubin Excretion Enhancer
EP2780364A2 (de) 2011-11-18 2014-09-24 Eleven Biotherapeutics, Inc. Proteine mit verbesserter halbwertzeit und anderen eigenschaften
BR112014018679A2 (pt) 2012-03-16 2017-07-04 Novozymes Biopharma Dk As variantes de albumina
EP2851429B1 (de) 2012-05-18 2019-07-24 Adda Biotech Inc. Protein und proteinkonjugate zur behandlung von diabetes und anwendungen davon
JP6498601B2 (ja) 2012-07-13 2019-04-10 ザイムワークス,インコーポレイテッド 多価ヘテロ多量体足場設計および構築物
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
BR112015010318A2 (pt) 2012-11-08 2017-08-22 Albumedix As Variantes de albumina
UY35315A (es) 2013-02-08 2014-09-30 Novartis Ag Anticuerpos anti-il-17a y su uso en el tratamiento de trastornos autoinmunes e inflamatorios
WO2014165093A2 (en) 2013-03-13 2014-10-09 Bristol-Myers Squibb Company Fibronectin based scaffold domains linked to serum albumin or a moiety binding thereto
SG11201510618YA (en) 2013-07-03 2016-03-30 Alder Biopharmaceuticals Inc Regulation of glucose metabolism using anti-cgrp antibodies
BR112016002198A2 (pt) 2013-08-14 2017-09-12 Novartis Ag métodos de tratamento de miosite por corpos de inclusão esporádica
WO2015067986A1 (en) 2013-11-07 2015-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Neuregulin allosteric anti-her3 antibody
WO2015081891A1 (en) 2013-12-06 2015-06-11 Baikang (Suzhou) Co., Ltd Bioreversable promoieties for nitrogen-containing and hydroxyl-containing drugs
WO2015097267A1 (en) * 2013-12-23 2015-07-02 Covalab mTG SUBSTRATES FOR COVALENT CONJUGATION OF COMPOUNDS
TW201622746A (zh) 2014-04-24 2016-07-01 諾華公司 改善或加速髖部骨折術後身體復原之方法
WO2015198199A1 (en) 2014-06-23 2015-12-30 Novartis Ag Hsa-gdf-15 fusion polypeptide and use thereof.
EP3161001A2 (de) 2014-06-25 2017-05-03 Novartis AG Il17-a spezifische antikörper die mit hyaluronan bindenden peptid-marker fusioniert sind
WO2016079597A1 (en) 2014-11-19 2016-05-26 Axon Neuroscience Se Humanized tau antibodies in alzheimer's disease
EP3229836B1 (de) 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Menschliche monoklonale antikörper gegen axl
EP3233916A4 (de) 2014-12-19 2018-06-06 Alder Biopharmaceuticals, Inc. Humanisierte anti-acth-antikörper und verwendungen davon
NL2014148B1 (en) 2015-01-16 2017-01-05 Univ Erasmus Med Ct Rotterdam Combination vaccine for camelids.
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
RU2021129201A (ru) 2015-05-19 2021-11-09 Йейл Юниверсити Композиции для лечения патологических состояний кальцификации и способы их применения
EP3298044B1 (de) 2015-05-22 2021-08-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Menschliche monoklonale antikörperfragmente zur hemmung sowohl der katalytischen cath-d-aktivität und als auch deren bindung an den lrp1-rezeptor
AU2016303688B2 (en) 2015-07-31 2023-06-15 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
CN108137674B (zh) 2015-08-20 2022-12-06 阿尔布梅迪克斯医疗有限公司 白蛋白变体和缀合物
EP3365027B1 (de) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu-spezifische antikörper und deren verwendeng zur hemmung von biofilm
HUE061424T2 (hu) 2015-10-30 2023-06-28 Univ California Növekedési faktor bétára reagáló polipeptidek transzformálása és azok felhasználási módszerei
CN108367053A (zh) 2015-12-22 2018-08-03 诺华股份有限公司 使用生长分化因子15(gdf-15)治疗或改善代谢性疾病的方法
WO2017162678A1 (en) 2016-03-22 2017-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Humanized anti-claudin-1 antibodies and uses thereof
CN109311977B (zh) 2016-04-15 2022-06-14 H.伦德贝克公司 人源化的抗pacap抗体及其用途
US11186634B2 (en) 2016-07-29 2021-11-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies targeting tumor associated macrophages and uses thereof
EP3506943A4 (de) 2016-09-02 2020-04-22 The Regents of The University of California Verfahren und zusammensetzungen mit interleukin-6-rezeptor-alpha-bindenden einkettigen variablen fragmenten
EP3565834A1 (de) 2017-01-04 2019-11-13 The Research Institute at Nationwide Children's Hospital Antikörperfragmente zur behandlung von biofilmbedingten erkrankungen
WO2018129078A1 (en) 2017-01-04 2018-07-12 Research Institute At Nationwide Children's Hospital Dnabii vaccines and antibodies with enhanced activity
WO2018158398A1 (en) 2017-03-02 2018-09-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
CA3056088A1 (en) 2017-03-15 2018-09-20 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
KR102628323B1 (ko) 2017-03-24 2024-01-22 노바르티스 아게 심장질환 예방 및 치료 방법
UY37758A (es) 2017-06-12 2019-01-31 Novartis Ag Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos
AU2018292579A1 (en) 2017-06-28 2019-12-05 Novartis Ag Methods for preventing and treating urinary incontinence
MX2020005473A (es) 2017-11-27 2020-08-27 Purdue Pharma Lp Anticuerpos humanizados que se dirigen al factor tisular humano.
EP3552631A1 (de) 2018-04-10 2019-10-16 Inatherys Antikörper-arzneimittel-konjugate und deren verwendungen zur behandlung von krebs
US20220047701A1 (en) 2018-09-10 2022-02-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of her2/neu antibody with heme for treating cancer
AU2019355194A1 (en) 2018-10-05 2021-04-22 Research Institute At Nationwide Children's Hospital Compositions and methods for enzymatic disruption of bacterial biofilms
US20220098252A1 (en) 2019-01-25 2022-03-31 Ospedale San Raffaele S.R.L. Inhibitor of dux4 and uses thereof
CN113631573B (zh) 2019-03-25 2024-06-04 国家医疗保健研究所 抗Tau抗体及其在制备用于治疗疾病的药物中的用途
KR20220019785A (ko) 2019-06-12 2022-02-17 노파르티스 아게 나트륨이뇨 펩티드 수용체 1 항체 및 사용 방법
CA3145385A1 (en) 2019-07-08 2021-01-14 Steven D. Goodman Antibody compositions for disrupting biofilms
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
CN114450304B (zh) 2019-09-27 2023-12-12 国家医疗保健研究所 抗苗勒管抑制物质抗体及其用途
CN115175680A (zh) 2019-10-18 2022-10-11 加利福尼亚大学董事会 Plxdc激活剂及其用于治疗血管病症的用途
EP4072682A1 (de) 2019-12-09 2022-10-19 Institut National de la Santé et de la Recherche Médicale (INSERM) Antikörper mit spezifität gegen her4 und verwendungen davon
WO2021140209A1 (en) 2020-01-10 2021-07-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Rspo1 proteins and their use
KR20210124867A (ko) 2020-04-06 2021-10-15 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료
KR20230008751A (ko) 2020-05-12 2023-01-16 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 피부 t-세포 림프종 및 tfh 유래된 림프종을 치료하는 신규한 방법
CA3187283A1 (en) 2020-06-29 2022-01-06 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-protein s single-domain antibodies and polypeptides comprising thereof
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
EP4259661A1 (de) 2020-12-14 2023-10-18 Novartis AG Reverse bindemittel für anti-natriuretische peptidrezeptor-1 (npr1)-antikörper und verwendungen davon
KR20240023123A (ko) 2021-06-22 2024-02-20 노파르티스 아게 화농성 한선염의 치료에 사용하기 위한 이중특이적 항체
WO2023285686A2 (en) 2021-07-15 2023-01-19 Diogenx Recombinant variants of r-spondin proteins and their use
KR20240049275A (ko) 2021-08-27 2024-04-16 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용한 군발성 두통의 치료
WO2023170247A1 (en) 2022-03-11 2023-09-14 Mablink Bioscience Antibody-drug conjugates and their uses
TW202405009A (zh) 2022-03-30 2024-02-01 瑞士商諾華公司 使用抗利尿鈉肽受體1(npr1)抗體治療障礙之方法
WO2024052503A1 (en) 2022-09-08 2024-03-14 Institut National de la Santé et de la Recherche Médicale Antibodies having specificity to ltbp2 and uses thereof
WO2024056668A1 (en) 2022-09-12 2024-03-21 Institut National de la Santé et de la Recherche Médicale New anti-itgb8 antibodies and its uses thereof
EP4389762A1 (de) 2022-12-23 2024-06-26 Ospedale San Raffaele S.r.l. Inhibitoren der dux4-aktivität und ihre therapeutische verwendung.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL66614A (en) * 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
EP0091527A3 (de) * 1981-12-14 1984-07-25 The President And Fellows Of Harvard College DNS Sequenzen, rekombinante DNS Moleküle und Verfahren zur Herstellung von menschlichem Serum Albumin ähnlichen Polypeptiden
JPS6041487A (ja) * 1983-04-25 1985-03-05 ジエネンテツク・インコ−ポレイテツド 酵母発現系でのアルフア因子配列の使用
JPS6087792A (ja) * 1983-09-23 1985-05-17 ジェネックス・コーポレイション 雑種制御領域
GB8510219D0 (en) * 1985-04-22 1985-05-30 Bass Plc Isolation of fermentation products
AU5890286A (en) * 1985-06-17 1986-12-24 Genex Corp. Cloned human serum albumin gene
GB8615701D0 (en) * 1986-06-27 1986-08-06 Delta Biotechnology Ltd Stable gene integration vector
GB8620926D0 (en) * 1986-08-29 1986-10-08 Delta Biotechnology Ltd Yeast promoter

Also Published As

Publication number Publication date
IE61050B1 (en) 1994-09-21
ZA888118B (en) 1989-07-26
CA1341298C (en) 2001-09-25
EP0322094B1 (de) 1992-12-02
HUT47977A (en) 1989-04-28
FI884993A (fi) 1989-05-01
HU209145B (en) 1994-03-28
KR0153516B1 (ko) 1998-10-15
DK600688A (da) 1989-06-21
AU619768B2 (en) 1992-02-06
FI101381B (fi) 1998-06-15
US5380712A (en) 1995-01-10
ES2053758T3 (es) 1994-08-01
DK600688D0 (da) 1988-10-28
FI884993A0 (fi) 1988-10-28
FI101381B1 (fi) 1998-06-15
GB8725529D0 (en) 1987-12-02
DE3876401T2 (de) 1993-04-22
IL88223A0 (en) 1989-06-30
KR890006668A (ko) 1989-06-15
DK175046B1 (da) 2004-05-10
JPH02194A (ja) 1990-01-05
IE883280L (en) 1989-04-30
IL88223A (en) 1994-10-07
AU2404688A (en) 1989-05-18
EP0322094A1 (de) 1989-06-28
ATE82858T1 (de) 1992-12-15
GR3007162T3 (de) 1993-07-30

Similar Documents

Publication Publication Date Title
ATE82858T1 (de) N-terminale fragmente von menschlichem serumalbumin.
FI873141A0 (fi) Daeggdjurs interleukin-4.
DE69533556D1 (de) N-terminal modifizierte Polypeptide, und Herstellungsprozess
ATE110276T1 (de) Blutersatz.
DE3874798D1 (de) Therapeutisches proteinagens in form von aerosol.
DE3884356D1 (de) Verfahren zur Herstellung von Fremdprotein in Hefe, Rekombinant DNS, Transformant.
ES2039666T3 (es) Concentrado de proteinas coagulables por la trombina, su procedimiento de obtencion y su utilizacion terapeutica.
DE69229862T2 (de) Cysteinfreie il-6 mutanten
DE69126049D1 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
DE3884680D1 (de) Äusseres Membranprotein F von Pseudomonas aeruginosa.
ATE82985T1 (de) Strukturelles phosphoprotein (pp 150) des menschlichen cytomegalovirus, seine herstellung und verwendung.
YU61893A (sh) Modifikovani faktor-4 krvnih pločica
DE58909261D1 (de) Ancrod-proteine, ihre herstellung und verwendung.
DE59106997D1 (de) Ancrod ähnliche proteine, ihre herstellung und verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVOZYMES DELTA LTD., NOTTINGHAM, GB